메뉴 건너뛰기




Volumn 12, Issue 9, 2016, Pages 504-517

The potential of endurance exercise-derived exosomes to treat metabolic diseases

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 21; FOLLISTATIN RELATED PROTEIN; GLUCAGON LIKE PEPTIDE 1; GROWTH DIFFERENTIATION FACTOR 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; IRISIN; LEUKEMIA INHIBITORY FACTOR; MICRORNA 1; MICRORNA 132; MICRORNA 192; MITOCHONDRIAL DNA; MYOSTATIN; SOMATOMEDIN C; VASCULOTROPIN A;

EID: 84969963050     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2016.76     Document Type: Review
Times cited : (319)

References (199)
  • 1
    • 9244222260 scopus 로고    scopus 로고
    • Endurance running and the evolution of Homo
    • Bramble, D. M. & Lieberman, D. E. Endurance running and the evolution of Homo. Nature 432, 345-352 (2004).
    • (2004) Nature , vol.432 , pp. 345-352
    • Bramble, D.M.1    Lieberman, D.E.2
  • 2
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: Skeletal muscle as a secretory organ
    • Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8, 457-465 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 3
    • 0035576798 scopus 로고    scopus 로고
    • Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content
    • Steensberg, A. et al. Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J. Physiol. 537, 633-639 (2001).
    • (2001) J. Physiol. , vol.537 , pp. 633-639
    • Steensberg, A.1
  • 4
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Thery, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2, 569-579 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 5
    • 84930540275 scopus 로고    scopus 로고
    • Proteomics of extracellular vesicles: Exosomes and ectosomes
    • Choi, D. S., Kim, D. K., Kim, Y. K. & Gho, Y. S. Proteomics of extracellular vesicles: exosomes and ectosomes. Mass Spectrom. Rev. 34, 474-490 (2015).
    • (2015) Mass Spectrom. Rev. , vol.34 , pp. 474-490
    • Choi, D.S.1    Kim, D.K.2    Kim, Y.K.3    Gho, Y.S.4
  • 6
    • 84893577906 scopus 로고    scopus 로고
    • A paradigm shift for extracellular vesicles as small RNA carriers: From cellular waste elimination to therapeutic applications
    • Hagiwara, K., Ochiya, T. & Kosaka, N. A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications. Drug Delivery Transl Res. 4, 31-37 (2014).
    • (2014) Drug Delivery Transl Res , vol.4 , pp. 31-37
    • Hagiwara, K.1    Ochiya, T.2    Kosaka, N.3
  • 8
    • 84892387470 scopus 로고    scopus 로고
    • Urinary exosomal microRNAs in incipient diabetic nephropathy
    • Barutta, F. et al. Urinary exosomal microRNAs in incipient diabetic nephropathy. PLoS ONE 8, e73798 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e73798
    • Barutta, F.1
  • 9
    • 84927581898 scopus 로고    scopus 로고
    • Pancreatic cancer-associated diabetes is an 'exosomopathy'
    • Korc, M. Pancreatic cancer-associated diabetes is an 'exosomopathy'. Clin. Cancer Res. 21, 1508-1510 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1508-1510
    • Korc, M.1
  • 10
    • 84893192136 scopus 로고    scopus 로고
    • Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease
    • Kranendonk, M. E. et al. Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease. Cardiovasc. Diabetol. 13, 37 (2014).
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 37
    • Kranendonk, M.E.1
  • 11
    • 85014619748 scopus 로고    scopus 로고
    • Biological properties of extracellular vesicles and their physiological functions
    • Yanez-Mo, M. et al. Biological properties of extracellular vesicles and their physiological functions. J. Extracell. Vesicles 4, 27066 (2015).
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 27066
    • Yanez-Mo, M.1
  • 12
    • 84894410450 scopus 로고    scopus 로고
    • Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice
    • Rahman, M. J., Regn, D., Bashratyan, R. & Dai, Y. D. Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice. Diabetes 63, 1008-1020 (2014).
    • (2014) Diabetes , vol.63 , pp. 1008-1020
    • Rahman, M.J.1    Regn, D.2    Bashratyan, R.3    Dai, Y.D.4
  • 13
    • 84888098593 scopus 로고    scopus 로고
    • Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis
    • Zubiri, I. et al. Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. J. Proteomics 96, 92-102 (2014).
    • (2014) J. Proteomics , vol.96 , pp. 92-102
    • Zubiri, I.1
  • 14
    • 84937217413 scopus 로고    scopus 로고
    • Organizational update: The world health organization global status report on noncommunicable diseases 2014; One more landmark step in the combat against stroke and vascular disease
    • Mendis, S., Davis, S. & Norrving, B. Organizational update: The world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke 46, e121-e122 (2015).
    • (2015) Stroke , vol.46 , pp. e121-e122
    • Mendis, S.1    Davis, S.2    Norrving, B.3
  • 15
    • 0034727692 scopus 로고    scopus 로고
    • The economic burden of physical inactivity in Canada
    • Katzmarzyk, P. T., Gledhill, N. & Shephard, R. J. The economic burden of physical inactivity in Canada. CMAJ 163, 1435-1440 (2000).
    • (2000) CMAJ , vol.163 , pp. 1435-1440
    • Katzmarzyk, P.T.1    Gledhill, N.2    Shephard, R.J.3
  • 16
    • 1342279621 scopus 로고    scopus 로고
    • The economic costs associated with physical inactivity and obesity in Canada: An update
    • Katzmarzyk, P. T. & Janssen, I. The economic costs associated with physical inactivity and obesity in Canada: An update. Can. J. Appl. Physiol. 29, 90-115 (2004).
    • (2004) Can. J. Appl. Physiol. , vol.29 , pp. 90-115
    • Katzmarzyk, P.T.1    Janssen, I.2
  • 17
    • 49449085232 scopus 로고    scopus 로고
    • Reduced disability and mortality among aging runners: A 21-year longitudinal study
    • Chakravarty, E. F., Hubert, H. B., Lingala, V. B. & Fries, J. F. Reduced disability and mortality among aging runners: A 21-year longitudinal study. Arch. Intern. Med. 168, 1638-1164 (2008).
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1164-1638
    • Chakravarty, E.F.1    Hubert, H.B.2    Lingala, V.B.3    Fries, J.F.4
  • 18
    • 79952057929 scopus 로고    scopus 로고
    • Non-vigorous physical activity and all-cause mortality: Systematic review and meta-analysis of cohort studies
    • Woodcock, J., Franco, O. H., Orsini, N. & Roberts, I. Non-vigorous physical activity and all-cause mortality: systematic review and meta-analysis of cohort studies. Int. J. Epidemiol. 40, 121-138 (2011).
    • (2011) Int. J. Epidemiol. , vol.40 , pp. 121-138
    • Woodcock, J.1    Franco, O.H.2    Orsini, N.3    Roberts, I.4
  • 19
    • 84869778531 scopus 로고    scopus 로고
    • Changing physical activity behavior in type 2 diabetes: A systematic review and meta-analysis of behavioral interventions
    • Avery, L., Flynn, D., van Wersch, A., Sniehotta, F. F. & Trenell, M. I. Changing physical activity behavior in type 2 diabetes: A systematic review and meta-analysis of behavioral interventions. Diabetes Care 35, 2681-2689 (2012).
    • (2012) Diabetes Care , vol.35 , pp. 2681-2689
    • Avery, L.1    Flynn, D.2    Van Wersch, A.3    Sniehotta, F.F.4    Trenell, M.I.5
  • 20
    • 0025820742 scopus 로고
    • Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus
    • Helmrich, S. P., Ragland, D. R., Leung, R. W. & Paffenbarger, R. S. Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 325, 147-152 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , pp. 147-152
    • Helmrich, S.P.1    Ragland, D.R.2    Leung, R.W.3    Paffenbarger, R.S.4
  • 21
    • 84856996417 scopus 로고    scopus 로고
    • Diabetes and physical activity
    • American Association of Diabetes Educators.
    • American Association of Diabetes Educators. Diabetes and physical activity. Diabetes Educ. 38, 129-132 (2012).
