-
2
-
-
84876160000
-
The genetics of extreme longevity: lessons from the new England centenarian study
-
Sebastiani P and Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Frontiers in genetics. 2012; 3:277.
-
(2012)
Frontiers in genetics
, vol.3
, pp. 277
-
-
Sebastiani, P.1
Perls, T.T.2
-
3
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000; 408:255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
4
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366:461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
5
-
-
0036245337
-
Mechanisms of ageing: public or private?
-
Partridge L and Gems D. Mechanisms of ageing: public or private? Nature reviews Genetics. 2002; 3(3):165-175.
-
(2002)
Nature reviews Genetics
, vol.3
, Issue.3
, pp. 165-175
-
-
Partridge, L.1
Gems, D.2
-
6
-
-
84889264077
-
Genetics of healthy aging and longevity
-
Brooks-Wilson AR. Genetics of healthy aging and longevity. Human genetics. 2013; 132:1323-1338.
-
(2013)
Human genetics
, vol.132
, pp. 1323-1338
-
-
Brooks-Wilson, A.R.1
-
7
-
-
62849107974
-
Genetic determinants of ageing processes and diseases in later life
-
Bostock CV, Soiza RL and Whalley LJ. Genetic determinants of ageing processes and diseases in later life. Maturitas. 2009;62:225-229.
-
(2009)
Maturitas
, vol.62
, pp. 225-229
-
-
Bostock, C.V.1
Soiza, R.L.2
Whalley, L.J.3
-
8
-
-
39949083974
-
Lack of replication of genetic associations with human longevity
-
Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G and Puca AA. Lack of replication of genetic associations with human longevity. Biogerontology. 2008; 9:85-92.
-
(2008)
Biogerontology
, vol.9
, pp. 85-92
-
-
Novelli, V.1
Viviani Anselmi, C.2
Roncarati, R.3
Guffanti, G.4
Malovini, A.5
Piluso, G.6
Puca, A.A.7
-
10
-
-
23844551318
-
Minireview: role of the growth hormone/insulinlike growth factor system in mammalian aging
-
Bartke A. Minireview: role of the growth hormone/insulinlike growth factor system in mammalian aging. Endocrinology. 2005; 146:3718-3723.
-
(2005)
Endocrinology
, vol.146
, pp. 3718-3723
-
-
Bartke, A.1
-
11
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M, Bartke A and Antebi A. The endocrine regulation of aging by insulin-like signals. Science. 2003; 299:1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
12
-
-
84891785508
-
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
-
Blagosklonny MV. TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists. Cell death & disease. 2013; 4:e964.
-
(2013)
Cell death & disease
, vol.4
-
-
Blagosklonny, M.V.1
-
13
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV and Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell cycle. 2009; 8:1888-1895.
-
(2009)
Cell cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
14
-
-
84901022649
-
Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
-
Leontieva OV, Demidenko ZN and Blagosklonny MV. Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium. Cell death & disease. 2014; 5:e1214.
-
(2014)
Cell death & disease
, vol.5
-
-
Leontieva, O.V.1
Demidenko, Z.N.2
Blagosklonny, M.V.3
-
15
-
-
74449090245
-
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
-
Salminen A and Kaarniranta K. Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cellular signalling. 2010; 22:573-577.
-
(2010)
Cellular signalling
, vol.22
, pp. 573-577
-
-
Salminen, A.1
Kaarniranta, K.2
-
16
-
-
79961173138
-
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
-
Steelman LS, Chappell WH, Abrams SL, Kempf RC, Long J, Laidler P, Mijatovic S, Maksimovic-Ivanic D, Stivala F, Mazzarino MC, Donia M, Fagone P, Malaponte G, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging. 2011; 3:192-222.
-
(2011)
Aging
, vol.3
, pp. 192-222
-
-
Steelman, L.S.1
Chappell, W.H.2
Abrams, S.L.3
Kempf, R.C.4
Long, J.5
Laidler, P.6
Mijatovic, S.7
Maksimovic-Ivanic, D.8
Stivala, F.9
Mazzarino, M.C.10
Donia, M.11
Fagone, P.12
Malaponte, G.13
-
17
-
-
66149172131
-
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study
-
Anselmi CV, Malovini A, Roncarati R, Novelli V, Villa F, Condorelli G, Bellazzi R and Puca AA. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation research. 2009; 12:95-104.
-
(2009)
Rejuvenation research
, vol.12
, pp. 95-104
-
-
Anselmi, C.V.1
Malovini, A.2
Roncarati, R.3
Novelli, V.4
Villa, F.5
Condorelli, G.6
Bellazzi, R.7
Puca, A.A.8
-
18
-
-
62449083712
-
Association of FOXO3A variation with human longevity confirmed in German centenarians
-
Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S and Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:2700-2705.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 2700-2705
-
-
Flachsbart, F.1
Caliebe, A.2
Kleindorp, R.3
Blanche, H.4
von Eller-Eberstein, H.5
Nikolaus, S.6
Schreiber, S.7
Nebel, A.8
-
19
-
-
70350359126
-
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
-
Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human molecular genetics. 2009; 18:4897-4904.
-
(2009)
Human molecular genetics
, vol.18
, pp. 4897-4904
-
-
Li, Y.1
Wang, W.J.2
Cao, H.3
Lu, J.4
Wu, C.5
Hu, F.Y.6
Guo, J.7
Zhao, L.8
Yang, F.9
Zhang, Y.X.10
Li, W.11
Zheng, G.Y.12
Cui, H.13
-
20
-
-
52949122885
-
FOXO3A genotype is strongly associated with human longevity
-
Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B and Curb JD. FOXO3A genotype is strongly associated with human longevity. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:13987-13992.
