MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

Cell Reports

Volumn 9, Issue 6, 2014, Pages 2233-2249

  Baek, Guem Hee ^a   Tse, Yan F ^a   Hu, Zeping ^c   Cox, Derek ^a   Buboltz, Noah ^d   McCue, Peter ^d   Yeo, Charles J ^d   White, Michael A ^e   DeBerardinis, Ralph J ^b,c   Knudsen, Erik S ^a,b   Witkiewicz, Agnieszka K ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CHILDREN S MEDICAL CENTER   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 4; REACTIVE OXYGEN METABOLITE; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; AUTOPHAGY; CANCER CLASSIFICATION; CANCER INHIBITION; CANCER PROGNOSIS; CELL DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION REGULATION; GENE MUTATION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; METABOLIC STRESS; ONCOGENE K RAS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS ADENOCARCINOMA; PINOCYTOSIS; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; GENETICS; METABOLISM; MOUSE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ANIMALS; BIOMARKERS, TUMOR; CARCINOMA, PANCREATIC DUCTAL; CELL DEATH; CELL LINE, TUMOR; GLYCOLYSIS; HUMANS; MICE; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; OXIDATIVE PHOSPHORYLATION; PANCREATIC NEOPLASMS; PROGNOSIS; REACTIVE OXYGEN SPECIES;

EID: 84919863195     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.11.025     Document Type: Article

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