Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: A novel model of vascular aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 4, 2012, Pages 313-329

  Bailey Downs, Lora C ^a   Mitschelen, Matthew ^a   Sosnowska, Danuta ^a   Toth, Peter ^a   Pinto, John T ^b   Ballabh, Praveen ^b   Valcarcel Ares, M Noa ^a   Farley, Julie ^a   Koller, Akos ^b,c   Henthorn, Jim C ^a   Bass, Caroline ^d   Sonntag, William E ^a   Ungvari, Zoltan ^a   Csiszar, Anna ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

^d WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

endocrine; vascular aging

Indexed keywords

ANIMALIA; MUS;

GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; HMOX1 PROTEIN, MOUSE; HYDROGEN PEROXIDE; INSULIN LIKE GROWTH FACTOR 1, MOUSE; INSULIN-LIKE GROWTH FACTOR-1, MOUSE; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; NQO1 PROTEIN, MOUSE; OXIDIZED LOW DENSITY LIPOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SOMATOMEDIN C; TRANSCRIPTION FACTOR NRF2;

AGING; ANIMAL; AORTA; APOPTOSIS; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; FEMALE; GENE SILENCING; GENETICS; HYPERGLYCEMIA; LIVER; MALE; METABOLISM; MOUSE; OXIDATIVE STRESS; TISSUE CULTURE TECHNIQUE;

AGING; ANIMALS; AORTA; APOPTOSIS; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HYDROGEN PEROXIDE; HYPERGLYCEMIA; INSULIN-LIKE GROWTH FACTOR I; LIPOPROTEINS, LDL; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; TISSUE CULTURE TECHNIQUES;

EID: 84859077841     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr164     Document Type: Review

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