IGF-1 deficiency impairs neurovascular coupling in mice: Implications for cerebromicrovascular aging

Aging Cell

Volumn 14, Issue 6, 2015, Pages 1034-1044

  Toth, Peter ^a,b   Tarantini, Stefano ^a,c   Ashpole, Nicole M ^a   Tucsek, Zsuzsanna ^a   Milne, Ginger L ^d   Valcarcel Ares, Noa M ^a   Menyhart, Akos ^e   Farkas, Eszter ^e   Sonntag, William E ^a,f   Csiszar, Anna ^a,b,c,f   Ungvari, Zoltan ^a,b,c,f,g  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF SZEGED   (Hungary)

^f UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^g SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Arachidonic acid metabolites; Astrocyte; Endothelial dysfunction; Functional hyperemia; Insulin like growth factor 1; Neurovascular uncoupling; Nitric oxide; Somatomedin C; Vascular aging; Vascular cognitive impairment

Indexed keywords

ICOSANOID; METABOTROPIC RECEPTOR; SOMATOMEDIN C; INSULIN-LIKE GROWTH FACTOR-1, MOUSE; NITRIC OXIDE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN MICROCIRCULATION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; INSULIN LIKE GROWTH FACTOR 1 DEFICIENCY; LEARNING AND MEMORY TEST; MALE; MOUSE; NEUROVASCULAR COUPLING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SPATIAL MEMORY TEST; ANIMAL; BIOSYNTHESIS; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; MAZE TEST; METABOLISM; MICROVASCULATURE; PATHOPHYSIOLOGY; PHYSIOLOGY; SPATIAL MEMORY;

AGING; ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; INSULIN-LIKE GROWTH FACTOR I; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROVESSELS; NEUROVASCULAR COUPLING; NITRIC OXIDE; SPATIAL MEMORY;

EID: 84954318447     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12372     Document Type: Article

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