    • (2012) Diabetes Educ. , vol.38 , pp. 129-132
  • 22
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler, W. C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393-403 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1
  • 23
    • 70449517253 scopus 로고    scopus 로고
    • 10-year follow-up of diabetes incidence and weight loss in the diabetes prevention program outcomes study
    • Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 374, 1677-1686 (2009).
    • (2009) Lancet , vol.374 , pp. 1677-1686
  • 24
    • 4644235275 scopus 로고    scopus 로고
    • Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance
    • Hawley, J. A. Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes Metab. Res. Rev. 20, 383-393 (2004).
    • (2004) Diabetes Metab. Res. Rev. , vol.20 , pp. 383-393
    • Hawley, J.A.1
  • 25
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • Morino, K., Petersen, K. F. & Shulman, G. I. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55, S9-S15 (2006).
    • (2006) Diabetes , vol.55 , pp. S9-S15
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 26
    • 84958117435 scopus 로고    scopus 로고
    • Relationships between exercise, mitochondrial biogenesis and type 2 diabetes
    • Joseph, A. M. & Hood, D. A. Relationships between exercise, mitochondrial biogenesis and type 2 diabetes. Med. Sport Sci. 60, 48-61 (2014).
    • (2014) Med. Sport Sci. , vol.60 , pp. 48-61
    • Joseph, A.M.1    Hood, D.A.2
  • 27
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Morino, K. et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 115, 3587-3593 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3587-3593
    • Morino, K.1
  • 28
    • 73649100201 scopus 로고    scopus 로고
    • Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
    • Ritov, V. B. et al. Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am. J. Physiol. Endocrinol. Metab. 298, E49-E58 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E49-E58
    • Ritov, V.B.1
  • 29
    • 0028987309 scopus 로고
    • Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
    • Simoneau, J. A., Colberg, S. R., Thaete, F. L. & Kelley, D. E. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 9, 273-278 (1995).
    • (1995) FASEB J. , vol.9 , pp. 273-278
    • Simoneau, J.A.1    Colberg, S.R.2    Thaete, F.L.3    Kelley, D.E.4
  • 30
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell, B. B. & Shulman, G. I. Mitochondrial dysfunction and type 2 diabetes. Science 307, 384-387 (2005).
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 31
    • 33645074450 scopus 로고    scopus 로고
    • Etiology of insulin resistance
    • Petersen, K. F. & Shulman, G. I. Etiology of insulin resistance. Am. J. Med. 119, S10-16 (2006).
    • (2006) Am. J. Med. , vol.119 , pp. S10-S16
    • Petersen, K.F.1    Shulman, G.I.2
  • 32
    • 0028200755 scopus 로고
    • Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM
    • Dela, F. et al. Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM. Diabetes 43, 862-865 (1994).
    • (1994) Diabetes , vol.43 , pp. 862-865
    • Dela, F.1
  • 33
    • 0033928070 scopus 로고    scopus 로고
    • Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling
    • Greiwe, J. S., Holloszy, J. O. & Semenkovich, C. F. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. J. Appl. Physiol. 89, 176-181 (2000).
    • (2000) J. Appl. Physiol. , vol.89 , pp. 176-181
    • Greiwe, J.S.1    Holloszy, J.O.2    Semenkovich, C.F.3
  • 34
    • 0028809814 scopus 로고
    • Effect of 7-10 days of cycle ergometer exercise on skeletal muscle GLUT-4 protein content
    • Gulve, E. A. & Spina, R. J. Effect of 7-10 days of cycle ergometer exercise on skeletal muscle GLUT-4 protein content. J. Appl. Physiol. 79, 1562-1566 (1995).
    • (1995) J. Appl. Physiol. , vol.79 , pp. 1562-1566
    • Gulve, E.A.1    Spina, R.J.2
  • 35
    • 0029869732 scopus 로고    scopus 로고
    • Increments in skeletal muscle GLUT-1 and GLUT-4 after endurance training in humans
    • Phillips, S. M., Han, X. X., Green, H. J. & Bonen, A. Increments in skeletal muscle GLUT-1 and GLUT-4 after endurance training in humans. Am. J. Physiol. 270, E456-E462 (1996).
    • (1996) Am. J. Physiol. , vol.270 , pp. E456-E462
    • Phillips, S.M.1    Han, X.X.2    Green, H.J.3    Bonen, A.4
  • 36
    • 0028287972 scopus 로고
    • Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle
    • Ren, J. M., Semenkovich, C. F., Gulve, E. A., Gao, J. & Holloszy, J. O. Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. J. Biol. Chem. 269, 14396-14401 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 14396-14401
    • Ren, J.M.1    Semenkovich, C.F.2    Gulve, E.A.3    Gao, J.4    Holloszy, J.O.5
  • 37
    • 76049130230 scopus 로고    scopus 로고
    • Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity?
    • Langin, D. Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity? Biochim. Biophys. Acta 1801, 372-376 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 372-376
    • Langin, D.1
  • 38
    • 84884840427 scopus 로고    scopus 로고
    • Turning WAT into BAT: A review on regulators controlling the browning of white adipocytes
    • Lo, K. A. & Sun, L. Turning WAT into BAT: A review on regulators controlling the browning of white adipocytes. Biosci. Rep. 33, e00065 (2013).
    • (2013) Biosci. Rep. , vol.33 , pp. e00065
    • Lo, K.A.1    Sun, L.2
  • 39
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom, P. et al. A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012).
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1
  • 40
    • 84943402947 scopus 로고    scopus 로고
    • Brown and beige fat: Physiological roles beyond heat generation
    • Kajimura, S., Spiegelman, B. M. & Seale, P. Brown and beige fat: physiological roles beyond heat generation. Cell Metab. 22, 546-559 (2015).
    • (2015) Cell Metab. , vol.22 , pp. 546-559
    • Kajimura, S.1    Spiegelman, B.M.2    Seale, P.3
  • 41
    • 84938568273 scopus 로고    scopus 로고
    • Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress
    • Sidossis, L. S. et al. Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab. 22, 219-227 (2015).
    • (2015) Cell Metab. , vol.22 , pp. 219-227
    • Sidossis, L.S.1
  • 42
    • 84924390413 scopus 로고    scopus 로고
    • Irisin - A myth rather than an exercise-inducible myokine
    • Albrecht, E. et al. Irisin - a myth rather than an exercise-inducible myokine. Sci. Rep. 5, 8889 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 8889
    • Albrecht, E.1
  • 43
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao, R. R. et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157, 1279-1291 (2014).
    • (2014) Cell , vol.157 , pp. 1279-1291
    • Rao, R.R.1
  • 44
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee, P. et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 19, 302-309 (2014).
    • (2014) Cell Metab. , vol.19 , pp. 302-309
    • Lee, P.1
  • 45
    • 84952877232 scopus 로고    scopus 로고
    • Burn induces browning of the subcutaneous white adipose tissue in mice and humans
    • Patsouris, D. et al. Burn induces browning of the subcutaneous white adipose tissue in mice and humans. Cell Rep. 13, 1538-1544 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 1538-1544
    • Patsouris, D.1
  • 46
    • 37849052672 scopus 로고    scopus 로고
    • Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    • Boveris, A. & Navarro, A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic. Biol. Med. 44, 224-229 (2008).
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 224-229
    • Boveris, A.1    Navarro, A.2
  • 47
    • 79952753140 scopus 로고    scopus 로고
    • Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
    • Safdar, A. et al. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc. Natl Acad. Sci. USA 108, 4135-4140 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4135-4140
    • Safdar, A.1
  • 48
    • 63849186508 scopus 로고    scopus 로고
    • Exercise and adrenaline increase PGC-1? mRNA expression in rat adipose tissue
    • Sutherland, L. N., Bomhof, M. R., Capozzi, L. C., Basaraba, S. A. & Wright, D. C. Exercise and adrenaline increase PGC-1? mRNA expression in rat adipose tissue. J. Physiol. 587, 1607-1617 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 1607-1617
    • Sutherland, L.N.1    Bomhof, M.R.2    Capozzi, L.C.3    Basaraba, S.A.4    Wright, D.C.5
  • 49
    • 84947045067 scopus 로고    scopus 로고
    • Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain
    • Clark-Matott, J. et al. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. Neurobiol. Aging 36, 2972-2983 (2015).
