메뉴 건너뛰기




Volumn 4, Issue MAR, 2016, Pages

Overcoming hypoxia-mediated tumor progression: Combinatorial approaches targeting pH regulation, angiogenesis and immune dysfunction

Author keywords

Angiogenesis; Carbonic anhydrase IX; Hypoxia; Immune checkpoint inhibitors; Monocarboxylate transporter; Tumor microenvironment

Indexed keywords


EID: 84971594533     PISSN: None     EISSN: 2296634X     Source Type: Journal    
DOI: 10.3389/fcell.2016.00027     Document Type: Review
Times cited : (112)

References (163)
  • 1
    • 84863625224 scopus 로고    scopus 로고
    • A CXCL1 paracrine network links cancer chemoresistance and metastasis
    • Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P. G., et al. (2012). A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 150, 165-178. doi: 10.1016/j.cell.2012.04.042
    • (2012) Cell , vol.150 , pp. 165-178
    • Acharyya, S.1    Oskarsson, T.2    Vanharanta, S.3    Malladi, S.4    Kim, J.5    Morris, P.G.6
  • 2
    • 67651091693 scopus 로고    scopus 로고
    • In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
    • Ahlskog, J. K. J., Dumelin, C. E., Trüssel, S., Mårlind, J., and Neri, D. (2009). In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives. Bioorg. Med. Chem. Lett. 19, 4851-4856. doi: 10.1016/j.bmcl.2009.06.022
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 4851-4856
    • Ahlskog, J.K.J.1    Dumelin, C.E.2    Trüssel, S.3    Mårlind, J.4    Neri, D.5
  • 3
    • 84919863195 scopus 로고    scopus 로고
    • MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies
    • Baek, G., Tse, Y. F., Hu, Z., Cox, D., Buboltz, N., McCue, P., et al. (2014). MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies. Cell Rep. 9, 2233-2249. doi: 10.1016/j.celrep.2014.11.025
    • (2014) Cell Rep , vol.9 , pp. 2233-2249
    • Baek, G.1    Tse, Y.F.2    Hu, Z.3    Cox, D.4    Buboltz, N.5    McCue, P.6
  • 4
    • 84940878452 scopus 로고    scopus 로고
    • Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival
    • Baenke, F., Dubuis, S., Brault, C., Weigelt, B., Dankworth, B., Griffiths, B., et al. (2015). Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. J. Pathol. 237, 152-165. doi: 10.1002/path.4562
    • (2015) J. Pathol , vol.237 , pp. 152-165
    • Baenke, F.1    Dubuis, S.2    Brault, C.3    Weigelt, B.4    Dankworth, B.5    Griffiths, B.6
  • 5
    • 84886377822 scopus 로고    scopus 로고
    • Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia
    • Baginska, J., Viry, E., Berchem, G., Poli, A., Noman, M. Z., van Moer, K., et al. (2013). Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia. Proc. Natl. Acad. Sci. U.S.A. 110, 17450-17455. doi: 10.1073/pnas.1304790110
    • (2013) Proc. Natl. Acad. Sci. U.S.A , vol.110 , pp. 17450-17455
    • Baginska, J.1    Viry, E.2    Berchem, G.3    Poli, A.4    Noman, M.Z.5    van Moer, K.6
  • 6
    • 84865835733 scopus 로고    scopus 로고
    • Targeting the metabolic microenvironment of tumors
    • Bailey, K. M., Wojtkowiak, J. W., Hashim, A. I., and Gillies, R. J. (2012). Targeting the metabolic microenvironment of tumors. Adv. Pharmacol. 65, 63-107. doi: 10.1016/B978-0-12-397927-8.00004-X
    • (2012) Adv. Pharmacol , vol.65 , pp. 63-107
    • Bailey, K.M.1    Wojtkowiak, J.W.2    Hashim, A.I.3    Gillies, R.J.4
  • 7
    • 84255170452 scopus 로고    scopus 로고
    • Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide
    • Barsoum, I. B., Hamilton, T. K., Li, X., Cotechini, T., Miles, E. A., Siemens, D. R., et al. (2011). Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res. 71, 7433-7441. doi: 10.1158/0008-5472.CAN-11-2104
    • (2011) Cancer Res , vol.71 , pp. 7433-7441
    • Barsoum, I.B.1    Hamilton, T.K.2    Li, X.3    Cotechini, T.4    Miles, E.A.5    Siemens, D.R.6
  • 8
    • 84918591282 scopus 로고    scopus 로고
    • Mechanisms of hypoxia-mediated immune escape in cancer
    • Barsoum, I. B., Koti, M., Siemens, D. R., and Graham, C. H. (2014a). Mechanisms of hypoxia-mediated immune escape in cancer. Cancer Res. 74, 7185-7190. doi: 10.1158/0008-5472.CAN-14-2598
    • (2014) Cancer Res , vol.74 , pp. 7185-7190
    • Barsoum, I.B.1    Koti, M.2    Siemens, D.R.3    Graham, C.H.4
  • 9
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    • Barsoum, I. B., Smallwood, C. A., Siemens, D. R., and Graham, C. H. (2014b). A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 74, 665-674. doi: 10.1158/0008-5472.CAN-13-0992
    • (2014) Cancer Res , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 10
    • 84873989235 scopus 로고    scopus 로고
    • Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM.CAIX in immunocompetent mouse models
    • Birkhäuser, F. D., Koya, R. C., Neufeld, C., Rampersaud, E. N., Lu, X., Micewicz, E. D., et al. (2013). Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM.CAIX in immunocompetent mouse models. J. Immunother. 36, 102-111. doi: 10.1097/CJI.0b013e31827bec97
    • (2013) J. Immunother , vol.36 , pp. 102-111
    • Birkhäuser, F.D.1    Koya, R.C.2    Neufeld, C.3    Rampersaud, E.N.4    Lu, X.5    Micewicz, E.D.6
  • 11
    • 84918565034 scopus 로고    scopus 로고
    • Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport
    • Bola, B. M., Chadwick, A. L., Michopoulos, F., Blount, K. G., Telfer, B. A., Williams, K. J., et al. (2014). Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol. Cancer Ther. 13, 2805-2816. doi: 10.1158/1535-7163.MCT-13-1091
    • (2014) Mol. Cancer Ther , vol.13 , pp. 2805-2816
    • Bola, B.M.1    Chadwick, A.L.2    Michopoulos, F.3    Blount, K.G.4    Telfer, B.A.5    Williams, K.J.6
  • 14
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R., Tykodi, S. S., Chow, L. Q., Hwu, W. J., Topalian, S. L., Hwu, P., et al. (2012). Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465. doi: 10.1056/NEJMoa1200694
    • (2012) N. Engl. J. Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 15
    • 70350545729 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions
    • Bronte, V. (2009). Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions. Eur. J. Immunol. 39, 2670-2672. doi: 10.1002/eji.200939892
    • (2009) Eur. J. Immunol , vol.39 , pp. 2670-2672
    • Bronte, V.1
  • 16
    • 1542399581 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re
    • Brouwers, A. H., van Eerd, J. E., Frielink, C., Oosterwijk, E., Oyen, W. J., Corstens, F. H., et al. (2004). Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re. J. Nucl. Med. 45, 327-337
    • (2004) J. Nucl. Med , vol.45 , pp. 327-337
    • Brouwers, A.H.1    van Eerd, J.E.2    Frielink, C.3    Oosterwijk, E.4    Oyen, W.J.5    Corstens, F.H.6
  • 17
    • 84891930215 scopus 로고    scopus 로고
    • Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
    • Casazza, A., Laoui, D., Wenes, M., Rizzolio, S., Bassani, N., Mambretti, M., et al. (2013). Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 24, 695-709. doi: 10.1016/j.ccr.2013.11.007
    • (2013) Cancer Cell , vol.24 , pp. 695-709
    • Casazza, A.1    Laoui, D.2    Wenes, M.3    Rizzolio, S.4    Bassani, N.5    Mambretti, M.6
  • 18
    • 84944534047 scopus 로고    scopus 로고
    • Carving out its niche: a role for carbonic anhydrase IX in pre-metastatic niche development
    • Chafe, S. C., and Dedhar, S. (2015). Carving out its niche: a role for carbonic anhydrase IX in pre-metastatic niche development. Oncoimmunology 4:e1048955. doi: 10.1080/2162402X.2015.1048955
    • (2015) Oncoimmunology , vol.4
    • Chafe, S.C.1    Dedhar, S.2
  • 19
    • 84937512463 scopus 로고    scopus 로고
    • Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production
    • Chafe, S. C., Lou, Y., Sceneay, J., Vallejo, M., Hamilton, M. J., McDonald, P. C., et al. (2015). Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. Cancer Res. 75, 996-1008. doi: 10.1158/0008-5472.CAN-14-3000
    • (2015) Cancer Res , vol.75 , pp. 996-1008
    • Chafe, S.C.1    Lou, Y.2    Sceneay, J.3    Vallejo, M.4    Hamilton, M.J.5    McDonald, P.C.6
  • 20
    • 84935025716 scopus 로고    scopus 로고
    • Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo
    • Chang, D. K., Moniz, R. J., Xu, Z., Sun, J., Signoretti, S., Zhu, Q., et al. (2015). Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo. Mol. Cancer 14, 119. doi: 10.1186/s12943-015-0384-3
    • (2015) Mol. Cancer , vol.14 , pp. 119
