메뉴 건너뛰기




Volumn 15, Issue 5, 2016, Pages 774-782

The role of PGC1α in cancer metabolism and its therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

EID: 84969584358     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-15-0621     Document Type: Review
Times cited : (146)

References (119)
  • 1
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • Boroughs LK, DeBerardinis RJ.Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol 2015;17:351-9.
    • (2015) Nat Cell Biol , vol.17 , pp. 351-359
    • Boroughs, L.K.1    DeBerardinis, R.J.2
  • 2
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 2012;21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 3
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: Cell biology, physiology, and clinical opportunities
    • Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest 2013;123: 3678-84.
    • (2013) J Clin Invest , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 5
    • 84881177291 scopus 로고    scopus 로고
    • Serine, glycine and one-carbon units: Cancer metabolism in full circle
    • Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer 2013;13:572-83.
    • (2013) Nat Rev Cancer , vol.13 , pp. 572-583
    • Locasale, J.W.1
  • 6
    • 84927133194 scopus 로고    scopus 로고
    • Targetingmitochondria metabolismfor cancer therapy
    • Weinberg SE, Chandel NS. Targetingmitochondria metabolismfor cancer therapy. Nat Chem Biol 2015;11:9-15.
    • (2015) Nat Chem Biol , vol.11 , pp. 9-15
    • Weinberg, S.E.1    Chandel, N.S.2
  • 8
    • 84901487313 scopus 로고    scopus 로고
    • Targetingmetabolic changes in cancer: Novel therapeutic approaches
    • Bobrovnikova-Marjon E, Hurov JB. Targetingmetabolic changes in cancer: novel therapeutic approaches. Annu Rev Med 2014;65:157-70.
    • (2014) Annu Rev Med , vol.65 , pp. 157-170
    • Bobrovnikova-Marjon, E.1    Hurov, J.B.2
  • 9
    • 84925834424 scopus 로고    scopus 로고
    • Rewired metabolism in drug-resistant leukemia cells: A metabolic switch hallmarked by reduced dependence on exogenous glutamine
    • Staubert C, Bhuiyan H, Lindahl A, Broom OJ, Zhu Y, IslamS, et al. Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine. J Biol Chem 2015;290:8348-59.
    • (2015) J Biol Chem , vol.290 , pp. 8348-8359
    • Staubert, C.1    Bhuiyan, H.2    Lindahl, A.3    Broom, O.J.4    Zhu, Y.5    Islam, S.6
  • 10
    • 84856544687 scopus 로고    scopus 로고
    • PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling
    • Jones AW, Yao Z, Vicencio JM, Karkucinska-Wieckowska A, Szabadkai G. PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling. Mitochondrion 2012;12:86-99.
    • (2012) Mitochondrion , vol.12 , pp. 86-99
    • Jones, A.W.1    Yao, Z.2    Vicencio, J.M.3    Karkucinska-Wieckowska, A.4    Szabadkai, G.5
  • 11
    • 84861980898 scopus 로고    scopus 로고
    • The diverse role of the PPARgamma coactivator 1 family of transcriptional coactivators in cancer
    • Girnun GD. The diverse role of the PPARgamma coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol 2012;23: 381-8.
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 381-388
    • Girnun, G.D.1
  • 12
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006;116:615-22.
    • (2006) J Clin Invest , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 13
    • 47949104798 scopus 로고    scopus 로고
    • The role of exercise and PGC1alpha in inflammation and chronic disease
    • Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 2008;454:463-9.
    • (2008) Nature , vol.454 , pp. 463-469
    • Handschin, C.1    Spiegelman, B.M.2
  • 14
    • 79953186142 scopus 로고    scopus 로고
    • PGC-1 coactivators in the control of energy metabolism
    • Liu C, Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin 2011;43:248-57.
    • (2011) Acta Biochim Biophys Sin , vol.43 , pp. 248-257
    • Liu, C.1    Lin, J.D.2
  • 15
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005;1:361-70.
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 16
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional coactivator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    • Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, et al. Transcriptional coactivator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002;418:797-801.
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3    Zhang, C.Y.4    Wu, Z.5    Boss, O.6
  • 17
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    • Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A 2003;100: 7111-6.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 18
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolismin humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolismin humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003;100:8466-71.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6
  • 19
    • 2342477730 scopus 로고    scopus 로고
    • Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    • Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 2004;101:6570-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6570-6575
    • Mootha, V.K.1    Handschin, C.2    Arlow, D.3    Xie, X.4    St Pierre, J.5    Sihag, S.6
  • 20
    • 18144411313 scopus 로고    scopus 로고
    • SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1(alpha)
    • Nemoto S, Fergusson MM, Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1(alpha). J Biol Chem 2005;280:16456-60.
