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Volumn 2, Issue 8, 2003, Pages 668-676

Understanding 'global' systems biology: Metabonomics and the continuum of metabolism

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL; PROBIOTIC AGENT; XENOBIOTIC AGENT;

EID: 0043069547     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1157     Document Type: Review
Times cited : (1010)

References (60)
  • 1
    • 85015077644 scopus 로고    scopus 로고
    • The digital code of DNA
    • Hood, L. & Galas, D. The digital code of DNA. Nature 421, 444-448(2003).
    • (2003) Nature , vol.421 , pp. 444-448
    • Hood, L.1    Galas, D.2
  • 2
    • 0035369987 scopus 로고    scopus 로고
    • Key challenges for toxicologists in the 21st Century
    • Smith, L. L. Key challenges for toxicologists in the 21st Century. Trend. Pharm. Sci. 22, 281-285 (2001).
    • (2001) Trend. Pharm. Sci. , vol.22 , pp. 281-285
    • Smith, L.L.1
  • 3
    • 0035160371 scopus 로고    scopus 로고
    • A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
    • Raamsdonk, L. M. et al. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotech. 19, 45-50(2001).
    • (2001) Nature Biotech. , vol.19 , pp. 45-50
    • Raamsdonk, L.M.1
  • 4
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi, S. P., Rochon, Y., Franza, B. R. & Aebersold, R. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19, 1720-1730 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3    Aebersold, R.4
  • 5
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data
    • Nicholson, J. K., Lindon, J. C. & Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica 29, 1181-1189 (1999).
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 7
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon, J. C., Nicholson, J. K., Holmes, E. & Everett, J. R. Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn. Reson. 12, 289-320(2000).
    • (2000) Concepts Magn. Reson. , vol.12 , pp. 289-320
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3    Everett, J.R.4
  • 8
    • 0036913503 scopus 로고    scopus 로고
    • 1H NMR-based metabonomics
    • 1H NMR-based metabonomics. Nature Med. 8, 1439-1444 (2002).
    • (2002) Nature Med. , vol.8 , pp. 1439-1444
    • Brindle, J.T.1
  • 9
    • 1342346205 scopus 로고    scopus 로고
    • KEGG: Kyoto Encyclopaedia of genes and genomes
    • Release 26. April
    • KEGG: Kyoto Encyclopaedia of genes and genomes. Release 26. April 2003.
    • (2003)
  • 10
    • 0029045069 scopus 로고
    • Recent developments beyond metabolic control analysis
    • Kacser, H. Recent developments beyond metabolic control analysis. Biochem. Soc. Trans. 23, 387-391 (1973).
    • (1973) Biochem. Soc. Trans. , vol.23 , pp. 387-391
    • Kacser, H.1
  • 12
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer, U. A. & Zanger, U. M. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 13
    • 0037306343 scopus 로고    scopus 로고
    • Drug metabolism and individualized medicine
    • Srivastava, P. Drug metabolism and individualized medicine. Curr. Drug Metab. 4, 33-44 (2003).
    • (2003) Curr. Drug Metab. , vol.4 , pp. 33-44
    • Srivastava, P.1
  • 14
    • 0037184794 scopus 로고    scopus 로고
    • Polymorphism of cytochrome P450 and xenobiotic toxicity
    • Ingelman-Sundberg, M. Polymorphism of cytochrome P450 and xenobiotic toxicity. Toxicology 181, 447-452 (2002).
    • (2002) Toxicology , vol.181 , pp. 447-452
    • Ingelman-Sundberg, M.1
  • 15
    • 0035102719 scopus 로고    scopus 로고
    • CYP3A genetics in drug metabolism
    • Eichelbaum, M. & Burk, O. CYP3A genetics in drug metabolism. Nature Med. 7, 285-288 (2001).
    • (2001) Nature Med. , vol.7 , pp. 285-288
    • Eichelbaum, M.1    Burk, O.2
  • 16
    • 0034959461 scopus 로고    scopus 로고
    • Identification and functional characterization of eight CYP3A4 protein variants
    • Eiselt, R. et al. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics 11, 447-458 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 447-458
    • Eiselt, R.1
  • 17
    • 0030962538 scopus 로고    scopus 로고
    • Association of extracolonic manifestations of familial adenomatous polyposis with acetylation phenotype in a large FAP kindred
    • Scott, R. J. et al. Association of extracolonic manifestations of familial adenomatous polyposis with acetylation phenotype in a large FAP kindred. Eur. J. Hum. Genet. 5, 43-49 (1997).