    • Chang, D.K.1    Moniz, R.J.2    Xu, Z.3    Sun, J.4    Signoretti, S.5    Zhu, Q.6
  • 21
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., et al. (2009). Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res. 69, 358-368. doi: 10.1158/0008-5472.CAN-08-2470
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferrière, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6
  • 22
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • Conley, S. J., Gheordunescu, E., Kakarala, P., Newman, B., Korkaya, H., Heath, A. N., et al. (2012). Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U.S.A. 109, 2784-2789. doi: 10.1073/pnas.1018866109
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 2784-2789
    • Conley, S.J.1    Gheordunescu, E.2    Kakarala, P.3    Newman, B.4    Korkaya, H.5    Heath, A.N.6
  • 23
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J. I., Cheng, P., et al. (2010). HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439-2453. doi: 10.1084/jem.20100587
    • (2010) J. Exp. Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6
  • 24
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., et al. (2003). Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9, 562-567. doi: 10.1038/nm863
    • (2003) Nat. Med , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 25
    • 84873727788 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity
    • Currie, M. J., Beardsley, B. E., Harris, G. C., Gunningham, S. P., Dachs, G. U., Dijkstra, B., et al. (2013). Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity. Hum. Pathol. 44, 402-411. doi: 10.1016/j.humpath.2012.06.004
    • (2013) Hum. Pathol , vol.44 , pp. 402-411
    • Currie, M.J.1    Beardsley, B.E.2    Harris, G.C.3    Gunningham, S.P.4    Dachs, G.U.5    Dijkstra, B.6
  • 26
    • 84891705036 scopus 로고    scopus 로고
    • pH sensing and regulation in cancer
    • Damaghi, M., Wojtkowiak, J. W., and Gillies, R. J. (2013). pH sensing and regulation in cancer. Front. Physiol. 4:370. doi: 10.3389/fphys.2013.00370
    • (2013) Front. Physiol , vol.4 , pp. 370
    • Damaghi, M.1    Wojtkowiak, J.W.2    Gillies, R.J.3
  • 27
    • 84945460646 scopus 로고    scopus 로고
    • Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future
    • Datta, N. R., Ordóñez, S. G., Gaipl, U. S., Paulides, M. M., Crezee, H., Gellermann, J., et al. (2015). Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future. Cancer Treat. Rev. 41, 742-753. doi: 10.1016/j.ctrv.2015.05.009
    • (2015) Cancer Treat. Rev , vol.41 , pp. 742-753
    • Datta, N.R.1    Ordóñez, S.G.2    Gaipl, U.S.3    Paulides, M.M.4    Crezee, H.5    Gellermann, J.6
  • 28
    • 34548083337 scopus 로고    scopus 로고
    • A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma
    • Davis, I. D., Wiseman, G. A., Lee, F. T., Gansen, D. N., Hopkins, W., Papenfuss, A. T., et al. (2007). A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma. Cancer Immun. 7, 13
    • (2007) Cancer Immun , vol.7 , pp. 13
    • Davis, I.D.1    Wiseman, G.A.2    Lee, F.T.3    Gansen, D.N.4    Hopkins, W.5    Papenfuss, A.T.6
  • 29
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
    • De Bock, K., Mazzone, M., and Carmeliet, P. (2011). Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat. Rev. Clin. Oncol. 8, 393-404. doi: 10.1038/nrclinonc.2011.83
    • (2011) Nat. Rev. Clin. Oncol , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 30
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., et al. (2011). Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1, 54-67. doi: 10.1158/2159-8274.CD-10-0028
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5    Madden, S.F.6
  • 31
    • 84867660436 scopus 로고    scopus 로고
    • Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells
    • De Saedeleer, C. J., Copetti, T., Porporato, P. E., Verrax, J., Feron, O., and Sonveaux, P. (2012). Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. PLoS ONE 7:e46571. doi: 10.1371/journal.pone.0046571
    • (2012) PLoS ONE , vol.7
    • De Saedeleer, C.J.1    Copetti, T.2    Porporato, P.E.3    Verrax, J.4    Feron, O.5    Sonveaux, P.6
  • 32
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E., Cole, D. J., and Montero, A. J. (2009). Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol. Immunother. 58, 49-59. doi: 10.1007/s00262-008-0523-4
    • (2009) Cancer Immunol. Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 33
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., et al. (2010). Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 70, 7465-7475. doi: 10.1158/0008-5472.CAN-10-1439
    • (2010) Cancer Res , vol.70 , pp. 7465-7475
    • Doedens, A.L.1    Stockmann, C.2    Rubinstein, M.P.3    Liao, D.4    Zhang, N.5    DeNardo, D.G.6
  • 34
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty, J. R., and Cleveland, J. L. (2013). Targeting lactate metabolism for cancer therapeutics. J. Clin. Invest. 123, 3685-3692. doi: 10.1172/JCI69741
    • (2013) J. Clin. Invest , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 35
    • 18544363923 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., et al. (2002). Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793-800. doi: 10.1038/nm0902-1039c
    • (2002) Nat. Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 36
    • 84906282434 scopus 로고    scopus 로고
    • Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
    • Doyen, J., Trastour, C., Ettore, F., Peyrottes, I., Toussant, N., Gal, J., et al. (2014). Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome. Biochem. Biophys. Res. Commun. 451, 54-61. doi: 10.1016/j.bbrc.2014.07.050
    • (2014) Biochem. Biophys. Res. Commun , vol.451 , pp. 54-61
    • Doyen, J.1    Trastour, C.2    Ettore, F.3    Peyrottes, I.4    Toussant, N.5    Gal, J.6
  • 37
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du, R., Lu, K. V., Petritsch, C., Liu, P., Ganss, R., Passegué, E., et al. (2008). HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13, 206-220. doi: 10.1016/j.ccr.2008.01.034
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegué, E.6
  • 38
    • 84887019683 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs
    • Dubois, L., Peeters, S. G., van Kuijk, S. J., Yaromina, A., Lieuwes, N. G., Saraya, R., et al. (2013). Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs. Radiother. Oncol. 108, 523-528. doi: 10.1016/j.radonc.2013.06.018
    • (2013) Radiother. Oncol , vol.108 , pp. 523-528
    • Dubois, L.1    Peeters, S.G.2    van Kuijk, S.J.3    Yaromina, A.4    Lieuwes, N.G.5    Saraya, R.6
  • 39
    • 79960359073 scopus 로고    scopus 로고
    • Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
    • Dubois, L., Peeters, S., Lieuwes, N. G., Geusens, N., Thiry, A., Wigfield, S., et al. (2011). Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiother. Oncol. 99, 424-431. doi: 10.1016/j.radonc.2011.05.045
    • (2011) Radiother. Oncol , vol.99 , pp. 424-431
    • Dubois, L.1    Peeters, S.2    Lieuwes, N.G.3    Geusens, N.4    Thiry, A.5    Wigfield, S.6
  • 40
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos, J. M., Lee, C. R., Cruz-Munoz, W., Bjarnason, G. A., Christensen, J. G., and Kerbel, R. S. (2009). Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239. doi: 10.1016/j.ccr.2009.01.021
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 41
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., et al. (2009). Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15, 35-44. doi: 10.1016/j.ccr.2008.11.012
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6
  • 42
    • 84874886049 scopus 로고    scopus 로고
    • Acidity generated by the tumor microenvironment drives local invasion
    • Estrella, V., Chen, T., Lloyd, M., Wojtkowiak, J., Cornnell, H. H., Ibrahim-Hashim, A., et al. (2013). Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 73, 1524-1535. doi: 10.1158/0008-5472.CAN-12-2796
    • (2013) Cancer Res , vol.73 , pp. 1524-1535
    • Estrella, V.1    Chen, T.2    Lloyd, M.3    Wojtkowiak, J.4    Cornnell, H.H.5    Ibrahim-Hashim, A.6
  • 43
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: key players in tumor immune escape and angiogenesis
    • Facciabene, A., Motz, G. T., and Coukos, G. (2012). T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res. 72, 2162-2171. doi: 10.1158/0008-5472.CAN-11-3687
    • (2012) Cancer Res , vol.72 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 44
