메뉴 건너뛰기




Volumn 58, Issue 8, 2015, Pages 1699-1703

Hepatokines: unlocking the multi-organ network in metabolic diseases

Author keywords

Beta cell; Glucose homeostasis; Hepatokines; Liver; Metabolic diseases; NAFLD; Type 2 diabetes

Indexed keywords

ANGIOPOIETIN LIKE PROTEIN 8; BETATROPHIN; FETUIN A; FIBROBLAST GROWTH FACTOR 21; HEPATOKINE; LIVER PROTEIN; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR; LIPASIN PROTEIN, HUMAN; PEPTIDE HORMONE;

EID: 84937522427     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3634-4     Document Type: Editorial
Times cited : (78)

References (23)
  • 1
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • COI: 1:CAS:528:DC%2BC3sXjtVaktb4%3D, PID: 23337953
    • Stefan N, Haring HU (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9:144–152
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Haring, H.U.2
  • 2
    • 84897109882 scopus 로고    scopus 로고
    • Inventing new medicines: the FGF21 story
    • COI: 1:CAS:528:DC%2BC2cXhtlKjsrY%3D, PID: 24749049
    • Kharitonenkov A, Adams AC (2014) Inventing new medicines: the FGF21 story. Mol Metab 3:221–229
    • (2014) Mol Metab , vol.3 , pp. 221-229
    • Kharitonenkov, A.1    Adams, A.C.2
  • 3
    • 84901821975 scopus 로고    scopus 로고
    • FGF21-based pharmacotherapy—potential utility for metabolic disorders
    • COI: 1:CAS:528:DC%2BC2cXls1Orsr0%3D, PID: 24709036
    • Gimeno RE, Moller DE (2014) FGF21-based pharmacotherapy—potential utility for metabolic disorders. Trends Endocrinol Metab 25:303–311
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 303-311
    • Gimeno, R.E.1    Moller, D.E.2
  • 4
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • COI: 1:STN:280:DyaE2c%2FmslGrtA%3D%3D, PID: 4767369
    • Coleman DL (1973) Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9:294–298
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 5
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • COI: 1:CAS:528:DC%2BD3cXls1Kls7g%3D, PID: 10949030
    • Michael MD, Kulkarni RN, Postic C et al (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87–97
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 6
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • COI: 1:CAS:528:DC%2BC38XhtFWms73L, PID: 22842477
    • Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279–1285
    • (2012) Nat Med , vol.18 , pp. 1279-1285
    • Pal, D.1    Dasgupta, S.2    Kundu, R.3
  • 7
    • 84895814181 scopus 로고    scopus 로고
    • Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression
    • PID: 24551137
    • Ochi A, Mori K, Emoto M et al (2014) Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression. PLoS One 9, e88704
    • (2014) PLoS One , vol.9
    • Ochi, A.1    Mori, K.2    Emoto, M.3
  • 8
    • 50749118593 scopus 로고
    • The internal secretion of the pancreas
    • COI: 1:CAS:528:DyaB38XhtFegtw%3D%3D
    • Banting FG, Best CH (1922) The internal secretion of the pancreas. J Lab Clin Med 7:251–266
    • (1922) J Lab Clin Med , vol.7 , pp. 251-266
    • Banting, F.G.1    Best, C.H.2
  • 9
    • 84874241199 scopus 로고    scopus 로고
    • Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states
    • PID: 23375376
    • El Ouaamari A, Kawamori D, Dirice E et al (2013) Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 3:401–410
    • (2013) Cell Rep , vol.3 , pp. 401-410
    • El Ouaamari, A.1    Kawamori, D.2    Dirice, E.3
  • 10
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: a hormone that controls pancreatic beta cell proliferation
    • COI: 1:CAS:528:DC%2BC3sXmslelu7o%3D, PID: 23623304
    • Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153:747–758
    • (2013) Cell , vol.153 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 11
    • 84908331466 scopus 로고    scopus 로고
    • ANGPTL8/betatrophin does not control pancreatic beta cell expansion
    • COI: 1:CAS:528:DC%2BC2cXhvVanur7N, PID: 25417115
    • Gusarova V, Alexa CA, Na E et al (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159:691–696
