Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Radiotherapy and Oncology

Volumn 108, Issue 3, 2013, Pages 523-528

  Dubois, Ludwig ^a   Peeters, Sarah G J A ^a   Van Kuijk, Simon J A ^a   Yaromina, Ala ^a,b   Lieuwes, Natasja G ^a   Saraya, Ruchi ^a   Biemans, Rianne ^a   Rami, Marouan ^c   Parvathaneni, Nanda Kumar ^a,c   Vullo, Daniela ^d   Vooijs, Marc ^a   Supuran, Claudiu T ^d   Winum, Jean Yves ^c   Lambin, Philippe ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITÉ DE MONTPELLIER   (France)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

5 Nitroimidazole; Carbonic anhydrase IX (CAIX); Dual targeting; Radiotherapy; Sulfamide

Indexed keywords

ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE IX; DH 348; NITROIMIDAZOLE; SULFANILAMIDE; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RADIOTHERAPY; CARCINOMA CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MONOTHERAPY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; TUMOR GROWTH; TUMOR VOLUME;

5-NITROIMIDAZOLE; CARBONIC ANHYDRASE IX (CAIX); DUAL TARGETING; RADIOTHERAPY; SULFAMIDE;

ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; MICE; NITROIMIDAZOLES; RADIATION-SENSITIZING AGENTS;

EID: 84887019683     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.018     Document Type: Article

References (21)

1. C.P. Potter, and A.L. Harris Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer Br J Cancer 89 2003 2 7
2. P.C. McDonald, J.Y. Winum, C.T. Supuran, and S. Dedhar Recent developments in targeting carbonic anhydrase IX for cancer therapeutics Oncotarget 3 2012 84 97
3. E. Svastova, A. Hulikova, and M. Rafajova Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH FEBS Lett 577 2004 439 445
4. P. Swietach, S. Patiar, C.T. Supuran, A.L. Harris, and R.D. Vaughan-Jones The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths J Biol Chem 284 2009 20299 20310
5. D. Neri, and C.T. Supuran Interfering with pH regulation in tumours as a therapeutic strategy Nat Rev Drug Discov 10 2011 767 777
6. L. Dubois, K. Douma, and C.T. Supuran Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors Radiother Oncol 83 2007 367 373
7. L. Dubois, N.G. Lieuwes, and A. Maresca Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model Radiother Oncol 92 2009 423 428
8. L. Dubois, S. Peeters, and N.G. Lieuwes Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation Radiother Oncol 99 2011 424 431
9. J.K. Ahlskog, C.E. Dumelin, S. Trussel, J. Marlind, and D. Neri In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives Bioorg Med Chem Lett 19 2009 4851 4856
10. F. Buller, M. Steiner, and K. Frey Selection of carbonic anhydrase IX inhibitors from one million DNA-encoded compounds ACS Chem Biol 6 2011 336 344
11. Y. Lou, P.C. McDonald, and A. Oloumi Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors Cancer Res 71 2011 3364 3376
12. R.G. Gieling, M. Babur, and L. Mamnani Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts J Med Chem 55 2012 5591 5600
13. R.G. Gieling, C.A. Parker, and L.A. De Costa Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cells in vitro J Enzyme Inhib Med Chem 28 2013 360 369
14. J. Overgaard, M. Overgaard, O.S. Nielsen, A.K. Pedersen, and A.R. Timothy A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo Br J Cancer 46 1982 904 911
15. J. Overgaard, H.S. Hansen, and M. Overgaard A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish head and neck cancer study (DAHANCA) protocol 5-85 Radiother Oncol 46 1998 135 146
16. T. van den Beucken, C.H. Ramaekers, K. Rouschop, M. Koritzinsky, and B.G. Wouters Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment Radiother Oncol 92 2009 437 442
17. M. Nordsmark, S.M. Bentzen, and V. Rudat Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study Radiother Oncol 77 2005 18 24
18. A. Yaromina, H. Thames, X. Zhou, S. Hering, W. Eicheler, and A. Dörfler Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation Radiother Oncol 96 2010 116 122
19. U.G. Sattler, S.S. Meyer, and V. Quennet Glycolytic metabolism and tumour response to fractionated irradiation Radiother Oncol 94 2010 102 109
20. A. McIntyre, S. Patiar, and S. Wigfield Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy Clin Cancer Res 18 2012 3100 3111
21. C. Sugie, Y. Shibamoto, and M. Ito Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo J Radiat Res 46 2005 453 459