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L. P., et al. (2011). Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475, 226-230. doi: 10.1038/nature10169
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3    Balint, K.4    Barchetti, A.5    Wang, L.P.6
  • 45
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-associated macrophages
    • Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., et al. (2014). The cellular and molecular origin of tumor-associated macrophages. Science 344, 921-925. doi: 10.1126/science.1252510
    • (2014) Science , vol.344 , pp. 921-925
    • Franklin, R.A.1    Liao, W.2    Sarkar, A.3    Kim, M.V.4    Bivona, M.R.5    Liu, K.6
  • 46
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich, D. I., and Nagaraj, S. (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174. doi: 10.1038/nri2506
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 47
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • Gabrilovich, D. I., Ostrand-Rosenberg, S., and Bronte, V. (2012). Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253-268. doi: 10.1038/nri3175
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 48
    • 84945969574 scopus 로고    scopus 로고
    • carbonic anhydrase activity monitored in vivo by hyperpolarized 13C-magnetic resonance spectroscopy demonstrates its importance for ph regulation in tumors
    • Gallagher, F. A., Sladen, H., Kettunen, M. I., Serrao, E. M., Rodrigues, T. B., Wright, A., et al. (2015). carbonic anhydrase activity monitored in vivo by hyperpolarized 13C-magnetic resonance spectroscopy demonstrates its importance for ph regulation in tumors. Cancer Res. 75, 4109-4118. doi: 10.1158/0008-5472.CAN-15-0857
    • (2015) Cancer Res , vol.75 , pp. 4109-4118
    • Gallagher, F.A.1    Sladen, H.2    Kettunen, M.I.3    Serrao, E.M.4    Rodrigues, T.B.5    Wright, A.6
  • 49
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby, R. A., and Gillies, R. J. (2008). A microenvironmental model of carcinogenesis. Nat. Rev. Cancer 8, 56-61. doi: 10.1038/nrc2255
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 50
    • 84862290784 scopus 로고    scopus 로고
    • Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts
    • Gieling, R. G., Babur, M., Mamnani, L., Burrows, N., Telfer, B. A., Carta, F., et al. (2012). Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J. Med. Chem. 55, 5591-5600. doi: 10.1021/jm300529u
    • (2012) J. Med. Chem , vol.55 , pp. 5591-5600
    • Gieling, R.G.1    Babur, M.2    Mamnani, L.3    Burrows, N.4    Telfer, B.A.5    Carta, F.6
  • 51
    • 84926669244 scopus 로고    scopus 로고
    • Metabolism and its sequelae in cancer evolution and therapy
    • Gillies, R. J., and Gatenby, R. A. (2015). Metabolism and its sequelae in cancer evolution and therapy. Cancer J. 21, 88-96. doi: 10.1097/PPO.0000000000000102
    • (2015) Cancer J , vol.21 , pp. 88-96
    • Gillies, R.J.1    Gatenby, R.A.2
  • 52
    • 46749121459 scopus 로고    scopus 로고
    • Causes and consequences of increased glucose metabolism of cancers
    • Gillies, R. J., Robey, I., and Gatenby, R. A. (2008). Causes and consequences of increased glucose metabolism of cancers. J. Nucl. Med. 49(Suppl. 2), 24S-42S. doi: 10.1016/s1359-6349(08)71425-3
    • (2008) J. Nucl. Med , vol.49 , pp. 24S-42S
    • Gillies, R.J.1    Robey, I.2    Gatenby, R.A.3
  • 53
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies, R. J., Verduzco, D., and Gatenby, R. A. (2012). Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat. Rev. Cancer 12, 487-493. doi: 10.1038/nrc3298
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 54
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: an overview of preclinical and translational research
    • Grosso, J. F., and Jure-Kunkel, M. N. (2013). CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun. 13, 5
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 55
    • 84937829481 scopus 로고    scopus 로고
    • Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer
    • Guo, Z., Wang, H., Meng, F., Li, J., and Zhang, S. (2015). Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer. J. Transl. Med. 13, 247. doi: 10.1186/s12967-015-0613-y
    • (2015) J. Transl. Med , vol.13 , pp. 247
    • Guo, Z.1    Wang, H.2    Meng, F.3    Li, J.4    Zhang, S.5
  • 56
    • 84893092415 scopus 로고    scopus 로고
    • Monocarboxylic acid transport
    • Halestrap, A. P. (2013). Monocarboxylic acid transport. Compr. Physiol. 3, 1611-1643. doi: 10.1002/cphy.c130008
    • (2013) Compr. Physiol , vol.3 , pp. 1611-1643
    • Halestrap, A.P.1
  • 57
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan, D., and Coussens, L. M. (2012). Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309-322. doi: 10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 58
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 59
    • 84941784087 scopus 로고    scopus 로고
    • Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA
    • Harney, A. S., Arwert, E. N., Entenberg, D., Wang, Y., Guo, P., Qian, B. Z., et al. (2015). Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA. Cancer Discov. 5, 932-943. doi: 10.1158/2159-8290.CD-15-0012
    • (2015) Cancer Discov , vol.5 , pp. 932-943
    • Harney, A.S.1    Arwert, E.N.2    Entenberg, D.3    Wang, Y.4    Guo, P.5    Qian, B.Z.6
  • 60
    • 84958120328 scopus 로고    scopus 로고
    • Metabolic heterogeneity in human lung tumors
    • Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., et al. (2016). Metabolic heterogeneity in human lung tumors. Cell 164, 681-694. doi: 10.1016/j.cell.2015.12.034
    • (2016) Cell , vol.164 , pp. 681-694
    • Hensley, C.T.1    Faubert, B.2    Yuan, Q.3    Lev-Cohain, N.4    Jin, E.5    Kim, J.6
  • 61
    • 84901334642 scopus 로고    scopus 로고
    • Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
    • Highfill, S. L., Cui, Y., Giles, A. J., Smith, J. P., Zhang, H., Morse, E., et al. (2014). Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci. Transl. Med. 6:237ra267. doi: 10.1126/scitranslmed.3007974
    • (2014) Sci. Transl. Med , vol.6 , pp. 237ra267
    • Highfill, S.L.1    Cui, Y.2    Giles, A.J.3    Smith, J.P.4    Zhang, H.5    Morse, E.6
  • 62
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., et al. (2010). Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723. doi: 10.1056/NEJMoa1003466
    • (2010) N. Engl. J. Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 63
    • 84859385707 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    • Hu, Y. L., DeLay, M., Jahangiri, A., Molinaro, A. M., Rose, S. D., Carbonell, W. S., et al. (2012). Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 72, 1773-1783. doi: 10.1158/0008-5472.CAN-11-3831
    • (2012) Cancer Res , vol.72 , pp. 1773-1783
    • Hu, Y.L.1    DeLay, M.2    Jahangiri, A.3    Molinaro, A.M.4    Rose, S.D.5    Carbonell, W.S.6
  • 64
    • 84925262623 scopus 로고    scopus 로고
    • Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma
    • Hu-Lieskovan, S., Mok, S., Homet Moreno, B., Tsoi, J., Robert, L., Goedert, L., et al. (2015). Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci. Transl. Med. 7:279ra241. doi: 10.1126/scitranslmed.aaa4691
    • (2015) Sci. Transl. Med , vol.7
    • Hu-Lieskovan, S.1    Mok, S.2    Homet Moreno, B.3    Tsoi, J.4    Robert, L.5    Goedert, L.6
  • 65
    • 84912096468 scopus 로고    scopus 로고
    • Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
    • Jain, R. K. (2014). Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26, 605-622. doi: 10.1016/j.ccell.2014.10.006
    • (2014) Cancer Cell , vol.26 , pp. 605-622
    • Jain, R.K.1
  • 66
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • Joyce, J. A., and Fearon, D. T. (2015). T cell exclusion, immune privilege, and the tumor microenvironment. Science 348, 74-80. doi: 10.1126/science.aaa6204
    • (2015) Science , vol.348 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2
  • 67
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila, M. R., and de Sauvage, F. J. (2013). Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346-354. doi: 10.1038/nature12626
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 68
    • 84877728919 scopus 로고    scopus 로고
    • The emerging 'hallmarks' of metabolic reprogramming and immune evasion: distinct or linked?
