Does reduced IGF-1R signaling in igf1r +/- mice alter aging?

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Bokov, Alex F ^a,b   Garg, Neha ^b   Ikeno, Yuji ^a,b,c   Thakur, Sachin ^b   Musi, Nicolas ^a,b,c   DeFronzo, Ralph A ^b   Zhang, Ning ^b   Erickson, Rebecca C ^d   Gelfond, Jon ^a   Hubbard, Gene B ^a,b   Adamo, Martin L ^a,b   Richardson, Arlan ^a,b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d The University of Texas at Austin   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIQUAT; MESSENGER RNA; PARAQUAT; PROTEIN KINASE B; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C;

AGING; AGRICULTURE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENZYME ACTIVATION; GLUCOSE INTOLERANCE; HAPLOINSUFFICIENCY; INSULIN RESISTANCE; LIFESPAN; LIVER INJURY; LONGEVITY; MOUSE; NONHUMAN; PATHOLOGY; PROTEIN BLOOD LEVEL; SAMPLE SIZE; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SURVIVAL; WILD TYPE; ANIMAL; C57BL MOUSE; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE TOLERANCE TEST; HUMAN; MALE; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; PHYSIOLOGY;

INVERTEBRATA; MUS;

AGING; ANIMALS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 81755176061     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026891     Document Type: Article

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