-
1
-
-
0345798150
-
Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
-
Abramsson A., Lindblom P., Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J.Clin. Invest. 2003, 112:1142-1151.
-
(2003)
J.Clin. Invest.
, vol.112
, pp. 1142-1151
-
-
Abramsson, A.1
Lindblom, P.2
Betsholtz, C.3
-
2
-
-
84894277482
-
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma
-
Aguilera K.Y., Rivera L.B., Hur H., Carbon J.G., Toombs J.E., Goldstein C.D., Dellinger M.T., Castrillon D.H., Brekken R.A. Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res. 2014, 74:1032-1044.
-
(2014)
Cancer Res.
, vol.74
, pp. 1032-1044
-
-
Aguilera, K.Y.1
Rivera, L.B.2
Hur, H.3
Carbon, J.G.4
Toombs, J.E.5
Goldstein, C.D.6
Dellinger, M.T.7
Castrillon, D.H.8
Brekken, R.A.9
-
3
-
-
84878609062
-
Bevacizumab-induced normalization of blood vessels in tumors hampers antibody uptake
-
Arjaans M., Oude Munnink T.H., Oosting S.F., Terwisscha van Scheltinga A.G., Gietema J.A., Garbacik E.T., Timmer-Bosscha H., Lub-de Hooge M.N., Schröder C.P., de Vries E.G. Bevacizumab-induced normalization of blood vessels in tumors hampers antibody uptake. Cancer Res. 2013, 73:3347-3355.
-
(2013)
Cancer Res.
, vol.73
, pp. 3347-3355
-
-
Arjaans, M.1
Oude Munnink, T.H.2
Oosting, S.F.3
Terwisscha van Scheltinga, A.G.4
Gietema, J.A.5
Garbacik, E.T.6
Timmer-Bosscha, H.7
Lub-de Hooge, M.N.8
Schröder, C.P.9
de Vries, E.G.10
-
4
-
-
84893872087
-
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
-
Barsoum I.B., Smallwood C.A., Siemens D.R., Graham C.H. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 2014, 74:665-674.
-
(2014)
Cancer Res.
, vol.74
, pp. 665-674
-
-
Barsoum, I.B.1
Smallwood, C.A.2
Siemens, D.R.3
Graham, C.H.4
-
5
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor T.T., Sorensen A.G., di Tomaso E., Zhang W.T., Duda D.G., Cohen K.S., Kozak K.R., Cahill D.P., Chen P.J., Zhu M., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11:83-95.
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
Zhang, W.T.4
Duda, D.G.5
Cohen, K.S.6
Kozak, K.R.7
Cahill, D.P.8
Chen, P.J.9
Zhu, M.10
-
6
-
-
84887419886
-
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
-
Batchelor T.T., Gerstner E.R., Emblem K.E., Duda D.G., Kalpathy-Cramer J., Snuderl M., Ancukiewicz M., Polaskova P., Pinho M.C., Jennings D., et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc. Natl. Acad. Sci. USA 2013, 110:19059-19064.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 19059-19064
-
-
Batchelor, T.T.1
Gerstner, E.R.2
Emblem, K.E.3
Duda, D.G.4
Kalpathy-Cramer, J.5
Snuderl, M.6
Ancukiewicz, M.7
Polaskova, P.8
Pinho, M.C.9
Jennings, D.10
-
8
-
-
84857131874
-
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia
-
Bottos A., Martini M., Di Nicolantonio F., Comunanza V., Maione F., Minassi A., Appendino G., Bussolino F., Bardelli A. Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc. Natl. Acad. Sci. USA 2012, 109:E353-E359.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E353-E359
-
-
Bottos, A.1
Martini, M.2
Di Nicolantonio, F.3
Comunanza, V.4
Maione, F.5
Minassi, A.6
Appendino, G.7
Bussolino, F.8
Bardelli, A.9
-
9
-
-
39749114978
-
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
-
Bristow R.G., Hill R.P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer 2008, 8:180-192.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 180-192
-
-
Bristow, R.G.1
Hill, R.P.2
-
10
-
-
81155123190
-
RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Brufsky A.M., Hurvitz S., Perez E., Swamy R., Valero V., O'Neill V., Rugo H.S. RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J.Clin. Oncol. 2011, 29:4286-4293.
-
(2011)
J.Clin. Oncol.
, vol.29
, pp. 4286-4293
-
-
Brufsky, A.M.1
Hurvitz, S.2
Perez, E.3
Swamy, R.4
Valero, V.5
O'Neill, V.6
Rugo, H.S.7
-
11
-
-
75149149879
-
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors
-
Butler J.M., Kobayashi H., Rafii S. Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat. Rev. Cancer 2010, 10:138-146.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 138-146
-
-
Butler, J.M.1
Kobayashi, H.2
Rafii, S.3
-
12
-
-
84861861104
-
Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
-
Calcinotto A., Filipazzi P., Grioni M., Iero M., De Milito A., Ricupito A., Cova A., Canese R., Jachetti E., Rossetti M., et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Res. 2012, 72:2746-2756.
-
(2012)
Cancer Res.
, vol.72
, pp. 2746-2756
-
-
Calcinotto, A.1
Filipazzi, P.2
Grioni, M.3
Iero, M.4
De Milito, A.5
Ricupito, A.6
Cova, A.7
Canese, R.8
Jachetti, E.9
Rossetti, M.10
-
13
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
14
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
Carmeliet P., Jain R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473:298-307.
-
(2011)
Nature
, vol.473
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
15
-
-
84897990135
-
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
-
Casazza A., Di Conza G., Wenes M., Finisguerra V., Deschoemaeker S., Mazzone M. Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment. Oncogene 2014, 33:1743-1754.
-
(2014)
Oncogene
, vol.33
, pp. 1743-1754
-
-
Casazza, A.1
Di Conza, G.2
Wenes, M.3
Finisguerra, V.4
Deschoemaeker, S.5
Mazzone, M.6
-
16
-
-
77953596688
-
Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor?
-
Castets M., Mehlen P. Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor?. Cell Cycle 2010, 9:1466-1471.
-
(2010)
Cell Cycle
, vol.9
, pp. 1466-1471
-
-
Castets, M.1
Mehlen, P.2
-
17
-
-
84863655863
-
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
-
Chauhan V.P., Stylianopoulos T., Martin J.D., Popović Z., Chen O., Kamoun W.S., Bawendi M.G., Fukumura D., Jain R.K. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotechnol. 2012, 7:383-388.
-
(2012)
Nat. Nanotechnol.
, vol.7
, pp. 383-388
-
-
Chauhan, V.P.1
Stylianopoulos, T.2
Martin, J.D.3
Popović, Z.4
Chen, O.5
Kamoun, W.S.6
Bawendi, M.G.7
Fukumura, D.8
Jain, R.K.9
-
18
-
-
84885129359
-
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
-
Chauhan V.P., Martin J.D., Liu H., Lacorre D.A., Jain S.R., Kozin S.V., Stylianopoulos T., Mousa A.S., Han X., Adstamongkonkul P., et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat. Commun. 2013, 4:2516.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2516
-
-
Chauhan, V.P.1
Martin, J.D.2
Liu, H.3
Lacorre, D.A.4
Jain, S.R.5
Kozin, S.V.6
Stylianopoulos, T.7
Mousa, A.S.8
Han, X.9
Adstamongkonkul, P.10
-
19
-
-
84904244854
-
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure
-
Chauhan V.P., Boucher Y., Ferrone C.R., Roberge S., Martin J.D., Stylianopoulos T., Bardeesy N., DePinho R.A., Padera T.P., Munn L.L., Jain R.K. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell 2014, 26:14-15.
-
(2014)
Cancer Cell
, vol.26
, pp. 14-15
-
-
Chauhan, V.P.1
Boucher, Y.2
Ferrone, C.R.3
Roberge, S.4
Martin, J.D.5
Stylianopoulos, T.6
Bardeesy, N.7
DePinho, R.A.8
Padera, T.P.9
Munn, L.L.10
Jain, R.K.11
-
20
-
-
84896492282
-
Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1α/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice
-
Chen Y., Huang Y., Reiberger T., Duyverman A.M., Huang P., Samuel R., Hiddingh L., Roberge S., Koppel C., Lauwers G.Y., et al. Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1α/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice. Hepatology 2014, 59:1435-1447.
-
(2014)
Hepatology
, vol.59
, pp. 1435-1447
-
-
Chen, Y.1
Huang, Y.2
Reiberger, T.3
Duyverman, A.M.4
Huang, P.5
Samuel, R.6
Hiddingh, L.7
Roberge, S.8
Koppel, C.9
Lauwers, G.Y.10
-
21
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
Cheng A.L., Kang Y.K., Chen Z., Tsao C.J., Qin S., Kim J.S., Luo R., Feng J., Ye S., Yang T.S., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009, 10:25-34.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
-
22
-
-
67650281734
-
Fibronectin is an important regulator of flow-induced vascular remodeling
-
Chiang H.Y., Korshunov V.A., Serour A., Shi F., Sottile J. Fibronectin is an important regulator of flow-induced vascular remodeling. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1074-1079.
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 1074-1079
-
-
Chiang, H.Y.1
Korshunov, V.A.2
Serour, A.3
Shi, F.4
Sottile, J.5
-
23
-
-
84863718886
-
Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
-
Chung A.S., Kowanetz M., Wu X., Zhuang G., Ngu H., Finkle D., Komuves L., Peale F., Ferrara N. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J.Pathol. 2012, 227:404-416.
-
(2012)
J.Pathol.
, vol.227
, pp. 404-416
-
-
Chung, A.S.1
Kowanetz, M.2
Wu, X.3
Zhuang, G.4
Ngu, H.5
Finkle, D.6
Komuves, L.7
Peale, F.8
Ferrara, N.9
-
24
-
-
84883745262
-
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
-
Chung A.S., Wu X., Zhuang G., Ngu H., Kasman I., Zhang J., Vernes J.-M., Jiang Z., Meng Y.G., Peale F.V., et al. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat. Med. 2013, 19:1114-1123.
-
(2013)
Nat. Med.