    • Kareva, I., and Hahnfeldt, P. (2013). The emerging 'hallmarks' of metabolic reprogramming and immune evasion: distinct or linked? Cancer Res. 73, 2737-2742. doi: 10.1158/0008-5472.can-12-3696
    • (2013) Cancer Res , vol.73 , pp. 2737-2742
    • Kareva, I.1    Hahnfeldt, P.2
  • 69
    • 84955171378 scopus 로고    scopus 로고
    • Estrogen and progesterone differentially regulate carbonic anhydrase II, III, IX, XII, and XIII in ovariectomized rat uteri
    • Karim, K., Giribabu, N., Muniandy, S., and Salleh, N. (2016). Estrogen and progesterone differentially regulate carbonic anhydrase II, III, IX, XII, and XIII in ovariectomized rat uteri. Syst. Biol. Reprod. Med. 62, 57-68. doi: 10.3109/19396368.2015.1112699
    • (2016) Syst. Biol. Reprod. Med , vol.62 , pp. 57-68
    • Karim, K.1    Giribabu, N.2    Muniandy, S.3    Salleh, N.4
  • 70
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel, R. S. (2008). Tumor angiogenesis. N. Engl. J. Med. 358, 2039-2049. doi: 10.1056/NEJMra0706596
    • (2008) N. Engl. J. Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 71
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim, K., Skora, A. D., Li, Z., Liu, Q., Tam, A. J., Blosser, R. L., et al. (2014). Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc. Natl. Acad. Sci. U.S.A. 111, 11774-11779. doi: 10.1073/pnas.1410626111
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , pp. 11774-11779
    • Kim, K.1    Skora, A.D.2    Li, Z.3    Liu, Q.4    Tam, A.J.5    Blosser, R.L.6
  • 72
    • 84868207640 scopus 로고    scopus 로고
    • Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1alpha
    • Kim, Y. J., Lee, H. J., Kim, T. M., Eisinger-Mathason, T. S., Zhang, A. Y., Schmidt, B., et al. (2013). Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1alpha. Int. J. Cancer 132, 29-41. doi: 10.1002/ijc.27666
    • (2013) Int. J. Cancer , vol.132 , pp. 29-41
    • Kim, Y.J.1    Lee, H.J.2    Kim, T.M.3    Eisinger-Mathason, T.S.4    Zhang, A.Y.5    Schmidt, B.6
  • 73
    • 84898627356 scopus 로고    scopus 로고
    • A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors
    • Krall, N., Pretto, F., Decurtins, W., Bernardes, G. J., Supuran, C. T., and Neri, D. (2014). A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors. Angew. Chem. Int. Ed Engl. 53, 4231-4235. doi: 10.1002/anie.201310709
    • (2014) Angew. Chem. Int. Ed Engl , vol.53 , pp. 4231-4235
    • Krall, N.1    Pretto, F.2    Decurtins, W.3    Bernardes, G.J.4    Supuran, C.T.5    Neri, D.6
  • 74
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: cancer's Achilles' heel
    • Kroemer, G., and Pouyssegur, J. (2008). Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13, 472-482. doi: 10.1016/j.ccr.2008.05.005
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 75
    • 84906874906 scopus 로고    scopus 로고
    • Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer
    • Lambert, J. M., and Chari, R. V. (2014). Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer. J. Med. Chem. 57, 6949-6964. doi: 10.1021/jm500766w
    • (2014) J. Med. Chem , vol.57 , pp. 6949-6964
    • Lambert, J.M.1    Chari, R.V.2
  • 76
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
    • Laoui, D., Van Overmeire, E., Di Conza, G., Aldeni, C., Keirsse, J., Morias, Y., et al. (2014). Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res. 74, 24-30. doi: 10.1158/0008-5472.CAN-13-1196
    • (2014) Cancer Res , vol.74 , pp. 24-30
    • Laoui, D.1    Van Overmeire, E.2    Di Conza, G.3    Aldeni, C.4    Keirsse, J.5    Morias, Y.6
  • 77
    • 84939242207 scopus 로고    scopus 로고
    • Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition
    • Ledaki, I., McIntyre, A., Wigfield, S., Buffa, F., McGowan, S., Baban, D., et al. (2015). Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Oncotarget 6, 19413-19427. doi: 10.18632/oncotarget.4989
    • (2015) Oncotarget , vol.6 , pp. 19413-19427
    • Ledaki, I.1    McIntyre, A.2    Wigfield, S.3    Buffa, F.4    McGowan, S.5    Baban, D.6
  • 78
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch, R., Chiche, J., Marchiq, I., Naiken, T., Ilc, K., Murray, C. M., et al. (2011). CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc. Natl. Acad. Sci. U.S.A. 108, 16663-16668. doi: 10.1073/pnas.1106123108
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilc, K.5    Murray, C.M.6
  • 79
    • 70450223507 scopus 로고    scopus 로고
    • Generating specificity and diversity in the transcriptional response to hypoxia
    • Lendahl, U., Lee, K. L., Yang, H., and Poellinger, L. (2009). Generating specificity and diversity in the transcriptional response to hypoxia. Nat. Rev. Genet. 10, 821-832. doi: 10.1038/nrg2665
    • (2009) Nat. Rev. Genet , vol.10 , pp. 821-832
    • Lendahl, U.1    Lee, K.L.2    Yang, H.3    Poellinger, L.4
  • 80
    • 84887098421 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
    • Lock, F. E., McDonald, P. C., Lou, Y., Serrano, I., Chafe, S. C., Ostlund, C., et al. (2013). Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene 32, 5210-5219. doi: 10.1038/onc.2012.550
    • (2013) Oncogene , vol.32 , pp. 5210-5219
    • Lock, F.E.1    McDonald, P.C.2    Lou, Y.3    Serrano, I.4    Chafe, S.C.5    Ostlund, C.6
  • 81
    • 79955490807 scopus 로고    scopus 로고
    • Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors
    • Lou, Y., McDonald, P. C., Oloumi, A., Chia, S., Ostlund, C., Ahmadi, A., et al. (2011). Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71, 3364-3376. doi: 10.1158/0008-5472.CAN-10-4261
    • (2011) Cancer Res , vol.71 , pp. 3364-3376
    • Lou, Y.1    McDonald, P.C.2    Oloumi, A.3    Chia, S.4    Ostlund, C.5    Ahmadi, A.6
  • 82
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu, H., Forbes, R. A., and Verma, A. (2002). Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem. 277, 23111-23115. doi: 10.1074/jbc.M202487200
    • (2002) J. Biol. Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 83
    • 84939811814 scopus 로고    scopus 로고
    • Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
    • Lu, H., Samanta, D., Xiang, L., Zhang, H., Hu, H., Chen, I., et al. (2015). Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc. Natl. Acad. Sci. U.S.A. 112, E4600-E4609. doi: 10.1073/pnas.1513433112
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. E4600-E4609
    • Lu, H.1    Samanta, D.2    Xiang, L.3    Zhang, H.4    Hu, H.5    Chen, I.6
  • 84
    • 84938350452 scopus 로고    scopus 로고
    • Combination cancer immunotherapy and new immunomodulatory targets
    • Mahoney, K. M., Rennert, P. D., and Freeman, G. J. (2015). Combination cancer immunotherapy and new immunomodulatory targets. Nat. Rev. Drug Discov. 14, 561-584. doi: 10.1038/nrd4591
    • (2015) Nat. Rev. Drug Discov , vol.14 , pp. 561-584
    • Mahoney, K.M.1    Rennert, P.D.2    Freeman, G.J.3
  • 85
    • 84959164423 scopus 로고    scopus 로고
    • Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H symporters
