메뉴 건너뛰기




Volumn 22, Issue 4, 2012, Pages 547-560

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CARBON; GLUTATHIONE;

EID: 84867595989     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2012.08.014     Document Type: Article
Times cited : (399)

References (45)
  • 1
    • 23744450399 scopus 로고    scopus 로고
    • Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach
    • Abramson J.S., Shipp M.A. Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood 2005, 106:1164-1174.
    • (2005) Blood , vol.106 , pp. 1164-1174
    • Abramson, J.S.1    Shipp, M.A.2
  • 3
    • 78649891511 scopus 로고    scopus 로고
    • Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis
    • Barger J.F., Plas D.R. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis. Endocr. Relat. Cancer 2010, 17:R287-R304.
    • (2010) Endocr. Relat. Cancer , vol.17
    • Barger, J.F.1    Plas, D.R.2
  • 4
    • 53149098608 scopus 로고    scopus 로고
    • Potential of peroxisome proliferator-activated receptor gamma antagonist compounds as therapeutic agents for a wide range of cancer types
    • Burton J.D., Goldenberg D.M., Blumenthal R.D. Potential of peroxisome proliferator-activated receptor gamma antagonist compounds as therapeutic agents for a wide range of cancer types. PPAR Res. 2008, 2008:494161.
    • (2008) PPAR Res. , vol.2008 , pp. 494161
    • Burton, J.D.1    Goldenberg, D.M.2    Blumenthal, R.D.3
  • 5
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068. Cancer Genome Atlas Research Network.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 6
  • 7
    • 35648942133 scopus 로고    scopus 로고
    • 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease
    • Choe L., D'Ascenzo M., Relkin N.R., Pappin D., Ross P., Williamson B., Guertin S., Pribil P., Lee K.H. 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease. Proteomics 2007, 7:3651-3660.
    • (2007) Proteomics , vol.7 , pp. 3651-3660
    • Choe, L.1    D'Ascenzo, M.2    Relkin, N.R.3    Pappin, D.4    Ross, P.5    Williamson, B.6    Guertin, S.7    Pribil, P.8    Lee, K.H.9
  • 11
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis R.J., Mancuso A., Daikhin E., Nissim I., Yudkoff M., Wehrli S., Thompson C.B. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. USA 2007, 104:19345-19350.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 12
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 13
    • 33744462050 scopus 로고    scopus 로고
    • Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • Doughty C.A., Bleiman B.F., Wagner D.J., Dufort F.J., Mataraza J.M., Roberts M.F., Chiles T.C. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 2006, 107:4458-4465.
    • (2006) Blood , vol.107 , pp. 4458-4465
    • Doughty, C.A.1    Bleiman, B.F.2    Wagner, D.J.3    Dufort, F.J.4    Mataraza, J.M.5    Roberts, M.F.6    Chiles, T.C.7
  • 14
    • 0023584209 scopus 로고
    • Evaluation of inhibitors of fatty acid oxidation in rat myocytes
    • El-Aleem S.A., Schulz H. Evaluation of inhibitors of fatty acid oxidation in rat myocytes. Biochem. Pharmacol. 1987, 36:4307-4312.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 4307-4312
    • El-Aleem, S.A.1    Schulz, H.2
  • 15
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • Fan T.W., Lane A.N., Higashi R.M., Farag M.A., Gao H., Bousamra M., Miller D.M. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009, 8:41.
    • (2009) Mol. Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 16
    • 73349104435 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation
    • Garcia-Bates T.M., Baglole C.J., Bernard M.P., Murant T.I., Simpson-Haidaris P.J., Phipps R.P. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J. Immunol. 2009, 183:6903-6912.
    • (2009) J. Immunol. , vol.183 , pp. 6903-6912
    • Garcia-Bates, T.M.1    Baglole, C.J.2    Bernard, M.P.3    Murant, T.I.4    Simpson-Haidaris, P.J.5    Phipps, R.P.6
  • 17
    • 0037093411 scopus 로고    scopus 로고
    • Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
    • Guppy M., Leedman P., Zu X., Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem. J. 2002, 364:309-315.
    • (2002) Biochem. J. , vol.364 , pp. 309-315
    • Guppy, M.1    Leedman, P.2    Zu, X.3    Russell, V.4
  • 19
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol W.H., Bounds P.L., Dang C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 2011, 11:325-337.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 20
    • 33748438978 scopus 로고    scopus 로고
    • Redox regulation of endogenous substrate oxidation by cardiac mitochondria
    • Korge P., Weiss J.N. Redox regulation of endogenous substrate oxidation by cardiac mitochondria. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H1436-H1445.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Korge, P.1    Weiss, J.N.2
  • 21
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 2005, 5:251-262.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 251-262
    • Küppers, R.1
  • 23
    • 18844467411 scopus 로고    scopus 로고
    • T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
