Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress

Aging Cell

Volumn 11, Issue 4, 2012, Pages 668-674

  Wang, Min ^a   Miller, Richard A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Aging; Amino acid deprivation; Autophagy; GHRKO; Oxidative stress; Snell dwarf

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER; GROWTH HORMONE RECEPTOR; HYDROGEN PEROXIDE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PARAQUAT; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; FEMALE; FIBROBLAST; LONGEVITY; LYSOSOME; MALE; MOUSE; MUTANT; NONHUMAN; NUTRIENT LIMITATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CULTURE MEDIA; FEMALE; FIBROBLASTS; HYDROGEN PEROXIDE; LONGEVITY; MALE; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; MICE, MUTANT STRAINS; OXIDATIVE STRESS; PARAQUAT; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, SOMATOTROPIN; RIBOSOMAL PROTEIN S6 KINASES; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR PIT-1;

MUS;

EID: 84864008371     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00833.x     Document Type: Article

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