    • Marchiq, I., and Pouysségur, J. (2015). Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H symporters. J. Mol. Med. (Berl). 94, 155-171. doi: 10.1007/s00109-015-1307-x
    • (2015) J. Mol. Med. (Berl) , vol.94 , pp. 155-171
    • Marchiq, I.1    Pouysségur, J.2
  • 86
    • 84899771418 scopus 로고    scopus 로고
    • Carbonic Anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells
    • McDonald, P. C., and Dedhar, S. (2014). Carbonic Anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. Subcell. Biochem. 75, 255-269. doi: 10.1007/978-94-007-7359-2_13
    • (2014) Subcell. Biochem , vol.75 , pp. 255-269
    • McDonald, P.C.1    Dedhar, S.2
  • 87
    • 84859870939 scopus 로고    scopus 로고
    • Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
    • McDonald, P. C., Winum, J. Y., Supuran, C. T., and Dedhar, S. (2012). Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 3, 84-97. doi: 10.18632/oncotarget.422
    • (2012) Oncotarget , vol.3 , pp. 84-97
    • McDonald, P.C.1    Winum, J.Y.2    Supuran, C.T.3    Dedhar, S.4
  • 88
    • 84926166792 scopus 로고    scopus 로고
    • Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality
    • McIntyre, A., and Harris, A. L. (2015). Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality. EMBO Mol. Med. 7, 368-379. doi: 10.15252/emmm.201404271
    • (2015) EMBO Mol. Med , vol.7 , pp. 368-379
    • McIntyre, A.1    Harris, A.L.2
  • 89
    • 84861762712 scopus 로고    scopus 로고
    • Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy
    • McIntyre, A., Patiar, S., Wigfield, S., Li, J. L., Ledaki, I., Turley, H., et al. (2012). Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin. Cancer Res. 18, 3100-3111. doi: 10.1158/1078-0432.CCR-11-1877
    • (2012) Clin. Cancer Res , vol.18 , pp. 3100-3111
    • McIntyre, A.1    Patiar, S.2    Wigfield, S.3    Li, J.L.4    Ledaki, I.5    Turley, H.6
  • 90
    • 84939121706 scopus 로고    scopus 로고
    • Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy
    • Messmer, M. N., Netherby, C. S., Banik, D., and Abrams, S. I. (2015). Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy. Cancer Immunol. Immunother. 64, 1-13. doi: 10.1007/s00262-014-1639-3
    • (2015) Cancer Immunol. Immunother , vol.64 , pp. 1-13
    • Messmer, M.N.1    Netherby, C.S.2    Banik, D.3    Abrams, S.I.4
  • 91
    • 79951983770 scopus 로고    scopus 로고
    • Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials
    • Miles, D., Harbeck, N., Escudier, B., Hurwitz, H., Saltz, L., Van Cutsem, E., et al. (2011). Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials. J. Clin. Oncol. 29, 83-88. doi: 10.1200/JCO.2010.30.2794
    • (2011) J. Clin. Oncol , vol.29 , pp. 83-88
    • Miles, D.1    Harbeck, N.2    Escudier, B.3    Hurwitz, H.4    Saltz, L.5    Van Cutsem, E.6
  • 92
    • 84891831968 scopus 로고    scopus 로고
    • Sunitinib objective response in metastatic renal cell carcinoma: analysis of 1059 patients treated on clinical trials
    • Molina, A. M., Lin, X., Korytowsky, B., Matczak, E., Lechuga, M. J., Wiltshire, R., et al. (2014). Sunitinib objective response in metastatic renal cell carcinoma: analysis of 1059 patients treated on clinical trials. Eur. J. Cancer 50, 351-358. doi: 10.1016/j.ejca.2013.08.021
    • (2014) Eur. J. Cancer , vol.50 , pp. 351-358
    • Molina, A.M.1    Lin, X.2    Korytowsky, B.3    Matczak, E.4    Lechuga, M.J.5    Wiltshire, R.6
  • 93
    • 78650580513 scopus 로고    scopus 로고
    • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment
    • Moon, E. J., Sonveaux, P., Porporato, P. E., Danhier, P., Gallez, B., Batinic-Haberle, I., et al. (2010). NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. Proc. Natl. Acad. Sci. U.S.A. 107, 20477-20482. doi: 10.1073/pnas.1006646107
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 20477-20482
    • Moon, E.J.1    Sonveaux, P.2    Porporato, P.E.3    Danhier, P.4    Gallez, B.5    Batinic-Haberle, I.6
  • 94
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz, G. T., and Coukos, G. (2013). Deciphering and reversing tumor immune suppression. Immunity 39, 61-73. doi: 10.1016/j.immuni.2013.07.005
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 95
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi, K., Laoui, D., Gysemans, C., Baeten, M., Stangé, G., Van den Bossche, J., et al. (2010). Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70, 5728-5739. doi: 10.1158/0008-5472.CAN-09-4672
    • (2010) Cancer Res , vol.70 , pp. 5728-5739
    • Movahedi, K.1    Laoui, D.2    Gysemans, C.3    Baeten, M.4    Stangé, G.5    Van den Bossche, J.6
  • 96
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch, C., Giannoudis, A., and Lewis, C. E. (2004). Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104, 2224-2234. doi: 10.1182/blood-2004-03-1109
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 97
    • 84971602476 scopus 로고    scopus 로고
    • Phase 2 study of lutetium 177-labeled anti-carbonic anhydrase IX monoclonal antibody girentuximab in patients with advanced renal cell carcinoma
    • [Epub ahead of print]
    • Muselaers, C. H. J., Boers-Sonderen, M. J., van Oostenbrugge, T. J., Boerman, O. C., Desar, I. M. E., Stillebroer, A. B., et al. (2015). Phase 2 study of lutetium 177-labeled anti-carbonic anhydrase IX monoclonal antibody girentuximab in patients with advanced renal cell carcinoma. Eur. Urol. doi: 10.1016/j.eururo.2015.11.033. [Epub ahead of print]
    • (2015) Eur. Urol
    • Muselaers, C.H.J.1    Boers-Sonderen, M.J.2    van Oostenbrugge, T.J.3    Boerman, O.C.4    Desar, I.M.E.5    Stillebroer, A.B.6
  • 98
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • Neri, D., and Supuran, C. T. (2011). Interfering with pH regulation in tumours as a therapeutic strategy. Nat. Rev. Drug Discov. 10, 767-777. doi: 10.1038/nrd3554
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 99
    • 84942919454 scopus 로고    scopus 로고
    • A threshold level of intratumor CD8+ T-cell PD1 expression dictates therapeutic response to anti-PD1
    • Ngiow, S. F., Young, A., Jacquelot, N., Yamazaki, T., Enot, D., Zitvogel, L., et al. (2015). A threshold level of intratumor CD8+ T-cell PD1 expression dictates therapeutic response to anti-PD1. Cancer Res. 75, 3800-3811. doi: 10.1158/0008-5472.CAN-15-1082
    • (2015) Cancer Res , vol.75 , pp. 3800-3811
    • Ngiow, S.F.1    Young, A.2    Jacquelot, N.3    Yamazaki, T.4    Enot, D.5    Zitvogel, L.6
  • 100
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., et al. (2014). PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 211, 781-790. doi: 10.1084/jem.20131916
    • (2014) J. Exp. Med , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3    Hasmim, M.4    Karray, S.5    Dessen, P.6
  • 101
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy, R., and Pollard, J. W. (2014). Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49-61. doi: 10.1016/j.immuni.2014.06.010
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 102
    • 38849201787 scopus 로고    scopus 로고
    • Carbonic anhydrase IX/G250/MN: a molecule too good to be true?