    • (2015) Neurobiol. Aging , vol.36 , pp. 2972-2983
    • Clark-Matott, J.1
  • 51
    • 84889797049 scopus 로고    scopus 로고
    • Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women
    • Devries, M. C. et al. Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women. J. Clin. Endocrinol. Metab. 98, 4852-4862 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 4852-4862
    • Devries, M.C.1
  • 52
    • 46649094770 scopus 로고    scopus 로고
    • Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women
    • Devries, M. C. et al. Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women. Free Radic. Biol. Med. 45, 503-511 (2008).
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 503-511
    • Devries, M.C.1
  • 53
    • 84886251367 scopus 로고    scopus 로고
    • Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: The RESOLVE randomized trial
    • Dutheil, F. et al. Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: The RESOLVE randomized trial. Int. J. Cardiol. 168, 3634-3642 (2013).
    • (2013) Int. J. Cardiol. , vol.168 , pp. 3634-3642
    • Dutheil, F.1
  • 54
    • 84877766822 scopus 로고    scopus 로고
    • Effect of exercise training on diastolic function in metabolic syndrome
    • Lalande, S., Petrella, R. J. & Shoemaker, J. K. Effect of exercise training on diastolic function in metabolic syndrome. Appl. Physiol. Nutr. Metab. 38, 545-550 (2013).
    • (2013) Appl. Physiol. Nutr. Metab. , vol.38 , pp. 545-550
    • Lalande, S.1    Petrella, R.J.2    Shoemaker, J.K.3
  • 55
    • 84880314536 scopus 로고    scopus 로고
    • Mediterranean diet, moderate-to-high intensity training, and health-related quality of life in adults with metabolic syndrome
    • Landaeta-Diaz, L. et al. Mediterranean diet, moderate-to-high intensity training, and health-related quality of life in adults with metabolic syndrome. Eur. J. Prev. Cardiol. 20, 555-564 (2013).
    • (2013) Eur. J. Prev. Cardiol. , vol.20 , pp. 555-564
    • Landaeta-Diaz, L.1
  • 56
    • 84863738623 scopus 로고    scopus 로고
    • Perilipin family (PLIN) proteins in human skeletal muscle: The effect of sex, obesity, and endurance training
    • Peters, S. J. et al. Perilipin family (PLIN) proteins in human skeletal muscle: The effect of sex, obesity, and endurance training. Appl. Physiol. Nutr. Metab. 37, 724-735 (2012).
    • (2012) Appl. Physiol. Nutr. Metab. , vol.37 , pp. 724-735
    • Peters, S.J.1
  • 57
    • 84878918349 scopus 로고    scopus 로고
    • Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men
    • Samjoo, I. A. et al. Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men. PLoS ONE 8, e66322 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e66322
    • Samjoo, I.A.1
  • 58
    • 84886676236 scopus 로고    scopus 로고
    • The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men
    • Samjoo, I. A., Safdar, A., Hamadeh, M. J., Raha, S. & Tarnopolsky, M. A. The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. Nutr. Diabetes 3, e88 (2013).
    • (2013) Nutr. Diabetes , vol.3 , pp. e88
    • Samjoo, I.A.1    Safdar, A.2    Hamadeh, M.J.3    Raha, S.4    Tarnopolsky, M.A.5
  • 59
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney, D. J., Parise, G., Melov, S., Safdar, A. & Tarnopolsky, M. A. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J. 19, 1498-1500 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 62
    • 74549226174 scopus 로고    scopus 로고
    • Community exercise: A vital component to healthy aging
    • discussion 79-83
    • Stuart, M., Chard, S., Benvenuti, F. & Steinwachs, S. Community exercise: A vital component to healthy aging. Healthc. Pap. 10, 23-28; discussion 79-83 (2009).
    • (2009) Healthc. Pap. , vol.10 , pp. 23-28
    • Stuart, M.1    Chard, S.2    Benvenuti, F.3    Steinwachs, S.4
  • 63
    • 77952312333 scopus 로고    scopus 로고
    • Physical activity and health
    • Kruk, J. Physical activity and health. Asian Pac. J. Cancer Prev. 10, 721-728 (2009).
    • (2009) Asian Pac. J. Cancer Prev. , vol.10 , pp. 721-728
    • Kruk, J.1
  • 64
    • 84928348920 scopus 로고    scopus 로고
    • Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging
    • Crane, J. D. et al. Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. Aging Cell 14, 625-634 (2015).
    • (2015) Aging Cell , vol.14 , pp. 625-634
    • Crane, J.D.1
  • 65
    • 73349119978 scopus 로고    scopus 로고
    • Physical activity, obesity and risk for esophageal adenocarcinoma
    • Balbuena, L. & Casson, A. G. Physical activity, obesity and risk for esophageal adenocarcinoma. Future Oncol. 5, 1051-1063 (2009).
    • (2009) Future Oncol. , vol.5 , pp. 1051-1063
    • Balbuena, L.1    Casson, A.G.2
  • 66
    • 76149090499 scopus 로고    scopus 로고
    • Exercise performance by hemodialysis patients: A review of the literature
    • Brenner, I. Exercise performance by hemodialysis patients: A review of the literature. Physician Sportsmed. 37, 84-96 (2009).
    • (2009) Physician Sportsmed. , vol.37 , pp. 84-96
    • Brenner, I.1
  • 67
    • 70449837103 scopus 로고    scopus 로고
    • Physical activity and prevention of cardiovascular disease in older adults
    • viii
    • Buchner, D. M. Physical activity and prevention of cardiovascular disease in older adults. Clin. Geriatr. Med. 25, 661-675, viii (2009).
    • (2009) Clin. Geriatr. Med. , vol.25 , pp. 661-675
    • Buchner, D.M.1
  • 69
    • 80054044902 scopus 로고    scopus 로고
    • Skeletal muscle and beyond: The role of exercise as a mediator of systemic mitochondrial biogenesis
    • Little, J. P., Safdar, A., Benton, C. R. & Wright, D. C. Skeletal muscle and beyond: The role of exercise as a mediator of systemic mitochondrial biogenesis. Appl. Physiol. Nutr. Metab. 36, 598-607 (2011).
    • (2011) Appl. Physiol. Nutr. Metab. , vol.36 , pp. 598-607
    • Little, J.P.1    Safdar, A.2    Benton, C.R.3    Wright, D.C.4
  • 70
    • 71249157791 scopus 로고    scopus 로고
    • The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk
    • Pedersen, B. K. The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk. J. Physiol. 587, 5559-5568 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 5559-5568
    • Pedersen, B.K.1
  • 71
    • 70350159156 scopus 로고    scopus 로고
    • F Adolph distinguished lecture: Muscle as an endocrine organ: IL-6 and other myokines
    • Pedersen, B. K. Edward, F. Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines. J. Appl. Physiol. 107, 1006-1014 (2009).
    • (2009) J. Appl. Physiol. , vol.107 , pp. 1006-1014
    • Pedersen, B.K.1    Edward2
  • 72
    • 78651379305 scopus 로고    scopus 로고
    • Muscles and their myokines
    • Pedersen, B. K. Muscles and their myokines. J. Exp. Biol. 214, 337-346 (2011).
    • (2011) J. Exp. Biol. , vol.214 , pp. 337-346
    • Pedersen, B.K.1
  • 73
    • 84881016307 scopus 로고    scopus 로고
    • Muscle-to-organ cross talk mediated by myokines
    • Pedersen, L. & Hojman, P. Muscle-to-organ cross talk mediated by myokines. Adipocyte 1, 164-167 (2012).
    • (2012) Adipocyte , vol.1 , pp. 164-167
    • Pedersen, L.1    Hojman, P.2
  • 74
    • 84896046600 scopus 로고    scopus 로고
    • Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression
    • Li, Z. Y. et al. Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression. CNS Neurosci. Ther. 20, 344-354 (2014).
    • (2014) CNS Neurosci. Ther. , vol.20 , pp. 344-354
    • Li, Z.Y.1
  • 75
    • 84952664099 scopus 로고    scopus 로고
    • Implications of exercise-induced adipo-myokines in bone metabolism
    • Lombardi, G., Sanchis-Gomar, F., Perego, S., Sansoni, V. & Banfi, G. Implications of exercise-induced adipo-myokines in bone metabolism. Endocrine http://dx. doi. org/10. 1007/s12020-015-0834-0 (2015).
