메뉴 건너뛰기




Volumn 21, Issue 7, 2014, Pages 1061-1070

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis

Author keywords

DNA damage; glycolysis; metabolism; oxidative phosphorylation; PGC 1 ; receptor interacting protein 1

Indexed keywords

CYTOCHROME C; CYTOCHROME C OXIDASE; DNA; LACTATE DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN 1; UNCLASSIFIED DRUG; AGFG1 PROTEIN, HUMAN; NUCLEOPORIN; PPARGC1A PROTEIN, HUMAN; RNA BINDING PROTEIN; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 84902294427     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.25     Document Type: Article
Times cited : (29)

References (56)
  • 1
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 3
    • 84856087055 scopus 로고    scopus 로고
    • Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    • Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 2012; 148: 259-272.
    • (2012) Cell , vol.148 , pp. 259-272
    • Zhang, W.C.1    Shyh-Chang, N.2    Yang, H.3    Rai, A.4    Umashankar, S.5    Ma, S.6
  • 4
    • 84870874690 scopus 로고    scopus 로고
    • The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
    • Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151: 1185-1199.
    • (2012) Cell , vol.151 , pp. 1185-1199
    • Sebastian, C.1    Zwaans, B.M.2    Silberman, D.M.3    Gymrek, M.4    Goren, A.5    Zhong, L.6
  • 5
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev 2011; 11: 85-95.
    • (2011) Nat Rev , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 6
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21: 297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 7
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 2010; 330: 1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 8
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang CV. Links between metabolism and cancer. Gene Dev 2012; 26: 877-890.
    • (2012) Gene Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 10
    • 48549115155 scopus 로고    scopus 로고
    • The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway
    • Park S, Ramnarain DB, Hatanpaa KJ, Mickey BE, Saha D, Paulmurugan R et al. The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway. EMBO Rep 2008; 9: 766-773.
    • (2008) EMBO Rep , vol.9 , pp. 766-773
    • Park, S.1    Ramnarain, D.B.2    Hatanpaa, K.J.3    Mickey, B.E.4    Saha, D.5    Paulmurugan, R.6
  • 11
    • 33747634058 scopus 로고    scopus 로고
    • The essential role of the death domain kinase receptorinteracting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation
    • Lin Y, Yang Q, Wang X, Liu ZG. The essential role of the death domain kinase receptorinteracting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J Biol Chem 2006; 281: 23525-23532.
    • (2006) J Biol Chem , vol.281 , pp. 23525-23532
    • Lin, Y.1    Yang, Q.2    Wang, X.3    Liu, Z.G.4
  • 12
    • 67650638892 scopus 로고    scopus 로고
    • RIP kinases at the crossroads of cell death and survival
    • Declercq W, Vanden Berghe T, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009; 138: 229-232.
    • (2009) Cell , vol.138 , pp. 229-232
    • Declercq, W.1    Vanden Berghe, T.2    Vandenabeele, P.3
  • 13
    • 33644763298 scopus 로고    scopus 로고
    • Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis
    • Temkin V, Huang Q, Liu H, Osada H, Pope RM. Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 2006; 26: 2215-2225.
    • (2006) Mol Cell Biol , vol.26 , pp. 2215-2225
    • Temkin, V.1    Huang, Q.2    Liu, H.3    Osada, H.4    Pope, R.M.5
  • 14
    • 0034685982 scopus 로고    scopus 로고
    • The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria
    • Kasof GM, Prosser JC, Liu D, Lorenzi MV, Gomes BC. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett 2000; 473: 285-291.
    • (2000) FEBS Lett , vol.473 , pp. 285-291
    • Kasof, G.M.1    Prosser, J.C.2    Liu, D.3    Lorenzi, M.V.4    Gomes, B.C.5
  • 15
    • 84862909353 scopus 로고    scopus 로고
    • The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
    • Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012; 148: 228-243.
    • (2012) Cell , vol.148 , pp. 228-243