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 13987-13992
-
-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
Chen, R.4
Grove, J.S.5
Yano, K.6
Masaki, K.H.7
Willcox, D.C.8
Rodriguez, B.9
Curb, J.D.10
-
21
-
-
0037365789
-
ATM and related protein kinases: safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nature reviews Cancer. 2003; 3:155-168.
-
(2003)
Nature reviews Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
22
-
-
4444339751
-
ATM and ataxia telangiectasia
-
McKinnon PJ. ATM and ataxia telangiectasia. EMBO reports. 2004; 5:772-776.
-
(2004)
EMBO reports
, vol.5
, pp. 772-776
-
-
McKinnon, P.J.1
-
23
-
-
77957889331
-
A functional single nucleotide polymorphism in promoter of ATM is associated with longevity
-
Chen T, Dong B, Lu Z, Tian B, Zhang J, Zhou J, Wu H, Zhang Y, Wu J, Lin P, Zhang J, Xu H and Mo X. A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. Mechanisms of ageing and development. 2010; 131:636-640.
-
(2010)
Mechanisms of ageing and development
, vol.131
, pp. 636-640
-
-
Chen, T.1
Dong, B.2
Lu, Z.3
Tian, B.4
Zhang, J.5
Zhou, J.6
Wu, H.7
Zhang, Y.8
Wu, J.9
Lin, P.10
Zhang, J.11
Xu, H.12
Mo, X.13
-
24
-
-
84879685652
-
Ataxiatelangiectasia mutated (ATM) genetic variant in Italian centenarians
-
Piaceri I, Bagnoli S, Tedde A, Sorbi S and Nacmias B. Ataxiatelangiectasia mutated (ATM) genetic variant in Italian centenarians. Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2013; 34:573-575.
-
(2013)
Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
, vol.34
, pp. 573-575
-
-
Piaceri, I.1
Bagnoli, S.2
Tedde, A.3
Sorbi, S.4
Nacmias, B.5
-
25
-
-
79952015071
-
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3
-
Kaplan RC, Petersen AK, Chen MH, Teumer A, Glazer NL, Doring A, Lam CS, Friedrich N, Newman A, Muller M, Yang Q, Homuth G, Cappola A, et al. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Human molecular genetics. 2011; 20:1241-1251.
-
(2011)
Human molecular genetics
, vol.20
, pp. 1241-1251
-
-
Kaplan, R.C.1
Petersen, A.K.2
Chen, M.H.3
Teumer, A.4
Glazer, N.L.5
Doring, A.6
Lam, C.S.7
Friedrich, N.8
Newman, A.9
Muller, M.10
Yang, Q.11
Homuth, G.12
Cappola, A.13
-
26
-
-
0031442972
-
Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions
-
Rajaram S, Baylink DJ and Mohan S. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocrine reviews. 1997; 18:801-831.
-
(1997)
Endocrine reviews
, vol.18
, pp. 801-831
-
-
Rajaram, S.1
Baylink, D.J.2
Mohan, S.3
-
27
-
-
0028864667
-
Induction of the growth inhibitor IGFbinding protein 3 by p53
-
Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N. Induction of the growth inhibitor IGFbinding protein 3 by p53. Nature. 1995; 377:646-649.
-
(1995)
Nature
, vol.377
, pp. 646-649
-
-
Buckbinder, L.1
Talbott, R.2
Velasco-Miguel, S.3
Takenaka, I.4
Faha, B.5
Seizinger, B.R.6
Kley, N.7
-
28
-
-
77952163120
-
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
-
Feng Z. p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. Cold Spring Harbor perspectives in biology. 2010; 2:a001057.
-
(2010)
Cold Spring Harbor perspectives in biology
, vol.2
-
-
Feng, Z.1
-
29
-
-
77954310492
-
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
-
Feng Z and Levine AJ. The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends in cell biology. 2010; 20:427-434.
-
(2010)
Trends in cell biology
, vol.20
, pp. 427-434
-
-
Feng, Z.1
Levine, A.J.2
-
30
-
-
61449231779
-
Glucose and lipid profile of a long-lived rural Han Chinese population and their families in southwest China
-
Gong YY, Xie L, Zhou WP, Zhang YP, Gong YY, Xie L, Lian SG, Yang J, Wang XY, Yang Z, Gao SJ, Xu LY and Zhou WP. Glucose and lipid profile of a long-lived rural Han Chinese population and their families in southwest China. Journal of the American Geriatrics Society. 2009; 57:567-568.
-
(2009)
Journal of the American Geriatrics Society
, vol.57
, pp. 567-568
-
-
Gong, Y.Y.1
Xie, L.2
Zhou, W.P.3
Zhang, Y.P.4
Gong, Y.Y.5
Xie, L.6
Lian, S.G.7
Yang, J.8
Wang, X.Y.9
Yang, Z.10
Gao, S.J.11
Xu, L.Y.12
Zhou, W.P.13
-
32
-
-
32444433647
-
Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
-
Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M and Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis and rheumatism. 2006; 54:533-539.
-
(2006)
Arthritis and rheumatism
, vol.54
, pp. 533-539
-
-
Valdes, A.M.1
Van Oene, M.2
Hart, D.J.3
Surdulescu, G.L.4
Loughlin, J.5
Doherty, M.6
Spector, T.D.7
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