    • (2015) Endocrine
    • Lombardi, G.1    Sanchis-Gomar, F.2    Perego, S.3    Sansoni, V.4    Banfi, G.5
  • 76
    • 84942097139 scopus 로고    scopus 로고
    • Adipose-brain crosstalk: Do adipokines have a role in neuroprotection?
    • Little, J. P. & Safdar, A. Adipose-brain crosstalk: do adipokines have a role in neuroprotection? Neural Regen. Res. 10, 1381-1382 (2015).
    • (2015) Neural Regen. Res. , vol.10 , pp. 1381-1382
    • Little, J.P.1    Safdar, A.2
  • 78
    • 84937522427 scopus 로고    scopus 로고
    • Hepatokines: Unlocking the multi-organ network in metabolic diseases
    • Iroz, A., Couty, J. P. & Postic, C. Hepatokines: unlocking the multi-organ network in metabolic diseases. Diabetologia 58, 1699-1703 (2015).
    • (2015) Diabetologia , vol.58 , pp. 1699-1703
    • Iroz, A.1    Couty, J.P.2    Postic, C.3
  • 79
    • 2942702298 scopus 로고    scopus 로고
    • The metabolic role of IL-6 produced during exercise: Is IL-6 an exercise factor?
    • Pedersen, B. K. et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc. Nutr. Soc. 63, 263-267 (2004).
    • (2004) Proc. Nutr. Soc. , vol.63 , pp. 263-267
    • Pedersen, B.K.1
  • 80
    • 36749027249 scopus 로고    scopus 로고
    • IL-6 signalling in exercise and disease
    • Pedersen, B. K. IL-6 signalling in exercise and disease. Biochem. Soc. Trans. 35, 1295-1297 (2007).
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 1295-1297
    • Pedersen, B.K.1
  • 81
    • 34247130827 scopus 로고    scopus 로고
    • Physiological roles of muscle-derived interleukin-6 in response to exercise
    • Pedersen, B. K. & Fischer, C. P. Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr. Opin. Clin. Nutr. Metab. Care 10, 265-271 (2007).
    • (2007) Curr. Opin. Clin. Nutr. Metab. Care , vol.10 , pp. 265-271
    • Pedersen, B.K.1    Fischer, C.P.2
  • 82
    • 33947720482 scopus 로고    scopus 로고
    • Beneficial health effects of exercise - The role of IL-6 as a myokine
    • Pedersen, B. K. & Fischer, C. P. Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol. Sci. 28, 152-156 (2007).
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 152-156
    • Pedersen, B.K.1    Fischer, C.P.2
  • 83
    • 0036152683 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop mature-onset obesity
    • Wallenius, V. et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 8, 75-79 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 75-79
    • Wallenius, V.1
  • 84
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and ? Cells
    • Ellingsgaard, H. et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and ? Cells. Nat. Med. 17, 1481-1489 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1
  • 85
    • 84890319864 scopus 로고    scopus 로고
    • Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver
    • Seldin, M. M. et al. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J. Biol. Chem. 288, 36073-36082 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 36073-36082
    • Seldin, M.M.1
  • 86
    • 84859488137 scopus 로고    scopus 로고
    • Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
    • Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z. & Wong, G. W. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J. Biol. Chem. 287, 11968-11980 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 11968-11980
    • Seldin, M.M.1    Peterson, J.M.2    Byerly, M.S.3    Wei, Z.4    Wong, G.W.5
  • 87
    • 33644823811 scopus 로고    scopus 로고
    • Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure
    • Florholmen, G. et al. Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure. Diabetologia 49, 724-731 (2006).
    • (2006) Diabetologia , vol.49 , pp. 724-731
    • Florholmen, G.1
  • 88
    • 67349109400 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
    • Matthews, V. B. et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia 52, 1409-1418 (2009).
    • (2009) Diabetologia , vol.52 , pp. 1409-1418
    • Matthews, V.B.1
  • 89
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    • Kim, K. H. et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat. Med. 19, 83-92 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 83-92
    • Kim, K.H.1
  • 90
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu, J. et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58, 250-259 (2009).
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1
  • 91
    • 84937724386 scopus 로고    scopus 로고
    • Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
    • Hansen, J. S. et al. Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans. Mol. Metab. 4, 551-560 (2015).
    • (2015) Mol. Metab. , vol.4 , pp. 551-560
    • Hansen, J.S.1
  • 92
    • 33747884524 scopus 로고    scopus 로고
    • Exercise and dexamethasone oppositely modulate ?-cell function and survival via independent pathways in 90% pancreatectomized rats
    • Choi, S. B., Jang, J. S., Hong, S. M., Jun, D. W. & Park, S. Exercise and dexamethasone oppositely modulate ?-cell function and survival via independent pathways in 90% pancreatectomized rats. J. Endocrinol. 190, 471-482 (2006).
    • (2006) J. Endocrinol. , vol.190 , pp. 471-482
    • Choi, S.B.1    Jang, J.S.2    Hong, S.M.3    Jun, D.W.4    Park, S.5
  • 93
    • 84875212874 scopus 로고    scopus 로고
    • Exercise-induced insulin-like growth factor i system concentrations after training in women
    • Gregory, S. M. et al. Exercise-induced insulin-like growth factor I system concentrations after training in women. Med. Sci. Sports Exerc. 45, 420-428 (2013).
    • (2013) Med. Sci. Sports Exerc. , vol.45 , pp. 420-428
    • Gregory, S.M.1
  • 94
    • 84962506062 scopus 로고    scopus 로고
    • Does endurance training affect IGF-1/ IGFBP-3 and insulin sensitivity in patients with type 2 diabetes?
    • Mohajeri Tehrani, M. R., Tajvidi, M., Kahrizi, S. & Hedayati, M. Does endurance training affect IGF-1/ IGFBP-3 and insulin sensitivity in patients with type 2 diabetes? J. Sports Med. Phys. Fitness 55, 1004-1012 (2015).
    • (2015) J. Sports Med. Phys. Fitness , vol.55 , pp. 1004-1012
    • Mohajeri Tehrani, M.R.1    Tajvidi, M.2    Kahrizi, S.3    Hedayati, M.4
  • 95
    • 84879870121 scopus 로고    scopus 로고
    • Betatrophin fuels ? Cell proliferation: First step toward regenerative therapy?
    • Lickert, H. Betatrophin fuels ? Cell proliferation: first step toward regenerative therapy? Cell Metab. 18, 5-6 (2013).
    • (2013) Cell Metab. , vol.18 , pp. 5-6
    • Lickert, H.1
  • 96
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: A hormone that controls pancreatic ? Cell proliferation
    • Yi, P., Park, J. S. & Melton, D. A. Betatrophin: A hormone that controls pancreatic ? Cell proliferation. Cell 153, 747-758 (2013).
    • (2013) Cell , vol.153 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 97
    • 84908331466 scopus 로고    scopus 로고
    • ANGPTL8/betatrophin does not control pancreatic ? Cell expansion
    • Gusarova, V. et al. ANGPTL8/betatrophin does not control pancreatic ? Cell expansion. Cell 159, 691-696 (2014).
    • (2014) Cell , vol.159 , pp. 691-696
    • Gusarova, V.1
  • 98
    • 84939527932 scopus 로고    scopus 로고
    • Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects
    • Abu-Farha, M. et al. Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects. Cardiovasc. Diabetol. 14, 112 (2015).
    • (2015) Cardiovasc. Diabetol. , vol.14 , pp. 112
    • Abu-Farha, M.1
  • 99
    • 84948845304 scopus 로고    scopus 로고
    • Circulating levels of betatrophin and irisin are not associated with pancreatic ?-cell function in previously diagnosed type 2 diabetes mellitus patients
    • Wang, L. et al. Circulating levels of betatrophin and irisin are not associated with pancreatic ?-cell function in previously diagnosed type 2 diabetes mellitus patients. J. Diabetes Res. 2016, 2616539 (2016).