, vol.19
, pp. 1114-1123
-
-
Chung, A.S.1
Wu, X.2
Zhuang, G.3
Ngu, H.4
Kasman, I.5
Zhang, J.6
Vernes, J.-M.7
Jiang, Z.8
Meng, Y.G.9
Peale, F.V.10
-
25
-
-
84907223092
-
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
-
Colegio O.R., Chu N.Q., Szabo A.L., Chu T., Rhebergen A.M., Jairam V., Cyrus N., Brokowski C.E., Eisenbarth S.C., Phillips G.M., et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014, 513:559-563.
-
(2014)
Nature
, vol.513
, pp. 559-563
-
-
Colegio, O.R.1
Chu, N.Q.2
Szabo, A.L.3
Chu, T.4
Rhebergen, A.M.5
Jairam, V.6
Cyrus, N.7
Brokowski, C.E.8
Eisenbarth, S.C.9
Phillips, G.M.10
-
26
-
-
84887456534
-
Role of endothelial cell metabolism in vessel sprouting
-
De Bock K., Georgiadou M., Carmeliet P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab. 2013, 18:634-647.
-
(2013)
Cell Metab.
, vol.18
, pp. 634-647
-
-
De Bock, K.1
Georgiadou, M.2
Carmeliet, P.3
-
27
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
-
Demetri G.D., van Oosterom A.T., Garrett C.R., Blackstein M.E., Shah M.H., Verweij J., McArthur G., Judson I.R., Heinrich M.C., Morgan J.A., et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006, 368:1329-1338.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
-
28
-
-
65249183165
-
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
-
di Tomaso E., London N., Fuja D., Logie J., Tyrrell J.A., Kamoun W., Munn L.L., Jain R.K. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS ONE 2009, 4:e5123.
-
(2009)
PLoS ONE
, vol.4
, pp. e5123
-
-
di Tomaso, E.1
London, N.2
Fuja, D.3
Logie, J.4
Tyrrell, J.A.5
Kamoun, W.6
Munn, L.L.7
Jain, R.K.8
-
29
-
-
77954991606
-
Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer
-
Duda D.G., Willett C.G., Ancukiewicz M., di Tomaso E., Shah M., Czito B.G., Bentley R., Poleski M., Lauwers G.Y., Carroll M., et al. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. Oncologist 2010, 15:577-583.
-
(2010)
Oncologist
, vol.15
, pp. 577-583
-
-
Duda, D.G.1
Willett, C.G.2
Ancukiewicz, M.3
di Tomaso, E.4
Shah, M.5
Czito, B.G.6
Bentley, R.7
Poleski, M.8
Lauwers, G.Y.9
Carroll, M.10
-
30
-
-
79954606458
-
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
-
Duda D.G., Kozin S.V., Kirkpatrick N.D., Xu L., Fukumura D., Jain R.K. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?. Clin. Cancer Res. 2011, 17:2074-2080.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 2074-2080
-
-
Duda, D.G.1
Kozin, S.V.2
Kirkpatrick, N.D.3
Xu, L.4
Fukumura, D.5
Jain, R.K.6
-
31
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J.Clin. Oncol. 2002, 20:4368-4380.
-
(2002)
J.Clin. Oncol.
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
32
-
-
84890571003
-
Cabozantinib in progressive medullary thyroid cancer
-
Elisei R., Schlumberger M.J., Müller S.P., Schöffski P., Brose M.S., Shah M.H., Licitra L., Jarzab B., Medvedev V., Kreissl M.C., et al. Cabozantinib in progressive medullary thyroid cancer. J.Clin. Oncol. 2013, 31:3639-3646.
-
(2013)
J.Clin. Oncol.
, vol.31
, pp. 3639-3646
-
-
Elisei, R.1
Schlumberger, M.J.2
Müller, S.P.3
Schöffski, P.4
Brose, M.S.5
Shah, M.H.6
Licitra, L.7
Jarzab, B.8
Medvedev, V.9
Kreissl, M.C.10
-
33
-
-
84883760198
-
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy
-
Emblem K.E., Mouridsen K., Bjornerud A., Farrar C.T., Jennings D., Borra R.J., Wen P.Y., Ivy P., Batchelor T.T., Rosen B.R., et al. Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nat. Med. 2013, 19:1178-1183.
-
(2013)
Nat. Med.
, vol.19
, pp. 1178-1183
-
-
Emblem, K.E.1
Mouridsen, K.2
Bjornerud, A.3
Farrar, C.T.4
Jennings, D.5
Borra, R.J.6
Wen, P.Y.7
Ivy, P.8
Batchelor, T.T.9
Rosen, B.R.10
-
34
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Siebels M., Negrier S., Chevreau C., Solska E., Desai A.A., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N.Engl. J. Med. 2007, 356:125-134. TARGET Study Group.
-
(2007)
N.Engl. J. Med.
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
-
35
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
-
Escudier B., Bellmunt J., Négrier S., Bajetta E., Melichar B., Bracarda S., Ravaud A., Golding S., Jethwa S., Sneller V. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J.Clin. Oncol. 2010, 28:2144-2150.
-
(2010)
J.Clin. Oncol.
, vol.28
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Négrier, S.3
Bajetta, E.4
Melichar, B.5
Bracarda, S.6
Ravaud, A.7
Golding, S.8
Jethwa, S.9
Sneller, V.10
-
36
-
-
84888816383
-
Dual HER2 inhibition in combination with anti-VEGF treatment is active in heavily pretreated HER2-positive breast cancer
-
Falchook G.S., Moulder S.L., Wheler J.J., Jiang Y., Bastida C.C., Kurzrock R. Dual HER2 inhibition in combination with anti-VEGF treatment is active in heavily pretreated HER2-positive breast cancer. Ann. Oncol. 2013, 24:3004-3011.
-
(2013)
Ann. Oncol.
, vol.24
, pp. 3004-3011
-
-
Falchook, G.S.1
Moulder, S.L.2
Wheler, J.J.3
Jiang, Y.4
Bastida, C.C.5
Kurzrock, R.6
-
37
-
-
0034635995
-
Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model
-
Fang J., Shing Y., Wiederschain D., Yan L., Butterfield C., Jackson G., Harper J., Tamvakopoulos G., Moses M.A. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc. Natl. Acad. Sci. USA 2000, 97:3884-3889.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3884-3889
-
-
Fang, J.1
Shing, Y.2
Wiederschain, D.3
Yan, L.4
Butterfield, C.5
Jackson, G.6
Harper, J.7
Tamvakopoulos, G.8
Moses, M.A.9
-
38
-
-
84857506147
-
Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy
-
Farsaci B., Higgins J.P., Hodge J.W. Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy. Int. J. Cancer 2012, 130:1948-1959.
-
(2012)
Int. J. Cancer
, vol.130
, pp. 1948-1959
-
-
Farsaci, B.1
Higgins, J.P.2
Hodge, J.W.3
-
39
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2002, 2:795-803.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 795-803
-
-
Ferrara, N.1
-
40
-
-
77954563464
-
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
-
Finger E.C., Giaccia A.J. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev. 2010, 29:285-293.
-
(2010)
Cancer Metastasis Rev.
, vol.29
, pp. 285-293
-
-
Finger, E.C.1
Giaccia, A.J.2
-
41
-
-
56749174211
-
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
-
Fischer C., Mazzone M., Jonckx B., Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?. Nat. Rev. Cancer 2008, 8:942-956.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 942-956
-
-
Fischer, C.1
Mazzone, M.2
Jonckx, B.3
Carmeliet, P.4
-
42
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N.Engl. J. Med. 1971, 285:1182-1186.
-
(1971)
N.Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
43
-
-
84886313817
-
Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects invitro and invivo
-
Foy K.C., Miller M.J., Moldovan N., Carson Iii W.E., Kaumaya P.T.P. Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects invitro and invivo. OncoImmunology 2012, 1:1048-1060.
-
(2012)
OncoImmunology
, vol.1
, pp. 1048-1060
-
-
Foy, K.C.1
Miller, M.J.2
Moldovan, N.3
Carson Iii, W.E.4
Kaumaya, P.T.P.5
-
44
-
-
79251468712
-
Mouse models of advanced spontaneous metastasis for experimental therapeutics
-
Francia G., Cruz-Munoz W., Man S., Xu P., Kerbel R.S. Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat. Rev. Cancer 2011, 11:135-141.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 135-141
-
-
Francia, G.1
Cruz-Munoz, W.2
Man, S.3
Xu, P.4
Kerbel, R.S.5
-
45
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
-
Fuchs C.S., Tomasek J., Yong C.J., Dumitru F., Passalacqua R., Goswami C., Safran H., dos Santos L.V., Aprile G., Ferry D.R., et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2014, 383:31-39. REGARD Trial Investigators.
-
(2014)
Lancet
, vol.383
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
Dumitru, F.4
Passalacqua, R.5
Goswami, C.6
Safran, H.7
dos Santos, L.V.8
Aprile, G.9
Ferry, D.R.10
-
47
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich D.I., Ishida T., Nadaf S., Ohm J.E., Carbone D.P. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 1999, 5:2963-2970.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
Ishida, T.2
Nadaf, S.3
Ohm, J.E.4
Carbone, D.P.5
-
49
-
-
84879477431
-
AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer
-
Gianni L., Romieu G.H., Lichinitser M., Serrano S.V., Mansutti M., Pivot X., Mariani P., Andre F., Chan A., Lipatov O., et al. AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J.Clin. Oncol. 2013, 31:1719-1725.
-
(2013)
J.Clin. Oncol.
, vol.31
, pp. 1719-1725
-
-
Gianni, L.1
Romieu, G.H.2
Lichinitser, M.3
Serrano, S.V.4
Mansutti, M.5
Pivot, X.6
Mariani, P.7
Andre, F.8
Chan, A.9
Lipatov, O.10
-
50
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio B.J., Catalano P.J., Meropol N.J., O'Dwyer P.J., Mitchell E.P., Alberts S.R., Schwartz M.A., Benson A.B. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J.Clin. Oncol. 2007, 25:1539-1544. Eastern Cooperative Oncology Group Study E3200.
-
(2007)
J.Clin. Oncol.
