Rewired metabolism in drug-resistant leukemia cells: A metabolic switch hallmarked by reduced dependence on exogenous glutamine

Journal of Biological Chemistry

Volumn 290, Issue 13, 2015, Pages 8348-8359

  Stäubert, Claudia ^a,b,d   Bhuiyan, Hasanuzzaman ^c   Lindahl, Anna ^c   Broom, Oliver Jay ^a   Zhu, Yafeng ^c   Islam, Saiful ^c   Linnarsson, Sten ^c   Lehtiö, Janne ^c   Nordström, Anders ^d  

^a UMEÅ UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

^d UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMOTHERAPY; DISEASES; DRUG THERAPY; FATTY ACIDS; PHYSIOLOGY;

CANCER CHEMOTHERAPY; DRUG RESISTANCE; FATTY ACID METABOLISM; LEUKEMIA CELLS; METABOLIC COST; METABOLOMICS; THERAPEUTIC STRATEGY;

METABOLISM;

DAUNORUBICIN; FATTY ACID; FENOFIBRATE; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; MULTIDRUG RESISTANCE PROTEIN; PANTOTHENIC ACID; PERHEXILINE; RNA; VALSPODAR; 3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A ACYLTRANSFERASE; ANTINEOPLASTIC AGENT; CYCLOSPORIN DERIVATIVE; ENOYL COENZYME A HYDRATASE; FATTY ACID OXIDATION COMPLEX; ISOMERASE; MESSENGER RNA; TRANSCRIPTOME;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RESISTANCE; CELL METABOLISM; CELL VIABILITY ASSAY; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE EXPRESSION; HUMAN; HUMAN CELL; ISOTOPE LABELING; LEUKEMIA CELL; MASS SPECTROMETRY; METABOLOMICS; MYELOID LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; T CELL LEUKEMIA; BIOSYNTHESIS; DRUG POTENTIATION; DRUG RESISTANCE; GENETICS; GLYCOLYSIS; LEUKEMIA; METABOLISM; METABOLOME; OXIDATION REDUCTION REACTION; PHYSIOLOGY; TUMOR CELL LINE;

3-HYDROXYACYL COA DEHYDROGENASES; ACETYL-COA C-ACYLTRANSFERASE; ANTINEOPLASTIC AGENTS; CARBON-CARBON DOUBLE BOND ISOMERASES; CELL LINE, TUMOR; CYCLOSPORINS; DAUNORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENOYL-COA HYDRATASE; FATTY ACIDS; GLUTAMINE; GLYCOLYSIS; HUMANS; LEUKEMIA; METABOLOME; OXIDATION-REDUCTION; P-GLYCOPROTEIN; PANTOTHENIC ACID; PERHEXILINE; RACEMASES AND EPIMERASES; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84925834424     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.618769     Document Type: Article

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