    • (2016) J. Diabetes Res. , vol.2016 , pp. 2616539
    • Wang, L.1
  • 100
    • 84957096660 scopus 로고    scopus 로고
    • Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training
    • Abu-Farha, M. et al. Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training. PLoS ONE 11, e0147367 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0147367
    • Abu-Farha, M.1
  • 101
    • 84896714429 scopus 로고    scopus 로고
    • Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128
    • Adlakha, Y. K. & Saini, N. Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol. Cancer 13, 33 (2014).
    • (2014) Mol. Cancer , vol.13 , pp. 33
    • Adlakha, Y.K.1    Saini, N.2
  • 102
    • 84878550243 scopus 로고    scopus 로고
    • Epigenetic regulation of muscle phenotype and adaptation: A potential role in COPD muscle dysfunction
    • Barreiro, E. & Sznajder, J. I. Epigenetic regulation of muscle phenotype and adaptation: A potential role in COPD muscle dysfunction. J. Appl. Physiol. 114, 1263-1272 (2013).
    • (2013) J. Appl. Physiol. , vol.114 , pp. 1263-1272
    • Barreiro, E.1    Sznajder, J.I.2
  • 103
    • 84904509858 scopus 로고    scopus 로고
    • MicroRNAs: The fine modulators of liver development and function
    • Chen, Y. & Verfaillie, C. M. MicroRNAs: The fine modulators of liver development and function. Liver Int. 34, 976-990 (2014).
    • (2014) Liver Int. , vol.34 , pp. 976-990
    • Chen, Y.1    Verfaillie, C.M.2
  • 105
    • 84881353260 scopus 로고    scopus 로고
    • MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy
    • Kuppusamy, K. T., Sperber, H. & Ruohola-Baker, H. MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy. Curr. Mol. Med. 13, 757-764 (2013).
    • (2013) Curr. Mol. Med. , vol.13 , pp. 757-764
    • Kuppusamy, K.T.1    Sperber, H.2    Ruohola-Baker, H.3
  • 106
    • 84879815377 scopus 로고    scopus 로고
    • Developmental expression and evolution of muscle-specific microRNAs conserved in vertebrates
    • Tani, S., Kuraku, S., Sakamoto, H., Inoue, K. & Kusakabe, R. Developmental expression and evolution of muscle-specific microRNAs conserved in vertebrates. Evol. Dev. 15, 293-304 (2013).
    • (2013) Evol. Dev. , vol.15 , pp. 293-304
    • Tani, S.1    Kuraku, S.2    Sakamoto, H.3    Inoue, K.4    Kusakabe, R.5
  • 107
    • 84889087658 scopus 로고    scopus 로고
    • A rapidly evolving revolution in stem cell biology and medicine
    • Trounson, A. A rapidly evolving revolution in stem cell biology and medicine. Reprod. Biomed. Online 27, 756-764 (2013).
    • (2013) Reprod. Biomed. Online , vol.27 , pp. 756-764
    • Trounson, A.1
  • 108
    • 84894230474 scopus 로고    scopus 로고
    • MicroRNAs in bovine adipogenesis: Genomic context, expression and function
    • Romao, J. M., Jin, W., He, M., McAllister, T. & Guan, L. L. MicroRNAs in bovine adipogenesis: genomic context, expression and function. BMC Genomics 15, 137 (2014).
    • (2014) BMC Genomics , vol.15 , pp. 137
    • Romao, J.M.1    Jin, W.2    He, M.3    McAllister, T.4    Guan, L.L.5
  • 109
    • 77949857315 scopus 로고    scopus 로고
    • The microRNA MIR-696 regulates PGC-1? in mouse skeletal muscle in response to physical activity
    • Aoi, W. et al. The microRNA miR-696 regulates PGC-1? in mouse skeletal muscle in response to physical activity. Am. J. Physiol. Endocrinol. Metab. 298, E799-E806 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E799-E806
    • Aoi, W.1
  • 110
    • 79955622870 scopus 로고    scopus 로고
    • Molecular mechanisms of muscle plasticity with exercise
    • Hoppeler, H., Baum, O., Lurman, G. & Mueller, M. Molecular mechanisms of muscle plasticity with exercise. Compr. Physiol. 1, 1383-1412 (2011).
    • (2011) Compr. Physiol. , vol.1 , pp. 1383-1412
    • Hoppeler, H.1    Baum, O.2    Lurman, G.3    Mueller, M.4
  • 112
    • 84893579528 scopus 로고    scopus 로고
    • Muscle specific miRNAs are induced by testosterone and independently upregulated by age
    • Nielsen, S. et al. Muscle specific miRNAs are induced by testosterone and independently upregulated by age. Front. Physiol. 4, 394 (2013).
    • (2013) Front. Physiol. , vol.4 , pp. 394
    • Nielsen, S.1
  • 113
    • 77958199189 scopus 로고    scopus 로고
    • Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
    • Nielsen, S. et al. Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle. J. Physiol. 588, 4029-4037 (2010).
    • (2010) J. Physiol. , vol.588 , pp. 4029-4037
    • Nielsen, S.1
  • 114
    • 84893197806 scopus 로고    scopus 로고
    • The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy
    • Ooi, J. Y., Bernardo, B. C. & McMullen, J. R. The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy. Future Med. Chem. 6, 205-222 (2014).
    • (2014) Future Med. Chem. , vol.6 , pp. 205-222
    • Ooi, J.Y.1    Bernardo, B.C.2    McMullen, J.R.3
  • 115
    • 84884286848 scopus 로고    scopus 로고
    • Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training
    • Russell, A. P. et al. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J. Physiol. 591, 4637-4653 (2013).
    • (2013) J. Physiol. , vol.591 , pp. 4637-4653
    • Russell, A.P.1
  • 116
    • 66149090410 scopus 로고    scopus 로고
    • MiRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice
    • Safdar, A., Abadi, A., Akhtar, M., Hettinga, B. P. & Tarnopolsky, M. A. miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice. PLoS ONE 4, e5610 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5610
    • Safdar, A.1    Abadi, A.2    Akhtar, M.3    Hettinga, B.P.4    Tarnopolsky, M.A.5
  • 117
    • 80053374569 scopus 로고    scopus 로고
    • Modulation of microRNAs during exercise and disease in human skeletal muscle
    • author reply 219
    • Timmons, J. A. Modulation of microRNAs during exercise and disease in human skeletal muscle. Exerc. Sport Sci. Rev. 39, 218; author reply 219 (2011).
    • (2011) Exerc. Sport Sci. Rev. , vol.39 , pp. 218
    • Timmons, J.A.1
  • 118
    • 71049132736 scopus 로고    scopus 로고
    • The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/ myocyte enhancer factor 2C pathway
    • Granjon, A. et al. The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/ myocyte enhancer factor 2C pathway. Diabetes 58, 2555-2564 (2009).
    • (2009) Diabetes , vol.58 , pp. 2555-2564
    • Granjon, A.1
  • 119
    • 84924995986 scopus 로고    scopus 로고
    • Circulating MIR-192 and MIR-193b are markers of prediabetes and are modulated by an exercise intervention
    • Parrizas, M. et al. Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention. J. Clin. Endocrinol. Metab. 100, E407-E415 (2015).
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. E407-E415
    • Parrizas, M.1
  • 120
    • 84962191103 scopus 로고    scopus 로고
    • Cell microRNAs: Small but powerful
    • Filios, S. R. & Shalev, A. ?-cell microRNAs: small but powerful. Diabetes 64, 3631-3644 (2015).
    • (2015) Diabetes , vol.64 , pp. 3631-3644
    • Filios, S.R.1    Shalev, A.2
  • 121
    • 84890124194 scopus 로고    scopus 로고
    • Identification of particular groups of microRNAs that positively or negatively impact on ? Cell function in obese models of type 2 diabetes
    • Nesca, V. et al. Identification of particular groups of microRNAs that positively or negatively impact on ? Cell function in obese models of type 2 diabetes. Diabetologia 56, 2203-2212 (2013).