    • Oosterwijk, E. (2008). Carbonic anhydrase IX/G250/MN: a molecule too good to be true? BJU Int. 101, 527-528. doi: 10.1111/j.1464-410x.2007.07431.x
    • (2008) BJU Int , vol.101 , pp. 527-528
    • Oosterwijk, E.1
  • 103
    • 84878454886 scopus 로고    scopus 로고
    • Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma
    • Oosterwijk-Wakka, J. C., Boerman, O. C., Mulders, P. F., and Oosterwijk, E. (2013). Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int. J. Mol. Sci. 14, 11402-11423. doi: 10.3390/ijms140611402
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 11402-11423
    • Oosterwijk-Wakka, J.C.1    Boerman, O.C.2    Mulders, P.F.3    Oosterwijk, E.4
  • 104
    • 79952808077 scopus 로고    scopus 로고
    • Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
    • Pacchiano, F., Carta, F., McDonald, P. C., Lou, Y., Vullo, D., Scozzafava, A., et al. (2011). Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J. Med. Chem. 54, 1896-1902. doi: 10.1021/jm101541x
    • (2011) J. Med. Chem , vol.54 , pp. 1896-1902
    • Pacchiano, F.1    Carta, F.2    McDonald, P.C.3    Lou, Y.4    Vullo, D.5    Scozzafava, A.6
  • 105
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Viñals, F., et al. (2009). Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231. doi: 10.1016/j.ccr.2009.01.027
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Viñals, F.6
  • 106
    • 84938657323 scopus 로고    scopus 로고
    • Potential proinvasive or metastatic effects of preclinical antiangiogenic therapy are prevented by concurrent chemotherapy
    • Paez-Ribes, M., Man, S., Xu, P., and Kerbel, R. S. (2015). Potential proinvasive or metastatic effects of preclinical antiangiogenic therapy are prevented by concurrent chemotherapy. Clin. Cancer Res. 21, 5488-5498. doi: 10.1158/1078-0432.CCR-15-0915
    • (2015) Clin. Cancer Res , vol.21 , pp. 5488-5498
    • Paez-Ribes, M.1    Man, S.2    Xu, P.3    Kerbel, R.S.4
  • 107
    • 84908141221 scopus 로고    scopus 로고
    • HIF transcription factors, inflammation, and immunity
    • Palazon, A., Goldrath, A. W., Nizet, V., and Johnson, R. S. (2014). HIF transcription factors, inflammation, and immunity. Immunity 41, 518-528. doi: 10.1016/j.immuni.2014.09.008
    • (2014) Immunity , vol.41 , pp. 518-528
    • Palazon, A.1    Goldrath, A.W.2    Nizet, V.3    Johnson, R.S.4
  • 108
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • Palucka, K., and Banchereau, J. (2013). Dendritic-cell-based therapeutic cancer vaccines. Immunity 39, 38-48. doi: 10.1016/j.immuni.2013.07.004
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 109
    • 84872861339 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-alpha/hypoxia inducible Factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein e expression in breast cancer stem cells
    • Papi, A., Storci, G., Guarnieri, T., De Carolis, S., Bertoni, S., Avenia, N., et al. (2013). Peroxisome proliferator activated receptor-alpha/hypoxia inducible Factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein e expression in breast cancer stem cells. PLoS ONE 8:e54968. doi: 10.1371/journal.pone.0054968
    • (2013) PLoS ONE , vol.8
    • Papi, A.1    Storci, G.2    Guarnieri, T.3    De Carolis, S.4    Bertoni, S.5    Avenia, N.6
  • 110
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. (2012). The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264. doi: 10.1038/nrc3239
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 111
    • 84883182637 scopus 로고    scopus 로고
    • Disrupting proton dynamics and energy metabolism for cancer therapy
    • Parks, S. K., Chiche, J., and Pouyssegur, J. (2013). Disrupting proton dynamics and energy metabolism for cancer therapy. Nat. Rev. Cancer 13, 611-623. doi: 10.1038/nrc3579
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 611-623
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 112
    • 84958119923 scopus 로고    scopus 로고
    • Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export
    • Parks, S. K., Cormerais, Y., Marchiq, I., and Pouysségur, J. (2015). Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export. Mol. Aspects Med. 47-48, 3-14. doi: 10.1016/j.mam.2015.12.001
    • (2015) Mol. Aspects Med , vol.47-48 , pp. 3-14
    • Parks, S.K.1    Cormerais, Y.2    Marchiq, I.3    Pouysségur, J.4
  • 113
    • 84923193781 scopus 로고    scopus 로고
    • Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use
    • Pastorek, J., and Pastorekova, S. (2015). Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use. Semin. Cancer Biol. 31, 52-64. doi: 10.1016/j.semcancer.2014.08.002
    • (2015) Semin. Cancer Biol , vol.31 , pp. 52-64
    • Pastorek, J.1    Pastorekova, S.2
  • 114
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova, N. N., and Thompson, C. B. (2016). The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27-47. doi: 10.1016/j.cmet.2015.12.006
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 115
    • 84926646150 scopus 로고    scopus 로고
    • Common responses of tumors and wounds to hypoxia
    • Payen, V. L., Brisson, L., Dewhirst, M. W., and Sonveaux, P. (2015a). Common responses of tumors and wounds to hypoxia. Cancer J. 21, 75-87. doi: 10.1097/PPO.0000000000000098
    • (2015) Cancer J , vol.21 , pp. 75-87
    • Payen, V.L.1    Brisson, L.2    Dewhirst, M.W.3    Sonveaux, P.4
  • 116
    • 84949521347 scopus 로고    scopus 로고
    • Metabolic changes associated with tumor metastasis, part 1, tumor pH, glycolysis and the pentose phosphate pathway
    • Payen, V. L., Porporato, P. E., Baselet, B., and Sonveaux, P. (2015b). Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. Cell. Mol. Life Sci. 73, 1333-1348. doi: 10.1007/s00018-015-2098-5
    • (2015) Cell. Mol. Life Sci , vol.73 , pp. 1333-1348
    • Payen, V.L.1    Porporato, P.E.2    Baselet, B.3    Sonveaux, P.4
  • 117
    • 84863116661 scopus 로고    scopus 로고
    • Therapeutic mechanism and efficacy of the antibody drug-conjugate BAY 79-4620 targeting human carbonic anhydrase 9
    • Petrul, H. M., Schatz, C. A., Kopitz, C. C., Adnane, L., McCabe, T. J., Trail, P., et al. (2011). Therapeutic mechanism and efficacy of the antibody drug-conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol. Cancer Ther. 11, 340-349. doi: 10.1158/1535-7163.mct-11-0523
    • (2011) Mol. Cancer Ther , vol.11 , pp. 340-349
    • Petrul, H.M.1    Schatz, C.A.2    Kopitz, C.C.3    Adnane, L.4    McCabe, T.J.5    Trail, P.6
  • 118
    • 84896701206 scopus 로고    scopus 로고
    • Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer
    • Polanski, R., Hodgkinson, C. L., Fusi, A., Nonaka, D., Priest, L., Kelly, P., et al. (2014). Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin. Cancer Res. 20, 926-937. doi: 10.1158/1078-0432.CCR-13-2270
    • (2014) Clin. Cancer Res , vol.20 , pp. 926-937
    • Polanski, R.1    Hodgkinson, C.L.2    Fusi, A.3    Nonaka, D.4    Priest, L.5    Kelly, P.6
  • 119
    • 84943143633 scopus 로고    scopus 로고
    • In vivo loss of function screening reveals carbonic anhydrase IX as a key modulator of tumor initiating potential in primary pancreatic tumors
    • Pore, N., Jalla, S., Liu, Z., Higgs, B., Sorio, C., Scarpa, A., et al. (2015). In vivo loss of function screening reveals carbonic anhydrase IX as a key modulator of tumor initiating potential in primary pancreatic tumors. Neoplasia 17, 473-480. doi: 10.1016/j.neo.2015.05.001
    • (2015) Neoplasia , vol.17 , pp. 473-480
    • Pore, N.1    Jalla, S.2    Liu, Z.3    Higgs, B.4    Sorio, C.5    Scarpa, A.6
  • 120
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouysségur, J., Dayan, F., and Mazure, N. M. (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443. doi: 10.1038/nature04871
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 122
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail, D. F., and Joyce, J. A. (2013). Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19, 1423-1437. doi: 10.1038/nm.3394