    • (1997) Eur. J. Hum. Genet. , vol.5 , pp. 43-49
    • Scott, R.J.1
  • 18
    • 0030741819 scopus 로고    scopus 로고
    • Analysis of CYP2D6 expression in human lung: Implications for the association between CYP2D6 activity and susceptibility to lung cancer
    • Kivistö K. T. et al. Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer. Pharmacogenetics 7, 295-302 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 295-302
    • Kivistö, K.T.1
  • 19
    • 0033408498 scopus 로고    scopus 로고
    • Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a west African population
    • Griese, E. U., Asante-Poku, S., Ofori-Adjei D., Mikus, G. & Eichelbaum, M. Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a west African population. Pharmacogenetics 9, 715-723 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 715-723
    • Griese, E.U.1    Asante-Poku, S.2    Ofori-Adjei, D.3    Mikus, G.4    Eichelbaum, M.5
  • 20
    • 0035133641 scopus 로고    scopus 로고
    • Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from Western Australia
    • Griese, E. U. et al. Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from Western Australia. Pharmacogenetics 11, 69-76 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 69-76
    • Griese, E.U.1
  • 21
    • 0037471164 scopus 로고    scopus 로고
    • The thin line between gut commensal and pathogen
    • Gilmore, M. S. & Ferretti, J. J. The thin line between gut commensal and pathogen. Science 299,1999-2002 (2003).
    • (2003) Science , vol.299 , pp. 1999-2002
    • Gilmore, M.S.1    Ferretti, J.J.2
  • 22
    • 0004143441 scopus 로고
    • Normal Microflora
    • (Chapman and Hall, )
    • Tannock, G. W. Normal Microflora (Chapman and Hall, 1995).
    • (1995)
    • Tannock, G.W.1
  • 23
    • 0037470975 scopus 로고    scopus 로고
    • A genomic, view of the human-Bacteroides thetaiotaomicron symbiosis
    • Xu, J. et al. A genomic, view of the human-Bacteroides thetaiotaomicron symbiosis. Science 299, 2074-2076 (2003).
    • (2003) Science , vol.299 , pp. 2074-2076
    • Xu, J.1
  • 24
    • 0037158038 scopus 로고    scopus 로고
    • Probiotics: Their tiny worlds are under scrutiny
    • Beale, B. Probiotics: Their tiny worlds are under scrutiny. The Scientist 16, 20-22 (2002).
    • (2002) The Scientist , vol.16 , pp. 20-22
    • Beale, B.1
  • 25
    • 0036298165 scopus 로고    scopus 로고
    • Aberrant composition of gut microflora of allergic infants: A target of bifidobacterial therapy at weaning
    • Kirjavainen, P. V. et al. Aberrant composition of gut microflora of allergic infants: a target of bifidobacterial therapy at weaning. Gut 51, 51-55 (2002).
    • (2002) Gut , vol.51 , pp. 51-55
    • Kirjavainen, P.V.1
  • 26
    • 0037380812 scopus 로고    scopus 로고
    • Nutrigenomics: Goals and Strategies
    • Muller, M. & Kersten, S. Nutrigenomics: Goals and Strategies. Nature Gen. 4, 315-322 (2003).
    • (2003) Nature Gen. , vol.4 , pp. 315-322
    • Muller, M.1    Kersten, S.2
  • 27
    • 0037177527 scopus 로고    scopus 로고
    • Balancing life-style and genomics research for disease prevention
    • Willet, W. C. Balancing life-style and genomics research for disease prevention. Science 296, 695-698 (2002).
    • (2002) Science , vol.296 , pp. 695-698
    • Willet, W.C.1
  • 28
    • 0027223985 scopus 로고
    • Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol)
    • Ghauri, F., McLean, A., Beales, D., Wilson, I. D. & Nicholson, J. K. Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol). Biochem. Pharmacol. 46, 953-957 (1993).
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 953-957
    • Ghauri, F.1    McLean, A.2    Beales, D.3    Wilson, I.D.4    Nicholson, J.K.5
  • 30
    • 0025240419 scopus 로고
    • Relationship between uptake and elimination of toluene and debrisoquine hydroxylation polymorphism
    • Lof, A. et al. Relationship between uptake and elimination of toluene and debrisoquine hydroxylation polymorphism. Clin. Pharmacol. Ther. 47, 412-417 (1990).