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
O'Dwyer, P.J.4
Mitchell, E.P.5
Alberts, S.R.6
Schwartz, M.A.7
Benson, A.B.8
-
52
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
Goel S., Duda D.G., Xu L., Munn L.L., Boucher Y., Fukumura D., Jain R.K. Normalization of the vasculature for treatment of cancer and other diseases. Physiol. Rev. 2011, 91:1071-1121.
-
(2011)
Physiol. Rev.
, vol.91
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
Jain, R.K.7
-
53
-
-
84861215641
-
Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology
-
Goel S., Fukumura D., Jain R.K. Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology. Proc. Natl. Acad. Sci. USA 2012, 109:E1214.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E1214
-
-
Goel, S.1
Fukumura, D.2
Jain, R.K.3
-
54
-
-
84883174690
-
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression
-
Goel S., Gupta N., Walcott B.P., Snuderl M., Kesler C.T., Kirkpatrick N.D., Heishi T., Huang Y., Martin J.D., Ager E., et al. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J.Natl. Cancer Inst. 2013, 105:1188-1201.
-
(2013)
J.Natl. Cancer Inst.
, vol.105
, pp. 1188-1201
-
-
Goel, S.1
Gupta, N.2
Walcott, B.P.3
Snuderl, M.4
Kesler, C.T.5
Kirkpatrick, N.D.6
Heishi, T.7
Huang, Y.8
Martin, J.D.9
Ager, E.10
-
55
-
-
84916931723
-
Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease
-
Goveia J., Stapor P., Carmeliet P. Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease. EMBO Mol. Med. 2014, 6:1105-1120.
-
(2014)
EMBO Mol. Med.
, vol.6
, pp. 1105-1120
-
-
Goveia, J.1
Stapor, P.2
Carmeliet, P.3
-
56
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A., Van Cutsem E., Sobrero A., Siena S., Falcone A., Ychou M., Humblet Y., Bouché O., Mineur L., Barone C., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013, 381:303-312. CORRECT Study Group.
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
Siena, S.4
Falcone, A.5
Ychou, M.6
Humblet, Y.7
Bouché, O.8
Mineur, L.9
Barone, C.10
-
57
-
-
43749112760
-
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
-
Hamzah J., Jugold M., Kiessling F., Rigby P., Manzur M., Marti H.H., Rabie T., Kaden S., Gröne H.J., Hämmerling G.J., et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 2008, 453:410-414.
-
(2008)
Nature
, vol.453
, pp. 410-414
-
-
Hamzah, J.1
Jugold, M.2
Kiessling, F.3
Rigby, P.4
Manzur, M.5
Marti, H.H.6
Rabie, T.7
Kaden, S.8
Gröne, H.J.9
Hämmerling, G.J.10
-
58
-
-
84858590826
-
Accessories to the crime: functions of cells recruited to the tumor microenvironment
-
Hanahan D., Coussens L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21:309-322.
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
59
-
-
84872278131
-
Phase I trial of OTS11101, an anti-angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor
-
Hayashi H., Kurata T., Fujisaka Y., Kawakami H., Tanaka K., Okabe T., Takeda M., Satoh T., Yoshida K., Tsunoda T., et al. Phase I trial of OTS11101, an anti-angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor. Cancer Sci. 2013, 104:98-104.
-
(2013)
Cancer Sci.
, vol.104
, pp. 98-104
-
-
Hayashi, H.1
Kurata, T.2
Fujisaka, Y.3
Kawakami, H.4
Tanaka, K.5
Okabe, T.6
Takeda, M.7
Satoh, T.8
Yoshida, K.9
Tsunoda, T.10
-
60
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellström M., Phng L.K., Hofmann J.J., Wallgard E., Coultas L., Lindblom P., Alva J., Nilsson A.K., Karlsson L., Gaiano N., et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007, 445:776-780.
-
(2007)
Nature
, vol.445
, pp. 776-780
-
-
Hellström, M.1
Phng, L.K.2
Hofmann, J.J.3
Wallgard, E.4
Coultas, L.5
Lindblom, P.6
Alva, J.7
Nilsson, A.K.8
Karlsson, L.9
Gaiano, N.10
-
61
-
-
84877799305
-
Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies
-
Heskamp S., Boerman O.C., Molkenboer-Kuenen J.D.M., Oyen W.J.G., van der Graaf W.T.A., van Laarhoven H.W.M. Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies. Int. J. Cancer 2013, 133:307-314.
-
(2013)
Int. J. Cancer
, vol.133
, pp. 307-314
-
-
Heskamp, S.1
Boerman, O.C.2
Molkenboer-Kuenen, J.D.M.3
Oyen, W.J.G.4
van der Graaf, W.T.A.5
van Laarhoven, H.W.M.6
-
62
-
-
0032516078
-
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
-
Hobbs S.K., Monsky W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., Jain R.K. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA 1998, 95:4607-4612.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4607-4612
-
-
Hobbs, S.K.1
Monsky, W.L.2
Yuan, F.3
Roberts, W.G.4
Griffith, L.5
Torchilin, V.P.6
Jain, R.K.7
-
63
-
-
84964313298
-
Bevacizumab plus ipilimumab in patients with metastatic melanoma
-
Hodi F.S., Lawrence D., Lezcano C., Wu X., Zhou J., Sasada T., Zeng W., Giobbie-Hurder A., Atkins M.B., Ibrahim N., et al. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res 2014, 2:632-642.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 632-642
-
-
Hodi, F.S.1
Lawrence, D.2
Lezcano, C.3
Wu, X.4
Zhou, J.5
Sasada, T.6
Zeng, W.7
Giobbie-Hurder, A.8
Atkins, M.B.9
Ibrahim, N.10
-
64
-
-
0037109023
-
Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein
-
Huang X., Wong M.K., Yi H., Watkins S., Laird A.D., Wolf S.F., Gorelik E. Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein. Cancer Res. 2002, 62:5727-5735.
-
(2002)
Cancer Res.
, vol.62
, pp. 5727-5735
-
-
Huang, X.1
Wong, M.K.2
Yi, H.3
Watkins, S.4
Laird, A.D.5
Wolf, S.F.6
Gorelik, E.7
-
65
-
-
77954890371
-
Targeting the ANGPT-TIE2 pathway in malignancy
-
Huang H., Bhat A., Woodnutt G., Lappe R. Targeting the ANGPT-TIE2 pathway in malignancy. Nat. Rev. Cancer 2010, 10:575-585.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 575-585
-
-
Huang, H.1
Bhat, A.2
Woodnutt, G.3
Lappe, R.4
-
66
-
-
84867902940
-
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
-
Huang Y., Yuan J., Righi E., Kamoun W.S., Ancukiewicz M., Nezivar J., Santosuosso M., Martin J.D., Martin M.R., Vianello F., et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc. Natl. Acad. Sci. USA 2012, 109:17561-17566.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 17561-17566
-
-
Huang, Y.1
Yuan, J.2
Righi, E.3
Kamoun, W.S.4
Ancukiewicz, M.5
Nezivar, J.6
Santosuosso, M.7
Martin, J.D.8
Martin, M.R.9
Vianello, F.10
-
67
-
-
84877870613
-
Vascular normalization as an emerging strategy to enhance cancer immunotherapy
-
Huang Y., Goel S., Duda D.G., Fukumura D., Jain R.K. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res. 2013, 73:2943-2948.
-
(2013)
Cancer Res.
, vol.73
, pp. 2943-2948
-
-
Huang, Y.1
Goel, S.2
Duda, D.G.3
Fukumura, D.4
Jain, R.K.5
-
68
-
-
0037149539
-
Tumour biology: herceptin acts as an anti-angiogenic cocktail
-
Izumi Y., Xu L., di Tomaso E., Fukumura D., Jain R.K. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002, 416:279-280.
-
(2002)
Nature
, vol.416
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
di Tomaso, E.3
Fukumura, D.4
Jain, R.K.5
-
69
-
-
0023909330
-
Determinants of tumor blood flow: a review
-
Jain R.K. Determinants of tumor blood flow: a review. Cancer Res. 1988, 48:2641-2658.
-
(1988)
Cancer Res.
, vol.48
, pp. 2641-2658
-
-
Jain, R.K.1
-
70
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
Jain R.K. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat. Med. 2001, 7:987-989.
-
(2001)
Nat. Med.
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
71
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
72
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
-
Jain R.K. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J.Clin. Oncol. 2013, 31:2205-2218.
-
(2013)
J.Clin. Oncol.
, vol.31
, pp. 2205-2218
-
-
Jain, R.K.1
-
73
-
-
84893465503
-
An indirect way to tame cancer
-
Jain R.K. An indirect way to tame cancer. Sci. Am. 2014, 310:46-53.
-
(2014)
Sci. Am.
, vol.310
, pp. 46-53
-
-
Jain, R.K.1
-
74
-
-
0032169018
-
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor
-
Jain R.K., Safabakhsh N., Sckell A., Chen Y., Jiang P., Benjamin L., Yuan F., Keshet E. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA 1998, 95:10820-10825.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10820-10825
-
-
Jain, R.K.1
Safabakhsh, N.2
Sckell, A.3
Chen, Y.4
Jiang, P.5
Benjamin, L.6
Yuan, F.7
Keshet, E.8
-
75
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
Jain R.K., Duda D.G., Clark J.W., Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat. Clin. Pract. Oncol. 2006, 3:24-40.
-
(2006)
Nat. Clin. Pract. Oncol.
, vol.3
, pp. 24-40
-
-
Jain, R.K.1
Duda, D.G.2
Clark, J.W.3
Loeffler, J.S.4
-
76
-
-
34548267693
-
Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization
-
Jain R.K., Finn A.V., Kolodgie F.D., Gold H.K., Virmani R. Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization. Nat. Clin. Pract. Cardiovasc. Med. 2007, 4:491-502.
-
(2007)
Nat. Clin. Pract. Cardiovasc. Med.
, vol.4
, pp. 491-502
-
-
Jain, R.K.1
Finn, A.V.2
Kolodgie, F.D.3
Gold, H.K.4
Virmani, R.5
-
78
-
-
17144430502
-
The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent
-
Jodele S., Chantrain C.F., Blavier L., Lutzko C., Crooks G.M., Shimada H., Coussens L.M., Declerck Y.A. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 2005, 65:3200-3208.
