Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Molecular Cell

Volumn 59, Issue 2, 2015, Pages 285-297

  Egan, Daniel F ^a   Chun, Matthew G H ^a   Vamos, Mitchell ^c   Zou, Haixia ^c   Rong, Juan ^c   Miller, Chad J ^d   Lou, Hua Jane ^d   Raveendra Panickar, Dhanya ^c   Yang, Chih Cheng ^c   Sheffler, Douglas J ^c   Teriete, Peter ^c   Asara, John M ^e,f   Turk, Benjamin E ^d   Cosford, Nicholas D P ^c   Shaw, Reuben J ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c BURNHAM INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SBI 0206965; ULK1 PROTEIN; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; RECOMBINANT PROTEIN; SBI-0206965; SIGNAL PEPTIDE; SMALL INTERFERING RNA; ULK1 PROTEIN, HUMAN; ULK1 PROTEIN, MOUSE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; PEPTIDE LIBRARY; PROTEIN ANALYSIS; TUMOR CELL; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; CONSENSUS SEQUENCE; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE; PHOSPHORYLATION; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; AUTOPHAGY; BENZAMIDES; CATALYTIC DOMAIN; CELL SURVIVAL; CELLS, CULTURED; CONSENSUS SEQUENCE; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY;

EID: 84937523899     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.05.031     Document Type: Article

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