-
1
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehár J., Kryukov G.V., Sonkin D., et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012, 483:603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
Wilson, C.J.7
Lehár, J.8
Kryukov, G.V.9
Sonkin, D.10
-
2
-
-
82555205202
-
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
-
French Familial Melanoma Study Group
-
Bertolotto C., Lesueur F., Giuliano S., Strub T., de Lichy M., Bille K., Dessen P., d'Hayer B., Mohamdi H., Remenieras A., et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature 2011, 480:94-98. French Familial Melanoma Study Group.
-
(2011)
Nature
, vol.480
, pp. 94-98
-
-
Bertolotto, C.1
Lesueur, F.2
Giuliano, S.3
Strub, T.4
de Lichy, M.5
Bille, K.6
Dessen, P.7
d'Hayer, B.8
Mohamdi, H.9
Remenieras, A.10
-
3
-
-
73949140415
-
Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
-
Bogunovic D., O'Neill D.W., Belitskaya-Levy I., Vacic V., Yu Y.L., Adams S., Darvishian F., Berman R., Shapiro R., Pavlick A.C., et al. Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc. Natl. Acad. Sci. USA 2009, 106:20429-20434.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20429-20434
-
-
Bogunovic, D.1
O'Neill, D.W.2
Belitskaya-Levy, I.3
Vacic, V.4
Yu, Y.L.5
Adams, S.6
Darvishian, F.7
Berman, R.8
Shapiro, R.9
Pavlick, A.C.10
-
4
-
-
80054716866
-
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer
-
Chang C.Y., Kazmin D., Jasper J.S., Kunder R., Zuercher W.J., McDonnell D.P. The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell 2011, 20:500-510.
-
(2011)
Cancer Cell
, vol.20
, pp. 500-510
-
-
Chang, C.Y.1
Kazmin, D.2
Jasper, J.S.3
Kunder, R.4
Zuercher, W.J.5
McDonnell, D.P.6
-
5
-
-
77952562382
-
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
-
Choo A.Y., Kim S.G., Vander Heiden M.G., Mahoney S.J., Vu H., Yoon S.O., Cantley L.C., Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 2010, 38:487-499.
-
(2010)
Mol. Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
Kim, S.G.2
Vander Heiden, M.G.3
Mahoney, S.J.4
Vu, H.5
Yoon, S.O.6
Cantley, L.C.7
Blenis, J.8
-
6
-
-
0034601487
-
Genomic analysis of metastasis reveals an essential role for RhoC
-
Clark E.A., Golub T.R., Lander E.S., Hynes R.O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000, 406:532-535.
-
(2000)
Nature
, vol.406
, pp. 532-535
-
-
Clark, E.A.1
Golub, T.R.2
Lander, E.S.3
Hynes, R.O.4
-
7
-
-
36749081539
-
MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham J.T., Rodgers J.T., Arlow D.H., Vazquez F., Mootha V.K., Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007, 450:736-740.
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
8
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
Diehn M., Cho R.W., Lobo N.A., Kalisky T., Dorie M.J., Kulp A.N., Qian D., Lam J.S., Ailles L.E., Wong M., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
Cho, R.W.2
Lobo, N.A.3
Kalisky, T.4
Dorie, M.J.5
Kulp, A.N.6
Qian, D.7
Lam, J.S.8
Ailles, L.E.9
Wong, M.10
-
9
-
-
79957944105
-
Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks
-
Eichner L.J., Giguère V. Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion 2011, 11:544-552.
-
(2011)
Mitochondrion
, vol.11
, pp. 544-552
-
-
Eichner, L.J.1
Giguère, V.2
-
10
-
-
79953210362
-
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
-
Fernandez-Marcos P.J., Auwerx J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 2011, 93:884S-890S.
-
(2011)
Am. J. Clin. Nutr.
, vol.93
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
-
11
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
12
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway L.A., Widlund H.R., Rubin M.A., Getz G., Berger A.J., Ramaswamy S., Beroukhim R., Milner D.A., Granter S.R., Du J., et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005, 436:117-122.