    • (2014) Cell , vol.159 , pp. 691-696
    • Gusarova, V.1    Alexa, C.A.2    Na, E.3
  • 12
    • 84931566375 scopus 로고    scopus 로고
    • Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice
    • PID: 25917759
    • Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA (2015) Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia. doi:10.1007/s00125-015-3590-z
    • (2015) Diabetologia
    • Cox, A.R.1    Lam, C.J.2    Bonnyman, C.W.3    Chavez, J.4    Rios, J.S.5    Kushner, J.A.6
  • 13
    • 84890906093 scopus 로고    scopus 로고
    • Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhsFKqtLzL, PID: 24078058
    • Espes D, Lau J, Carlsson PO (2014) Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia 57:50–53
    • (2014) Diabetologia , vol.57 , pp. 50-53
    • Espes, D.1    Lau, J.2    Carlsson, P.O.3
  • 14
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
    • COI: 1:CAS:528:DC%2BD2sXmslOqsrY%3D, PID: 17550778
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E (2007) Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5:426–437
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 15
    • 69249238074 scopus 로고    scopus 로고
    • Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
    • COI: 1:CAS:528:DC%2BD1MXhtVOisbzI, PID: 19660458
    • Iizuka K, Takeda J, Horikawa Y (2009) Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett 583:2882–2886
    • (2009) FEBS Lett , vol.583 , pp. 2882-2886
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 17
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3cXpsVGnu74%3D, PID: 20451522
    • Dushay J, Chui PC, Gopalakrishnan GS et al (2010) Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139:456–463
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 18
    • 84904292910 scopus 로고    scopus 로고
    • A link between hepatic glucose production and peripheral energy metabolism via hepatokines
    • COI: 1:CAS:528:DC%2BC2cXpvFWmt7k%3D, PID: 25061558
    • Abdul-Wahed A, Gautier-Stein A, Casteras S et al (2014) A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Mol Metab 3:531–543
    • (2014) Mol Metab , vol.3 , pp. 531-543
    • Abdul-Wahed, A.1    Gautier-Stein, A.2    Casteras, S.3
  • 19
    • 84856527774 scopus 로고    scopus 로고
    • Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice
    • COI: 1:CAS:528:DC%2BC38XitVelsrs%3D, PID: 22251704
    • Anson M, Crain-Denoyelle AM, Baud V et al (2012) Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J Clin Invest 122:586–599
    • (2012) J Clin Invest , vol.122 , pp. 586-599
    • Anson, M.1    Crain-Denoyelle, A.M.2    Baud, V.3
  • 20
    • 84892732372 scopus 로고    scopus 로고
    • Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver
    • PID: 24390366
    • Okumura A, Unoki-Kubota H, Matsushita Y et al (2013) Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver. Biosci Trends 7:276–283
    • (2013) Biosci Trends , vol.7 , pp. 276-283
    • Okumura, A.1    Unoki-Kubota, H.2    Matsushita, Y.3
  • 21
    • 79956113302 scopus 로고    scopus 로고
    • Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans
    • COI: 1:CAS:528:DC%2BC3MXotlOlurw%3D, PID: 21325103
    • Yu H, Xia F, Lam KS et al (2011) Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem 57:691–700
    • (2011) Clin Chem , vol.57 , pp. 691-700
    • Yu, H.1    Xia, F.2    Lam, K.S.3
  • 22
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhsVShtbrN, PID: 24011069
    • Gaich G, Chien JY, Fu H et al (2013) The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab 18:333–340
    • (2013) Cell Metab , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3
  • 23
    • 84921325509 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function
    • COI: 1:CAS:528:DC%2BC2MXhsV2ltb4%3D, PID: 25359298
    • Kim JH, Bae KH, Choi YK et al (2015) Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function. Diabetes Obes Metab 17:161–169
    • (2015) Diabetes Obes Metab , vol.17 , pp. 161-169
    • Kim, J.H.1    Bae, K.H.2    Choi, Y.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.