    • (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 412-417
    • Lof, A.1
  • 31
    • 0038546993 scopus 로고    scopus 로고
    • Determination of urinary hippuratic acid and O-cresol levels as biological indicators of toluene exposure in shoe-workers and glure sniffers
    • Cok, I., Dagdelen, A. & Gokce, E. Determination of urinary hippuratic acid and O-cresol levels as biological indicators of toluene exposure in shoe-workers and glure sniffers. Biomarkers 8, 119-127 (2003).
    • (2003) Biomarkers , vol.8 , pp. 119-127
    • Cok, I.1    Dagdelen, A.2    Gokce, E.3
  • 32
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary derived aromatics in the rat
    • Phipps, A. N., Stewart, J., Wright, B. & Wilson, I. D. Effect of diet on the urinary excretion of hippuric acid and other dietary derived aromatics in the rat. Xenobiotica 28, 527-537 (1998).
    • (1998) Xenobiotica , vol.28 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4
  • 33
    • 0035870843 scopus 로고    scopus 로고
    • HPLC-NMR spectroscopic and chemometric studies on metabolic variation in Sprague Dawley rats
    • Gavaghan, C. L. et al. HPLC-NMR spectroscopic and chemometric studies on metabolic variation in Sprague Dawley rats. Anal. Biochem. 291, 245-252 (2001).
    • (2001) Anal. Biochem. , vol.291 , pp. 245-252
    • Gavaghan, C.L.1
  • 34
    • 0004225573 scopus 로고
    • (eds. Katchevsky, D. K. & Nair, P. P.) (Plenum, )
    • Murphy, G. M. The Bile Acids Vol. 4 (eds. Katchevsky, D. K. & Nair, P. P.) (Plenum, 1988).
    • (1988) The Bile Acids , vol.4
    • Murphy, G.M.1
  • 35
    • 0022377742 scopus 로고
    • Serum unconjugated bile acids: Qualitative and quantitative profiles in ileal resection and bacterial overgrowth
    • Setchell, K. D., Harrison, D. L., Gilbert, J. M. & Mupthy, G. M. Serum unconjugated bile acids: qualitative and quantitative profiles in ileal resection and bacterial overgrowth. Clin. Chim. Acta 152, 297-306 (1985).
    • (1985) Clin. Chim. Acta , vol.152 , pp. 297-306
    • Setchell, K.D.1    Harrison, D.L.2    Gilbert, J.M.3    Mupthy, G.M.4
  • 36
    • 0024581162 scopus 로고
    • The biotransformed metabolite profiles in blood after intravenous administration of dehydrocholic acid
    • Yoneda, M. et al. The biotransformed metabolite profiles in blood after intravenous administration of dehydrocholic acid. Am. J. Gastroenterol. 84, 290-295 (1989).
    • (1989) Am. J. Gastroenterol. , vol.84 , pp. 290-295
    • Yoneda, M.1
  • 37
    • 0024347174 scopus 로고
    • Increased oxidoreduction of deoxycholic acid in cholecystectomised patients
    • Einarsson, K., Nilsell, K. & Bjorkhem, I. Increased oxidoreduction of deoxycholic acid in cholecystectomised patients. Gut 30, 1275-1278 (1989).
    • (1989) Gut , vol.30 , pp. 1275-1278
    • Einarsson, K.1    Nilsell, K.2    Bjorkhem, I.3
  • 39
    • 0242325152 scopus 로고    scopus 로고
    • Metabonomic investigations into the acclimatisation of axenic rats to a normal gut microflora
    • (in the press)
    • Nicholls, A. N., Mortishire-Smith, R. & Nicholson, J. K. Metabonomic investigations into the acclimatisation of axenic rats to a normal gut microflora. Chem. Res. Toxicol. (in the press).
    • Chem. Res. Toxicol.
    • Nicholls, A.N.1    Mortishire-Smith, R.2    Nicholson, J.K.3
  • 40
    • 0014813667 scopus 로고
    • The physiological role of liver alcohol dehydrogenase
    • Krebs, H. A. & Perkins, J. R. The physiological role of liver alcohol dehydrogenase.Biochem. J. 118, 635-644 (1970).