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
Getz, G.4
Berger, A.J.5
Ramaswamy, S.6
Beroukhim, R.7
Milner, D.A.8
Granter, S.R.9
Du, J.10
-
13
-
-
43549113135
-
PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91
-
Grabacka M., Placha W., Urbanska K., Laidler P., Plonka P.M., Reiss K. PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91. Pigment Cell Melanoma Res. 2008, 21:388-396.
-
(2008)
Pigment Cell Melanoma Res.
, vol.21
, pp. 388-396
-
-
Grabacka, M.1
Placha, W.2
Urbanska, K.3
Laidler, P.4
Plonka, P.M.5
Reiss, K.6
-
14
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
15
-
-
35648937073
-
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
-
Handschin C., Chin S., Li P., Liu F., Maratos-Flier E., Lebrasseur N.K., Yan Z., Spiegelman B.M. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J. Biol. Chem. 2007, 282:30014-30021.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 30014-30021
-
-
Handschin, C.1
Chin, S.2
Li, P.3
Liu, F.4
Maratos-Flier, E.5
Lebrasseur, N.K.6
Yan, Z.7
Spiegelman, B.M.8
-
16
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001, 413:179-183.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
-
17
-
-
38849203228
-
In vivo switching of human melanoma cells between proliferative and invasive states
-
Hoek K.S., Eichhoff O.M., Schlegel N.C., Döbbeling U., Kobert N., Schaerer L., Hemmi S., Dummer R. In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res. 2008, 68:650-656.
-
(2008)
Cancer Res.
, vol.68
, pp. 650-656
-
-
Hoek, K.S.1
Eichhoff, O.M.2
Schlegel, N.C.3
Döbbeling, U.4
Kobert, N.5
Schaerer, L.6
Hemmi, S.7
Dummer, R.8
-
18
-
-
1542373685
-
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
-
Kelly D.P., Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004, 18:357-368.
-
(2004)
Genes Dev.
, vol.18
, pp. 357-368
-
-
Kelly, D.P.1
Scarpulla, R.C.2
-
20
-
-
33744534726
-
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
-
Lerin C., Rodgers J.T., Kalume D.E., Kim S.H., Pandey A., Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 2006, 3:429-438.
-
(2006)
Cell Metab.
, vol.3
, pp. 429-438
-
-
Lerin, C.1
Rodgers, J.T.2
Kalume, D.E.3
Kim, S.H.4
Pandey, A.5
Puigserver, P.6
-
21
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002, 418:797-801.
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
-
22
-
-
38849166096
-
Modeling genomic diversity and tumor dependency in malignant melanoma
-
Lin W.M., Baker A.C., Beroukhim R., Winckler W., Feng W., Marmion J.M., Laine E., Greulich H., Tseng H., Gates C., et al. Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 2008, 68:664-673.
-
(2008)
Cancer Res.
, vol.68
, pp. 664-673
-
-
Lin, W.M.1
Baker, A.C.2
Beroukhim, R.3
Winckler, W.4
Feng, W.5
Marmion, J.M.6
Laine, E.7
Greulich, H.8
Tseng, H.9
Gates, C.10
-
23
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat J., Grueneberg D.A., Yang X., Kim S.Y., Kloepfer A.M., Hinkle G., Piqani B., Eisenhaure T.M., Luo B., Grenier J.K., et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 2006, 124:1283-1298.
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
Grueneberg, D.A.2
Yang, X.3
Kim, S.Y.4
Kloepfer, A.M.5
Hinkle, G.6
Piqani, B.7
Eisenhaure, T.M.8
Luo, B.9
Grenier, J.K.10
-
24
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstråle M., Laurila E., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 2003, 34:267-273.
-
(2003)
Nat. Genet.