-
(2005)
Cancer Res.
, vol.65
, pp. 3200-3208
-
-
Jodele, S.1
Chantrain, C.F.2
Blavier, L.3
Lutzko, C.4
Crooks, G.M.5
Shimada, H.6
Coussens, L.M.7
Declerck, Y.A.8
-
79
-
-
84861215805
-
Tumor-targeted TNFα stabilizes tumor vessels and enhances active immunotherapy
-
Johansson A., Hamzah J., Payne C.J., Ganss R. Tumor-targeted TNFα stabilizes tumor vessels and enhances active immunotherapy. Proc. Natl. Acad. Sci. USA 2012, 109:7841-7846.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 7841-7846
-
-
Johansson, A.1
Hamzah, J.2
Payne, C.J.3
Ganss, R.4
-
80
-
-
84858079914
-
PI3K/AKT/mTOR Pathway in Angiogenesis
-
Karar J., Maity A. PI3K/AKT/mTOR Pathway in Angiogenesis. Front Mol Neurosci 2011, 4:51.
-
(2011)
Front Mol Neurosci
, vol.4
, pp. 51
-
-
Karar, J.1
Maity, A.2
-
81
-
-
40449100456
-
Perivascular nitric oxide gradients normalize tumor vasculature
-
Kashiwagi S., Tsukada K., Xu L., Miyazaki J., Kozin S.V., Tyrrell J.A., Sessa W.C., Gerweck L.E., Jain R.K., Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nat. Med. 2008, 14:255-257.
-
(2008)
Nat. Med.
, vol.14
, pp. 255-257
-
-
Kashiwagi, S.1
Tsukada, K.2
Xu, L.3
Miyazaki, J.4
Kozin, S.V.5
Tyrrell, J.A.6
Sessa, W.C.7
Gerweck, L.E.8
Jain, R.K.9
Fukumura, D.10
-
82
-
-
84655161946
-
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
-
Keith B., Johnson R.S., Simon M.C. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2012, 12:9-22.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
83
-
-
80051889719
-
Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
-
Keizman D., Huang P., Eisenberger M.A., Pili R., Kim J.J., Antonarakis E.S., Hammers H., Carducci M.A. Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination. Eur. J. Cancer 2011, 47:1955-1961.
-
(2011)
Eur. J. Cancer
, vol.47
, pp. 1955-1961
-
-
Keizman, D.1
Huang, P.2
Eisenberger, M.A.3
Pili, R.4
Kim, J.J.5
Antonarakis, E.S.6
Hammers, H.7
Carducci, M.A.8
-
84
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler H.L., Niedzwiecki D., Hollis D., Sutherland S., Schrag D., Hurwitz H., Innocenti F., Mulcahy M.F., O'Reilly E., Wozniak T.F., et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J.Clin. Oncol. 2010, 28:3617-3622.
-
(2010)
J.Clin. Oncol.
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
Sutherland, S.4
Schrag, D.5
Hurwitz, H.6
Innocenti, F.7
Mulcahy, M.F.8
O'Reilly, E.9
Wozniak, T.F.10
-
85
-
-
63549105681
-
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
-
Ko J.S., Zea A.H., Rini B.I., Ireland J.L., Elson P., Cohen P., Golshayan A., Rayman P.A., Wood L., Garcia J., et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 2009, 15:2148-2157.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2148-2157
-
-
Ko, J.S.1
Zea, A.H.2
Rini, B.I.3
Ireland, J.L.4
Elson, P.5
Cohen, P.6
Golshayan, A.7
Rayman, P.A.8
Wood, L.9
Garcia, J.10
-
86
-
-
84868595744
-
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases
-
Kodack D.P., Chung E., Yamashita H., Incio J., Duyverman A.M., Song Y., Farrar C.T., Huang Y., Ager E., Kamoun W., et al. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc. Natl. Acad. Sci. USA 2012, 109:E3119-E3127.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E3119-E3127
-
-
Kodack, D.P.1
Chung, E.2
Yamashita, H.3
Incio, J.4
Duyverman, A.M.5
Song, Y.6
Farrar, C.T.7
Huang, Y.8
Ager, E.9
Kamoun, W.10
-
87
-
-
84875992738
-
Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells
-
Kozono S., Ohuchida K., Eguchi D., Ikenaga N., Fujiwara K., Cui L., Mizumoto K., Tanaka M. Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res. 2013, 73:2345-2356.
-
(2013)
Cancer Res.
, vol.73
, pp. 2345-2356
-
-
Kozono, S.1
Ohuchida, K.2
Eguchi, D.3
Ikenaga, N.4
Fujiwara, K.5
Cui, L.6
Mizumoto, K.7
Tanaka, M.8
-
88
-
-
84863092492
-
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials
-
Lambrechts D., Claes B., Delmar P., Reumers J., Mazzone M., Yesilyurt B.T., Devlieger R., Verslype C., Tejpar S., Wildiers H., et al. VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol. 2012, 13:724-733.
-
(2012)
Lancet Oncol.
, vol.13
, pp. 724-733
-
-
Lambrechts, D.1
Claes, B.2
Delmar, P.3
Reumers, J.4
Mazzone, M.5
Yesilyurt, B.T.6
Devlieger, R.7
Verslype, C.8
Tejpar, S.9
Wildiers, H.10
-
89
-
-
84875998274
-
Markers of response for the antiangiogenic agent bevacizumab
-
Lambrechts D., Lenz H.J., de Haas S., Carmeliet P., Scherer S.J. Markers of response for the antiangiogenic agent bevacizumab. J.Clin. Oncol. 2013, 31:1219-1230.
-
(2013)
J.Clin. Oncol.
, vol.31
, pp. 1219-1230
-
-
Lambrechts, D.1
Lenz, H.J.2
de Haas, S.3
Carmeliet, P.4
Scherer, S.J.5
-
90
-
-
84867268459
-
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2
-
Lawler P.R., Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med 2012, 2:a006627.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006627
-
-
Lawler, P.R.1
Lawler, J.2
-
91
-
-
84862776944
-
From stem cells to cancer stem cells: HIF takes the stage
-
Lee K.E., Simon M.C. From stem cells to cancer stem cells: HIF takes the stage. Curr. Opin. Cell Biol. 2012, 24:232-235.
-
(2012)
Curr. Opin. Cell Biol.
, vol.24
, pp. 232-235
-
-
Lee, K.E.1
Simon, M.C.2
-
92
-
-
33845343558
-
Vascular endothelial growth factor blockade reduces intratumoral regulatory Tcells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
-
Li B., Lalani A.S., Harding T.C., Luan B., Koprivnikar K., Huan Tu G., Prell R., VanRoey M.J., Simmons A.D., Jooss K. Vascular endothelial growth factor blockade reduces intratumoral regulatory Tcells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin. Cancer Res. 2006, 12:6808-6816.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6808-6816
-
-
Li, B.1
Lalani, A.S.2
Harding, T.C.3
Luan, B.4
Koprivnikar, K.5
Huan Tu, G.6
Prell, R.7
VanRoey, M.J.8
Simmons, A.D.9
Jooss, K.10
-
93
-
-
84867362497
-
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
-
Liu J., Liao S., Diop-Frimpong B., Chen W., Goel S., Naxerova K., Ancukiewicz M., Boucher Y., Jain R.K., Xu L. TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc. Natl. Acad. Sci. USA 2012, 109:16618-16623.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 16618-16623
-
-
Liu, J.1
Liao, S.2
Diop-Frimpong, B.3
Chen, W.4
Goel, S.5
Naxerova, K.6
Ancukiewicz, M.7
Boucher, Y.8
Jain, R.K.9
Xu, L.10
-
94
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet J.M., Ricci S., Mazzaferro V., Hilgard P., Gane E., Blanc J.F., de Oliveira A.C., Santoro A., Raoul J.L., Forner A., et al. Sorafenib in advanced hepatocellular carcinoma. N.Engl. J. Med. 2008, 359:378-390. SHARP Investigators Study Group.
-
(2008)
N.Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
-
95
-
-
84905706340
-
Tumor vessel normalization by chloroquine independent of autophagy
-
Maes H., Kuchnio A., Peric A., Moens S., Nys K., De Bock K., Quaegebeur A., Schoors S., Georgiadou M., Wouters J., et al. Tumor vessel normalization by chloroquine independent of autophagy. Cancer Cell 2014, 26:190-206.
-
(2014)
Cancer Cell
, vol.26
, pp. 190-206
-
-
Maes, H.1
Kuchnio, A.2
Peric, A.3
Moens, S.4
Nys, K.5
De Bock, K.6
Quaegebeur, A.7
Schoors, S.8
Georgiadou, M.9
Wouters, J.10
-
96
-
-
16844373504
-
Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
-
Magnussen A., Kasman I.M., Norberg S., Baluk P., Murray R., McDonald D.M. Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels. Cancer Res. 2005, 65:2712-2721.
-
(2005)
Cancer Res.
, vol.65
, pp. 2712-2721
-
-
Magnussen, A.1
Kasman, I.M.2
Norberg, S.3
Baluk, P.4
Murray, R.5
McDonald, D.M.6
-
97
-
-
70449428715
-
Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
-
Maione F., Molla F., Meda C., Latini R., Zentilin L., Giacca M., Seano G., Serini G., Bussolino F., Giraudo E. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J.Clin. Invest. 2009, 119:3356-3372.
-
(2009)
J.Clin. Invest.
, vol.119
, pp. 3356-3372
-
-
Maione, F.1
Molla, F.2
Meda, C.3
Latini, R.4
Zentilin, L.5
Giacca, M.6
Seano, G.7
Serini, G.8
Bussolino, F.9
Giraudo, E.10
-
98
-
-
34447117552
-
A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism
-
Manning E.A., Ullman J.G.M., Leatherman J.M., Asquith J.M., Hansen T.R., Armstrong T.D., Hicklin D.J., Jaffee E.M., Emens L.A. A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clin. Cancer Res. 2007, 13:3951-3959.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3951-3959
-
-
Manning, E.A.1
Ullman, J.G.M.2
Leatherman, J.M.3
Asquith, J.M.4
Hansen, T.R.5
Armstrong, T.D.6
Hicklin, D.J.7
Jaffee, E.M.8
Emens, L.A.9
-
99
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone M., Dettori D., Leite de Oliveira R., Loges S., Schmidt T., Jonckx B., Tian Y.M., Lanahan A.A., Pollard P., Ruiz de Almodovar C., et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009, 136:839-851.