    • Lee G., Elwood F., McNally J., Weiszmann J., Lindstrom M., Amaral K., Nakamura M., Miao S., Cao P., Learned R.M., et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J. Biol. Chem. 2002, 277:19649-19657.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19649-19657
    • Lee, G.1    Elwood, F.2    McNally, J.3    Weiszmann, J.4    Lindstrom, M.5    Amaral, K.6    Nakamura, M.7    Miao, S.8    Cao, P.9    Learned, R.M.10
  • 25
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • Lenz G., Staudt L.M. Aggressive lymphomas. N. Engl. J. Med. 2010, 362:1417-1429.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 27
    • 84862016091 scopus 로고    scopus 로고
    • Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    • Marin-Valencia I., Yang C., Mashimo T., Cho S., Baek H., Yang X.L., Rajagopalan K.N., Maddie M., Vemireddy V., Zhao Z., et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab. 2012, 15:827-837.
    • (2012) Cell Metab. , vol.15 , pp. 827-837
    • Marin-Valencia, I.1    Yang, C.2    Mashimo, T.3    Cho, S.4    Baek, H.5    Yang, X.L.6    Rajagopalan, K.N.7    Maddie, M.8    Vemireddy, V.9    Zhao, Z.10
  • 28
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry J.D., Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 1997, 244:1-14.
    • (1997) Eur. J. Biochem. , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 29
    • 84866028455 scopus 로고    scopus 로고
    • Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B-cell lymphoma
    • Monti S., Chapuy B., Takeyama K., Rodig S., Hao Y., Yeda K., Inguilizian H., Mermel C., Curie T., Dogan A., et al. Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B-cell lymphoma. Cancer Cell 2012, 22:359-372.
    • (2012) Cancer Cell , vol.22 , pp. 359-372
    • Monti, S.1    Chapuy, B.2    Takeyama, K.3    Rodig, S.4    Hao, Y.5    Yeda, K.6    Inguilizian, H.7    Mermel, C.8    Curie, T.9    Dogan, A.10
  • 30
    • 20144382754 scopus 로고    scopus 로고
    • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
    • Monti S., Savage K.J., Kutok J.L., Feuerhake F., Kurtin P., Mihm M., Wu B., Pasqualucci L., Neuberg D., Aguiar R.C., et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005, 105:1851-1861.
    • (2005) Blood , vol.105 , pp. 1851-1861
    • Monti, S.1    Savage, K.J.2    Kutok, J.L.3    Feuerhake, F.4    Kurtin, P.5    Mihm, M.6    Wu, B.7    Pasqualucci, L.8    Neuberg, D.9    Aguiar, R.C.10
  • 32
    • 43549098260 scopus 로고    scopus 로고
    • The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    • Morrish F., Neretti N., Sedivy J.M., Hockenbery D.M. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle 2008, 7:1054-1066.
    • (2008) Cell Cycle , vol.7 , pp. 1054-1066
    • Morrish, F.1    Neretti, N.2    Sedivy, J.M.3    Hockenbery, D.M.4
  • 33
    • 0018424570 scopus 로고
    • Fatty acid oxidation to H2O by Ehrlich ascites carcinoma in mice
    • Ookhtens M., Baker N. Fatty acid oxidation to H2O by Ehrlich ascites carcinoma in mice. Cancer Res. 1979, 39:973-980.
    • (1979) Cancer Res. , vol.39 , pp. 973-980
    • Ookhtens, M.1    Baker, N.2
  • 34
    • 0021466891 scopus 로고
    • Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
    • Ookhtens M., Kannan R., Lyon I., Baker N. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am. J. Physiol. 1984, 247:R146-R153.
    • (1984) Am. J. Physiol. , vol.247
    • Ookhtens, M.1    Kannan, R.2    Lyon, I.3    Baker, N.4
  • 35
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • Pike L.S., Smift A.L., Croteau N.J., Ferrick D.A., Wu M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 2011, 1807:726-734.
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 726-734
    • Pike, L.S.1    Smift, A.L.2    Croteau, N.J.3    Ferrick, D.A.4    Wu, M.5
  • 36
    • 33847674920 scopus 로고    scopus 로고
    • Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas
    • Polo J.M., Juszczynski P., Monti S., Cerchietti L., Ye K., Greally J.M., Shipp M., Melnick A. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc. Natl. Acad. Sci. USA 2007, 104:3207-3212.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3207-3212
    • Polo, J.M.1    Juszczynski, P.2    Monti, S.3    Cerchietti, L.4    Ye, K.5    Greally, J.M.6    Shipp, M.7    Melnick, A.8
  • 41
    • 77949967131 scopus 로고    scopus 로고
    • Targeting metabolic transformation for cancer therapy
    • Tennant D.A., Durán R.V., Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer 2010, 10:267-277.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 267-277
    • Tennant, D.A.1    Durán, R.V.2    Gottlieb, E.3
  • 42
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 43
    • 0043192901 scopus 로고    scopus 로고
    • A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
    • Wright G., Tan B., Rosenwald A., Hurt E.H., Wiestner A., Staudt L.M. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA 2003, 100:9991-9996.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9991-9996
    • Wright, G.1    Tan, B.2    Rosenwald, A.3    Hurt, E.H.4    Wiestner, A.5    Staudt, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.