Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: A controlled study in a genetically homogeneous population

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 6, 1998, Pages 1953-1958

  Kranzler, John H ^a   Rosenbloom, Arlan L ^b   Martinez, Victor ^c   Guevara Aguirre, Jaime ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c Inst Endocrinol   (Ecuador)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RECEPTOR; SOMATOMEDIN C;

ACADEMIC ACHIEVEMENT; ADOLESCENT; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; ECUADOR; FEMALE; GENE MUTATION; GENETIC HETEROGENEITY; GROWTH HORMONE DEFICIENCY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYPOGLYCEMIA; INTELLIGENCE; ISRAEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOMETRY; RELATIVE; SCHOOL CHILD; SIBLING;

ADOLESCENT; CHILD; COGNITION; ECUADOR; FEMALE; HOMOZYGOTE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTELLIGENCE; MALE; MUTATION; RECEPTORS, SOMATOTROPIN; RNA SPLICING;

EID: 0031732891     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.6.1953     Document Type: Article

References (40)

1. Laron Z, Pertzelan A, Mannheimer S. 1966 Genetic pituitary dwarfism with high serum levels of growth hormone. A new inborn error of metabolism? Isr J Med Sci. 2:152-155.
2. Frankel JJ, Laron Z. 1968 Psychological aspects of pituitary insufficiency in children and adolescents with special reference to growth hormone. Isr J Med Sci. 4:953-961.
3. Galatzer A, Aran O, Nagelberg J, Rubitzek J, Laron Z. 1993 Cognitive and psychosocial functioning of young adults with Laron syndrome. In: Laron Z, Parks JS, eds. Lessons from Laron syndrome (LS) 1996-1992. Basel: Karger; 53-60.
4. Woods KA, Camacho-Huebner C, Savage MO, Clark AJL. 1996 Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor-I gene. N Engl J Med. 335:1363-1365.
5. Rosenbloom AL, Savage MO, Blum WF, Guevara-Aguirre J, Rosenfeld RG. 1992 Clinical and biochemical characteristics of growth hormone receptor deficiency (Laron syndrome). Acta Paediatr. 383(Suppl):121-124.
6. Rosenbloom AL, Guevara-Aguirre J, Rosenfeld RG, Fielder PJ. 1996 The little women of Loja-growth hormone-receptor deficiency in an inbred population of southern Ecuador. N Engl J Med. 323:1367-1374.
7. Proctor BE, Kranzler JH, Martinez V, Guevara-Aguire J, Rosenbloom AL. 1996 Cross-cultural validation of the Matrix Analogies Test. Poster presented at the Annual Convention of the Florida Association of School Psychologists, Ft. Lauderdale FL.
8. Naglieri JA. 1985 Manual for the Matrix Analogies Test-Expanded Form. New York: Psy Corp.
9. Raven JC, Court JH, Raven J. 1991 Manual for the Raven's progressive matrices and vocabulary scales. London: Lewis.
10. Jensen AR. 1980 Bias in mental testing. New York: Free Press.
11. Neisser U, Boodoo G, Bouchard Jr TJ, et al. 1996 Intelligence: knowns and unknowns. Am Psychol. 51:77-101.
12. Berg MA, Peoples R, Perez-Jurado L, et al. 1994 Receptor mutations and haplotypes in growth hormone receptor deficiency: a global survey and identification of the Ecuadorian E180 splice mutation in an oriental Jewish patient. Acta Paediatr. 399(Suppl):112-114.
13. Vernon PA. 1987 Speed of information-processing and intelligence. Norwood: Ablex.
14. Larson GE, Alderton DL. 1992 The structure and capacity of thought: some comments on the cognitive underpinnings of g. In: Detterman DK, ed Current topics in human intelligence: is mind modular or unitary? Norwood: Ablex; 141-156.
15. Vernon PA. 1990 An overview of chronometric measures of intelligence. Sch Psy Rev. 19:399-410.
16. Vernon PA. 1990 The use of biological measures to estimate behavioral intelligence. Educ Psychol. 25:293-304.
17. Jensen AR. 1987 Individual differences in the Hick paradigm. In: Vernon PA, ed. Speed of information processing and intelligence. Norwood: Ablex; 101-175.
18. Kranzler JH, Jensen AR. 1989 Inspection time and intelligence: a meta-analysis. Intell. 13:329-347.