-
(2009)
Cell
, vol.136
, pp. 839-851
-
-
Mazzone, M.1
Dettori, D.2
Leite de Oliveira, R.3
Loges, S.4
Schmidt, T.5
Jonckx, B.6
Tian, Y.M.7
Lanahan, A.A.8
Pollard, P.9
Ruiz de Almodovar, C.10
-
100
-
-
84862184774
-
Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer
-
Meyerhardt J.A., Ancukiewicz M., Abrams T.A., Schrag D., Enzinger P.C., Chan J.A., Kulke M.H., Wolpin B.M., Goldstein M., Blaszkowsky L., et al. Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. PLoS ONE 2012, 7:e38231.
-
(2012)
PLoS ONE
, vol.7
, pp. e38231
-
-
Meyerhardt, J.A.1
Ancukiewicz, M.2
Abrams, T.A.3
Schrag, D.4
Enzinger, P.C.5
Chan, J.A.6
Kulke, M.H.7
Wolpin, B.M.8
Goldstein, M.9
Blaszkowsky, L.10
-
101
-
-
77954700380
-
Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Miles D.W., Chan A., Dirix L.Y., Cortés J., Pivot X., Tomczak P., Delozier T., Sohn J.H., Provencher L., Puglisi F., et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J.Clin. Oncol. 2010, 28:3239-3247.
-
(2010)
J.Clin. Oncol.
, vol.28
, pp. 3239-3247
-
-
Miles, D.W.1
Chan, A.2
Dirix, L.Y.3
Cortés, J.4
Pivot, X.5
Tomczak, P.6
Delozier, T.7
Sohn, J.H.8
Provencher, L.9
Puglisi, F.10
-
102
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K., Wang M., Gralow J., Dickler M., Cobleigh M., Perez E.A., Shenkier T., Cella D., Davidson N.E. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N.Engl. J. Med. 2007, 357:2666-2676.
-
(2007)
N.Engl. J. Med.
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
Dickler, M.4
Cobleigh, M.5
Perez, E.A.6
Shenkier, T.7
Cella, D.8
Davidson, N.E.9
-
103
-
-
84880757177
-
Deciphering and reversing tumor immune suppression
-
Motz G.T., Coukos G. Deciphering and reversing tumor immune suppression. Immunity 2013, 39:61-73.
-
(2013)
Immunity
, vol.39
, pp. 61-73
-
-
Motz, G.T.1
Coukos, G.2
-
104
-
-
84902124970
-
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
-
Motz G.T., Santoro S.P., Wang L.P., Garrabrant T., Lastra R.R., Hagemann I.S., Lal P., Feldman M.D., Benencia F., Coukos G. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat. Med. 2014, 20:607-615.
-
(2014)
Nat. Med.
, vol.20
, pp. 607-615
-
-
Motz, G.T.1
Santoro, S.P.2
Wang, L.P.3
Garrabrant, T.4
Lastra, R.R.5
Hagemann, I.S.6
Lal, P.7
Feldman, M.D.8
Benencia, F.9
Coukos, G.10
-
105
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Rixe O., Oudard S., Negrier S., Szczylik C., Kim S.T., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N.Engl. J. Med. 2007, 356:115-124.
-
(2007)
N.Engl. J. Med.
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
-
106
-
-
84876974877
-
Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial
-
Motzer R.J., Escudier B., Tomczak P., Hutson T.E., Michaelson M.D., Negrier S., Oudard S., Gore M.E., Tarazi J., Hariharan S., et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol. 2013, 14:552-562.
-
(2013)
Lancet Oncol.
, vol.14
, pp. 552-562
-
-
Motzer, R.J.1
Escudier, B.2
Tomczak, P.3
Hutson, T.E.4
Michaelson, M.D.5
Negrier, S.6
Oudard, S.7
Gore, M.E.8
Tarazi, J.9
Hariharan, S.10
-
107
-
-
60549103097
-
Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth
-
Nasarre P., Thomas M., Kruse K., Helfrich I., Wolter V., Deppermann C., Schadendorf D., Thurston G., Fiedler U., Augustin H.G. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res. 2009, 69:1324-1333.
-
(2009)
Cancer Res.
, vol.69
, pp. 1324-1333
-
-
Nasarre, P.1
Thomas, M.2
Kruse, K.3
Helfrich, I.4
Wolter, V.5
Deppermann, C.6
Schadendorf, D.7
Thurston, G.8
Fiedler, U.9
Augustin, H.G.10
-
108
-
-
80053563164
-
Interfering with pH regulation in tumours as a therapeutic strategy
-
Neri D., Supuran C.T. Interfering with pH regulation in tumours as a therapeutic strategy. Nat. Rev. Drug Discov. 2011, 10:767-777.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 767-777
-
-
Neri, D.1
Supuran, C.T.2
-
109
-
-
0030200835
-
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity
-
Netti P.A., Roberge S., Boucher Y., Baxter L.T., Jain R.K. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc. Res. 1996, 52:27-46.
-
(1996)
Microvasc. Res.
, vol.52
, pp. 27-46
-
-
Netti, P.A.1
Roberge, S.2
Boucher, Y.3
Baxter, L.T.4
Jain, R.K.5
-
110
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated Tcell activation
-
Noman M.Z., Desantis G., Janji B., Hasmim M., Karray S., Dessen P., Bronte V., Chouaib S. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated Tcell activation. J.Exp. Med. 2014, 211:781-790.
-
(2014)
J.Exp. Med.
, vol.211
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
Bronte, V.7
Chouaib, S.8
-
111
-
-
84904406680
-
Tumor-associated macrophages: from mechanisms to therapy
-
Noy R., Pollard J.W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014, 41:49-61.
-
(2014)
Immunity
, vol.41
, pp. 49-61
-
-
Noy, R.1
Pollard, J.W.2
-
112
-
-
82555191051
-
Cancer immunology-analysis of host and tumor factors for personalized medicine
-
Ogino S., Galon J., Fuchs C.S., Dranoff G. Cancer immunology-analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol 2011, 8:711-719.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 711-719
-
-
Ogino, S.1
Galon, J.2
Fuchs, C.S.3
Dranoff, G.4
-
113
-
-
84905103883
-
Fibroblast heterogeneity in the cancer wound
-
Öhlund D., Elyada E., Tuveson D. Fibroblast heterogeneity in the cancer wound. J.Exp. Med. 2014, 211:1503-1523.
-
(2014)
J.Exp. Med.
, vol.211
, pp. 1503-1523
-
-
Öhlund, D.1
Elyada, E.2
Tuveson, D.3
-
114
-
-
84870688010
-
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability invivo
-
Orsenigo F., Giampietro C., Ferrari A., Corada M., Galaup A., Sigismund S., Ristagno G., Maddaluno L., Koh G.Y., Franco D., et al. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability invivo. Nat. Commun. 2012, 3:1208.
-
(2012)
Nat. Commun.
, vol.3
, pp. 1208
-
-
Orsenigo, F.1
Giampietro, C.2
Ferrari, A.3
Corada, M.4
Galaup, A.5
Sigismund, S.6
Ristagno, G.7
Maddaluno, L.8
Koh, G.Y.9
Franco, D.10
-
115
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
Özdemir B.C., Pentcheva-Hoang T., Carstens J.L., Zheng X., Wu C.C., Simpson T.R., Laklai H., Sugimoto H., Kahlert C., Novitskiy S.V., et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014, 25:719-734.
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Özdemir, B.C.1
Pentcheva-Hoang, T.2
Carstens, J.L.3
Zheng, X.4
Wu, C.C.5
Simpson, T.R.6
Laklai, H.7
Sugimoto, H.8
Kahlert, C.9
Novitskiy, S.V.10
-
116
-
-
1542320497
-
Pathology: cancer cells compress intratumour vessels
-
Padera T.P., Stoll B.R., Tooredman J.B., Capen D., di Tomaso E., Jain R.K. Pathology: cancer cells compress intratumour vessels. Nature 2004, 427:695.
-
(2004)
Nature
, vol.427
, pp. 695
-
-
Padera, T.P.1
Stoll, B.R.2
Tooredman, J.B.3
Capen, D.4
di Tomaso, E.5
Jain, R.K.6
-
117
-
-
84857702419
-
Molecular pathways: hypoxia response in immune cells fighting or promoting cancer
-
Palazón A., Aragonés J., Morales-Kastresana A., de Landázuri M.O., Melero I. Molecular pathways: hypoxia response in immune cells fighting or promoting cancer. Clin. Cancer Res. 2012, 18:1207-1213.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 1207-1213
-
-
Palazón, A.1
Aragonés, J.2
Morales-Kastresana, A.3
de Landázuri, M.O.4
Melero, I.5
-
118
-
-
84859156795
-
Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model
-
Pastuskovas C.V., Mundo E.E., Williams S.P., Nayak T.K., Ho J., Ulufatu S., Clark S., Ross S., Cheng E., Parsons-Reponte K., et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol. Cancer Ther. 2012, 11:752-762.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 752-762
-
-
Pastuskovas, C.V.1
Mundo, E.E.2
Williams, S.P.3
Nayak, T.K.4
Ho, J.5
Ulufatu, S.6
Clark, S.7
Ross, S.8
Cheng, E.9
Parsons-Reponte, K.10
-
119
-
-
59649085554
-
Angiogenesis: a team effort coordinated by notch
-
Phng L.K., Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev. Cell 2009, 16:196-208.
-
(2009)
Dev. Cell
, vol.16
, pp. 196-208
-
-
Phng, L.K.1
Gerhardt, H.2
-
120
-
-
67651173054
-
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2
-
Plotkin S.R., Stemmer-Rachamimov A.O., Barker F.G., Halpin C., Padera T.P., Tyrrell A., Sorensen A.G., Jain R.K., di Tomaso E. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N.Engl. J. Med. 2009, 361:358-367.