    • (2013) Nat. Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 123
    • 84887954229 scopus 로고    scopus 로고
    • Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates
    • Rami, M., Dubois, L., Parvathaneni, N. K., Alterio, V., van Kuijk, S. J., Monti, S. M., et al. (2013). Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates. J. Med. Chem. 56, 8512-8520. doi: 10.1021/jm4009532
    • (2013) J. Med. Chem , vol.56 , pp. 8512-8520
    • Rami, M.1    Dubois, L.2    Parvathaneni, N.K.3    Alterio, V.4    van Kuijk, S.J.5    Monti, S.M.6
  • 124
    • 67651166780 scopus 로고    scopus 로고
    • Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
    • Rapisarda, A., Hollingshead, M., Uranchimeg, B., Bonomi, C. A., Borgel, S. D., Carter, J. P., et al. (2009). Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol. Cancer Ther. 8, 1867-1877. doi: 10.1158/1535-7163.MCT-09-0274
    • (2009) Mol. Cancer Ther , vol.8 , pp. 1867-1877
    • Rapisarda, A.1    Hollingshead, M.2    Uranchimeg, B.3    Bonomi, C.A.4    Borgel, S.D.5    Carter, J.P.6
  • 125
    • 84863422466 scopus 로고    scopus 로고
    • Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
    • Rapisarda, A., and Melillo, G. (2012). Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia. Nat. Rev. Clin. Oncol. 9, 378-390. doi: 10.1038/nrclinonc.2012.64
    • (2012) Nat. Rev. Clin. Oncol , vol.9 , pp. 378-390
    • Rapisarda, A.1    Melillo, G.2
  • 126
    • 84930736841 scopus 로고    scopus 로고
    • Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer
    • Rohan, T. E., Xue, X., Lin, H. M., D'Alfonso, T. M., Ginter, P. S., Oktay, M. H., et al. (2014). Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J. Nat. Cancer Inst. 106:dju136. doi: 10.1093/jnci/dju136
    • (2014) J. Nat. Cancer Inst , vol.106
    • Rohan, T.E.1    Xue, X.2    Lin, H.M.3    D'Alfonso, T.M.4    Ginter, P.S.5    Oktay, M.H.6
  • 127
    • 84918530536 scopus 로고    scopus 로고
    • Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
    • Samanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., and Semenza, G. L. (2014). Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 111, E5429-E5438. doi: 10.1073/pnas.1421438111
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , pp. E5429-E5438
    • Samanta, D.1    Gilkes, D.M.2    Chaturvedi, P.3    Xiang, L.4    Semenza, G.L.5
  • 128
    • 84865130953 scopus 로고    scopus 로고
    • Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche
    • Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S., Andrews, D. M., et al. (2012). Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res. 72, 3906-3911. doi: 10.1158/0008-5472.CAN-11-3873
    • (2012) Cancer Res , vol.72 , pp. 3906-3911
    • Sceneay, J.1    Chow, M.T.2    Chen, A.3    Halse, H.M.4    Wong, C.S.5    Andrews, D.M.6
  • 129
    • 84871127292 scopus 로고    scopus 로고
    • Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    • Schlecker, E., Stojanovic, A., Eisen, C., Quack, C., Falk, C. S., Umansky, V., et al. (2012). Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J. Immunol. 189, 5602-5611. doi: 10.4049/jimmunol.1201018
    • (2012) J. Immunol , vol.189 , pp. 5602-5611
    • Schlecker, E.1    Stojanovic, A.2    Eisen, C.3    Quack, C.4    Falk, C.S.5    Umansky, V.6
  • 130
    • 84858785688 scopus 로고    scopus 로고
    • Antibody therapy of cancer
    • Scott, A. M., Wolchok, J. D., and Old, L. J. (2012). Antibody therapy of cancer. Nat. Rev. Cancer 12, 278-287. doi: 10.1038/nrc3236
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 278-287
    • Scott, A.M.1    Wolchok, J.D.2    Old, L.J.3
  • 131
    • 84893522300 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
    • Sedlakova, O., Svastova, E., Takacova, M., Kopacek, J., Pastorek, J., and Pastorekova, S. (2014). Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front. Physiol. 4:400. doi: 10.3389/fphys.2013.00400
    • (2014) Front. Physiol , vol.4 , pp. 400
    • Sedlakova, O.1    Svastova, E.2    Takacova, M.3    Kopacek, J.4    Pastorek, J.5    Pastorekova, S.6
  • 132
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby, M. J., Engelhardt, J. J., Quigley, M., Henning, K. A., Chen, T., Srinivasan, M., et al. (2013). Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 1, 32-42. doi: 10.1158/2326-6066.CIR-13-0013
    • (2013) Cancer Immunol Res , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3    Henning, K.A.4    Chen, T.5    Srinivasan, M.6
  • 133
    • 84897019542 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    • Semenza, G. L. (2014). Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu. Rev. Pathol. 9, 47-71. doi: 10.1146/annurev-pathol-012513-104720
    • (2014) Annu. Rev. Pathol , vol.9 , pp. 47-71
    • Semenza, G.L.1
  • 134
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei, F., Wu, X., Malik, A. K., Zhong, C., Baldwin, M. E., Schanz, S., et al. (2007). Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat. Biotechnol. 25, 911-920. doi: 10.1038/nbt1323
    • (2007) Nat. Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3    Zhong, C.4    Baldwin, M.E.5    Schanz, S.6
  • 135
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Shojaei, F., Wu, X., Qu, X., Kowanetz, M., Yu, L., Tan, M., et al. (2009). G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl. Acad. Sci. U.S.A. 106, 6742-6747. doi: 10.1073/pnas.0902280106
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3    Kowanetz, M.4    Yu, L.5    Tan, M.6
  • 136
    • 78751650361 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(R)) and interferon-alpha-2a in metastatic renal cell carcinoma patients
    • Siebels, M., Rohrmann, K., Oberneder, R., Stahler, M., Haseke, N., Beck, J., et al. (2011). A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(R)) and interferon-alpha-2a in metastatic renal cell carcinoma patients. World J. Urol. 29, 121-126. doi: 10.1007/s00345-010-0570-2
    • (2011) World J. Urol , vol.29 , pp. 121-126
    • Siebels, M.1    Rohrmann, K.2    Oberneder, R.3    Stahler, M.4    Haseke, N.5    Beck, J.6
  • 137
    • 49649105571 scopus 로고    scopus 로고
    • Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide
    • Siemens, D. R., Hu, N., Sheikhi, A. K., Chung, E., Frederiksen, L. J., Pross, H., et al. (2008). Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res. 68, 4746-4753. doi: 10.1158/0008-5472.CAN-08-0054
    • (2008) Cancer Res , vol.68 , pp. 4746-4753
    • Siemens, D.R.1    Hu, N.2    Sheikhi, A.K.3    Chung, E.4    Frederiksen, L.J.5    Pross, H.6
  • 138
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux, P., Végran, F., Schroeder, T., Wergin, M. C., Verrax, J., Rabbani, Z. N., et al. (2008). Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 118, 3930-3942. doi: 10.1172/jci36843
    • (2008) J. Clin. Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Végran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5    Rabbani, Z.N.6
  • 139
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann, C., Doedens, A., Weidemann, A., Zhang, N., Takeda, N., Greenberg, J. I., et al. (2008). Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456, 814-818. doi: 10.1038/nature07445
    • (2008) Nature , vol.456 , pp. 814-818
    • Stockmann, C.1    Doedens, A.2    Weidemann, A.3    Zhang, N.4    Takeda, N.5    Greenberg, J.I.6
  • 140
    • 84867818496 scopus 로고    scopus 로고
    • Inhibition of carbonic anhydrase IX as a novel anticancer mechanism
    • Supuran, C. T. (2012). Inhibition of carbonic anhydrase IX as a novel anticancer mechanism. World J. Clin. Oncol. 3, 98-103. doi: 10.5306/wjco.v3.i7.98
    • (2012) World J. Clin. Oncol , vol.3 , pp. 98-103
    • Supuran, C.T.1
  • 141
    • 0030017852 scopus 로고    scopus 로고
    • Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors
    • Surfus, J. E., Hank, J. A., Oosterwijk, E., Welt, S., Lindstrom, M. J., Albertini, M. R., et al. (1996). Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors. J. Immunother. Emphasis Tumor Immunol. 19, 184-191. doi: 10.1097/00002371-199605000-00003