19. Jensen AR. 1982 Reaction time and psychometric g. In Eysenck HJ, ed. A model for intelligence. Heidelberg: Springer-Verlag; 81-112.
20. Kranzler JH, Whang PA, Jensen AR. 1994 Task complexity and the speed and efficiency of elemental information-processing: another look at the nature of intellectual giftedness. Cont Educ Psy. 19:447-459.
21. Kranzler JH. 1994 Application of the techniques of mental chronometry to the study of learning disabilities. Person Indiv Differ. 16:853-859.
22. Nettelbeck T. 1987 Inspection time and intelligence. In: Vernon PA, ed. Speed of information-processing and intelligence. Norwood: Ablex; 295-346.
23. Guevara-Aguirre J, Rosenbloom AL. 1993 Psychosocial adaptation of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome. In: Laron Z, Parks JS, eds. Lessons from Laron syndrome (LS) 1996-1992 Basel: Karger; 61-64.
24. Wechsler D. 1949 Wechsler intelligence scale for children. New York: Psy Corp.
25. Najjar SS, Khachadurian AK, Ibawi MN, Blizzard RM. 1971 Dwarfism with elevated levels of plasma growth hormone. N Engl J Med. 284:809-812.
26. Kastrup KW, Andersen H, Hanssen KF. 1975 Increased immunoreactive plasma and urinary growth hormone in growth retardation with defective generation of somatomedin A (Laron's syndrome). Acta Paediatr Scand. 64:613-618.
27. Spadoni GL, Cianfarani S, Baldini A, et al. 1988 Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. Horm Metab Res. 20:450-452.
28. Van den Brande JL, Du Caju MVL, Visser HKA, Schopman W, Halking WHL, Dagenhart HJ. 1974 Primary somatomedin deficiency: case report. Arch Dis Child. 49:297-304.
29. Rosenbloom AL, Berg MA, Kasatkina EP, et al. 1995 Severe growth hormone insensitivity (Laron syndrome) due to nonsense mutation of the GH receptor in brothers from Russia. J Pediatr Endocrinol Metab. 8:159-165.
30. Elders MJ, Garland JT, Daughaday WA, Fisher DA, Whitney JE, Huges ER. 1973 Laron's dwarfism: studies on the nature of the defect. J Pediatr. 83:253-263.
31. Clemens RD, Costin G, Kogut MD. 1976 Laron dwarfism: growth and immunoreactive insulin following treatment with human growth hormone. J Pediatr. 88:427-433.
32. Hopp M, Rosenbloom AL, Griffiths J, Kgwete S, Vaccarello MA. 1996 Growth-hormone receptor deficiency (Laron syndrome) in black-African siblings. S Afr Med J. 86:268-270.
33. Saldanha PH, Toledo SPA. 1981 Familial dwarfism with high IF-GH: report of two affected sibs with genetic and epidemiological considerations. Hum Genet. 59:367-372.
34. Pierson M, Malaprade D, Fortier G, Belleville F, Lasbennes A, Wuilbereq L. 1978 Le nanisme familial de type Laron: deficit genetique primaire en somotomedine. Arch Fr Pediatr. 35:151-164.
35. Woods KA, Savage MO. 1996 Laron syndrome: typical and atypical forms. In: Ross RJM, Savage MO, eds. Growth hormone resistance. London: Bailliere-Tindall; 371-378.
36. Woods KA, Dastot F, Preece MA, et al. 1997 Extensive personal experience. Phenotype: genotype relationships in growth hormone insensitivity syndrome. J Clin Endocrinol Metab. 82:3529-3535.
37. Rivarola MA, Phillips III JA, Migean CJ, Heinrick JJ, Hjelle BJ. 1984 Phenotypic heterogeneity in familial isolated growth hormone deficiency type I-A. J Clin Endocrinol Metab. 59:34-40.
38. Cacciari E, Pirazzoli P, Gualandi S, et al. 1994 Molecular study of human growth hormone gene cluster in three families with isolated growth hormone deficiency and similar phenotype. Eur J Pediatr. 153:635-641.
39. Nishi Y, Okade S, Tajiri H, et al. 1993 Effect of IGF-1 on isolated GH deficiency type IA and Laron-type dwarfism. In: Laron Z, Parks JS, eds. Lessons from Laron syndrome (LS) 1996-1992. Basel: Karger; 244-253.
40. Ghizzoni L, Duquesnoy P, Torresani T, Vottero A, Goossens M, Bernasconi S. 1994 Isolated growth hormone deficiency type IA associated with a 45-kilobase gene deletion within the human growth hormone gene cluster in an Italian family. Pediatr Res. 36:654-659.