Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8512-8520

  Rami, Marouan ^a   Dubois, Ludwig ^b   Parvathaneni, Nanda Kumar ^a,b   Alterio, Vincenzo ^c   Van Kuijk, Simon J A ^b   Monti, Simona Maria ^c   Lambin, Philippe ^b   De Simone, Giuseppina ^c   Supuran, Claudiu T ^d   Winum, Jean Yves ^a  

^a INSTITUT CHARLES GERHARDT   (France)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c CNR   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(2 NITRO IMIDAZOL 1 YL) ACETIC ACID; 2 (2 NITRO IMIDAZOL 1 YL) N (3 SULFAMOYLPHENYL)ACETAMIDE; 2 (2 NITRO IMIDAZOL 1 YL) N (4 SULFAMOYLBENZYL)ACETAMIDE; 2 (2 NITRO IMIDAZOL 1 YL) N (4 SULFAMOYLPHENYL)ACETAMIDE; 2 (2 NITRO IMIDAZOL 1 YL) N [2 (4 SULFAMOYLPHENYL)ETHYL]ACETAMIDE; 2 (2 NITRO IMIDAZOL 1 YL)ETHYLAMINE; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DOXORUBICIN; N (3 SULFAMOYLPHENYL) N [(2 AMINOETHYL) 2 METHYL 5 NITROIMIDAZOLYL] THIOUREA; N (4 SULFAMOYLBENZYL) N [(2 AMINOETHYL) 2 METHYL 5 NITROIMIDAZOLYL] THIOUREA; N (4 SULFAMOYLPHENYL) N [(2 AMINOETHYL) 2 METHYL 5 NITROIMIDAZOLYL] THIOUREA; N (4 SULFAMOYLPHENYLETHYL) N [(2 AMINOETHYL) 2 METHYL 5 NITROIMIDAZOLYL] THIOUREA; N [2 (2 METHYL 5 NITRO IMIDAZOL 1 YL)ETHYL]SULFAMIDE; N [2 (2 METHYL IMIDAZOL 1 YL)PROPYL]SULFAMIDE; N [2 (2 NITRO IMIDAZOL 1 YL)ETHYL]SULFAMIDE; N METHANESULFONYL 1 (2 AMINOETHYL) 2 METHYL 5 NITROIMIDAZOLE; N METHANESULFONYL 2 (2 NITRO IMIDAZOL 1 YL)ETHYLAMINE; N[2 (2 METHYL 5 NITRO IMIDAZOL 1 YL)ETHYL]SULFAMATE; NITROIMIDAZOLE DERIVATIVE; SULFAMIDE DERIVATIVE; SULFONAMIDE; TERT BUTYL (2 NITRO IMIDAZOL 1 YL) ACETATE; UNCLASSIFIED DRUG;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOSENSITIZATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; X RAY CRYSTALLOGRAPHY;

AMIDES; ANOXIA; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HELA CELLS; HT29 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITROIMIDAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONIC ACIDS;

EID: 84887954229     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4009532     Document Type: Article

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