    • (1996) J. Immunother. Emphasis Tumor Immunol , vol.19 , pp. 184-191
    • Surfus, J.E.1    Hank, J.A.2    Oosterwijk, E.3    Welt, S.4    Lindstrom, M.J.5    Albertini, M.R.6
  • 142
    • 84878782832 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: a hypoxia-controlled 'catalyst' of cell migration
    • Svastova, E., and Pastorekova, S. (2013). Carbonic anhydrase IX: a hypoxia-controlled 'catalyst' of cell migration. Cell Adh. Migr. 7, 226-231. doi: 10.4161/cam.23257
    • (2013) Cell Adh. Migr , vol.7 , pp. 226-231
    • Svastova, E.1    Pastorekova, S.2
  • 143
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach, P., Hulikova, A., Vaughan-Jones, R. D., and Harris, A. L. (2010). New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 29, 6509-6521. doi: 10.1038/onc.2010.455
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 144
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge, J. E., and Gabrilovich, D. I. (2013). History of myeloid-derived suppressor cells. Nat. Rev. Cancer 13, 739-752. doi: 10.1038/nrc3581
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 145
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • Topalian, S. L., Drake, C. G., and Pardoll, D. M. (2015). Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27, 450-461. doi: 10.1016/j.ccell.2015.03.001
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 147
    • 84055176334 scopus 로고    scopus 로고
    • Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors
    • Touisni, N., Maresca, A., McDonald, P. C., Lou, Y., Scozzafava, A., Dedhar, S., et al. (2011). Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. J. Med. Chem. 54, 8271-8277. doi: 10.1021/jm200983e
    • (2011) J. Med. Chem , vol.54 , pp. 8271-8277
    • Touisni, N.1    Maresca, A.2    McDonald, P.C.3    Lou, Y.4    Scozzafava, A.5    Dedhar, S.6
  • 148
    • 84954349409 scopus 로고    scopus 로고
    • Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma
    • [Epub ahead of print]
    • Vaeteewoottacharn, K., Kariya, R., Dana, P., Fujikawa, S., Matsuda, K., Ohkuma, K., et al. (2016). Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma. Tumour Biol. doi: 10.1007/s13277-016-4785-8. [Epub ahead of print]
    • (2016) Tumour Biol
    • Vaeteewoottacharn, K.1    Kariya, R.2    Dana, P.3    Fujikawa, S.4    Matsuda, K.5    Ohkuma, K.6
  • 150
    • 84944463700 scopus 로고    scopus 로고
    • Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models
    • Ward, C., Meehan, J., Mullen, P., Supuran, C., Dixon, J. M., Thomas, J. S., et al. (2015). Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models. Oncotarget 6, 24856-24870. doi: 10.18632/oncotarget.4498
    • (2015) Oncotarget , vol.6 , pp. 24856-24870
    • Ward, C.1    Meehan, J.2    Mullen, P.3    Supuran, C.4    Dixon, J.M.5    Thomas, J.S.6
  • 151
    • 81155159685 scopus 로고    scopus 로고
    • Dysregulated pH: a perfect storm for cancer progression
    • Webb, B. A., Chimenti, M., Jacobson, M. P., and Barber, D. L. (2011). Dysregulated pH: a perfect storm for cancer progression. Nat. Rev. Cancer 11, 671-677. doi: 10.1038/nrc3110
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 671-677
    • Webb, B.A.1    Chimenti, M.2    Jacobson, M.P.3    Barber, D.L.4
  • 152
    • 84881232071 scopus 로고    scopus 로고
    • Recent molecular discoveries in angiogenesis and anti-angiogenic therapies in cancer
    • Welti, J., Loges, S., Dimmeler, S., and Carmeliet, P. (2013). Recent molecular discoveries in angiogenesis and anti-angiogenic therapies in cancer. J. Clin. Invest. 123, 3190-3200. doi: 10.1172/JCI70212
    • (2013) J. Clin. Invest , vol.123 , pp. 3190-3200
    • Welti, J.1    Loges, S.2    Dimmeler, S.3    Carmeliet, P.4
  • 153
    • 84991030573 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells-a new therapeutic target in the treatment of cancer
    • Wesolowski, R., Markowitz, J., and Carson, W. E. III (2013). Myeloid derived suppressor cells-a new therapeutic target in the treatment of cancer. J. Immunother. Cancer 1, 10. doi: 10.1186/2051-1426-1-10
    • (2013) J. Immunother. Cancer , vol.1 , pp. 10
    • Wesolowski, R.1    Markowitz, J.2    Carson, W.E.3
  • 154
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry, E. J., and Kurachi, M. (2015). Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15, 486-499. doi: 10.1038/nri3862
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 155
    • 84923169480 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX with small organic ligands
    • Wichert, M., and Krall, N. (2015). Targeting carbonic anhydrase IX with small organic ligands. Curr. Opin. Chem. Biol. 26, 48-54. doi: 10.1016/j.cbpa.2015.02.005
    • (2015) Curr. Opin. Chem. Biol , vol.26 , pp. 48-54
    • Wichert, M.1    Krall, N.2
  • 156
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson, W. R., and Hay, M. P. (2011). Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 11, 393-410. doi: 10.1038/nrc3064
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 158
    • 80053645045 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
    • Wong, C. C., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., et al. (2011). Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl. Acad. Sci. U.S.A. 108, 16369-16374. doi: 10.1073/pnas.1113483108
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 16369-16374
    • Wong, C.C.1    Gilkes, D.M.2    Zhang, H.3    Chen, J.4    Wei, H.5    Chaturvedi, P.6
  • 159
    • 77949716901 scopus 로고    scopus 로고
    • Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology
    • Xu, C., Lo, A., Yammanuru, A., Tallarico, A. S., Brady, K., Murakami, A., et al. (2010). Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS ONE 5:e9625. doi: 10.1371/journal.pone.0009625
    • (2010) PLoS ONE , vol.5
    • Xu, C.1    Lo, A.2    Yammanuru, A.3    Tallarico, A.S.4    Brady, K.5    Murakami, A.6
  • 160
    • 84949255251 scopus 로고    scopus 로고
    • Estrogen receptor-alpha directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer
    • Yang, J., AlTahan, A., Jones, D. T., Buffa, F. M., Bridges, E., Interiano, R. B., et al. (2015). Estrogen receptor-alpha directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proc. Natl. Acad. Sci. U.S.A. 112, 15172-15177. doi: 10.1073/pnas.1422015112
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 15172-15177
    • Yang, J.1    AlTahan, A.2    Jones, D.T.3    Buffa, F.M.4    Bridges, E.5    Interiano, R.B.6
  • 161
    • 78649813619 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain
    • Zatovicova, M., Jelenska, L., Hulikova, A., Csaderova, L., Ditte, Z., Ditte, P., et al. (2010). Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. Curr. Pharm. Des. 16, 3255-3263. doi: 10.2174/138161210793429832
    • (2010) Curr. Pharm. Des , vol.16 , pp. 3255-3263
    • Zatovicova, M.1    Jelenska, L.2    Hulikova, A.3    Csaderova, L.4    Ditte, Z.5    Ditte, P.6
  • 162
    • 84907695899 scopus 로고    scopus 로고
    • Monoclonal antibody G250 targeting CA: binding specificity, internalization and therapeutic effects in a non-renal cancer model
    • Zatovicova, M., Jelenska, L., Hulikova, A., Ditte, P., Ditte, Z., Csaderova, L., et al. (2014). Monoclonal antibody G250 targeting CA: binding specificity, internalization and therapeutic effects in a non-renal cancer model. Int. J. Oncol. 45, 2455-2467. doi: 10.3892/ijo.2014.2658
    • (2014) Int. J. Oncol , vol.45 , pp. 2455-2467
    • Zatovicova, M.1    Jelenska, L.2    Hulikova, A.3    Ditte, P.4    Ditte, Z.5    Csaderova, L.6
  • 163
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou, W. (2006). Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6, 295-307. doi: 10.1038/nri1806
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 295-307
    • Zou, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.