Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Abu Farha, Mohamed ^a   Sriraman, Devarajan ^a   Cherian, Preethi ^a   AlKhairi, Irina ^a   Elkum, Naser ^b   Behbehani, Kazem ^a   Abubaker, Jehad ^a  

^a DASMAN DIABETES INSTITUTE   (Kuwait)

^b SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

ANGPTL8 PROTEIN; BETATROPHIN; GLUCOSE; LIVER PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; ISOPROTEIN; LIPASIN PROTEIN, HUMAN; PEPTIDE HORMONE;

ADULT; ARTICLE; BODY FAT; BODY MASS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; EXERCISE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HEART RATE; HIP CIRCUMFERENCE; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OUTCOME ASSESSMENT; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; TOTAL BODY WATER; TREATMENT DURATION; WAIST CIRCUMFERENCE; BLOOD; EXERCISE TEST; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; PROCEDURES; UPREGULATION;

ADULT; BLOOD GLUCOSE; EXERCISE TEST; GENE EXPRESSION REGULATION; HUMANS; MIDDLE AGED; OBESITY; PEPTIDE HORMONES; PROTEIN ISOFORMS; UP-REGULATION;

EID: 84957096660     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147367     Document Type: Article

References (34)

1. Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: the last ten years. Cell 148: 1160-1171. doi: 10.1016/j.cell.2012.02.010 PMID: 22424227
2. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846. PMID: 17167471
3. Rhodes CJ (2005) Type 2 diabetes-A matter of beta-cell life and death? Science 307: 380-384. PMID: 15662003
4. Bonner-Weir S, Weir GC (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23: 857-861. PMID: 16003374
5. Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153: 747-758. doi: 10.1016/j.cell.2013.04.008 PMID: 23623304
6. Lickert H (2013) Betatrophin fuels beta cell proliferation: first step toward regenerative therapy? Cell Metab 18: 5-6. doi: 10.1016/j.cmet.2013.06.006 PMID: 23823472
7. Kugelberg E (2013) Diabetes: Betatrophin-inducing beta-cell expansion to treat diabetes mellitus? Nat Rev Endocrinol 9: 379.
8. Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, et al. (2012) Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A 109: 19751-19756. doi: 10.1073/pnas.1217552109 PMID: 23150577
9. Ren G, Kim JY, Smas CM (2012) Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303: E334-351. doi: 10.1152/ajpendo. 00084.2012 PMID: 22569073
10. Zhang R (2012) Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 424: 786-792. doi: 10.1016/j.bbrc.2012.07.038 PMID: 22809513
11. Fu Z, Yao F, Abou-Samra AB, Zhang R (2013) Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun 430: 1126-1131. doi: 10.1016/j.bbrc.2012.12.025 PMID: 23261442
12. Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, et al. (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159: 691-696. doi: 10.1016/j.cell.2014.09.027 PMID: 25417115
13. Yi P, Park JS, Melton DA (2014) Perspectives on the activities of ANGPTL8/betatrophin. Cell 159: 467-468. doi: 10.1016/j.cell.2014.09.028 PMID: 25417096
14. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA (2015) Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia.
15. Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Hu FB, et al. (2015) Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance. Sci Rep 5: 10949. doi: 10.1038/srep10949 PMID: 26077345
16. Chen J, Chen S, Huang P, Meng XL, Clayton S, Shen JS, et al. (2015) In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats. Diabetologia 58: 1036-1044. doi: 10.1007/s00125-015-3521-z PMID: 25720603
17. Yamada H, Saito T, Aoki A, Asano T, Yoshida M, Ikoma A, et al. (2015) Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes. Endocr J.
18. Guo K, Lu J, Yu H, Zhao F, Pan P, Zhang L, et al. (2015) Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals. Obesity (Silver Spring) 23: 793-797.
19. Ebert T, Kralisch S, Wurst U, Lossner U, Kratzsch J, Bluher M, et al. (2015) Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls. Eur J Endocrinol.
20. Chen X, Lu P, He W, Zhang J, Liu L, Yang Y, et al. (2015) Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. J Clin Endocrinol Metab 100: E96-100. doi: 10.1210/jc.2014-2300 PMID: 25303484
21. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R (2014) Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep 4: 5013. doi: 10.1038/srep05013 PMID: 24852694
22. Espes D, Martinell M, Carlsson PO (2014) Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol 2014: 323407. doi: 10.1155/2014/323407 PMID: 24963292
23. Espes D, Lau J, Carlsson PO (2013) Increased circulating levels of betatrophin in individuals with longstanding type 1 diabetes. Diabetologia.
24. Gomez-Ambrosi J, Pascual E, Catalan V, Rodriguez A, Ramirez B, Silva C, et al. (2014) Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes. J Clin Endocrinol Metab: jc20141568.
25. Fu Z, Abou-Samra AB, Zhang R (2014) An explanation for recent discrepancies in levels of human circulating betatrophin. Diabetologia.
26. Abu-Farha M, Tiss A, Abubaker J, Khadir A, Al-Ghimlas F, Al-Khairi I, et al. (2013) Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. PLoS One 8: e75342. doi: 10.1371/journal.pone.0075342 PMID: 24086512
27. Abubaker J, Tiss A, Abu-Farha M, Al-Ghimlas F, Al-Khairi I, Baturcam E, et al. (2013) DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise. PLoS One 8: e69217. doi: 10.1371/journal.pone.0069217 PMID: 23894433
28. Fenzl A, Itariu BK, Kosi L, Fritzer-Szekeres M, Kautzky-Willer A, Stulnig TM, et al. (2014) Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulinresistant individuals. Diabetologia.
29. Zhang R, Abou-Samra AB (2013) Emerging roles of Lipasin as a critical lipid regulator. Biochem Biophys Res Commun 432: 401-405. doi: 10.1016/j.bbrc.2013.01.129 PMID: 23415864
30. Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela DM, Cohen JC, et al. (2013) Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A 110: 16109-16114. doi: 10.1073/pnas.1315292110 PMID: 24043787
31. Zhang R, Abou-Samra AB (2014) A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. Cardiovasc Diabetol 13: 133. doi: 10.1186/s12933-014-0133-8 PMID: 25212743
32. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350. PMID: 11333990
33. Fodor JG, Adamo KB (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle. N Engl J Med 345: 696; author reply 696-697.
34. Zheng C, Liu Z (2015) Vascular function, insulin action, and exercise: an intricate interplay. Trends Endocrinol Metab.