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstråle, M.9
Laurila, E.10
-
25
-
-
2342477730
-
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
-
Mootha V.K., Handschin C., Arlow D., Xie X., St Pierre J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA 2004, 101:6570-6575.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6570-6575
-
-
Mootha, V.K.1
Handschin, C.2
Arlow, D.3
Xie, X.4
St Pierre, J.5
Sihag, S.6
Yang, W.7
Altshuler, D.8
Puigserver, P.9
Patterson, N.10
-
26
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
Ohta T., Iijima K., Miyamoto M., Nakahara I., Tanaka H., Ohtsuji M., Suzuki T., Kobayashi A., Yokota J., Sakiyama T., et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 2008, 68:1303-1309.
-
(2008)
Cancer Res.
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
-
27
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
Padmanabhan B., Tong K.I., Ohta T., Nakamura Y., Scharlock M., Ohtsuji M., Kang M.I., Kobayashi A., Yokoyama S., Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol. Cell 2006, 21:689-700.
-
(2006)
Mol. Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
Kang, M.I.7
Kobayashi, A.8
Yokoyama, S.9
Yamamoto, M.10
-
28
-
-
0037326196
-
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
-
Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 2003, 24:78-90.
-
(2003)
Endocr. Rev.
, vol.24
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
29
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
30
-
-
79960427057
-
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
-
Raj L., Ide T., Gurkar A.U., Foley M., Schenone M., Li X., Tolliday N.J., Golub T.R., Carr S.A., Shamji A.F., et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011, 475:231-234.
-
(2011)
Nature
, vol.475
, pp. 231-234
-
-
Raj, L.1
Ide, T.2
Gurkar, A.U.3
Foley, M.4
Schenone, M.5
Li, X.6
Tolliday, N.J.7
Golub, T.R.8
Carr, S.A.9
Shamji, A.F.10
-
31
-
-
0242349197
-
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
-
Rhee J., Inoue Y., Yoon J.C., Puigserver P., Fan M., Gonzalez F.J., Spiegelman B.M. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA 2003, 100:4012-4017.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4012-4017
-
-
Rhee, J.1
Inoue, Y.2
Yoon, J.C.3
Puigserver, P.4
Fan, M.5
Gonzalez, F.J.6
Spiegelman, B.M.7
-
32
-
-
49649103221
-
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
-
Riker A.I., Enkemann S.A., Fodstad O., Liu S., Ren S., Morris C., Xi Y., Howell P., Metge B., Samant R.S., et al. The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med. Genomics 2008, 1:13.
-
(2008)
BMC Med. Genomics
, vol.1
, pp. 13
-
-
Riker, A.I.1
Enkemann, S.A.2
Fodstad, O.3
Liu, S.4
Ren, S.5
Morris, C.6
Xi, Y.7
Howell, P.8
Metge, B.9
Samant, R.S.10
-
33
-
-
79951812916
-
Telomere dysfunction induces metabolic and mitochondrial compromise
-
Sahin E., Colla S., Liesa M., Moslehi J., Müller F.L., Guo M., Cooper M., Kotton D., Fabian A.J., Walkey C., et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470:359-365.
-
(2011)
Nature
, vol.470
, pp. 359-365
-
-
Sahin, E.1
Colla, S.2
Liesa, M.3
Moslehi, J.4
Müller, F.L.5
Guo, M.6
Cooper, M.7
Kotton, D.8
Fabian, A.J.9
Walkey, C.10
-
34
-
-
79957960940
-
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
-
Scarpulla R.C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim. Biophys. Acta 2011, 1813:1269-1278.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1269-1278
-
-
Scarpulla, R.C.1
-
35
-
-
2342592545
-
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
-
Schreiber S.N., Emter R., Hock M.B., Knutti D., Cardenas J., Podvinec M., Oakeley E.J., Kralli A. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc. Natl. Acad. Sci. USA 2004, 101:6472-6477.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6472-6477
-
-
Schreiber, S.N.1
Emter, R.2
Hock, M.B.3
Knutti, D.4
Cardenas, J.5
Podvinec, M.6
Oakeley, E.J.7
Kralli, A.8
-
36
-
-
81355153987
-
PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress
-
Sen N., Satija Y.K., Das S. PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress. Mol. Cell 2011, 44:621-634.