    • (1970) Biochem. J. , vol.118 , pp. 635-644
    • Krebs, H.A.1    Perkins, J.R.2
  • 41
    • 0024934835 scopus 로고
    • Metabolism of di (2-ethylhexyl)phthalate
    • Albro, P. W. & Lavenhar, S. R. Metabolism of di (2-ethylhexyl)phthalate. Drug Metab. Rev. 21, 13-34 (1989).
    • (1989) Drug Metab. Rev. , vol.21 , pp. 13-34
    • Albro, P.W.1    Lavenhar, S.R.2
  • 42
    • 0024906407 scopus 로고
    • Metabolism of DEHP: Effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMA Studies)
    • Astill, B. D. Metabolism of DEHP: Effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMA Studies). Drug Metab. Rev. 21, 35-53(1989).
    • (1989) Drug Metab. Rev. , vol.21 , pp. 35-53
    • Astill, B.D.1
  • 43
    • 0242293578 scopus 로고    scopus 로고
    • Do metabolic pathways for xenobiotics really exist?
    • (in the press)
    • Wilson, I. D. & Nicholson, J. K. Do metabolic pathways for xenobiotics really exist? Xenobiotica (in the press).
    • Xenobiotica
    • Wilson, I.D.1    Nicholson, J.K.2
  • 44
    • 0014526044 scopus 로고
    • Chemical aspects of penicillin allergy
    • Schwartz, M. A. Chemical aspects of penicillin allergy. J. Pharm. Sci. 58, 643-661 (1969).
    • (1969) J. Pharm. Sci. , vol.58 , pp. 643-661
    • Schwartz, M.A.1
  • 46
    • 0021321993 scopus 로고
    • Proton NMR studies of serum, plasma and urine from fasting normal, and diabetic subjects
    • Nicholson, J. K. et al. Proton NMR studies of serum, plasma and urine from fasting normal, and diabetic subjects. Biochem. J. 217, 365-375 (1984),
    • (1984) Biochem. J. , vol.217 , pp. 365-375
    • Nicholson, J.K.1
  • 48
    • 0034740588 scopus 로고    scopus 로고
    • HPLC/1H NMR spectroscopic studies of the reactive α-1-O-acyl isomer formed during acyl migration of S-naproxen β-1-O-acyl glucuronide
    • Corcoran, O., Mortensen, R. W., Hansen, S. H., Troke, J. & Nicholson, J. K. HPLC/1H NMR spectroscopic studies of the reactive α-1-O-acyl isomer formed during acyl migration of S-naproxen β-1-O-acyl glucuronide. Chem. Res. Toxicol. 14, 1363-1370 (2001).
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1363-1370
    • Corcoran, O.1    Mortensen, R.W.2    Hansen, S.H.3    Troke, J.4    Nicholson, J.K.5
  • 50
    • 0029851431 scopus 로고    scopus 로고
    • NMR spectroscopic and theoretical chemistry studies on the internal acyl migration reactions of the 1-O-acyl-β-glucopyranuronate conjugates of 2-, 3- and 4-trifluoromethylbenzoic acids
    • Nicholls, A. W. et al. NMR spectroscopic and theoretical chemistry studies on the internal acyl migration reactions of the 1-O-acyl-β-glucopyranuronate conjugates of 2-, 3- and 4-trifluoromethylbenzoic acids. Chem. Res. ToxicoL 9, 1414-1424 (1996).
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 1414-1424
    • Nicholls, A.W.1
  • 51
    • 0026532030 scopus 로고
    • Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
    • Spahn-Langguth, H. & Benet, L. Z. Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab. Rev. 24, 5-48 (1992).
    • (1992) Drug Metab. Rev. , vol.24 , pp. 5-48
    • Spahn-Langguth, H.1    Benet, L.Z.2
  • 52
    • 0028970481 scopus 로고
    • 1H NMR spectroscopic studies on the reactions of haloalkylamines with bicarbonate ions: Formation of N-carbamates and 2-oxazolidone in cell culture media and blood plasma
    • 1H NMR spectroscopic studies on the reactions of haloalkylamines with bicarbonate ions: Formation of N-carbamates and 2-oxazolidone in cell culture media and blood plasma. Chem. Res. Toxicol. 8, 1046-1053 (1995).
