MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells

Cell Metabolism

Volumn 22, Issue 4, 2015, Pages 590-605

  Sancho, Patricia ^a,b   Burgos Ramos, Emma ^b   Tavera, Alejandra ^b   Bou Kheir, Tony ^a   Jagust, Petra ^a   Schoenhals, Matthieu ^a   Barneda, David ^a   Sellers, Katherine ^c   Campos Olivas, Ramon ^b   Graña, Osvaldo ^b   Viera, Catarina R ^b   Yuneva, Mariia ^c   Sainz, Bruno ^b   Heeschen, Christopher ^a,b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Structural Biology and Biocomputing Programme   (Spain)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CITRININ; MENADIONE; MESSENGER RNA; METFORMIN; MYC PROTEIN; OLIGOMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RESVERATROL; ROTENONE; ANTINEOPLASTIC AGENT; CD133 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; PPARGC1A PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER STEM CELL; CELL CLONE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ADENOCARCINOMA; PHENOTYPE; PLASTICITY; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; GENE LIBRARY; GENETICS; METABOLISM; MITOCHONDRION; NUDE MOUSE; OXIDATIVE PHOSPHORYLATION; PANCREATIC NEOPLASMS; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL CULTURE;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; GENE LIBRARY; GLYCOPROTEINS; HUMANS; METFORMIN; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASTIC STEM CELLS; OXIDATIVE PHOSPHORYLATION; PANCREATIC NEOPLASMS; PEPTIDES; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VITAMIN K 3;

EID: 84943451038     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.08.015     Document Type: Article

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