    • (2013) Diabetologia , vol.56 , pp. 2203-2212
    • Nesca, V.1
  • 122
    • 84896792799 scopus 로고    scopus 로고
    • The miRNA plasma signature in response to acute aerobic exercise and endurance training
    • Nielsen, S. et al. The miRNA plasma signature in response to acute aerobic exercise and endurance training. PLoS ONE 9, e87308 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e87308
    • Nielsen, S.1
  • 123
    • 84857653584 scopus 로고    scopus 로고
    • Effects of exercise on microRNA expression in young males peripheral blood mononuclear cells
    • Radom-Aizik, S. et al. Effects of exercise on microRNA expression in young males peripheral blood mononuclear cells. Clin. Transl Sci. 5, 32-38 (2012).
    • (2012) Clin. Transl Sci. , vol.5 , pp. 32-38
    • Radom-Aizik, S.1
  • 124
    • 84925441485 scopus 로고    scopus 로고
    • Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic ?-cells
    • Guay, C., Menoud, V., Rome, S. & Regazzi, R. Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic ?-cells. Cell Commun. Signal. 13, 17 (2015).
    • (2015) Cell Commun. Signal. , vol.13 , pp. 17
    • Guay, C.1    Menoud, V.2    Rome, S.3    Regazzi, R.4
  • 125
    • 84930671195 scopus 로고    scopus 로고
    • Gene and microRNA expression responses to exercise; Relationship with insulin sensitivity
    • McLean, C. S. et al. Gene and microRNA expression responses to exercise; relationship with insulin sensitivity. PLoS ONE 10, e0127089 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0127089
    • McLean, C.S.1
  • 126
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1?-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha, V. K. et al. PGC-1?-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 127
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1? Gene in human skeletal muscle
    • Pilegaard, H., Saltin, B. & Neufer, P. D. Exercise induces transient transcriptional activation of the PGC-1? gene in human skeletal muscle. J. Physiol. 546, 851-858 (2003).
    • (2003) J. Physiol. , vol.546 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, P.D.3
  • 128
    • 79953232671 scopus 로고    scopus 로고
    • Exercise increases mitochondrial PGC-1? Content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis
    • Safdar, A. et al. Exercise increases mitochondrial PGC-1? Content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286, 10605-10617 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 10605-10617
    • Safdar, A.1
  • 129
    • 0042232315 scopus 로고    scopus 로고
    • PGC-1? In the regulation of hepatic glucose and energy metabolism
    • Lin, J. et al. PGC-1? in the regulation of hepatic glucose and energy metabolism. J. Biol. Chem. 278, 30843-30848 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 30843-30848
    • Lin, J.1
  • 130
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998).
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1
  • 131
    • 84893480253 scopus 로고    scopus 로고
    • Endothelial PGC-1? Mediates vascular dysfunction in diabetes
    • Sawada, N. et al. Endothelial PGC-1? mediates vascular dysfunction in diabetes. Cell Metab. 19, 246-258 (2014).
    • (2014) Cell Metab. , vol.19 , pp. 246-258
    • Sawada, N.1
  • 132
    • 0038699591 scopus 로고    scopus 로고
    • High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
    • Allen, J. et al. High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat. Biotechnol. 21, 692-696 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , pp. 692-696
    • Allen, J.1
  • 133
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    • An, J. et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat. Med. 10, 268-274 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 268-274
    • An, J.1
  • 134
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson, J. K. & Wilson, I. D. Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668-676 (2003).
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 135
    • 0035160371 scopus 로고    scopus 로고
    • A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
    • Raamsdonk, L. M. et al. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 19, 45-50 (2001).
    • (2001) Nat. Biotechnol. , vol.19 , pp. 45-50
    • Raamsdonk, L.M.1
  • 136
    • 77955603289 scopus 로고    scopus 로고
    • Metabolic signatures of exercise in human plasma
    • Lewis, G. D. et al. Metabolic signatures of exercise in human plasma. Sci. Transl Med. 2, 33ra37 (2010).
    • (2010) Sci. Transl Med. , vol.2 , pp. 33ra37
    • Lewis, G.D.1
  • 137
    • 85006219645 scopus 로고    scopus 로고
    • Metabolomic profiling of submaximal exercise at a standardised relative intensity in healthy adults
    • Muhsen Ali, A. et al. Metabolomic profiling of submaximal exercise at a standardised relative intensity in healthy adults. Metabolites 6, 9 (2016).
    • (2016) Metabolites , vol.6 , pp. 9
    • Muhsen Ali, A.1
  • 138
    • 0037225474 scopus 로고    scopus 로고
    • Leg and arm lactate and substrate kinetics during exercise
    • Van Hall, G. et al. Leg and arm lactate and substrate kinetics during exercise. Am. J. Physiol. Endocrinol. Metab. 284, E193-E205 (2003).
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284 , pp. E193-E205
    • Van Hall, G.1
  • 139
    • 0025144860 scopus 로고
    • Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise
    • Sahlin, K., Katz, A. & Broberg, S. Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise. Am. J. Physiol. 259, C834-C841 (1990).
    • (1990) Am. J. Physiol. , vol.259 , pp. C834-C841
    • Sahlin, K.1    Katz, A.2    Broberg, S.3
  • 140
    • 0026236051 scopus 로고
    • Effect of exercise on amino acid concentrations in skeletal muscle and plasma
    • Henriksson, J. Effect of exercise on amino acid concentrations in skeletal muscle and plasma. J. Exp. Biol. 160, 149-165 (1991).
    • (1991) J. Exp. Biol. , vol.160 , pp. 149-165
    • Henriksson, J.1
  • 141
    • 0031819666 scopus 로고    scopus 로고
    • Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise
    • Gibala, M. J., MacLean, D. A., Graham, T. E. & Saltin, B. Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise. Am. J. Physiol. 275, E235-E242 (1998).
    • (1998) Am. J. Physiol. , vol.275 , pp. E235-E242
    • Gibala, M.J.1    MacLean, D.A.2    Graham, T.E.3    Saltin, B.4
  • 143
    • 84960172990 scopus 로고    scopus 로고
    • A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
    • Jang, C. et al. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat. Med. 22, 421-426 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 421-426
    • Jang, C.1
  • 144
    • 0025041557 scopus 로고
    • Influence of ATP turnover and metabolite changes on IMP formation and glycolysis in rat skeletal muscle
    • Sahlin, K., Gorski, J. & Edstrom, L. Influence of ATP turnover and metabolite changes on IMP formation and glycolysis in rat skeletal muscle. Am. J. Physiol. 259, C409-C412 (1990).
    • (1990) Am. J. Physiol. , vol.259 , pp. C409-C412
    • Sahlin, K.1    Gorski, J.2    Edstrom, L.3
  • 145
    • 53549118277 scopus 로고    scopus 로고
    • The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
    • Sapieha, P. et al. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat. Med. 14, 1067-1076 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1067-1076
    • Sapieha, P.1
  • 146
    • 2442649129 scopus 로고    scopus 로고
    • Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
    • He, W. et al. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 429, 188-193 (2004).
    • (2004) Nature , vol.429 , pp. 188-193
    • He, W.1
  • 147
    • 84907485620 scopus 로고    scopus 로고
    • Browning of white adipose cells by intermediate metabolites: An adaptive mechanism to alleviate redox pressure
    • Carriere, A. et al. Browning of white adipose cells by intermediate metabolites: An adaptive mechanism to alleviate redox pressure. Diabetes 63, 3253-3265 (2014).
    • (2014) Diabetes , vol.63 , pp. 3253-3265
    • Carriere, A.1
  • 148
    • 84863838790 scopus 로고    scopus 로고
    • Membrane vesicle release in bacteria, eukaryotes, and archaea: A conserved yet underappreciated aspect of microbial life
    • Deatherage, B. L. & Cookson, B. T. Membrane vesicle release in bacteria, eukaryotes, and archaea: A conserved yet underappreciated aspect of microbial life. Infect. Immun. 80, 1948-1957 (2012).
    • (2012) Infect. Immun. , vol.80 , pp. 1948-1957
    • Deatherage, B.L.1    Cookson, B.T.2
  • 149
    • 77957959533 scopus 로고    scopus 로고
    • Biological functions and biogenesis of secreted bacterial outer membrane vesicles
    • Kulp, A. & Kuehn, M. J. Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu. Rev. Microbiol. 64, 163-184 (2010).