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 1046-1053
    • Anthony, M.1    McDowell, P.2    Holmes, E.3    Gray, T.4    Nicholson, J.K.5
  • 53
    • 0029617612 scopus 로고
    • Quantitative structure metabolism relationships and the prediction of phase II conjugation reactions of substituted phenols in the rat
    • Holmes, E. et al. Quantitative structure metabolism relationships and the prediction of phase II conjugation reactions of substituted phenols in the rat. Xenobiotica 25, 1269-1282(1995).
    • (1995) Xenobiotica , vol.25 , pp. 1269-1282
    • Holmes, E.1
  • 54
    • 0026495267 scopus 로고
    • Quantitative structure metabolism relationships for substituted benzoic acids in the rat using NMR spectroscopy, computational chemistry and pattern recognition methods
    • Ghauri, F. Y. K. et al. Quantitative structure metabolism relationships for substituted benzoic acids in the rat using NMR spectroscopy, computational chemistry and pattern recognition methods. Biochem. Pharmacol. 44, 1935-1946(1992).
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1935-1946
    • Ghauri, F.Y.K.1
  • 55
    • 0029863309 scopus 로고    scopus 로고
    • Quantitative structure metabolism relationships for substituted benzoic acids in the rabbit: Prediction of urinary excretion of glycine and glucuronide conjugates
    • Cupid, B. C., Bedell, C. R., Lindon, J. C., Wilson, I. D. & Nicholson, J. K. Quantitative structure metabolism relationships for substituted benzoic acids in the rabbit: prediction of urinary excretion of glycine and glucuronide conjugates. Xenobiotica 26, 157-176(1996).
    • (1996) Xenobiotica , vol.26 , pp. 157-176
    • Cupid, B.C.1    Bedell, C.R.2    Lindon, J.C.3    Wilson, I.D.4    Nicholson, J.K.5
  • 56
    • 0036260363 scopus 로고    scopus 로고
    • Determination of structure-metabolism relationships of substituted anilines for prediction of N-acetylation and N-oxanillic acid formation
    • Scarfe, G. B., Wilson, I. D., Lindon, J. C., Holmes, E. & Nicholson, J. K. Determination of structure-metabolism relationships of substituted anilines for prediction of N-acetylation and N-oxanillic acid formation. Xenobiotica 32, 267-277(2002).
    • (2002) Xenobiotica , vol.32 , pp. 267-277
    • Scarfe, G.B.1    Wilson, I.D.2    Lindon, J.C.3    Holmes, E.4    Nicholson, J.K.5
  • 57
    • 0035298747 scopus 로고    scopus 로고
    • High-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS) for the simultaneous analysis and identification of the metabolites of 2-bromo-4-trifluoromethylacetaniline in rat urine
    • Nicholson, J. K. et al. High-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS) for the simultaneous analysis and identification of the metabolites of 2-bromo-4-trifluoromethylacetaniline in rat urine. Anal. Chem. 73, 1491-1494 (2001).
    • (2001) Anal. Chem. , vol.73 , pp. 1491-1494
    • Nicholson, J.K.1
  • 58
    • 0037214092 scopus 로고    scopus 로고
    • Characterisation of putative pentose-containing conjugates as minor metabolites of 4-bromoaniline presenting the urine of rats following intraperitoneal administration
    • Major, H., Castro-Perez, J., Nicholson, J. K. & Wilson, I. D. Characterisation of putative pentose-containing conjugates as minor metabolites of 4-bromoaniline presenting the urine of rats following intraperitoneal administration. Rap. Comm. in Mass Spectrom. 17, 76-80 (2003).
    • (2003) Rap. Comm. in Mass Spectrom. , vol.17 , pp. 76-80
    • Major, H.1    Castro-Perez, J.2    Nicholson, J.K.3    Wilson, I.D.4
  • 60
    • 0028300848 scopus 로고
    • Improvement in the characterization of minor drug metabolites from HPLC-NMR studies through the use of quantified maximum entropy processing of NMR spectra
    • Seddon, M. J., Spraul, M., Wilson, I. D., Nicholson, J. K. & Lindon, J. C. Improvement in the characterization of minor drug metabolites from HPLC-NMR studies through the use of quantified maximum entropy processing of NMR spectra. J. Pharm Biomed. Anal. 12, 419-424 (1994).
    • (1994) J. Pharm. Biomed. Anal. , vol.12 , pp. 419-424
    • Seddon, M.J.1    Spraul, M.2    Wilson, I.D.3    Nicholson, J.K.4    Lindon, J.C.5


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