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Volumn 23, Issue 3, 2013, Pages 302-315

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PGC1 ALPHA; PROTEIN; UNCLASSIFIED DRUG;

EID: 84876436850     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2013.02.003     Document Type: Article
Times cited : (662)

References (78)
  • 16
    • 0038036009 scopus 로고
    • Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets
    • 2099-2012
    • Cutting W.C., Tainter M.L. Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets. J. Am. Med. Assoc. 1933, 101. 2099-2012.
    • (1933) J. Am. Med. Assoc. , vol.101
    • Cutting, W.C.1    Tainter, M.L.2
  • 17
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang C.V. Links between metabolism and cancer. Genes Dev. 2012, 26:877-890.
    • (2012) Genes Dev. , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 23
    • 33746888993 scopus 로고    scopus 로고
    • Mitochondriotoxic compounds for cancer therapy
    • Fantin V.R., Leder P. Mitochondriotoxic compounds for cancer therapy. Oncogene 2006, 25:4787-4797.
    • (2006) Oncogene , vol.25 , pp. 4787-4797
    • Fantin, V.R.1    Leder, P.2
  • 24
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 25
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
    • Finck B.N., Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 2006, 116:615-622.
    • (2006) J. Clin. Invest. , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 28
    • 84861980898 scopus 로고    scopus 로고
    • The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer
    • Girnun G.D. The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer. Semin. Cell Dev. Biol. 2012, 23:381-388.
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 381-388
    • Girnun, G.D.1
  • 29
    • 79956076149 scopus 로고    scopus 로고
    • Commentary. A picture of Mitf in melanoma immortality
    • Goding C.R. Commentary. A picture of Mitf in melanoma immortality. Oncogene 2011, 30:2304-2306.
    • (2011) Oncogene , vol.30 , pp. 2304-2306
    • Goding, C.R.1
  • 30
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V., Wellbrock C., Marais R. Melanoma biology and new targeted therapy. Nature 2007, 445:851-857.
    • (2007) Nature , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 32
    • 68649109608 scopus 로고    scopus 로고
    • The biology of PGC-1α and its therapeutic potential
    • Handschin C. The biology of PGC-1α and its therapeutic potential. Trends Pharmacol. Sci. 2009, 30:322-329.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 322-329
    • Handschin, C.1
  • 33
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    • Handschin C., Rhee J., Lin J., Tarr P.T., Spiegelman B.M. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc. Natl. Acad. Sci. USA 2003, 100:7111-7116.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 34
    • 80052753295 scopus 로고    scopus 로고
    • Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer
    • Haq R., Fisher D.E. Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. J. Clin. Oncol. 2011, 29:3474-3482.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3474-3482
    • Haq, R.1    Fisher, D.E.2
  • 35
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath T.J., Price E.R., Takemoto C., Badalian T., Fisher D.E. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 1998, 391:298-301.
    • (1998) Nature , vol.391 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 42
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly D.P., Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004, 18:357-368.
    • (2004) Genes Dev. , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 44
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 2000, 106:847-856.
    • (2000) J. Clin. Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 45
    • 84867421344 scopus 로고    scopus 로고
    • Transcriptional control of cardiac fuel metabolism and mitochondrial function
    • Leone T.C., Kelly D.P. Transcriptional control of cardiac fuel metabolism and mitochondrial function. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:175-182.
    • (2011) Cold Spring Harb. Symp. Quant. Biol. , vol.76 , pp. 175-182
    • Leone, T.C.1    Kelly, D.P.2
  • 48