    • (2005) J Biol Chem , vol.280 , pp. 16456-16460
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 21
    • 69249116960 scopus 로고    scopus 로고
    • SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interactionwith MyoD
    • Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interactionwith MyoD. J Biol Chem 2009;284:21872-80.
    • (2009) J Biol Chem , vol.284 , pp. 21872-21880
    • Amat, R.1    Planavila, A.2    Chen, S.L.3    Iglesias, R.4    Giralt, M.5    Villarroya, F.6
  • 22
    • 80052454265 scopus 로고    scopus 로고
    • ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1
    • Haemmerle G, Moustafa T, Woelkart G, Buttner S, Schmidt A, van de Weijer T, et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1. Nat Med 2011;17:1076-85.
    • (2011) Nat Med , vol.17 , pp. 1076-1085
    • Haemmerle, G.1    Moustafa, T.2    Woelkart, G.3    Buttner, S.4    Schmidt, A.5    Van De Weijer, T.6
  • 24
    • 0037064057 scopus 로고    scopus 로고
    • The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase i gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)
    • Louet JF, Hayhurst G, Gonzalez FJ, Girard J, Decaux JF. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem 2002;277: 37991-8000.
    • (2002) J Biol Chem , vol.277 , pp. 37991-38000
    • Louet, J.F.1    Hayhurst, G.2    Gonzalez, F.J.3    Girard, J.4    Decaux, J.F.5
  • 25
    • 11144221621 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase i (CPT-I alpha)
    • Zhang Y, Ma K, Song S, Elam MB, Cook GA, Park EA. Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha). J Biol Chem 2004;279:53963-71.
    • (2004) J Biol Chem , vol.279 , pp. 53963-53971
    • Zhang, Y.1    Ma, K.2    Song, S.3    Elam, M.B.4    Cook, G.A.5    Park, E.A.6
  • 26
    • 84870918556 scopus 로고    scopus 로고
    • PPARGC1A/PGC-1alpha, TFEB and enhanced proteostasis in Huntington disease: Defining regulatory linkages between energy production and protein-organelle quality control
    • La Spada AR. PPARGC1A/PGC-1alpha, TFEB and enhanced proteostasis in Huntington disease: defining regulatory linkages between energy production and protein-organelle quality control. Autophagy 2012;8: 1845-7.
    • (2012) Autophagy , vol.8 , pp. 1845-1847
    • La Spada, A.R.1
  • 27
    • 84863923855 scopus 로고    scopus 로고
    • PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function
    • Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, et al. PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci TranslMed 2012;4:142ra97.
    • (2012) Sci TranslMed , vol.4 , pp. 142ra97
    • Tsunemi, T.1    Ashe, T.D.2    Morrison, B.E.3    Soriano, K.R.4    Au, J.5    Roque, R.A.6
  • 28
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999;98:115-24.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5    Mootha, V.6
  • 29
    • 0032549811 scopus 로고    scopus 로고
    • A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P,WuZ, Park CW, Graves R, Wright M, Spiegelman BM. A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998;92:829-39.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 30
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-8.
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1    Wu, J.2    Jedrychowski, M.P.3    Korde, A.4    Ye, L.5    Lo, J.C.6
  • 31
    • 67649819237 scopus 로고    scopus 로고
    • Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes
    • Olmos Y, Valle I, Borniquel S, Tierrez A, Soria E, Lamas S, et al. Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem 2009;284:14476-84.
    • (2009) J Biol Chem , vol.284 , pp. 14476-14484
    • Olmos, Y.1    Valle, I.2    Borniquel, S.3    Tierrez, A.4    Soria, E.5    Lamas, S.6
  • 32
    • 84902546044 scopus 로고    scopus 로고
    • Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1alpha genes in neural stem cells treated with hydrogen peroxide
    • Abdanipour A, Tiraihi T, Noori-Zadeh A, Majdi A, Gosaili R. Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1alpha genes in neural stem cells treated with hydrogen peroxide. Mol Neurobiol 2014;49:1364-72.