-
(2009)
N.Engl. J. Med.
, vol.361
, pp. 358-367
-
-
Plotkin, S.R.1
Stemmer-Rachamimov, A.O.2
Barker, F.G.3
Halpin, C.4
Padera, T.P.5
Tyrrell, A.6
Sorensen, A.G.7
Jain, R.K.8
di Tomaso, E.9
-
121
-
-
84862893473
-
Pathological complete response and accelerated drug approval in early breast cancer
-
Prowell T.M., Pazdur R. Pathological complete response and accelerated drug approval in early breast cancer. N.Engl. J. Med. 2012, 366:2438-2441.
-
(2012)
N.Engl. J. Med.
, vol.366
, pp. 2438-2441
-
-
Prowell, T.M.1
Pazdur, R.2
-
122
-
-
84912134575
-
Next-generation AMD drugs to wed blockbusters
-
Ratner M. Next-generation AMD drugs to wed blockbusters. Nat. Biotechnol. 2014, 32:701-702.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 701-702
-
-
Ratner, M.1
-
123
-
-
84856743032
-
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948)
-
Raut C.P., Boucher Y., Duda D.G., Morgan J.A., Quek R., Ancukiewicz M., Lahdenranta J., Eder J.P., Demetri G.D., Jain R.K. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). PLoS ONE 2012, 7:e26331.
-
(2012)
PLoS ONE
, vol.7
, pp. e26331
-
-
Raut, C.P.1
Boucher, Y.2
Duda, D.G.3
Morgan, J.A.4
Quek, R.5
Ancukiewicz, M.6
Lahdenranta, J.7
Eder, J.P.8
Demetri, G.D.9
Jain, R.K.10
-
124
-
-
79851482955
-
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
-
Raymond E., Dahan L., Raoul J.L., Bang Y.J., Borbath I., Lombard-Bohas C., Valle J., Metrakos P., Smith D., Vinik A., et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N.Engl. J. Med. 2011, 364:501-513.
-
(2011)
N.Engl. J. Med.
, vol.364
, pp. 501-513
-
-
Raymond, E.1
Dahan, L.2
Raoul, J.L.3
Bang, Y.J.4
Borbath, I.5
Lombard-Bohas, C.6
Valle, J.7
Metrakos, P.8
Smith, D.9
Vinik, A.10
-
125
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
-
Reck M., von Pawel J., Zatloukal P., Ramlau R., Gorbounova V., Hirsh V., Leighl N., Mezger J., Archer V., Moore N., Manegold C. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann. Oncol. 2010, 21:1804-1809. BO17704 Study Group.
-
(2010)
Ann. Oncol.
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
Leighl, N.7
Mezger, J.8
Archer, V.9
Moore, N.10
Manegold, C.11
-
126
-
-
84892967581
-
Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial
-
Reck M., Kaiser R., Mellemgaard A., Douillard J.Y., Orlov S., Krzakowski M., von Pawel J., Gottfried M., Bondarenko I., Liao M., et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol. 2014, 15:143-155. LUME-Lung 1 Study Group.
-
(2014)
Lancet Oncol.
, vol.15
, pp. 143-155
-
-
Reck, M.1
Kaiser, R.2
Mellemgaard, A.3
Douillard, J.Y.4
Orlov, S.5
Krzakowski, M.6
von Pawel, J.7
Gottfried, M.8
Bondarenko, I.9
Liao, M.10
-
127
-
-
84866389239
-
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression
-
Reis M., Czupalla C.J., Ziegler N., Devraj K., Zinke J., Seidel S., Heck R., Thom S., Macas J., Bockamp E., et al. Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression. J.Exp. Med. 2012, 209:1611-1627.
-
(2012)
J.Exp. Med.
, vol.209
, pp. 1611-1627
-
-
Reis, M.1
Czupalla, C.J.2
Ziegler, N.3
Devraj, K.4
Zinke, J.5
Seidel, S.6
Heck, R.7
Thom, S.8
Macas, J.9
Bockamp, E.10
-
128
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim A.D., Oberstein P.E., Thomas D.H., Mirek E.T., Palermo C.F., Sastra S.A., Dekleva E.N., Saunders T., Becerra C.P., Tattersall I.W., et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014, 25:735-747.
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
Dekleva, E.N.7
Saunders, T.8
Becerra, C.P.9
Tattersall, I.W.10
-
129
-
-
84901810710
-
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
-
Richeldi L., du Bois R.M., Raghu G., Azuma A., Brown K.K., Costabel U., Cottin V., Flaherty K.R., Hansell D.M., Inoue Y., et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N.Engl. J. Med. 2014, 370:2071-2082. INPULSIS Trial Investigators.
-
(2014)
N.Engl. J. Med.
, vol.370
, pp. 2071-2082
-
-
Richeldi, L.1
du Bois, R.M.2
Raghu, G.3
Azuma, A.4
Brown, K.K.5
Costabel, U.6
Cottin, V.7
Flaherty, K.R.8
Hansell, D.M.9
Inoue, Y.10
-
130
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206
-
Rini B.I., Halabi S., Rosenberg J.E., Stadler W.M., Vaena D.A., Archer L., Atkins J.N., Picus J., Czaykowski P., Dutcher J., Small E.J. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J.Clin. Oncol. 2010, 28:2137-2143.
-
(2010)
J.Clin. Oncol.
, vol.28
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
Stadler, W.M.4
Vaena, D.A.5
Archer, L.6
Atkins, J.N.7
Picus, J.8
Czaykowski, P.9
Dutcher, J.10
Small, E.J.11
-
131
-
-
79953874259
-
RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
-
Robert N.J., Diéras V., Glaspy J., Brufsky A.M., Bondarenko I., Lipatov O.N., Perez E.A., Yardley D.A., Chan S.Y., Zhou X., et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J.Clin. Oncol. 2011, 29:1252-1260.
-
(2011)
J.Clin. Oncol.
, vol.29
, pp. 1252-1260
-
-
Robert, N.J.1
Diéras, V.2
Glaspy, J.3
Brufsky, A.M.4
Bondarenko, I.5
Lipatov, O.N.6
Perez, E.A.7
Yardley, D.A.8
Chan, S.Y.9
Zhou, X.10
-
132
-
-
84861102183
-
Dysfunction of the cochlea contributing to hearing loss in acoustic neuromas: an underappreciated entity
-
Roosli C., Linthicum F.H., Cureoglu S., Merchant S.N. Dysfunction of the cochlea contributing to hearing loss in acoustic neuromas: an underappreciated entity. Otol. Neurotol. 2012, 33:473-480.
-
(2012)
Otol. Neurotol.
, vol.33
, pp. 473-480
-
-
Roosli, C.1
Linthicum, F.H.2
Cureoglu, S.3
Merchant, S.N.4
-
133
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study
-
Saltz L.B., Clarke S., Díaz-Rubio E., Scheithauer W., Figer A., Wong R., Koski S., Lichinitser M., Yang T.S., Rivera F., et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J.Clin. Oncol. 2008, 26:2013-2019.
-
(2008)
J.Clin. Oncol.
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Díaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
Koski, S.7
Lichinitser, M.8
Yang, T.S.9
Rivera, F.10
-
134
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A., Lilenbaum R., Johnson D.H. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N.Engl. J. Med. 2006, 355:2542-2550.
-
(2006)
N.Engl. J. Med.
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
135
-
-
84891841003
-
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis
-
Schoors S., De Bock K., Cantelmo A.R., Georgiadou M., Ghesquière B., Cauwenberghs S., Kuchnio A., Wong B.W., Quaegebeur A., Goveia J., et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014, 19:37-48.
-
(2014)
Cell Metab.
, vol.19
, pp. 37-48
-
-
Schoors, S.1
De Bock, K.2
Cantelmo, A.R.3
Georgiadou, M.4
Ghesquière, B.5
Cauwenberghs, S.6
Kuchnio, A.7
Wong, B.W.8
Quaegebeur, A.9
Goveia, J.10
-
136
-
-
84908153461
-
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis
-
Seano G., Chiaverina G., Gagliardi P.A., di Blasio L., Puliafito A., Bouvard C., Sessa R., Tarone G., Sorokin L., Helley D., et al. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat. Cell Biol. 2014, 16:931-941.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 931-941
-
-
Seano, G.1
Chiaverina, G.2
Gagliardi, P.A.3
di Blasio, L.4
Puliafito, A.5
Bouvard, C.6
Sessa, R.7
Tarone, G.8
Sorokin, L.9
Helley, D.10
-
137
-
-
84939271253
-
Podosomes as novel players in endothelial biology
-
Published online August 7, 2014
-
Seano G., Daubon T., Genot E., Primo L. Podosomes as novel players in endothelial biology. Eur. J. Cell Biol. 2014, Published online August 7, 2014. 10.1016/j.ejcb.2014.07.009.
-
(2014)
Eur. J. Cell Biol.
-
-
Seano, G.1
Daubon, T.2
Genot, E.3
Primo, L.4
-
138
-
-
84897019542
-
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
-
Semenza G.L. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu. Rev. Pathol. 2014, 9:47-71.
-
(2014)
Annu. Rev. Pathol.
, vol.9
, pp. 47-71
-
-
Semenza, G.L.1
-
139
-
-
84863704553
-
Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
-
Sennino B., Ishiguro-Oonuma T., Wei Y., Naylor R.M., Williamson C.W., Bhagwandin V., Tabruyn S.P., You W.K., Chapman H.A., Christensen J.G., et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov 2012, 2:270-287.
-
(2012)
Cancer Discov
, vol.2
, pp. 270-287
-
-
Sennino, B.1
Ishiguro-Oonuma, T.2
Wei, Y.3
Naylor, R.M.4
Williamson, C.W.5
Bhagwandin, V.6
Tabruyn, S.P.7
You, W.K.8
Chapman, H.A.9
Christensen, J.G.10
-
140
-
-
84908127948
-
Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study
-
Seto T., Kato T., Nishio M., Goto K., Atagi S., Hosomi Y., Yamamoto N., Hida T., Maemondo M., Nakagawa K., et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study. Lancet Oncol. 2014, 15:1236-1244.
