A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Nature Medicine

Volumn 18, Issue 9, 2012, Pages 1350-1358

  Ito, Keisuke ^a,f,g   Carracedo, Arkaitz ^a,f,g,h   Weiss, Dror ^a   Arai, Fumio ^b   Ala, Ugo ^a   Avigan, David E ^a   Schafer, Zachary T ^c   Evans, Ronald M ^d   Suda, Toshio ^b   Lee, Chih Hao ^e   Pandolfi, Pier Paolo ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g CIC BIOGUNE   (Spain)

^h BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; EPOXIDE; ETOMOXIR; FATTY ACID; NUCLEAR PROTEIN; PML PROTEIN, MOUSE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DIVISION; CONTROLLED STUDY; FATTY ACID OXIDATION; FEMALE; GENE DELETION; HEMATOPOIETIC STEM CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CLONOGENIC ASSAY; DRUG EFFECT; DRUG POTENTIATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIVISION; COLONY-FORMING UNITS ASSAY; EPOXY COMPOUNDS; FATTY ACIDS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOPOIETIC STEM CELLS; IMMUNOPRECIPITATION; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; OXIDATION-REDUCTION; PPAR DELTA; REAL-TIME POLYMERASE CHAIN REACTION; THIAZOLES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84868632060     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2882     Document Type: Article

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