    • (2014) Mol Neurobiol , vol.49 , pp. 1364-1372
    • Abdanipour, A.1    Tiraihi, T.2    Noori-Zadeh, A.3    Majdi, A.4    Gosaili, R.5
  • 33
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006;127:397-408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3    Silvaggi, J.M.4    Rhee, J.5    Jager, S.6
  • 34
    • 84872225149 scopus 로고    scopus 로고
    • PGC1alpha and mitochondrial metabolism-emerging concepts and relevance in ageing and neurodegenerative disorders
    • Austin S, St-Pierre J. PGC1alpha and mitochondrial metabolism-emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci 2012;125:4963-71.
    • (2012) J Cell Sci , vol.125 , pp. 4963-4971
    • Austin, S.1    St-Pierre, J.2
  • 35
    • 14844328611 scopus 로고    scopus 로고
    • Tissue-specific regulation ofmetabolic pathways through the transcriptional coactivator PGC1-alpha
    • Puigserver P.Tissue-specific regulation ofmetabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes 2005;29:S5-9.
    • (2005) Int J Obes , vol.29 , pp. S5-S9
    • Puigserver, P.1
  • 36
    • 84919489013 scopus 로고    scopus 로고
    • Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer?
    • Wolf DA.Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer? Cancer Cell 2014;26:788-95.
    • (2014) Cancer Cell , vol.26 , pp. 788-795
    • Wolf, D.A.1
  • 37
    • 0032589689 scopus 로고    scopus 로고
    • Activation of PPARgamma coactivator-1 through transcription factor docking
    • Puigserver P, Adelmant G,Wu Z, Fan M, Xu J,O'Malley B, et al. Activation of PPARgamma coactivator-1 through transcription factor docking. Science 1999;286:1368-71.
    • (1999) Science , vol.286 , pp. 1368-1371
    • Puigserver, P.1    Adelmant, G.2    Wu, Z.3    Fan, M.4    Xu, J.5    O'Malley, B.6
  • 38
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003;423:550-5.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 39
    • 0034116143 scopus 로고    scopus 로고
    • A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
    • Knutti D, Kaul A, Kralli A. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol 2000;20:2411-22.
    • (2000) Mol Cell Biol , vol.20 , pp. 2411-2422
    • Knutti, D.1    Kaul, A.2    Kralli, A.3
  • 40
    • 0344413490 scopus 로고    scopus 로고
    • Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha
    • Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell 2003;12:1137-49.
    • (2003) Mol Cell , vol.12 , pp. 1137-1149
    • Wallberg, A.E.1    Yamamura, S.2    Malik, S.3    Spiegelman, B.M.4    Roeder, R.G.5
  • 41
    • 0033638283 scopus 로고    scopus 로고
    • Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
    • Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell 2000;6:307-16.
    • (2000) Mol Cell , vol.6 , pp. 307-316
    • Monsalve, M.1    Wu, Z.2    Adelmant, G.3    Puigserver, P.4    Fan, M.5    Spiegelman, B.M.6
  • 42
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007;104:12017-22.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 43
  • 44
    • 0035859836 scopus 로고    scopus 로고
    • Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
    • Knutti D, Kressler D, Kralli A. Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc Natl Acad Sci U S A 2001;98:9713-8.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9713-9718
    • Knutti, D.1    Kressler, D.2    Kralli, A.3
  • 45
    • 34250740323 scopus 로고    scopus 로고
    • Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
    • Li X, Monks B, Ge Q, BirnbaumMJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007;447:1012-6.
    • (2007) Nature , vol.447 , pp. 1012-1016
    • Li, X.1    Monks, B.2    Ge, Q.3    Birnbaum, M.J.4
  • 46
    • 70350031566 scopus 로고    scopus 로고
    • SUMOylation attenuates the function of PGC-1alpha
    • Rytinki MM, Palvimo JJ. SUMOylation attenuates the function of PGC-1alpha. J Biol Chem 2009;284:26184-93.
    • (2009) J Biol Chem , vol.284 , pp. 26184-26193
    • Rytinki, M.M.1    Palvimo, J.J.2
  • 47
    • 0035855905 scopus 로고    scopus 로고
    • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    • Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001;413:179-83.
    • (2001) Nature , vol.413 , pp. 179-183
    • Herzig, S.1    Long, F.2    Jhala, U.S.3    Hedrick, S.4    Quinn, R.5    Bauer, A.6
  • 48
    • 33644946603 scopus 로고    scopus 로고
    • Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha
    • Bianchi K, Vandecasteele G, Carli C, Romagnoli A, Szabadkai G, Rizzuto R. Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha. Cell Death Differ 2006;13: 586-96.
    • (2006) Cell Death Differ , vol.13 , pp. 586-596
    • Bianchi, K.1    Vandecasteele, G.2    Carli, C.3    Romagnoli, A.4    Szabadkai, G.5    Rizzuto, R.6
  • 49
    • 80155126156 scopus 로고    scopus 로고
    • PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis
    • Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, et al. PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res 2011;71:6888-98.
