-
1
-
-
0029870954
-
The war on cancer
-
Sporn,M.B. (1996) The war on cancer. Lancet, 347, 1377-1381.
-
(1996)
Lancet
, vol.347
, pp. 1377-1381
-
-
Sporn, M.B.1
-
2
-
-
84891585156
-
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ.
-
(2012)
-
-
Seyfried, T.N.1
-
3
-
-
0038481970
-
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
-
Fidler,I.J. (2003) The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat. Rev. Cancer, 3, 453-458.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 453-458
-
-
Fidler, I.J.1
-
4
-
-
77950020483
-
What are the hallmarks of cancer?
-
Lazebnik,Y. (2010) What are the hallmarks of cancer? Nat. Rev. Cancer, 10, 232-233.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 232-233
-
-
Lazebnik, Y.1
-
5
-
-
79952068436
-
Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance
-
Tarin,D. (2011) Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance. Semin. Cancer Biol., 21, 72-82.
-
(2011)
Semin. Cancer Biol.
, vol.21
, pp. 72-82
-
-
Tarin, D.1
-
6
-
-
84895815139
-
Confusion surrounds the origin of cancer
-
In Cancer As a Metabolic Disease: On the Origin Management, and Prevention of Cancer, John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Confusion surrounds the origin of cancer. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 15-29.
-
(2012)
, pp. 15-29
-
-
Seyfried, T.N.1
-
7
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan,D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
-
8
-
-
34848857387
-
Paradoxes in carcinogenesis: new opportunities for research directions
-
Baker,S.G. et al. (2007) Paradoxes in carcinogenesis: new opportunities for research directions. BMC Cancer, 7, 151.
-
(2007)
BMC Cancer
, vol.7
, pp. 151
-
-
Baker, S.G.1
-
9
-
-
7044264244
-
The somatic mutation theory of cancer: growing problems with the paradigm?
-
Soto,A.M. et al. (2004) The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays, 26, 1097-1107.
-
(2004)
Bioessays
, vol.26
, pp. 1097-1107
-
-
Soto, A.M.1
-
10
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein,B. et al. (2013) Cancer genome landscapes. Science, 339, 1546-1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
11
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov,L.B. et al. (2013) Signatures of mutational processes in human cancer. Nature, 500, 415-421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
12
-
-
84858726938
-
Is systems biology a promising approach to resolve controversies in cancer research?
-
Soto,A.M. et al. (2012) Is systems biology a promising approach to resolve controversies in cancer research? Cancer Cell Int., 12, 12.
-
(2012)
Cancer Cell Int.
, vol.12
, pp. 12
-
-
Soto, A.M.1
-
13
-
-
84862211488
-
Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
-
Seyfried,T.N. et al. (2012) Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res., 100, 310-326.
-
(2012)
Epilepsy Res.
, vol.100
, pp. 310-326
-
-
Seyfried, T.N.1
-
14
-
-
84895821101
-
Cancer as a metabolic disease: implications for novel therapeutics
-
Seyfried,T.N. (2013) Cancer as a metabolic disease: implications for novel therapeutics. Amer. Assoc. Cancer Res. Education Book, 2013, 31-36.
-
(2013)
Amer. Assoc. Cancer Res. Education Book
, vol.2013
, pp. 31-36
-
-
Seyfried, T.N.1
-
15
-
-
79955598077
-
Metabolic management of brain cancer
-
Seyfried,T.N. et al. (2011) Metabolic management of brain cancer. Biochim. Biophys. Acta, 1807, 577-594.
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 577-594
-
-
Seyfried, T.N.1
-
16
-
-
27744502691
-
Targeting energy metabolism in brain cancer: review and hypothesis
-
Seyfried,T.N. et al. (2005) Targeting energy metabolism in brain cancer: review and hypothesis. Nutr. Metab. (Lond)., 2, 30.
-
(2005)
Nutr. Metab. (Lond).
, vol.2
, pp. 30
-
-
Seyfried, T.N.1
-
17
-
-
77649277719
-
Cancer as a metabolic disease
-
Seyfried,T.N. et al. (2010) Cancer as a metabolic disease. Nutr. Metab. (Lond)., 7, 7.
-
(2010)
Nutr. Metab. (Lond).
, vol.7
, pp. 7
-
-
Seyfried, T.N.1
-
18
-
-
84920124904
-
Genes respiration, viruses, and cancer
-
In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer, John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Genes, respiration, viruses, and cancer. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 145-176.
-
(2012)
, pp. 145-176
-
-
Seyfried, T.N.1
-
19
-
-
79953158399
-
Exploring the genomes of cancer cells: progress and promise
-
Stratton,M.R. (2011) Exploring the genomes of cancer cells: progress and promise. Science, 331, 1553-1558.
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
20
-
-
84895834658
-
Nothing in cancer biology makes sense except in the light of evolution
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Nothing in cancer biology makes sense except in the light of evolution. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 261-275.
-
(2012)
Cancer As a Metabolic Disease: On the Origin Management, and Prevention of Cancer
, pp. 261-275
-
-
Seyfried, T.N.1
-
21
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell,P.C. (1976) The clonal evolution of tumor cell populations. Science, 194, 23-28.
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
22
-
-
78650382003
-
Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
-
Fojo,T. et al. (2010) Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin. Cancer Res., 16, 5972-5980.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5972-5980
-
-
Fojo, T.1
-
23
-
-
67649431893
-
Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
-
Rosell,R. et al. (2009) Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS One, 4, e5133.
-
(2009)
PLoS One
, vol.4
-
-
Rosell, R.1
-
24
-
-
84875485693
-
Cancer pharmacogenomics: early promise, but concerted effort needed
-
McLeod,H.L. (2013) Cancer pharmacogenomics: early promise, but concerted effort needed. Science, 339, 1563-1566.
-
(2013)
Science
, vol.339
, pp. 1563-1566
-
-
McLeod, H.L.1
-
25
-
-
28444486962
-
Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors
-
Hardy,P.A. et al. (2005) Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors. Cell Biol. Int., 29, 983-992.
-
(2005)
Cell Biol. Int.
, vol.29
, pp. 983-992
-
-
Hardy, P.A.1
-
26
-
-
0037805151
-
Untangling the roots of cancer
-
Gibbs,W.W. (2003) Untangling the roots of cancer. Sci. Am., 289, 56-65.
-
(2003)
Sci. Am.
, vol.289
, pp. 56-65
-
-
Gibbs, W.W.1
-
27
-
-
7544220203
-
A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation
-
Hameroff,S.R. (2004) A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation. