Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

Aging

Volumn 7, Issue 11, 2015, Pages 956-963

  van der Spoel, Evie ^a   Rozing, Maarten P ^a,b   Houwing Duistermaat, Jeanine J ^a   Eline Slagboom, P ^a,b   Beekman, Marian ^a,b   de Craen, Anton J M ^a,b   Westendorp, Rudi G J ^a,b,c   van Heemst, Diana ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Netherlands Consortium of Healthy Aging (NCHA)   (Netherlands)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Familial longevity; Functional status; Human; IGF 1 axis; Survival

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

AGED; FEMALE; HUMAN; LONGEVITY; MALE; PHYSIOLOGY; SIGNAL TRANSDUCTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MALE; SIGNAL TRANSDUCTION;

EID: 84949992609     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100841     Document Type: Article

References (33)

1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366:461-464.
2. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function. Science. 2001; 292:107-10.
3. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. Dwarf mice and the ageing process. Nature. 1996; 384:33.
4. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le BY. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003; 421:182-187.
5. van Heemst D. Insulin, IGF-1 and longevity. Aging and Disease. 2010; 1:147-157.
6. Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell. 2009; 8:460-472.
7. van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell. 2005; 4:79-85.
8. Euser SM, van Heemst D, van Wet P, Breteler MMB, Westendorp RGJ. Insulin/Insulin-Like Growth Factor-1 Signaling and Cognitive Function in Humans. Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 2008; 63:907-910.
9. Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai I, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:3438-442.
10. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans. Science Translational Medicine. 2011; 3.
11. Juul A, Flyvbjerg A, Frystyk J, Muller J, Skakkebaek NE. Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins-1 and-3 and IGFBP-3 protease activity in boys with normal or precocious puberty. Clinical Endocrinology. 1996; 44:515-523.
12. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. Journal of the National Cancer Institute. 2002; 94:972-980.
13. Hintz RL, Liu F, Rosenfeld RG, Kemp SF. Plasma Somatomedin-Binding Proteins in Hypopituitarism-Changes During Growth-Hormone Therapy. Journal of Clinical Endocrinology & Metabolism. 1981; 53:100-104.
14. Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Muller J, Skakkebaek NE. Serum Levels of Insulin-Like Growth-Factor (Igf)-Binding Protein-3 (Igfbp-3) in Healthy Infants, Children, and Adolescents-the Relation to Igf-I, Igf-Ii, Igfbp-1, Igfbp-2, Age, Sex, Body-Mass Index, and Pubertal Maturation. Journal of Clinical Endocrinology & Metabolism. 1995; 80:2534-2542.
15. Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res. 2003; 13:113-170.
16. Schoenmaker M, de Craen AJ, de Meijer PH, Beekman M, Blauw GJ, Slagboom PE, Westendorp RG. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet. 2006; 14:79-84.
17. Westendorp RG, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc. 2009; 57:1634-1637.
18. Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Bohringer S, van den Akker EB, de Craen AJM, Rivadeneira F, Uitterlinden AG, Westendorp RGJ, Goeman JJ, Slagboom PE, et al. Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age. 2013; 35:235-249.
19. Rozing MP, Westendorp RG, Frolich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D. Human insulin/IGF-1 and familial longevity at middle age. Aging (Albany NY). 2009; 1:714-722.
20. Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE, van Houwelingen JC. Weighted statistics for aggregation and linkage analysis of human longevity in selected families: The Leiden Longevity Study. Statistics in Medicine. 2009; 28:140-151.
21. Milman S, Atzmon G, Huffman DM, Wan JX, Crandall JP, Cohen P, Barzilai N. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014; 13:769-771.
22. Paolisso G, Ammendola S, DelBuono A, Gambardella A, Riondino M, Tagliamonte MR, Rizzo MR, Carella C, Varricchio M. Serum levels of insulin-like growth factor-I (IGF-I) and IGFbinding protein-3 in healthy centenarians: Relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. Journal of Clinical Endocrinology & Metabolism. 1997; 82:2204-2209.
23. Garinis GA, van der Horst GTJ, Vijg J, Hoeijmakers JHJ. DNA damage and ageing: new-age ideas for an age-old problem. Nature Cell Biology. 2008; 10:1241-1247.
24. Fontana L, Addante F, Copetti M, Paroni G, Fontana A, Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A. Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients. Aging Cell. 2013; 12:459-466.
25. Masternak MM, Panici JA, Bonkowski MS, Hughes LF, Bartke A. Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity. Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 2009; 64:516-521.
26. Wijsman CA, Rozing MP, Streefland TCM, le Cessie S, Mooijaart SP, Slagboom PE, Westendorp RGJ, Pijl H, van Heemst D. Familial longevity is marked by enhanced insulin sensitivity. Aging Cell. 2011; 10:114-121.
27. Paolisso G, Gambardella A, Ammendola S, DAmore A, Balbi V, Varricchio M, DOnofrio F. Glucose tolerance and insulin action in healthy centenarians. American Journal of Physiology-Endocrinology and Metabolism. 1996; 270:E890-E894.
28. Rozing MP, Westendorp RGJ, de Craen AJM, Frolich M, de Goeij MCM, Heijmans BT, Beekman M, Wijsman CA, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D. Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study. Journal of the American Geriatrics Society. 2010; 58:564-569.
29. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, et al. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metabolism. 2014; 19:407-417.
30. Aneke-Nash CS, Parrinello CM, Rajpathak SN, Rohan TE, Strotmeyer ES, Kritchevsky SB, Psaty BM, Buzkova P, Kizer JR, Newman AB, Strickler HD, Kaplan RC. Changes in Insulin-Like Growth Factor-I and Its Binding Proteins Are Associated with Diabetes Mellitus in Older Adults. Journal of the American Geriatrics Society. 2015; 63:902-909.
31. Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A. 2009; 106:2700-2705.
32. Drake NM, Park YJ, Shirali AS, Cleland TA, Soloway PD. Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1. Mammalian Genome. 2009; 20:654-663.
33. Bootsma-van der Wiel A, Gussekloo J, de Craen AJM, van Exel E, Knook DL, Lagaay AM, Westendorp RGJ. Disability in the oldest old: "Can do" or "do do"? Journal of the American Geriatrics Society. 2001; 49:909-914.