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J., Handschin C., Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005, 1:361-370.
    • (2005) Cell Metab. , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 49
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP
    • Lin J., Yang R., Tarr P.T., Wu P.-H., Handschin C., Li S., Yang W., Pei L., Uldry M., Tontonoz P., et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell 2005, 120:261-273.
    • (2005) Cell , vol.120 , pp. 261-273
    • Lin, J.1    Yang, R.2    Tarr, P.T.3    Wu, P.-H.4    Handschin, C.5    Li, S.6    Yang, W.7    Pei, L.8    Uldry, M.9    Tontonoz, P.10
  • 52
    • 50449102941 scopus 로고    scopus 로고
    • Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise
    • Miura S., Kai Y., Kamei Y., Ezaki O. Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise. Endocrinology 2008, 149:4527-4533.
    • (2008) Endocrinology , vol.149 , pp. 4527-4533
    • Miura, S.1    Kai, Y.2    Kamei, Y.3    Ezaki, O.4
  • 54
    • 78651418282 scopus 로고    scopus 로고
    • Mutant BRAF melanomas-dependence and resistance
    • Poulikakos P.I., Rosen N. Mutant BRAF melanomas-dependence and resistance. Cancer Cell 2011, 19:11-15.
    • (2011) Cancer Cell , vol.19 , pp. 11-15
    • Poulikakos, P.I.1    Rosen, N.2
  • 55
    • 63149194964 scopus 로고    scopus 로고
    • (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
    • Pratilas C.A., Taylor B.S., Ye Q., Viale A., Sander C., Solit D.B., Rosen N. (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc. Natl. Acad. Sci. USA 2009, 106:4519-4524.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4519-4524
    • Pratilas, C.A.1    Taylor, B.S.2    Ye, Q.3    Viale, A.4    Sander, C.5    Solit, D.B.6    Rosen, N.7
  • 61
    • 0345379057 scopus 로고
    • Use of dinitrophenol in nutritional disorders: a critical survey of clinical results
    • Tainter M.L., Cutting W.C., Stockton A.B. Use of dinitrophenol in nutritional disorders: a critical survey of clinical results. Am. J. Public Health Nations Health 1934, 24:1045-1053.
    • (1934) Am. J. Public Health Nations Health , vol.24 , pp. 1045-1053
    • Tainter, M.L.1    Cutting, W.C.2    Stockton, A.B.3
  • 63
    • 33646124709 scopus 로고    scopus 로고
    • Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    • Uldry M., Yang W., St-Pierre J., Lin J., Seale P., Spiegelman B.M. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006, 3:333-341.
    • (2006) Cell Metab. , vol.3 , pp. 333-341
    • Uldry, M.1    Yang, W.2    St-Pierre, J.3    Lin, J.4    Seale, P.5    Spiegelman, B.M.6
  • 64
    • 77954649705 scopus 로고    scopus 로고
    • "Transcription physiology" of pigment formation in melanocytes: central role of MITF
    • Vachtenheim J., Borovanský J. "Transcription physiology" of pigment formation in melanocytes: central role of MITF. Exp. Dermatol. 2010, 19:617-627.
    • (2010) Exp. Dermatol. , vol.19 , pp. 617-627
    • Vachtenheim, J.1    Borovanský, J.2
  • 65
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 67
    • 80053132439 scopus 로고    scopus 로고
    • Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels
    • Wang X., Moraes C.T. Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels. Mol. Oncol. 2011, 5:399-409.
    • (2011) Mol. Oncol. , vol.5 , pp. 399-409
    • Wang, X.1    Moraes, C.T.2
  • 68
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 70
    • 24144477947 scopus 로고    scopus 로고
    • Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    • Wellbrock C., Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J. Cell Biol. 2005, 170:703-708.
    • (2005) J. Cell Biol. , vol.170 , pp. 703-708
    • Wellbrock, C.1    Marais, R.2
  • 72
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise D.R., Thompson C.B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 2010, 35:427-433.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 73
    • 32444451567 scopus 로고    scopus 로고
    • Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
    • Wolfrum C., Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab. 2006, 3:99-110.
    • (2006) Cell Metab. , vol.3 , pp. 99-110
    • Wolfrum, C.1    Stoffel, M.2


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