    • (2010) Annu. Rev. Microbiol. , vol.64 , pp. 163-184
    • Kulp, A.1    Kuehn, M.J.2
  • 150
    • 33746606073 scopus 로고    scopus 로고
    • Outer membrane vesicle production by Escherichia coli is independent of membrane instability
    • McBroom, A. J., Johnson, A. P., Vemulapalli, S. & Kuehn, M. J. Outer membrane vesicle production by Escherichia coli is independent of membrane instability. J. Bacteriol. 188, 5385-5392 (2006).
    • (2006) J. Bacteriol. , vol.188 , pp. 5385-5392
    • McBroom, A.J.1    Johnson, A.P.2    Vemulapalli, S.3    Kuehn, M.J.4
  • 151
    • 73149088617 scopus 로고    scopus 로고
    • Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles
    • Lee, E. Y. et al. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics 9, 5425-5436 (2009).
    • (2009) Proteomics , vol.9 , pp. 5425-5436
    • Lee, E.Y.1
  • 152
    • 78650507281 scopus 로고    scopus 로고
    • Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
    • Rivera, J. et al. Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins. Proc. Natl Acad. Sci. USA 107, 19002-19007 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 19002-19007
    • Rivera, J.1
  • 153
    • 58149177342 scopus 로고    scopus 로고
    • Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components
    • Ellen, A. F. et al. Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components. Extremophiles 13, 67-79 (2009).
    • (2009) Extremophiles , vol.13 , pp. 67-79
    • Ellen, A.F.1
  • 154
    • 0012998399 scopus 로고    scopus 로고
    • The ultrastructure of Ignicoccus: Evidence for a novel outer membrane and for intracellular vesicle budding in an archaeon
    • Rachel, R., Wyschkony, I., Riehl, S. & Huber, H. The ultrastructure of Ignicoccus: evidence for a novel outer membrane and for intracellular vesicle budding in an archaeon. Archaea 1, 9-18 (2002).
    • (2002) Archaea , vol.1 , pp. 9-18
    • Rachel, R.1    Wyschkony, I.2    Riehl, S.3    Huber, H.4
  • 155
    • 84908085343 scopus 로고    scopus 로고
    • A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles
    • Sugiura, A., McLelland, G. L., Fon, E. A. & McBride, H. M. A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J. 33, 2142-2156 (2014).
    • (2014) EMBO J , vol.33 , pp. 2142-2156
    • Sugiura, A.1    McLelland, G.L.2    Fon, E.A.3    McBride, H.M.4
  • 156
    • 67949111205 scopus 로고    scopus 로고
    • Mitochondrial vesicles: An ancient process providing new links to peroxisomes
    • Andrade-Navarro, M. A., Sanchez-Pulido, L. & McBride, H. M. Mitochondrial vesicles: An ancient process providing new links to peroxisomes. Curr. Opin. Cell Biol. 21, 560-567 (2009).
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 560-567
    • Andrade-Navarro, M.A.1    Sanchez-Pulido, L.2    McBride, H.M.3
  • 157
    • 84856221632 scopus 로고    scopus 로고
    • A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
    • Soubannier, V. et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol. 22, 135-141 (2012).
    • (2012) Curr. Biol. , vol.22 , pp. 135-141
    • Soubannier, V.1
  • 158
    • 84897863239 scopus 로고    scopus 로고
    • Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
    • McLelland, G. L., Soubannier, V., Chen, C. X., McBride, H. M. & Fon, E. A. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 33, 282-295 (2014).
    • (2014) EMBO J. , vol.33 , pp. 282-295
    • McLelland, G.L.1    Soubannier, V.2    Chen, C.X.3    McBride, H.M.4    Fon, E.A.5
  • 159
    • 85007961966 scopus 로고    scopus 로고
    • MtDNA migration and the role of exosomes in horizontal gene transfer
    • Esquilin, Y., Queenan, C., Calabri, A. & Leonardi, D. mtDNA migration and the role of exosomes in horizontal gene transfer. Microsc. Microanal. 18, 286-287 (2012).
    • (2012) Microsc. Microanal. , vol.18 , pp. 286-287
    • Esquilin, Y.1    Queenan, C.2    Calabri, A.3    Leonardi, D.4
  • 160
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
    • Pan, B. T. & Johnstone, R. M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33, 967-978 (1983).
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 161
    • 84892990284 scopus 로고    scopus 로고
    • Cell-cell communication via extracellular membrane vesicles and its role in the immune response
    • Hwang, I. Cell-cell communication via extracellular membrane vesicles and its role in the immune response. Mol. Cells 36, 105-111 (2013).
    • (2013) Mol. Cells , vol.36 , pp. 105-111
    • Hwang, I.1
  • 162
    • 84894294740 scopus 로고    scopus 로고
    • Exosomes: Mediators of neurodegeneration, neuroprotection and therapeutics
    • Kalani, A., Tyagi, A. & Tyagi, N. Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol. Neurobiol. 49, 590-600 (2014).
    • (2014) Mol. Neurobiol. , vol.49 , pp. 590-600
    • Kalani, A.1    Tyagi, A.2    Tyagi, N.3
  • 163
    • 84886738545 scopus 로고    scopus 로고
    • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies
    • Record, M., Carayon, K., Poirot, M. & Silvente-Poirot, S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim. Biophys. Acta 1841, 108-120 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 108-120
    • Record, M.1    Carayon, K.2    Poirot, M.3    Silvente-Poirot, S.4
  • 164
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo, M., Raposo, G. & Thery, C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255-289 (2014).
    • (2014) Annu. Rev. Cell Dev. Biol. , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 165
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo, G. & Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373-383 (2013).
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 166
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: Extracellular organelles important in intercellular communication
    • Mathivanan, S., Ji, H. & Simpson, R. J. Exosomes: extracellular organelles important in intercellular communication. J. Proteomics 73, 1907-1920 (2010).
    • (2010) J. Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 167
    • 84877903383 scopus 로고    scopus 로고
    • Signaling pathways in exosomes biogenesis, secretion and fate
    • Urbanelli, L. et al. Signaling pathways in exosomes biogenesis, secretion and fate. Genes 4, 152-170 (2013).
    • (2013) Genes , vol.4 , pp. 152-170
    • Urbanelli, L.1
  • 168
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • Stuffers, S., Sem Wegner, C., Stenmark, H. & Brech, A. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 10, 925-937 (2009).
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1    Sem Wegner, C.2    Stenmark, H.3    Brech, A.4
  • 169
    • 67349114201 scopus 로고    scopus 로고
    • Acid sphingomyelinase activity triggers microparticle release from glial cells
    • Bianco, F. et al. Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 28, 1043-1054 (2009).
    • (2009) EMBO J. , vol.28 , pp. 1043-1054
    • Bianco, F.1
  • 170
    • 78751703517 scopus 로고    scopus 로고
    • Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    • Lachenal, G. et al. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity. Mol. Cell. Neurosci. 46, 409-418 (2011).
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 409-418
    • Lachenal, G.1
  • 171
    • 12744269555 scopus 로고    scopus 로고
    • Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner
    • Savina, A., Fader, C. M., Damiani, M. T. & Colombo, M. I. Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic 6, 131-143 (2005).
    • (2005) Traffic , vol.6 , pp. 131-143
    • Savina, A.1    Fader, C.M.2    Damiani, M.T.3    Colombo, M.I.4
  • 172
    • 0037443410 scopus 로고    scopus 로고
    • Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo
    • Skokos, D. et al. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J. Immunol. 170, 3037-3045 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3037-3045
    • Skokos, D.1
  • 173
    • 0037137593 scopus 로고    scopus 로고
    • Tumor-derived exosomes: A new source of tumor rejection antigens
    • Andre, F. et al. Tumor-derived exosomes: A new source of tumor rejection antigens. Vaccine 20 (Suppl. 4), A28-A31 (2002).
    • (2002) Vaccine , vol.20 , pp. A28-A31
    • Andre, F.1
  • 174
    • 84890327208 scopus 로고    scopus 로고
    • MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation
    • Aucher, A., Rudnicka, D. & Davis, D. M. MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation. J. Immunol. 191, 6250-6260 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 6250-6260
    • Aucher, A.1    Rudnicka, D.2    Davis, D.M.3
  • 175
    • 84919455345 scopus 로고    scopus 로고
    • Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation
    • Pope, S. M. & Lasser, C. Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation. J. Extracell. Vesicles 2, http://dx. doi. org/10. 3402/jev. v2i0. 22484 (2013).