-
(2014)
Lancet Oncol.
, vol.15
, pp. 1236-1244
-
-
Seto, T.1
Kato, T.2
Nishio, M.3
Goto, K.4
Atagi, S.5
Hosomi, Y.6
Yamamoto, N.7
Hida, T.8
Maemondo, M.9
Nakagawa, K.10
-
141
-
-
0024409952
-
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity
-
Sevick E.M., Jain R.K. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res. 1989, 49:3513-3519.
-
(1989)
Cancer Res.
, vol.49
, pp. 3513-3519
-
-
Sevick, E.M.1
Jain, R.K.2
-
142
-
-
77955406159
-
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
-
Shrimali R.K., Yu Z., Theoret M.R., Chinnasamy D., Restifo N.P., Rosenberg S.A. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 2010, 70:6171-6180.
-
(2010)
Cancer Res.
, vol.70
, pp. 6171-6180
-
-
Shrimali, R.K.1
Yu, Z.2
Theoret, M.R.3
Chinnasamy, D.4
Restifo, N.P.5
Rosenberg, S.A.6
-
143
-
-
84860130221
-
Anti-VEGF/VEGFR therapy for cancer: reassessing the target
-
Sitohy B., Nagy J.A., Dvorak H.F. Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 2012, 72:1909-1914.
-
(2012)
Cancer Res.
, vol.72
, pp. 1909-1914
-
-
Sitohy, B.1
Nagy, J.A.2
Dvorak, H.F.3
-
144
-
-
65949121859
-
Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma
-
Skuli N., Monferran S., Delmas C., Favre G., Bonnet J., Toulas C., Cohen-Jonathan Moyal E. Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma. Cancer Res. 2009, 69:3308-3316.
-
(2009)
Cancer Res.
, vol.69
, pp. 3308-3316
-
-
Skuli, N.1
Monferran, S.2
Delmas, C.3
Favre, G.4
Bonnet, J.5
Toulas, C.6
Cohen-Jonathan Moyal, E.7
-
145
-
-
84874760414
-
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
-
Snuderl M., Batista A., Kirkpatrick N.D., Ruiz de Almodovar C., Riedemann L., Walsh E.C., Anolik R., Huang Y., Martin J.D., Kamoun W., et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 2013, 152:1065-1076.
-
(2013)
Cell
, vol.152
, pp. 1065-1076
-
-
Snuderl, M.1
Batista, A.2
Kirkpatrick, N.D.3
Ruiz de Almodovar, C.4
Riedemann, L.5
Walsh, E.C.6
Anolik, R.7
Huang, Y.8
Martin, J.D.9
Kamoun, W.10
-
146
-
-
36348933839
-
Regression of radiation-induced macular edema after systemic bevacizumab
-
Solano J.M., Bakri S.J., Pulido J.S. Regression of radiation-induced macular edema after systemic bevacizumab. Can. J. Ophthalmol. 2007, 42:748-749.
-
(2007)
Can. J. Ophthalmol.
, vol.42
, pp. 748-749
-
-
Solano, J.M.1
Bakri, S.J.2
Pulido, J.S.3
-
147
-
-
80053086676
-
Fluid forces control endothelial sprouting
-
Song J.W., Munn L.L. Fluid forces control endothelial sprouting. Proc. Natl. Acad. Sci. USA 2011, 108:15342-15347.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 15342-15347
-
-
Song, J.W.1
Munn, L.L.2
-
148
-
-
67650463119
-
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
-
Sorensen A.G., Batchelor T.T., Zhang W.T., Chen P.J., Yeo P., Wang M., Jennings D., Wen P.Y., Lahdenranta J., Ancukiewicz M., et al. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res. 2009, 69:5296-5300.
-
(2009)
Cancer Res.
, vol.69
, pp. 5296-5300
-
-
Sorensen, A.G.1
Batchelor, T.T.2
Zhang, W.T.3
Chen, P.J.4
Yeo, P.5
Wang, M.6
Jennings, D.7
Wen, P.Y.8
Lahdenranta, J.9
Ancukiewicz, M.10
-
149
-
-
84862907876
-
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
-
Sorensen A.G., Emblem K.E., Polaskova P., Jennings D., Kim H., Ancukiewicz M., Wang M., Wen P.Y., Ivy P., Batchelor T.T., Jain R.K. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res. 2012, 72:402-407.
-
(2012)
Cancer Res.
, vol.72
, pp. 402-407
-
-
Sorensen, A.G.1
Emblem, K.E.2
Polaskova, P.3
Jennings, D.4
Kim, H.5
Ancukiewicz, M.6
Wang, M.7
Wen, P.Y.8
Ivy, P.9
Batchelor, T.T.10
Jain, R.K.11
-
150
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
-
Sternberg C.N., Davis I.D., Mardiak J., Szczylik C., Lee E., Wagstaff J., Barrios C.H., Salman P., Gladkov O.A., Kavina A., et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J.Clin. Oncol. 2010, 28:1061-1068.
-
(2010)
J.Clin. Oncol.
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
Barrios, C.H.7
Salman, P.8
Gladkov, O.A.9
Kavina, A.10
-
151
-
-
84887478772
-
Combining two strategies to improve perfusion and drug delivery in solid tumors
-
Stylianopoulos T., Jain R.K. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proc. Natl. Acad. Sci. USA 2013, 110:18632-18637.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 18632-18637
-
-
Stylianopoulos, T.1
Jain, R.K.2
-
152
-
-
84866557942
-
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
-
Stylianopoulos T., Martin J.D., Chauhan V.P., Jain S.R., Diop-Frimpong B., Bardeesy N., Smith B.L., Ferrone C.R., Hornicek F.J., Boucher Y., et al. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc. Natl. Acad. Sci. USA 2012, 109:15101-15108.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 15101-15108
-
-
Stylianopoulos, T.1
Martin, J.D.2
Chauhan, V.P.3
Jain, S.R.4
Diop-Frimpong, B.5
Bardeesy, N.6
Smith, B.L.7
Ferrone, C.R.8
Hornicek, F.J.9
Boucher, Y.10
-
153
-
-
84875930616
-
Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer
-
Suzuki H., Fukuhara M., Yamaura T., Mutoh S., Okabe N., Yaginuma H., Hasegawa T., Yonechi A., Osugi J., Hoshino M., et al. Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer. J.Transl. Med. 2013, 11:97.
-
(2013)
J.Transl. Med.
, vol.11
, pp. 97
-
-
Suzuki, H.1
Fukuhara, M.2
Yamaura, T.3
Mutoh, S.4
Okabe, N.5
Yaginuma, H.6
Hasegawa, T.7
Yonechi, A.8
Osugi, J.9
Hoshino, M.10
-
154
-
-
84894207820
-
Improved survival with bevacizumab in advanced cervical cancer
-
Tewari K.S., Sill M.W., Long H.J., Penson R.T., Huang H., Ramondetta L.M., Landrum L.M., Oaknin A., Reid T.J., Leitao M.M., et al. Improved survival with bevacizumab in advanced cervical cancer. N.Engl. J. Med. 2014, 370:734-743.
-
(2014)
N.Engl. J. Med.
, vol.370
, pp. 734-743
-
-
Tewari, K.S.1
Sill, M.W.2
Long, H.J.3
Penson, R.T.4
Huang, H.5
Ramondetta, L.M.6
Landrum, L.M.7
Oaknin, A.8
Reid, T.J.9
Leitao, M.M.10
-
155
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J., Koopman M., Cats A., Rodenburg C.J., Creemers G.J., Schrama J.G., Erdkamp F.L., Vos A.H., van Groeningen C.J., Sinnige H.A., et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N.Engl. J. Med. 2009, 360:563-572.
-
(2009)
N.Engl. J. Med.
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
Erdkamp, F.L.7
Vos, A.H.8
van Groeningen, C.J.9
Sinnige, H.A.10
-
156
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong R.T., Boucher Y., Kozin S.V., Winkler F., Hicklin D.J., Jain R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004, 64:3731-3736.
-
(2004)
Cancer Res.
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
157
-
-
84856403028
-
Mechanical compression drives cancer cells toward invasive phenotype
-
Tse J.M., Cheng G., Tyrrell J.A., Wilcox-Adelman S.A., Boucher Y., Jain R.K., Munn L.L. Mechanical compression drives cancer cells toward invasive phenotype. Proc. Natl. Acad. Sci. USA 2012, 109:911-916.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 911-916
-
-
Tse, J.M.1
Cheng, G.2
Tyrrell, J.A.3
Wilcox-Adelman, S.A.4
Boucher, Y.5
Jain, R.K.6
Munn, L.L.7
-
158
-
-
70350565505
-
Three-dimensional microscopy of the tumor microenvironment invivo using optical frequency domain imaging
-
Vakoc B.J., Lanning R.M., Tyrrell J.A., Padera T.P., Bartlett L.A., Stylianopoulos T., Munn L.L., Tearney G.J., Fukumura D., Jain R.K., Bouma B.E. Three-dimensional microscopy of the tumor microenvironment invivo using optical frequency domain imaging. Nat. Med. 2009, 15:1219-1223.
-
(2009)
Nat. Med.
, vol.15
, pp. 1219-1223
-
-
Vakoc, B.J.1
Lanning, R.M.2
Tyrrell, J.A.3
Padera, T.P.4
Bartlett, L.A.5
Stylianopoulos, T.6
Munn, L.L.7
Tearney, G.J.8
Fukumura, D.9
Jain, R.K.10
Bouma, B.E.11
-
159
-
-
33749332105
-
Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature
-
van Beijnum J.R., Dings R.P., van der Linden E., Zwaans B.M., Ramaekers F.C., Mayo K.H., Griffioen A.W. Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 2006, 108:2339-2348.