    • Wang, Z.1    Jiang, H.2    Chen, S.3    Du, F.4    Wang, X.5
  • 16
    • 67650812332 scopus 로고    scopus 로고
    • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    • Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325: 332-336.
    • (2009) Science , vol.325 , pp. 332-336
    • Zhang, D.W.1    Shao, J.2    Lin, J.3    Zhang, N.4    Lu, B.J.5    Lin, S.C.6
  • 17
    • 66149128126 scopus 로고    scopus 로고
    • The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma
    • Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM et al. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Res 2009; 69: 2809-2816.
    • (2009) Cancer Res , vol.69 , pp. 2809-2816
    • Park, S.1    Hatanpaa, K.J.2    Xie, Y.3    Mickey, B.E.4    Madden, C.J.5    Raisanen, J.M.6
  • 18
    • 0034732158 scopus 로고    scopus 로고
    • Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain
    • Roth J, Koch P, Contente A, Dobbelstein M. Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain. Oncogene 2000; 19: 1834-1842.
    • (2000) Oncogene , vol.19 , pp. 1834-1842
    • Roth, J.1    Koch, P.2    Contente, A.3    Dobbelstein, M.4
  • 19
    • 84857443702 scopus 로고    scopus 로고
    • The p53 network: Cellular and systemic DNA damage responses in aging and cancer
    • Reinhardt HC, Schumacher B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet 2012; 28: 128-136.
    • (2012) Trends Genet , vol.28 , pp. 128-136
    • Reinhardt, H.C.1    Schumacher, B.2
  • 20
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001; 276: 42462-42467.
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 21
    • 77950961695 scopus 로고    scopus 로고
    • GammaH2AX: A sensitive molecular marker of DNA damage and repair
    • Mah LJ, El-Osta A, Karagiannis TC. gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 2010; 24: 679-686.
    • (2010) Leukemia , vol.24 , pp. 679-686
    • Mah, L.J.1    El-Osta, A.2    Karagiannis, T.C.3
  • 22
    • 0033199892 scopus 로고    scopus 로고
    • Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
    • Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM et al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 1999; 59: 4375-4382.
    • (1999) Cancer Res , vol.59 , pp. 4375-4382
    • Sarkaria, J.N.1    Busby, E.C.2    Tibbetts, R.S.3    Roos, P.4    Taya, Y.5    Karnitz, L.M.6
  • 23
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40: 179-204.
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 24
    • 43049152912 scopus 로고    scopus 로고
    • TNF-alpha induces two distinct caspase-8 activation pathways
    • Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693-703.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 25
    • 33846317064 scopus 로고    scopus 로고
    • Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    • Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007; 292: C125-C136.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Wu, M.1    Neilson, A.2    Swift, A.L.3    Moran, R.4    Tamagnine, J.5    Parslow, D.6
  • 26
    • 79955408736 scopus 로고    scopus 로고
    • Role of nicotinamide in DNA damage, mutagenesis, and DNA repair
    • Surjana D, Halliday GM, Damian DL. Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. J Nucleic Acids 2010; 2010: 157591.
    • (2010) J Nucleic Acids , vol.2010 , pp. 157591
    • Surjana, D.1    Halliday, G.M.2    Damian, D.L.3
  • 28
    • 77955499804 scopus 로고    scopus 로고
    • Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
    • Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 2010; 38: 864-878.
    • (2010) Mol Cell , vol.38 , pp. 864-878
    • Lim, J.H.1    Lee, Y.M.2    Chun, Y.S.3    Chen, J.4    Kim, J.E.5    Park, J.W.6
  • 29
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 30
    • 77955610192 scopus 로고    scopus 로고
    • Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration
    • Borniquel S, Garcia-Quintans N, Valle I, Olmos Y, Wild B, Martinez-Granero F et al. Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration. Mol Cell Biol 2010; 30: 4035-4044.
    • (2010) Mol Cell Biol , vol.30 , pp. 4035-4044
