Decline in circulating insulin-like growth factors and mortality in older adults: Cardiovascular health study all-stars study

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 6, 2012, Pages 1970-1976

  Kaplan, Robert C ^a   Bùžková, Petra ^b   Cappola, Anne R ^c   Strickler, Howard D ^a   McGinn, Aileen P ^a   Mercer, Laina D ^b   Arnold, Alice M ^b   Pollak, Michael N ^d   Newman, Anne B ^e  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CREATININE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C;

AFRICAN AMERICAN; AGED; AGING; ALBUMIN BLOOD LEVEL; ARTICLE; BODY MASS; CAUCASIAN; CAUSE OF DEATH; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; FEMALE; HUMAN; LONGITUDINAL STUDY; MALE; MORTALITY; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RACE DIFFERENCE; RISK ASSESSMENT; SEX DIFFERENCE;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLLOW-UP STUDIES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LONGITUDINAL STUDIES; MALE; MORTALITY; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 84861982809     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-2967     Document Type: Article

References (25)

1. Le Roith D 1997 Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors.NEngl JMed336:633-640
2. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M 2004 Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363:1346-1353 (Pubitemid 38529873)
3. Vasan RS, Sullivan LM, D'Agostino RB, Roubenoff R, Harris T, Sawyer DB, Levy D, Wilson PW 2003 Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med 139:642-648
4. Kaplan RC, McGinn AP, Pollak MN, Kuller L, Strickler HD, Rohan TE, Cappola AR, Xue X, Psaty BM 2008 High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderly. Am Heart J 155:1006-1012
5. Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH 2006 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444:1038-1043 (Pubitemid 46018517)
6. Hilding A, Brismar K, Degerblad M, Thorén M, Hall K 1995 Altered relation between circulating levels of insulin-like growth factor-binding protein-1 and insulin in growth hormone-deficient patients and insulin-dependent diabetic patients compared to that in healthy subjects. J Clin Endocrinol Metab 80:2646-2652
7. Liu H, Bravata DM, Olkin I, Nayak S, Roberts B, Garber AM, Hoffman AR 2007 Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med 146:104-115 (Pubitemid 351640014)
8. Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, Grunfeld C 1996 Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 124:708-716 (Pubitemid 26117919)
9. Blackman MR, Sorkin JD, Münzer T, Bellantoni MF, Busby-White-head J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM 2002 Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288:2282-2292 (Pubitemid 35291758)
10. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell Jr FE, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO 2008 Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med 149:601-611
11. Perls TT, Reisman NR, Olshansky SJ 2005 Provision or distribution of growth hormone for "antiaging": clinical and legal issues. JAMA 294:2086-2090 (Pubitemid 41539943)
12. Kaplan RC, McGinn AP, Pollak MN, Kuller L, Strickler HD, Rohan TE, Xue X, Kritchevsky SB, Newman AB, Psaty BM 2008 Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults. J Am Geriatr Soc 56:652-660 (Pubitemid 351473531)
13. Hu D, Pawlikowska L, Kanaya A, Hsueh WC, Colbert L, Newman AB, Satterfield S, Rosen C, Cummings SR, Harris TB, Ziv E 2009 Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study. J Am Geriatr Soc 57:1213-1218
14. Brugts MP, van den Beld AW, Hofland LJ, van der Wansem K, van Koetsveld PM, Frystyk J, Lamberts SW, Janssen JA 2008 Low circulating insulin-like growth factor I bioactivity in elderly men is associated with increased mortality. J Clin Endocrinol Metab 93:2515-2522 (Pubitemid 352008515)
15. van Bunderen CC, van Nieuwpoort IC, van Schoor NM, Deeg DJ, Lips P, Drent ML 2010 The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: a population-based study. J Clin Endocrinol Metab 95:4616-4624
16. Friedrich N, Haring R, Nauck M, Lüdemann J, Rosskopf D, Spilcke-Liss E, Felix SB, Dörr M, Brabant G, Völzke H, Wallaschofski H 2009 Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J Clin Endocrinol Metab 94:1732-1739
17. Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D 2004 The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab 89:114-120 (Pubitemid 38183869)
18. Cushman M, Cornell ES, Howard PR, Bovill EG, Tracy RP 1995 Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem 41:264-270
19. Domené HM, Bengolea SV, Martínez AS, Ropelato MG, Pennisi P, Scaglia P, Heinrich JJ, Jasper HG 2004 Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. N Engl J Med 350:570-577 (Pubitemid 38160787)
20. Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P 2008 Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci USA 105:3438-3442 (Pubitemid 351723571)
21. Samstein B, Hoimes ML, Fan J, Frost RA, Gelato MC, Lang CH 1996 IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production. Biochem Biophys Res Commun 228:611-615 (Pubitemid 26396118)
22. Lang CH, Vary TC, Frost RA 2003 Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis. Endocrinology 144:3922-3933 (Pubitemid 37088747)
23. Leu JI, George DL 2007 Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev 21:3095-3109 (Pubitemid 350223527)
24. Newman AB, Sachs MC, Arnold AM, Fried LP, Kronmal R, Cushman M, Psaty BM, Harris TB, Robbins JA, Burke GL, Kuller LH, Lumley T 2009 Total and cause-specific mortality in the cardiovascular health study. J Gerontol A Biol Sci Med Sci 64:1251-1261
25. Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277 (Pubitemid 34879081)