    • (2011) Cancer Res , vol.71 , pp. 6888-6898
    • Bhalla, K.1    Hwang, B.J.2    Dewi, R.E.3    Ou, L.4    Twaddel, W.5    Fang, H.B.6
  • 50
    • 84913573550 scopus 로고    scopus 로고
    • Proteomic signatures associated with p53 mutational status in lung adenocarcinoma
    • Taguchi A,Delgado O, Celiktas M, KatayamaH,WangH, Gazdar AF, et al. Proteomic signatures associated with p53 mutational status in lung adenocarcinoma. Proteomics 2014;14:2750-9.
    • (2014) Proteomics , vol.14 , pp. 2750-2759
    • Taguchi, A.1    Delgado, O.2    Celiktas, M.3    Katayama, H.4    Wang, H.5    Gazdar, A.F.6
  • 52
    • 73549114238 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR
    • Shiota M, Yokomizo A, Tada Y, Inokuchi J, Tatsugami K, Kuroiwa K, et al. Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR. Mol Endocrinol 2010;24:114-27.
    • (2010) Mol Endocrinol , vol.24 , pp. 114-127
    • Shiota, M.1    Yokomizo, A.2    Tada, Y.3    Inokuchi, J.4    Tatsugami, K.5    Kuroiwa, K.6
  • 53
    • 84876448550 scopus 로고    scopus 로고
    • PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
    • Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, et al. PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell 2013;23:287-301.
    • (2013) Cancer Cell , vol.23 , pp. 287-301
    • Vazquez, F.1    Lim, J.H.2    Chim, H.3    Bhalla, K.4    Girnun, G.5    Pierce, K.6
  • 55
    • 84937525756 scopus 로고    scopus 로고
    • Suppression of PGC-1a is critical for reprogramming oxidative metabolism in renal cell carcinoma
    • LaGory EL, Wu C, Taniguchi CM, Ding CK, Chi JT, von Eyben R, et al. Suppression of PGC-1a is critical for reprogramming oxidative metabolism in renal cell carcinoma. Cell Rep 2015;12:116-27.
    • (2015) Cell Rep , vol.12 , pp. 116-127
    • LaGory, E.L.1    Wu, C.2    Taniguchi, C.M.3    Ding, C.K.4    Chi, J.T.5    Von Eyben, R.6
  • 56
    • 84943451038 scopus 로고    scopus 로고
    • MYC/PGC-1a balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells
    • Sancho P, Burgos-Ramos E, Tavera A, Bou Kheir T, Jagust P, Schoenhals M, et al. MYC/PGC-1a balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells. Cell Metab 2015;22: 590-605.
    • (2015) Cell Metab , vol.22 , pp. 590-605
    • Sancho, P.1    Burgos-Ramos, E.2    Tavera, A.3    Bou Kheir, T.4    Jagust, P.5    Schoenhals, M.6
  • 59
    • 49649103221 scopus 로고    scopus 로고
    • The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
    • Riker AI, Enkemann SA, Fodstad O, Liu S, Ren S, Morris C, et al. The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics 2008;1:13.
    • (2008) BMC Med Genomics , vol.1 , pp. 13
    • Riker, A.I.1    Enkemann, S.A.2    Fodstad, O.3    Liu, S.4    Ren, S.5    Morris, C.6
  • 60
    • 73949140415 scopus 로고    scopus 로고
    • Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
    • Bogunovic D, O'NeillDW,Belitskaya-Levy I, Vacic V, Yu YL, Adams S, et al. Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc Natl Acad Sci U S A 2009;106:20429-34.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20429-20434
    • Bogunovic, D.1    O'Neill, D.W.2    Belitskaya-Levy, I.3    Vacic, V.4    Yu, Y.L.5    Adams, S.6
  • 61
    • 84876787120 scopus 로고    scopus 로고
    • The masters talk: The PGC-1alpha-MITF axis as a melanoma energizer
    • Ronai Z.The masters talk: the PGC-1alpha-MITF axis as a melanoma energizer. Pigment Cell Melanoma Res 2013;26:294-295.
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 294-295
    • Ronai, Z.1
  • 63
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004;116:855-67.
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3    Lee, S.4    Niculescu-Duvaz, D.5    Good, V.M.6
  • 64
    • 78651418282 scopus 로고    scopus 로고
    • Mutant BRAF melanomas-dependence and resistance
    • Poulikakos PI, Rosen N. Mutant BRAF melanomas-dependence and resistance. Cancer Cell 2011;19:11-5.