    • Borniquel, S.1    Garcia-Quintans, N.2    Valle, I.3    Olmos, Y.4    Wild, B.5    Martinez-Granero, F.6
  • 31
    • 79951812916 scopus 로고    scopus 로고
    • Telomere dysfunction induces metabolic and mitochondrial compromise
    • Sahin E, Colla S, Liesa M, Moslehi J, Muller FL, Guo M et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011; 470: 359-365.
    • (2011) Nature , vol.470 , pp. 359-365
    • Sahin, E.1    Colla, S.2    Liesa, M.3    Moslehi, J.4    Muller, F.L.5    Guo, M.6
  • 32
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98: 115-124.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5    Mootha, V.6
  • 33
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005; 1: 361-370.
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 34
    • 53849088227 scopus 로고    scopus 로고
    • Transcriptional control of energy homeostasis by the estrogen-related receptors
    • Giguere V. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocrine Rev 2008; 29: 677-696.
    • (2008) Endocrine Rev , vol.29 , pp. 677-696
    • Giguere, V.1
  • 35
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Gene Dev 2004; 18: 357-368.
    • (2004) Gene Dev , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 36
    • 0026457218 scopus 로고
    • Nonviability of cells with oxidative defects in galactose medium: A screening test for affected patient fibroblasts
    • Robinson BH, Petrova-Benedict R, Buncic JR, Wallace DC. Nonviability of cells with oxidative defects in galactose medium: a screening test for affected patient fibroblasts. Biochem Med Metab Biol 1992; 48: 122-126.
    • (1992) Biochem Med Metab Biol , vol.48 , pp. 122-126
    • Robinson, B.H.1    Petrova-Benedict, R.2    Buncic, J.R.3    Wallace, D.C.4
  • 37
    • 68649109608 scopus 로고    scopus 로고
    • The biology of PGC-1alpha and its therapeutic potential
    • Handschin C. The biology of PGC-1alpha and its therapeutic potential. Trends Pharmacol Sci 2009; 30: 322-329.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 322-329
    • Handschin, C.1
  • 38
    • 84861980898 scopus 로고    scopus 로고
    • The diverse role of the PPARgamma coactivator 1 family of transcriptional coactivators in cancer
    • Girnun GD. The diverse role of the PPARgamma coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol 2012; 23: 381-388.
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 381-388
    • Girnun, G.D.1
  • 39
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis
    • Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011; 93: 884S-890S.
    • (2011) Am J Clin Nutr , vol.93
    • Fernandez-Marcos, P.J.1    Auwerx, J.2
  • 40
    • 28944447430 scopus 로고    scopus 로고
    • PIDD mediates NF-kappaB activation in response to DNA damage
    • Janssens S, Tinel A, Lippens S, Tschopp J. PIDD mediates NF-kappaB activation in response to DNA damage. Cell 2005; 123: 1079-1092.
    • (2005) Cell , vol.123 , pp. 1079-1092
    • Janssens, S.1    Tinel, A.2    Lippens, S.3    Tschopp, J.4
  • 41
    • 80052956828 scopus 로고    scopus 로고
    • Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis
    • Dengler MA, Staiger AM, Gutekunst M, Hofmann U, Doszczak M, Scheurich P et al. Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis. PLoS One 2011; 6: e25139.
    • (2011) PLoS One , vol.6
    • Dengler, M.A.1    Staiger, A.M.2    Gutekunst, M.3    Hofmann, U.4    Doszczak, M.5    Scheurich, P.6
  • 42
    • 0008756023 scopus 로고
    • The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process
    • Birnboim HC, Kanabus-Kaminska M. The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process. Proc Natl Acad Sci USA 1985; 82: 6820-6824.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 6820-6824
    • Birnboim, H.C.1    Kanabus-Kaminska, M.2
  • 43
    • 33746644254 scopus 로고    scopus 로고
    • 2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX
    • Tanaka T, Kurose A, Halicka HD, Traganos F, Darzynkiewicz Z. 2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX. Cell Cycle 2006; 5: 878-882.
    • (2006) Cell Cycle , vol.5 , pp. 878-882
    • Tanaka, T.1    Kurose, A.2    Halicka, H.D.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 44