-
(2006)
Blood
, vol.108
, pp. 2339-2348
-
-
van Beijnum, J.R.1
Dings, R.P.2
van der Linden, E.3
Zwaans, B.M.4
Ramaekers, F.C.5
Mayo, K.H.6
Griffioen, A.W.7
-
160
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E., Tabernero J., Lakomy R., Prenen H., Prausová J., Macarulla T., Ruff P., van Hazel G.A., Moiseyenko V., Ferry D., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J.Clin. Oncol. 2012, 30:3499-3506.
-
(2012)
J.Clin. Oncol.
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
Prenen, H.4
Prausová, J.5
Macarulla, T.6
Ruff, P.7
van Hazel, G.A.8
Moiseyenko, V.9
Ferry, D.10
-
161
-
-
84861098484
-
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
-
van der Graaf W.T., Blay J.Y., Chawla S.P., Kim D.W., Bui-Nguyen B., Casali P.G., Schöffski P., Aglietta M., Staddon A.P., Beppu Y., et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012, 379:1879-1886. EORTC Soft Tissue and Bone Sarcoma Group, PALETTE study groupPALETTE study group.
-
(2012)
Lancet
, vol.379
, pp. 1879-1886
-
-
van der Graaf, W.T.1
Blay, J.Y.2
Chawla, S.P.3
Kim, D.W.4
Bui-Nguyen, B.5
Casali, P.G.6
Schöffski, P.7
Aglietta, M.8
Staddon, A.P.9
Beppu, Y.10
-
162
-
-
84855931910
-
Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs
-
Van der Veldt A.A., Lubberink M., Bahce I., Walraven M., de Boer M.P., Greuter H.N., Hendrikse N.H., Eriksson J., Windhorst A.D., Postmus P.E., et al. Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs. Cancer Cell 2012, 21:82-91.
-
(2012)
Cancer Cell
, vol.21
, pp. 82-91
-
-
Van der Veldt, A.A.1
Lubberink, M.2
Bahce, I.3
Walraven, M.4
de Boer, M.P.5
Greuter, H.N.6
Hendrikse, N.H.7
Eriksson, J.8
Windhorst, A.D.9
Postmus, P.E.10
-
163
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
164
-
-
84957942518
-
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
-
Vasudev N.S., Reynolds A.R. Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 2014, 17:471-494.
-
(2014)
Angiogenesis
, vol.17
, pp. 471-494
-
-
Vasudev, N.S.1
Reynolds, A.R.2
-
165
-
-
79953329777
-
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis
-
Végran F., Boidot R., Michiels C., Sonveaux P., Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011, 71:2550-2560.
-
(2011)
Cancer Res.
, vol.71
, pp. 2550-2560
-
-
Végran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
166
-
-
84885636151
-
Specificity redirection by CAR with human VEGFR-1 affinity endows T lymphocytes with tumor-killing ability and anti-angiogenic potency
-
Wang W., Ma Y., Li J., Shi H.S., Wang L.Q., Guo F.C., Zhang J., Li D., Mo B.H., Wen F., et al. Specificity redirection by CAR with human VEGFR-1 affinity endows T lymphocytes with tumor-killing ability and anti-angiogenic potency. Gene Ther. 2013, 20:970-978.
-
(2013)
Gene Ther.
, vol.20
, pp. 970-978
-
-
Wang, W.1
Ma, Y.2
Li, J.3
Shi, H.S.4
Wang, L.Q.5
Guo, F.C.6
Zhang, J.7
Li, D.8
Mo, B.H.9
Wen, F.10
-
167
-
-
84655175698
-
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial
-
Wells S.A., Robinson B.G., Gagel R.F., Dralle H., Fagin J.A., Santoro M., Baudin E., Elisei R., Jarzab B., Vasselli J.R., et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J.Clin. Oncol. 2012, 30:134-141.
-
(2012)
J.Clin. Oncol.
, vol.30
, pp. 134-141
-
-
Wells, S.A.1
Robinson, B.G.2
Gagel, R.F.3
Dralle, H.4
Fagin, J.A.5
Santoro, M.6
Baudin, E.7
Elisei, R.8
Jarzab, B.9
Vasselli, J.R.10
-
168
-
-
84908139963
-
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
-
Wilke H., Muro K., Van Cutsem E., Oh S.C., Bodoky G., Shimada Y., Hironaka S., Sugimoto N., Lipatov O., Kim T.-Y., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol. 2014, 15:1224-1235. RAINBOW Study Group.
-
(2014)
Lancet Oncol.
, vol.15
, pp. 1224-1235
-
-
Wilke, H.1
Muro, K.2
Van Cutsem, E.3
Oh, S.C.4
Bodoky, G.5
Shimada, Y.6
Hironaka, S.7
Sugimoto, N.8
Lipatov, O.9
Kim, T.-Y.10
-
169
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett C.G., Boucher Y., di Tomaso E., Duda D.G., Munn L.L., Tong R.T., Chung D.C., Sahani D.V., Kalva S.P., Kozin S.V., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 2004, 10:145-147.
-
(2004)
Nat. Med.
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
di Tomaso, E.3
Duda, D.G.4
Munn, L.L.5
Tong, R.T.6
Chung, D.C.7
Sahani, D.V.8
Kalva, S.P.9
Kozin, S.V.10
-
170
-
-
67649921334
-
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
-
Willett C.G., Duda D.G., di Tomaso E., Boucher Y., Ancukiewicz M., Sahani D.V., Lahdenranta J., Chung D.C., Fischman A.J., Lauwers G.Y., et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J.Clin. Oncol. 2009, 27:3020-3026.
-
(2009)
J.Clin. Oncol.
, vol.27
, pp. 3020-3026
-
-
Willett, C.G.1
Duda, D.G.2
di Tomaso, E.3
Boucher, Y.4
Ancukiewicz, M.5
Sahani, D.V.6
Lahdenranta, J.7
Chung, D.C.8
Fischman, A.J.9
Lauwers, G.Y.10
-
171
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson W.R., Hay M.P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 2011, 11:393-410.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
172
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F., Kozin S.V., Tong R.T., Chae S.S., Booth M.F., Garkavtsev I., Xu L., Hicklin D.J., Fukumura D., di Tomaso E., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004, 6:553-563.
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
Xu, L.7
Hicklin, D.J.8
Fukumura, D.9
di Tomaso, E.10
-
173
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok J.D., Kluger H., Callahan M.K., Postow M.A., Rizvi N.A., Lesokhin A.M., Segal N.H., Ariyan C.E., Gordon R.A., Reed K., et al. Nivolumab plus ipilimumab in advanced melanoma. N.Engl. J. Med. 2013, 369:122-133.
-
(2013)
N.Engl. J. Med.
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
Segal, N.H.7
Ariyan, C.E.8
Gordon, R.A.9
Reed, K.10
-
174
-
-
84876717683
-
Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect invivo
-
Yasuda S., Sho M., Yamato I., Yoshiji H., Wakatsuki K., Nishiwada S., Yagita H., Nakajima Y. Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect invivo. Clin. Exp. Immunol. 2013, 172:500-506.
-
(2013)
Clin. Exp. Immunol.
, vol.172
, pp. 500-506
-
-
Yasuda, S.1
Sho, M.2
Yamato, I.3
Yoshiji, H.4
Wakatsuki, K.5
Nishiwada, S.6
Yagita, H.7
Nakajima, Y.8
-
175
-
-
79960408937
-
VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer
-
You W.K., Sennino B., Williamson C.W., Falcón B., Hashizume H., Yao L.C., Aftab D.T., McDonald D.M. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 2011, 71:4758-4768.
-
(2011)
Cancer Res.
, vol.71
, pp. 4758-4768
-
-
You, W.K.1
Sennino, B.2
Williamson, C.W.3
Falcón, B.4
Hashizume, H.5
Yao, L.C.6
Aftab, D.T.7
McDonald, D.M.8
-
176
-
-
0029949160
-
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
-
Yuan F., Chen Y., Dellian M., Safabakhsh N., Ferrara N., Jain R.K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA 1996, 93:14765-14770.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14765-14770
-
-
Yuan, F.1
Chen, Y.2
Dellian, M.3
Safabakhsh, N.4
Ferrara, N.5
Jain, R.K.6
-
177
-
-
0035882030
-
Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
-
Zhang X., Gaspard J.P., Chung D.C. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res. 2001, 61:6050-6054.
-
(2001)
Cancer Res.
, vol.61
, pp. 6050-6054
-
-
Zhang, X.1
Gaspard, J.P.2
Chung, D.C.3
-
178
-
-
84898874113
-
Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy
-
Zhang J., O'Carroll S.J., Henare K., Ching L.M., Ormonde S., Nicholson L.F., Danesh-Meyer H.V., Green C.R. Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy. FEBS Lett. 2014, 588:1365-1371.
-
(2014)
FEBS Lett.
, vol.588
, pp. 1365-1371
-
-
Zhang, J.1
O'Carroll, S.J.2
Henare, K.3
Ching, L.M.4
Ormonde, S.5
Nicholson, L.F.6
Danesh-Meyer, H.V.7
Green, C.R.8
-
179
-
-
3042663099
-
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
-
Zhou Z., Doi M., Wang J., Cao R., Liu B., Chan K.M., Kortesmaa J., Sorokin L., Cao Y., Tryggvason K. Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice. Cancer Res. 2004, 64:4059-4063.
-
(2004)
Cancer Res.
, vol.64
, pp. 4059-4063
-
-
Zhou, Z.1
Doi, M.2
Wang, J.3
Cao, R.4
Liu, B.5
Chan, K.M.6
Kortesmaa, J.7
Sorokin, L.8
Cao, Y.9
Tryggvason, K.10
-
180
-
-
84875181434
-
Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study
-
Zhu A.X., Ancukiewicz M., Supko J.G., Sahani D.V., Blaszkowsky L.S., Meyerhardt J.A., Abrams T.A., McCleary N.J., Bhargava P., Muzikansky A., et al. Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study. Clin. Cancer Res. 2013, 19:1557-1566.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 1557-1566
-
-
Zhu, A.X.1
Ancukiewicz, M.2
Supko, J.G.3
Sahani, D.V.4
Blaszkowsky, L.S.5
Meyerhardt, J.A.6
Abrams, T.A.7
McCleary, N.J.8
Bhargava, P.9
Muzikansky, A.10
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