Association between insulin-like growth factor I and bone mineral density in older women and men: The Framingham heart study

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 12, 1998, Pages 4257-4262

  Langlois, Jean A ^a,e   Rosen, Clifford J ^b   Visser, Marjolein ^a   Hannan, Marian T ^c   Harris, Tamara ^a   Wilson, Peter W F ^d   Kiel, Douglas P ^c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b ST JOSEPH HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

AGED; ARTICLE; BODY MASS; BONE ATROPHY; BONE DENSITY; BONE MASS; BONE MINERALIZATION; FEMALE; FEMUR; FOLLOW UP; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HUMAN; IMMOBILIZATION; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSSIFICATION; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN INTAKE; RADIUS; WEIGHT REDUCTION;

POMACANTHUS MACULOSUS;

EID: 0032452531     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.12.4257     Document Type: Article

References (56)

1. 1. Cummings S, Kelsey J, Nevitt M, O'Dowd K. 1985 Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 7:178-208.
2. 2. Melton L. 1993 Hip fractures: a worldwide problem today and tomorrow. Bone. 14:51-58.
3. 3. Keene G, Parker M, Pryor G. 1993 Mortality and morbidity after hip fractures. Br Med J. 307:1248-1250.
4. 4. Chrischilles E, Butler C, Davis C, Wallace R. 1991 A model of lifetime osteoporosis impact. Arch Intern Med. 151:2026-2032.
5. 5. Canalis E. 1997 Insulin-like growth factors and osteoporosis. Bone. 3:215-216.
6. 6. Marie P. 1997 Growth factors and bone formation in osteoporosis. Roles for IGF-I and TGF-beta. Rev Rhum Engl Ed. 64:44-53.
7. 7. Rudman D. 1985 Growth hormone, body composition, and aging. J Am Geriatr Soc. 33:800-807.
8. 8. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med. 323:1-6.
9. 9. Marcus R, Butterfield G, Holloway L, et al. 1990 Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab. 70:519-527.
10. 10. Rosen CJ, Kessenich CR. 1996 The role of insulin-like growth factor in senescence: clues for interventional strategies in the elderly. Endocrinologist. 6:102-108.
11. 11. Canalis E, McCarthy T, Centrella M. 1988 Growth factors and the regulation of bone remodeling. J Clin Invest. 81:277-281.
12. 12. Baylink DJ, Finkelman RD, Mohan S. 1993 Growth factors to stimulate bone formation. J Bone Miner Res. 8:S565-S572.
13. 13. Hayden JM, Mohan S, Baylink DJ. 1994 The insulin-like growth factor system and the coupling of formation to resorption. Bone. 17:93S-98S.
14. 14. Nicolas V, Prewett A, Bettica P, et al. 1994 Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging. J Clin Endocrinol Metab. 78:1011-1016.
15. 15. Boonen S, Aerssens J, Dequeker J, et al. 1997 Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor I: potential implications for age-related (Type II) osteoporotic fracture occurrence. Calcif Tissue Int. 61:173-178.
16. 16. Goodman-Gruen D, Barrett-Connor E. 1997 Epidemiology of insulin-like growth factor-I in elderly men and women: the Rancho Bernardo Study. Am J Epidemiol. 145:970-976.
17. 17. Harris TB, Kiel D, Roubenoff R, et al. 1997 Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study. J Am Geriatr Soc. 45:133-139.
18. 18. Porch JV, Jain K, Reilly A, et al. 1997 Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women. Am J Clin Nutr. 66:874-879.
19. 19. Hannan MT, Felson DT, Anderson JJ. 1992 Bone mineral density in elderly men and women: results from the Framingham Osteoporosis Study. J Bone Miner Res. 7:547-553.
20. 20. Ensrud KE, Palermo L, Black DM, et al. 1995 Hip and calcaneal bone loss increase with advancing age: longitudinal results from the Study of Osteoporotic Fractures. J Bone Miner Res. 10:1778-1787.
21. 21. Boonen S, Lesaffre E, Dequeker J, et al. 1996 Relationship between baseline insulin-like growth factor-I (IGF-I) and femoral bone density in women aged over 70 years: potential implications for the prevention of age-related bone loss. J Am Geriatr Soc. 44:1301-1306.
22. 22. Rudman D, Drinka PJ, Wilson CR, et al. 1994 Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol (Oxf). 40:653-661.
23. 23. Fall C, Hindmarsh P, Dennison E, Kellingray S, Barker D, Cooper C. 1998 Programming of growth hormone secretion and bone mineral density in elderly men: a hypothesis. J Clin Endocrinol and Metab. 83:135-139.
24. 24. Bennett AE, Wahner HW, Riggs BL, Hintz RL. 1984 Insulin-like growth factors I, and II: aging and bone density in women. J Clin Endocrinol Metab. 59:701-704.
25. 25. Lloyd ME, Hart DJ, Nandra D, et al. 1996 Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford Study. Ann Rheum Dis. 55:870-874.
26. 26. Sugimoto T, Nishiyama K, Kuribayashi F, Chihara K. 1997 Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. J Bone Miner Res. 12:1272-1279.
27. 27. Romagnoli E, Minisola S, Carnevale V, et al. 1993 Effect of estrogen deficiency on IGF-I plasma levels: relationship with bone mineral density in perimenopausal women. Calcif Tissue Int. 53:1-6.