    • 0021993763 scopus 로고
    • Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells
    • Jain VK, Kalia VK, Sharma R, Maharajan V, Menon M. Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int J Radiat Oncol Biol Phys 1985; 11: 943-950.
    • (1985) Int J Radiat Oncol Biol Phys , vol.11 , pp. 943-950
    • Jain, V.K.1    Kalia, V.K.2    Sharma, R.3    Maharajan, V.4    Menon, M.5
  • 45
    • 0035879414 scopus 로고    scopus 로고
    • Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines
    • Dwarkanath BS, Zolzer F, Chandana S, Bauch T, Adhikari JS, Muller WU et al. Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines. Int J Radiat Oncol Biol Phys 2001; 50: 1051-1061.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 1051-1061
    • Dwarkanath, B.S.1    Zolzer, F.2    Chandana, S.3    Bauch, T.4    Adhikari, J.S.5    Muller, W.U.6
  • 46
    • 84867877340 scopus 로고    scopus 로고
    • The NAD metabolome - A key determinant of cancer cell biology
    • Chiarugi A, Dolle C, Felici R, Ziegler M. The NAD metabolome-a key determinant of cancer cell biology. Nat Rev 2012; 12: 741-752.
    • (2012) Nat Rev , vol.12 , pp. 741-752
    • Chiarugi, A.1    Dolle, C.2    Felici, R.3    Ziegler, M.4
  • 47
    • 31544470589 scopus 로고    scopus 로고
    • 17-allylamino-17- demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway
    • Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y. 17-allylamino-17- demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 2006; 66: 1089-1095.
    • (2006) Cancer Res , vol.66 , pp. 1089-1095
    • Wang, X.1    Ju, W.2    Renouard, J.3    Aden, J.4    Belinsky, S.A.5    Lin, Y.6
  • 48
    • 34548410333 scopus 로고    scopus 로고
    • Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells
    • Wang P, Zhang J, Bellail A, Jiang W, Hugh J, Kneteman NM et al. Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells. Cell signalling 2007; 19: 2237-2246.
    • (2007) Cell Signalling , vol.19 , pp. 2237-2246
    • Wang, P.1    Zhang, J.2    Bellail, A.3    Jiang, W.4    Hugh, J.5    Kneteman, N.M.6
  • 49
    • 0037382303 scopus 로고    scopus 로고
    • The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
    • Hur GM, Lewis J, Yang Q, Lin Y, Nakano H, Nedospasov S et al. The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation. Gene Dev 2003; 17: 873-882.
    • (2003) Gene Dev , vol.17 , pp. 873-882
    • Hur, G.M.1    Lewis, J.2    Yang, Q.3    Lin, Y.4    Nakano, H.5    Nedospasov, S.6
  • 51
    • 79953282304 scopus 로고    scopus 로고
    • NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling
    • Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling. Cell 2011; 145: 92-103.
    • (2011) Cell , vol.145 , pp. 92-103
    • Biton, S.1    Ashkenazi, A.2
  • 52
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Gene Dev 2004; 18: 1272-1282.
    • (2004) Gene Dev , vol.18 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 53
    • 0033214236 scopus 로고    scopus 로고
    • Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    • Lin Y, Devin A, Rodriguez Y, Liu ZG. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 1999; 13: 2514-2526.
    • (1999) Genes Dev , vol.13 , pp. 2514-2526
    • Lin, Y.1    Devin, A.2    Rodriguez, Y.3    Liu, Z.G.4
  • 54
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 55
    • 0037342151 scopus 로고    scopus 로고
    • Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
    • Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 2003; 52: 642-649.
    • (2003) Diabetes , vol.52 , pp. 642-649
    • Daitoku, H.1    Yamagata, K.2    Matsuzaki, H.3    Hatta, M.4    Fukamizu, A.5
  • 56
    • 84855598935 scopus 로고    scopus 로고
    • Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease
    • Karamanlidis G, Bautista-Hernandez V, Fynn-Thompson F, Del Nido P, Tian R. Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease. Circ Heart Fail 2011; 4: 707-713.
    • (2011) Circ Heart Fail , vol.4 , pp. 707-713
    • Karamanlidis, G.1    Bautista-Hernandez, V.2    Fynn-Thompson, F.3    Del Nido, P.4    Tian, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.