A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

Nature Medicine

Volumn 22, Issue 4, 2016, Pages 421-426

  Jang, Cholsoon ^a,b   Oh, Sungwhan F ^b   Wada, Shogo ^a   Rowe, Glenn C ^b,f   Liu, Laura ^b   Chan, Mun Chun ^b   Rhee, James ^b,c   Hoshino, Atsushi ^a   Kim, Boa ^a   Ibrahim, Ayon ^a   Baca, Luisa G ^b   Kim, Esl ^b   Ghosh, Chandra C ^b   Parikh, Samir M ^b   Jiang, Aihua ^b   Chu, Qingwei ^a   Forman, Daniel E ^d   Lecker, Stewart H ^b   Krishnaiah, Saikumari ^a   Rabinowitz, Joshua D ^e   Weljie, Aalim M ^a   Baur, Joseph A ^a   Kasper, Dennis L ^b   Arany, Zoltan ^a   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e PRINCETON UNIVERSITY   (United States)

^f University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 2 METHYLPROPIONIC ACID; BRANCHED CHAIN AMINO ACID; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; VALINE; FATTY ACID; HYDROXYBUTYRIC ACID; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL WALL; CELL ACTIVATION; COMPARATIVE STUDY; DIABETES MELLITUS; FATTY ACID TRANSPORT; GENE SILENCING; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IN VIVO STUDY; INSULIN RESISTANCE; LIPID STORAGE; MOUSE; MUSCLE CELL; MUSCLE EXCITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKELETAL MUSCLE; ANIMAL; BIOSYNTHESIS; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; OBESITY; PATHOLOGY;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; FATTY ACIDS; HUMANS; HYDROXYBUTYRATES; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED NOD; MUSCLE, SKELETAL; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; TRANSCRIPTION FACTORS;

EID: 84960172990     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4057     Document Type: Article

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