28. 28. Ravn P, Overgaard K, Spencer EM, Christiansen C. 1995 Insulin-like growth factors I, and II in healthy women with and without established osteoporosis Eur J Endocrinol. 132:313-319.
29. 29. Wuster C, Blum WF, Schlemich S, Ranke MB, Siegler R. 1993 Decreased serum levels of insulin-like growth factors and IGF-binding protein-3 in osteoporosis. J Intern Med. 234:249-255.
30. 30. Reed BY, Zerwekh JE, Sakhaee K, Breslau N, Gottschalk F, Pak CYC. 1995 Serum IGF-I is low, and correlated with osteoblastic surface in idiopathic osteoporosis. J Bone Miner Res. 10:1218-1224.
31. 31. Kurland ES, Rosen CJ, Cosman F, et al. 1997 Insulin-like growth factor-I in men with idiopathic osteoporosis. J Clin Endocrinol Metab. 82:2799-2805.
32. 32. Felson DT, Zhang Y, Hannan MT, Anderson JJ. 1993 Effects of weight and body mass index on bone mineral density in men and women: the Framingham Study. J Bone Miner Res. 8:567-573.
33. 33. Clemmons DR, Underwood LE. 1991 Nutritional regulation of IGF-I and IGF binding proteins. Annu Rev Nutr. 11:393-412.
34. 34. Orwoll ES. 1992 The effects of dietary protein insufficiency and excess on bone health. Bone. 13:343-350.
35. 35. Hannan MT, Tucker K, Dawson-Hughes B, Felson DT, Kiel DP. 1997 Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res. 12(Suppl 1):S151 (Abstract).
36. 36. Bonjour JP, Schürch MA, Chevalley T, Ammann P, Rizzoli R. 1997 Protein intake, IGF-I and osteoporosis. Osteoporosis Int. (Suppl 3):S36-S42.
37. 37. Dawber TR. 1980 The Framingham Study. Cambridge, MA: Harvard University Press.
38. 38. Hintz RL, Liu F, Chang D, Seegan G. 1988 A sensitive radioimmunoassay for somatomedin-C/insulin-like growth factor-I based on synthetic insulin-like growth factor 57-70. Horm Metab Res. 20:344-347.
39. 39. Grogean T, Vereault D, Millard PS, et al. 1997 A comparative analysis of methods to measure insulin-like growth factor-I in human serum. Endocrinol Metab Ser. 4:109-114.
40. 40. Willett WC, Sampson L, Stampfer MJ, et al. 1985 Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 122:51-65.
41. 41. Barrett-Connor E, Goodman-Gruen D. 1998 Gender differences in insulin-like growth factor and bone mineral density association in old age: the Rancho Bernardo Study. J Bone Miner Res. 13:1343-1349.
42. 42. Johansson AG, Eriksen EF, Lindh E, et al. 1997 Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. J Clin Endocrinol Metab. 82:2795-2798.
43. 43. Poehlman ET, Toth MJ, Ades PA, Rosen CJ. 1997 Menopause-associated changes in plasma lipids, insulin-like growth factor-I, and blood pressure: a longitudinal study. Eur J Clin Invest. 27:322-326.
44. 44. Rosen CJ, Dimal HP, Vereault D, et al. 1997 Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. Bone. 21:217-223.
45. 45. Foresta C, Ruzza G, Mioni R, et al. 1984 Osteoporosis and decline in gonadal function in the elderly male. Horm Res. 19:18-22.
46. 46. Meier DE, Orwoll Keenan EJ, Fagerstrom RM. 1987 Marked decline in trabecular bone mineral content in healthy men with age: lack of association with sex steroid levels. J Am Geriatr Soc. 35:189-197.
47. 47. Pfeilschifter J, Scheidt-Nave C, Leidig-Bruckner G, et al. 1996 Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50-to 80-year-old men and women. J Clin Endocrinol Metab. 81:2534-2540.
48. 48. Rudman D, Feller AG, Cohn L, Shetty KR, Rudman IW, Draper MW. 1991 Effects of human growth hormone on body composition in elderly men. Horm Res. 36(Suppl 1):73-81.
49. 49. Cuttica CM, Castoldi L, Gorrini GP, et al. 1997 Effects of 6-month administration of recombinant human growth hormone to healthy elderly subjects. Aging Clin Exp Res. 9:193-197.
50. 50. Holloway L, Butterfield G, Hintz RL, Gesundheit N, Marcus R. 1994 Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J Clin Endocrinol Metab. 79:470-479.
51. 51. Yarasheski KE, Campbell JA, Kohrt WM. 1997 Effect of resistance exercise and growth hormone on bone density in older men. Clin Endocrinol (Oxf). 47:223-229.
52. 52. Holloway L, Kohlmeier L, Kent K, Marcus R. 1997 Skeletal effects of cyclic recombinant human growth hormone and salmon calcitonin in osteopenic postmenopausal women. J Clin Endocrinol Metab. 82:1111-1117.
53. 53. Erdtsieck RJ, Pols HA, Valk NK, et al. 1995 Treatment of post-menopausal osteoporosis with a combination of growth hormone and pamidronate: a placebo controlled trial. Clin Endocrinol (Oxf). 43:557-565.
54. 54. MacLean D, Kiel DP, Rosen CJ. 1995 Low dose rhGH for frail elders stimulates bone turnover in a dose-dependent manner. J Bone Miner Res. 10:S458 (Abstract).
55. 55. Ghiron LJ, Thompson JL, Holloway L, et al. 1995 The effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women. J Bone Miner Res. 10:1844-1852.
56. 56. Rosen CJ, Mohan S, Hunter J, Vereault D, Baylink DJ. 1997 Seasonal changes in bone density and in serum IGFBP-4 levels are associated with calcium intake and parathyroid hormone (PTH) concentrations in elderly New England women. J Bone Miner Res. 12:S166 (Abstract).