    • (2011) Cancer Cell , vol.19 , pp. 11-15
    • Poulikakos, P.I.1    Rosen, N.2
  • 68
    • 84918582539 scopus 로고    scopus 로고
    • Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation inmelanoma
    • Gopal YN, Rizos H, Chen G, Deng W, Frederick DT, Cooper ZA, et al. Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation inmelanoma. Cancer Res 2014;74:7037-47.
    • (2014) Cancer Res , vol.74 , pp. 7037-7047
    • Gopal, Y.N.1    Rizos, H.2    Chen, G.3    Deng, W.4    Frederick, D.T.5    Cooper, Z.A.6
  • 69
    • 84936073972 scopus 로고    scopus 로고
    • Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease
    • Huss JM, Garbacz WG, Xie W. Constitutive activities of estrogen-related receptors: transcriptional regulation of metabolism by the ERR pathways in health and disease. Biochim Biophys Acta 2015;1852:1912-27.
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 1912-1927
    • Huss, J.M.1    Garbacz, W.G.2    Xie, W.3
  • 70
    • 79958035502 scopus 로고    scopus 로고
    • Kinase suppressor of ras 1 (KSR1) regulates PGC1alpha and estrogen-related receptor alpha to promote oncogenic Ras-dependent anchorage-independent growth
    • Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE. Kinase suppressor of ras 1 (KSR1) regulates PGC1alpha and estrogen-related receptor alpha to promote oncogenic Ras-dependent anchorage-independent growth. Mol Cell Biol 2011;31:2453-61.
    • (2011) Mol Cell Biol , vol.31 , pp. 2453-2461
    • Fisher, K.W.1    Das, B.2    Kortum, R.L.3    Chaika, O.V.4    Lewis, R.E.5
  • 71
    • 84893465244 scopus 로고    scopus 로고
    • Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth
    • Sun RC, Denko NC. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 2014;19:285-92.
    • (2014) Cell Metab , vol.19 , pp. 285-292
    • Sun, R.C.1    Denko, N.C.2
  • 72
    • 84858165848 scopus 로고    scopus 로고
    • PGC-1alpha promotes the growth of ErbB2/Neu-inducedmammary tumors by regulating nutrient supply
    • Klimcakova E, Chenard V, McGuirk S, Germain D, Avizonis D, Muller WJ, et al. PGC-1alpha promotes the growth of ErbB2/Neu-inducedmammary tumors by regulating nutrient supply. Cancer Res 2012;72:1538-46.
    • (2012) Cancer Res , vol.72 , pp. 1538-1546
    • Klimcakova, E.1    Chenard, V.2    McGuirk, S.3    Germain, D.4    Avizonis, D.5    Muller, W.J.6
  • 73
    • 39749140405 scopus 로고    scopus 로고
    • HIFindependent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    • Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, et al. HIFindependent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008;451:1008-12.
    • (2008) Nature , vol.451 , pp. 1008-1012
    • Arany, Z.1    Foo, S.Y.2    Ma, Y.3    Ruas, J.L.4    Bommi-Reddy, A.5    Girnun, G.6
  • 75
    • 84920616812 scopus 로고    scopus 로고
    • PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promotemetastasis
    • 1-15
    • LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, et al. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promotemetastasis. Nat Cell Biol 2014;16:992-1003, 1-15.
    • (2014) Nat Cell Biol , vol.16 , pp. 992-1003
    • LeBleu, V.S.1    O'Connell, J.T.2    Gonzalez Herrera, K.N.3    Wikman, H.4    Pantel, K.5    Haigis, M.C.6
  • 76
    • 84880921757 scopus 로고    scopus 로고
    • The PGC-1/ERR signaling axis in cancer
    • Deblois G, St-Pierre J, Giguere V. The PGC-1/ERR signaling axis in cancer. Oncogene 2013;32:3483-90.
    • (2013) Oncogene , vol.32 , pp. 3483-3490
    • Deblois, G.1    St-Pierre, J.2    Giguere, V.3
  • 79
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • Viale A, Pettazzoni P, Lyssiotis CA, Ying H, SanchezN,MarchesiniM, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 2014;514:628-32.
    • (2014) Nature , vol.514 , pp. 628-632
    • Viale, A.1    Pettazzoni, P.2    Lyssiotis, C.A.3    Ying, H.4    Sanchez, N.5    Marchesini, M.6
  • 80
    • 74949089659 scopus 로고    scopus 로고
    • Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
    • Samudio I,Harmancey R, FieglM, Kantarjian H, Konopleva M, Korchin B, et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 2010;120:142-56.