    • (2013) J. Extracell. Vesicles , vol.2
    • Pope, S.M.1    Lasser, C.2
  • 176
    • 84881400770 scopus 로고    scopus 로고
    • Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7. 5 cells
    • Ramakrishnaiah, V. et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7. 5 cells. Proc. Natl Acad. Sci. USA 110, 13109-13113 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 13109-13113
    • Ramakrishnaiah, V.1
  • 177
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers, J. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 7, 297-303 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 297-303
    • Wolfers, J.1
  • 178
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: A compendium of exosomal proteins and RNA
    • Mathivanan, S. & Simpson, R. J. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics 9, 4997-5000 (2009).
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 179
    • 33644927263 scopus 로고    scopus 로고
    • Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
    • Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol. 172, 923-935 (2006).
    • (2006) J. Cell Biol. , vol.172 , pp. 923-935
    • Booth, A.M.1
  • 180
    • 84870575710 scopus 로고    scopus 로고
    • Exosome-mediated delivery of siRNA in vitro and in vivo
    • El-Andaloussi, S. et al. Exosome-mediated delivery of siRNA in vitro and in vivo. Nat. Protoc. 7, 2112-2126 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 2112-2126
    • El-Andaloussi, S.1
  • 181
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles
    • Lotvall, J. et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J. Extracell. Vesicles 3, 26913 (2014).
    • (2014) J. Extracell. Vesicles , vol.3 , pp. 26913
    • Lotvall, J.1
  • 182
    • 84927133965 scopus 로고    scopus 로고
    • Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice
    • Aswad, H. et al. Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice. Diabetologia 57, 2155-2164 (2014).
    • (2014) Diabetologia , vol.57 , pp. 2155-2164
    • Aswad, H.1
  • 183
    • 0035112481 scopus 로고    scopus 로고
    • Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • Hood, D. A. Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J. Appl. Physiol. 90, 1137-1157 (2001).
    • (2001) J. Appl. Physiol. , vol.90 , pp. 1137-1157
    • Hood, D.A.1
  • 184
    • 84894282996 scopus 로고    scopus 로고
    • Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: A new paradigm for myoblast-myotube cross talk?
    • Forterre, A. et al. Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: A new paradigm for myoblast-myotube cross talk? PLoS ONE 9, e84153 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e84153
    • Forterre, A.1
  • 185
    • 84949129837 scopus 로고    scopus 로고
    • Proteomic analysis of secreted proteins from skeletal muscle cells during differentiation
    • Ojimaa, K. O. et al. Proteomic analysis of secreted proteins from skeletal muscle cells during differentiation. EuPA Open Proteom. 5, 1-9 (2014).
    • (2014) EuPA Open Proteom. , vol.5 , pp. 1-9
    • Ojimaa, K.O.1
  • 186
    • 84944355473 scopus 로고    scopus 로고
    • Physical exercise induces rapid release of small extracellular vesicles into the circulation
    • Fruhbeis, C., Helmig, S., Tug, S., Simon, P. & Kramer-Albers, E. M. Physical exercise induces rapid release of small extracellular vesicles into the circulation. J. Extracell. Vesicles 4, 28239 (2015).
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 28239
    • Fruhbeis, C.1    Helmig, S.2    Tug, S.3    Simon, P.4    Kramer-Albers, E.M.5
  • 187
    • 84944355404 scopus 로고    scopus 로고
    • Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles
    • Helmig, S., Fruhbeis, C., Kramer-Albers, E. M., Simon, P. & Tug, S. Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles. Eur. J. Appl. Physiol. 115, 2271-2280 (2015).
    • (2015) Eur. J. Appl. Physiol. , vol.115 , pp. 2271-2280
    • Helmig, S.1    Fruhbeis, C.2    Kramer-Albers, E.M.3    Simon, P.4    Tug, S.5
  • 188
    • 80052969709 scopus 로고    scopus 로고
    • Exosomes from human CD34+ stem cells mediate their proangiogenic paracrine activity
    • Sahoo, S. et al. Exosomes from human CD34+ stem cells mediate their proangiogenic paracrine activity. Circ. Res. 109, 724-728 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 724-728
    • Sahoo, S.1
  • 189
    • 84978523970 scopus 로고    scopus 로고
    • Effect of acute exercise on circulating angiogenic cell and microparticle populations
    • Lansford, K. A. et al. Effect of acute exercise on circulating angiogenic cell and microparticle populations. Exp. Physiol. 101, 155-167 (2015).
    • (2015) Exp. Physiol. , vol.101 , pp. 155-167
    • Lansford, K.A.1
  • 190
    • 84942475355 scopus 로고    scopus 로고
    • Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women
    • Harris, E., Rakobowchuk, M. & Birch, K. M. Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women. PLoS ONE 9, e108720 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e108720
    • Harris, E.1    Rakobowchuk, M.2    Birch, K.M.3
  • 191
    • 84938764391 scopus 로고    scopus 로고
    • Cardiosome mediated regulation of MMP9 in diabetic heart: Role of mir29b and mir455 in exercise
    • Chaturvedi, P., Kalani, A., Medina, I., Familtseva, A. & Tyagi, S. C. Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise. J. Cell. Mol. Med. 19, 2153-2161 (2015).
    • (2015) J. Cell. Mol. Med. , vol.19 , pp. 2153-2161
    • Chaturvedi, P.1    Kalani, A.2    Medina, I.3    Familtseva, A.4    Tyagi, S.C.5
  • 192
    • 85016490706 scopus 로고    scopus 로고
    • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
    • Wiklander, O. P. et al. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J. Extracell. Vesicles 4, 26316 (2015).
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 26316
    • Wiklander, O.P.1
  • 193
    • 84959884970 scopus 로고    scopus 로고
    • Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes
    • Garcia, N. A., Moncayo-Arlandi, J., Sepulveda, P. & Diez-Juan, A. Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes. Cardiovasc. Res. 109, 397-408 (2016).
    • (2016) Cardiovasc. Res. , vol.109 , pp. 397-408
    • Garcia, N.A.1    Moncayo-Arlandi, J.2    Sepulveda, P.3    Diez-Juan, A.4
  • 194
    • 79959330841 scopus 로고    scopus 로고
    • Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
    • Sokolova, V. et al. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf. B Biointerfaces 87, 146-150 (2011).
    • (2011) Colloids Surf. B Biointerfaces , vol.87 , pp. 146-150
    • Sokolova, V.1
  • 195
    • 84906888575 scopus 로고    scopus 로고
    • Exosomes in prostate cancer: Putting together the pieces of a puzzle
    • Soekmadji, C., Russell, P. J. & Nelson, C. C. Exosomes in prostate cancer: putting together the pieces of a puzzle. Cancers (Basel) 5, 1522-1544 (2013).
    • (2013) Cancers (Basel) , vol.5 , pp. 1522-1544
    • Soekmadji, C.1    Russell, P.J.2    Nelson, C.C.3
  • 196
    • 79958851262 scopus 로고    scopus 로고
    • An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle
    • Little, J. P., Safdar, A., Bishop, D., Tarnopolsky, M. A. & Gibala, M. J. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle. Am. J. Physiol. Reg. Integr. Comp. Physiol. 300, R1303-R1310 (2011).
    • (2011) Am. J. Physiol. Reg. Integr. Comp. Physiol. , vol.300 , pp. R1303-R1310
    • Little, J.P.1    Safdar, A.2    Bishop, D.3    Tarnopolsky, M.A.4    Gibala, M.J.5
  • 197
    • 84884211378 scopus 로고    scopus 로고
    • Interval training in men at risk for insulin resistance
    • Earnest, C. P. et al. Interval training in men at risk for insulin resistance. Int. J. Sports Med. 34, 355-363 (2013).
    • (2013) Int. J. Sports Med. , vol.34 , pp. 355-363
    • Earnest, C.P.1
  • 198
    • 38949163772 scopus 로고    scopus 로고
    • Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults
    • Tarnopolsky, M. et al. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS ONE 2, e991 (2007).
    • (2007) PLoS ONE , vol.2 , pp. e991
    • Tarnopolsky, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.