Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

Oncotarget

Volumn 6, Issue 23, 2015, Pages 19413-19427

  Ledaki, Ioanna ^a   McIntyre, Alan ^a   Wigfield, Simon ^a   Buffa, Francesca ^a   McGowan, Simon ^a   Baban, Dilair ^b   Li, Ji liang ^a   Harris, Adrian L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Carbonic anhydrase IX; EMT; Hypoxia; Stem cells; Tumour heterogeneity

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; A 366; ALDEHYDE DEHYDROGENASE ISOENZYME 1; BUTYRIC ACID; CARBONATE DEHYDRATASE IX; HISTONE DEACETYLASE; METHYLTRANSFERASE INHIBITOR; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; PEPTIDES AND PROTEINS; PROTEIN LIN28; PROTEIN TWIST1; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; VORINOSTAT; WNT2 PROTEIN; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; HISTONE DEACETYLASE INHIBITOR; ISOENZYME; TUMOR ANTIGEN;

ABCC2 GENE; ALDH1 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CA9 GENE; CANCER STEM CELL; CELL HETEROGENEITY; CELL HYPOXIA; CELL RENEWAL; CELL SUBPOPULATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA MODIFICATION; ENZYME INDUCTION; ENZYME INHIBITION; EPIGENETICS; FEMALE; GENE; GENE LOCUS; LIN28 GENE; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SOX2 GENE; TUMOR GROWTH; TWIST1 GENE; WNT2 GENE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HCT 116 CELL LINE; HUMAN; MCF-7 CELL LINE; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE IX; CARBONIC ANHYDRASES; CELL HYPOXIA; CELL LINE, TUMOR; ENZYME INDUCTION; FEMALE; HCT116 CELLS; HETEROGRAFTS; HISTONE DEACETYLASE INHIBITORS; HUMANS; ISOENZYMES; MALE; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASTIC STEM CELLS;

EID: 84939242207     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4989     Document Type: Article

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