    • (2010) J Clin Invest , vol.120 , pp. 142-156
    • Samudio, I.1    Harmancey, R.2    Fiegl, M.3    Kantarjian, H.4    Konopleva, M.5    Korchin, B.6
  • 81
    • 84867595989 scopus 로고    scopus 로고
    • Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
    • Caro P, Kishan AU, Norberg E, Stanley IA, Chapuy B, Ficarro SB, et al. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell 2012;22:547-60.
    • (2012) Cancer Cell , vol.22 , pp. 547-560
    • Caro, P.1    Kishan, A.U.2    Norberg, E.3    Stanley, I.A.4    Chapuy, B.5    Ficarro, S.B.6
  • 83
    • 79956326256 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    • Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 2011;25:1041-51.
    • (2011) Genes Dev , vol.25 , pp. 1041-1051
    • Zaugg, K.1    Yao, Y.2    Reilly, P.T.3    Kannan, K.4    Kiarash, R.5    Mason, J.6
  • 84
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 2000;20:1868-76.
    • (2000) Mol Cell Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 85
    • 84857641358 scopus 로고    scopus 로고
    • The role of peroxisome proliferatoractivated receptors in carcinogenesis and chemoprevention
    • Peters JM, Shah YM, Gonzalez FJ. The role of peroxisome proliferatoractivated receptors in carcinogenesis and chemoprevention. Nat Rev Cancer 2012;12:181-95.
    • (2012) Nat Rev Cancer , vol.12 , pp. 181-195
    • Peters, J.M.1    Shah, Y.M.2    Gonzalez, F.J.3
  • 87
    • 84868632060 scopus 로고    scopus 로고
    • A PML-PPARdelta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
    • Ito K, Carracedo A,Weiss D, Arai F, Ala U, Avigan DE, et al. A PML-PPARdelta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 2012;18:1350-8.
    • (2012) Nat Med , vol.18 , pp. 1350-1358
    • Ito, K.1    Carracedo, A.2    Weiss, D.3    Arai, F.4    Ala, U.5    Avigan, D.E.6
  • 88
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010;468:701-4.
    • (2010) Nature , vol.468 , pp. 701-704
    • Gan, B.1    Hu, J.2    Jiang, S.3    Liu, Y.4    Sahin, E.5    Zhuang, L.6
  • 89
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006;441:1068-74.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 90
    • 61349187121 scopus 로고    scopus 로고
    • A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
    • Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev 2009;19:51-9.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 51-59
    • Ito, K.1    Bernardi, R.2    Pandolfi, P.P.3
  • 91
    • 84934325574 scopus 로고    scopus 로고
    • Mitochondrial biogenesis is required for the anchorageindependent survival and propagation of stem-like cancer cells
    • De Luca A, Fiorillo M, Peiris-Pages M, Ozsvari B, Smith DL, Sanchez-Alvarez R, et al. Mitochondrial biogenesis is required for the anchorageindependent survival and propagation of stem-like cancer cells. Oncotarget 2015;6:14777-95.
    • (2015) Oncotarget , vol.6 , pp. 14777-14795
    • De Luca, A.1    Fiorillo, M.2    Peiris-Pages, M.3    Ozsvari, B.4    Smith, D.L.5    Sanchez-Alvarez, R.6
  • 92
    • 1842531175 scopus 로고    scopus 로고
    • Androgen receptor coregulators in prostate cancer: Mechanisms and clinical implications
    • Rahman M, Miyamoto H, Chang C. Androgen receptor coregulators in prostate cancer: mechanisms and clinical implications. Clin Cancer Res 2004;10:2208-19.
    • (2004) Clin Cancer Res , vol.10 , pp. 2208-2219
    • Rahman, M.1    Miyamoto, H.2    Chang, C.3
  • 93
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J 2011;30:2719-33.
    • (2011) EMBO J , vol.30 , pp. 2719-2733
    • Massie, C.E.1    Lynch, A.2    Ramos-Montoya, A.3    Boren, J.4    Stark, R.5    Fazli, L.6
  • 94
    • 85027952132 scopus 로고    scopus 로고
    • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alphamediated metabolic switch
    • Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, et al. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alphamediated metabolic switch. Oncogene 2014;33:5251-61.