-
(2011)
Mol. Cell
, vol.44
, pp. 621-634
-
-
Sen, N.1
Satija, Y.K.2
Das, S.3
-
37
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
Shibata T., Ohta T., Tong K.I., Kokubu A., Odogawa R., Tsuta K., Asamura H., Yamamoto M., Hirohashi S. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc. Natl. Acad. Sci. USA 2008, 105:13568-13573.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
Asamura, H.7
Yamamoto, M.8
Hirohashi, S.9
-
38
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
Singh A., Misra V., Thimmulappa R.K., Lee H., Ames S., Hoque M.O., Herman J.G., Baylin S.B., Sidransky D., Gabrielson E., et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006, 3:e420.
-
(2006)
PLoS Med.
, vol.3
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
-
39
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jäger S., Handschin C., Zheng K., Lin J., Yang W., et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127:397-408.
-
(2006)
Cell
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jäger, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
-
40
-
-
79956120349
-
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
-
Strub T., Giuliano S., Ye T., Bonet C., Keime C., Kobi D., Le Gras S., Cormont M., Ballotti R., Bertolotto C., Davidson I. Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene 2011, 30:2319-2332.
-
(2011)
Oncogene
, vol.30
, pp. 2319-2332
-
-
Strub, T.1
Giuliano, S.2
Ye, T.3
Bonet, C.4
Keime, C.5
Kobi, D.6
Le Gras, S.7
Cormont, M.8
Ballotti, R.9
Bertolotto, C.10
Davidson, I.11
-
41
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 2005, 102:15545-15550.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
42
-
-
77956095537
-
Mitochondria and cell death: outer membrane permeabilization and beyond
-
Tait S.W., Green D.R. Mitochondria and cell death: outer membrane permeabilization and beyond. Nature Rev. Mol. Cell Biol. 2010, 11:621-632.
-
(2010)
Nature Rev. Mol. Cell Biol.
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
43
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P.J., Achanta G., Arlinghaus R.B., Liu J., Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006, 10:241-252.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
Chiao, P.J.7
Achanta, G.8
Arlinghaus, R.B.9
Liu, J.10
Huang, P.11
-
44
-
-
67650071137
-
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
-
Trachootham D., Alexandre J., Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?. Nat. Rev. Drug Discov. 2009, 8:579-591.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
46
-
-
28544438180
-
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
-
Wende A.R., Huss J.M., Schaeffer P.J., Giguère V., Kelly D.P. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol. 2005, 25:10684-10694.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10684-10694
-
-
Wende, A.R.1
Huss, J.M.2
Schaeffer, P.J.3
Giguère, V.4
Kelly, D.P.5
-
47
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B., Thompson C.B. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl. Acad. Sci. USA 2008, 105:18782-18787.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
48
-
-
82555187007
-
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
-
Yokoyama S., Woods S.L., Boyle G.M., Aoude L.G., MacGregor S., Zismann V., Gartside M., Cust A.E., Haq R., Harland M., et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature 2011, 480:99-103.
-
(2011)
Nature
, vol.480
, pp. 99-103
-
-
Yokoyama, S.1
Woods, S.L.2
Boyle, G.M.3
Aoude, L.G.4
MacGregor, S.5
Zismann, V.6
Gartside, M.7
Cust, A.E.8
Haq, R.9
Harland, M.10
-
49
-
-
79956326256
-
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
-
Zaugg K., Yao Y., Reilly P.T., Kannan K., Kiarash R., Mason J., Huang P., Sawyer S.K., Fuerth B., Faubert B., et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011, 25:1041-1051.
-
(2011)
Genes Dev.
, vol.25
, pp. 1041-1051
-
-
Zaugg, K.1
Yao, Y.2
Reilly, P.T.3
Kannan, K.4
Kiarash, R.5
Mason, J.6
Huang, P.7
Sawyer, S.K.8
Fuerth, B.9
Faubert, B.10
|