    • (2014) Oncogene , vol.33 , pp. 5251-5261
    • Tennakoon, J.B.1    Shi, Y.2    Han, J.J.3    Tsouko, E.4    White, M.A.5    Burns, A.R.6
  • 95
    • 77957865282 scopus 로고    scopus 로고
    • Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)
    • Smeenk L, Lohrum M. Behind the scenes: unravelling the molecular mechanisms of p53 target gene selectivity (Review). Int J Oncol 2010; 37:1061-70.
    • (2010) Int J Oncol , vol.37 , pp. 1061-1070
    • Smeenk, L.1    Lohrum, M.2
  • 96
    • 81355153987 scopus 로고    scopus 로고
    • PGC-1a, a key modulator of p53, promotes cell survival upon metabolic stress
    • Sen N, Satija YK, Das S. PGC-1a, a key modulator of p53, promotes cell survival upon metabolic stress. Mol Cell 2011;44:621-34.
    • (2011) Mol Cell , vol.44 , pp. 621-634
    • Sen, N.1    Satija, Y.K.2    Das, S.3
  • 97
    • 81355133172 scopus 로고    scopus 로고
    • PGC1a confers specificity-metabolic stress and p53-dependent transcription
    • Cioce M, Blandino G.PGC1a confers specificity-metabolic stress and p53-dependent transcription. Mol Cell 2011;44:515-6.
    • (2011) Mol Cell , vol.44 , pp. 515-516
    • Cioce, M.1    Blandino, G.2
  • 98
    • 84902294427 scopus 로고    scopus 로고
    • RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1a-mediated mitochondrial oxidative phosphorylation and glycolysis
    • ChenW,WangQ, Bai L, ChenW,Wang X, Tellez CS, et al. RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1a-mediated mitochondrial oxidative phosphorylation and glycolysis. Cell Death Differ 2014;21:1061-70.
    • (2014) Cell Death Differ , vol.21 , pp. 1061-1070
    • Chen, W.1    Wang, Q.2    Bai, L.3    Chen, W.4    Wang, X.5    Tellez, C.S.6
  • 99
    • 84867877340 scopus 로고    scopus 로고
    • The NAD metabolome - A key determinant of cancer cell biology
    • Chiarugi A, Dolle C, Felici R, Ziegler M. The NAD metabolome - a key determinant of cancer cell biology. Nat Rev Cancer 2012;12: 741-52.
    • (2012) Nat Rev Cancer , vol.12 , pp. 741-752
    • Chiarugi, A.1    Dolle, C.2    Felici, R.3    Ziegler, M.4
  • 100
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    • Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 2007;26:1913-23.
    • (2007) EMBO J , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3    Lerin, C.4    Kim, S.H.5    Mostoslavsky, R.6
  • 101
    • 84892181024 scopus 로고    scopus 로고
    • Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human
    • Kulkarni SR, Donepudi AC, Xu J, Wei W, Cheng QC, Driscoll MV, et al. Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human. Antioxid Redox Signal 2014;20:15-30.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 15-30
    • Kulkarni, S.R.1    Donepudi, A.C.2    Xu, J.3    Wei, W.4    Cheng, Q.C.5    Driscoll, M.V.6
  • 102
    • 84904157844 scopus 로고    scopus 로고
    • Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1alpha/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents
    • DoMT, Kim HG, Choi JH, Jeong HG. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1alpha/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free Radic Biol Med 2014;74:21-34.
    • (2014) Free Radic Biol Med , vol.74 , pp. 21-34
    • Do, M.T.1    Kim, H.G.2    Choi, J.H.3    Jeong, H.G.4
  • 103
    • 84861127026 scopus 로고    scopus 로고
    • Metformin use is associated with better survival of diabetic patients with pancreatic cancer
    • Sadeghi N, Abbruzzese JL, Yeung SC, Hassan M, Li D. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res 2012;18:2905-12.
    • (2012) Clin Cancer Res , vol.18 , pp. 2905-2912
    • Sadeghi, N.1    Abbruzzese, J.L.2    Yeung, S.C.3    Hassan, M.4    Li, D.5
  • 104
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang CV.Links between metabolism and cancer. Genes Dev 2012;26: 877-90.
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 105
    • 84903976031 scopus 로고    scopus 로고
    • Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization
    • Lim JH, Luo C, Vazquez F, Puigserver P. Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization. Cancer Res 2014;74:3535-45.
    • (2014) Cancer Res , vol.74 , pp. 3535-3545
    • Lim, J.H.1    Luo, C.2    Vazquez, F.3    Puigserver, P.4
  • 106
    • 15444380906 scopus 로고    scopus 로고
    • The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer
    • Watkins G, Douglas-Jones A, Mansel RE, Jiang WG. The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer. Oncol Rep 2004;12:483-8.
    • (2004) Oncol Rep , vol.12 , pp. 483-488
    • Watkins, G.1    Douglas-Jones, A.2    Mansel, R.E.3    Jiang, W.G.4
  • 107
    • 0345167182 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: Reduced expression of PPARgamma-coactivator 1 (PGC-1)
    • Feilchenfeldt J, Brundler MA, Soravia C, Totsch M, Meier CA. Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1). Cancer Lett 2004;203:25-33.
    • (2004) Cancer Lett , vol.203 , pp. 25-33
    • Feilchenfeldt, J.1    Brundler, M.A.2    Soravia, C.3    Totsch, M.4    Meier, C.A.5
  • 108
    • 75149166058 scopus 로고    scopus 로고
    • PPAR(gamma)/PGC-1(alpha) pathway in E-cadherin expression and motility ofHepG2 cells
    • Lee HJ, Su Y, Yin PH, Lee HC, Chi CW. PPAR(gamma)/PGC-1(alpha) pathway in E-cadherin expression and motility ofHepG2 cells. Anticancer Res 2009;29:5057-63.
    • (2009) Anticancer Res , vol.29 , pp. 5057-5063
    • Lee, H.J.1    Su, Y.2    Yin, P.H.3    Lee, H.C.4    Chi, C.W.5
  • 109
    • 34247346466 scopus 로고    scopus 로고
    • PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway
    • Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, et al. PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res 2007;17:363-73.
    • (2007) Cell Res , vol.17 , pp. 363-373
    • Zhang, Y.1    Ba, Y.2    Liu, C.3    Sun, G.4    Ding, L.5    Gao, S.6
  • 110
    • 0042524273 scopus 로고    scopus 로고
    • Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes
    • Jiang WG, Douglas-Jones A, Mansel RE. Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes. Int J Cancer 2003;106:752-7.
    • (2003) Int J Cancer , vol.106 , pp. 752-757
    • Jiang, W.G.1    Douglas-Jones, A.2    Mansel, R.E.3
  • 111
    • 79955634801 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate
    • D'Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A 2011;108:6603-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 6603-6608
    • D'Errico, I.1    Salvatore, L.2    Murzilli, S.3    Lo Sasso, G.4    Latorre, D.5    Martelli, N.6
  • 112
    • 84894479646 scopus 로고    scopus 로고
    • Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferatoractivated receptor gamma coactivator-1a (PGC-1a) and mitostatin
    • Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, et al. Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferatoractivated receptor gamma coactivator-1a (PGC-1a) and mitostatin. J Biol Chem 2014;289:4952-68.
    • (2014) J Biol Chem , vol.289 , pp. 4952-4968
    • Neill, T.1    Torres, A.2    Buraschi, S.3    Owens, R.T.4    Hoek, J.B.5    Baffa, R.6
  • 114
    • 84929649410 scopus 로고    scopus 로고
    • AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab
    • Li X, Lu Y, Lu H, Luo J, Hong Y, Fan Z. AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab. Oncotarget 2015;6:11507-18.
    • (2015) Oncotarget , vol.6 , pp. 11507-11518
    • Li, X.1    Lu, Y.2    Lu, H.3    Luo, J.4    Hong, Y.5    Fan, Z.6
  • 115
    • 84898450608 scopus 로고    scopus 로고
    • Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress
    • Zhang JG, Hong DF, Zhang CW, Sun XD, Wang ZF, Shi Y, et al. Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. Cancer Sci 2014;105: 445-54.
    • (2014) Cancer Sci , vol.105 , pp. 445-454
    • Zhang, J.G.1    Hong, D.F.2    Zhang, C.W.3    Sun, X.D.4    Wang, Z.F.5    Shi, Y.6
  • 116
    • 84937523899 scopus 로고    scopus 로고
    • Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates
    • Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, et al. Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates. Mol Cell 2015;59:285-97.
    • (2015) Mol Cell , vol.59 , pp. 285-297
    • Egan, D.F.1    Chun, M.G.2    Vamos, M.3    Zou, H.4    Rong, J.5    Miller, C.J.6
  • 119
    • 84941659899 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
    • Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, et al. Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies. Cancer Immunol Res 2015;3:1236-47.
    • (2015) Cancer Immunol Res , vol.3 , pp. 1236-1247
    • Hossain, F.1    Al-Khami, A.A.2    Wyczechowska, D.3    Hernandez, C.4    Zheng, L.5    Reiss, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.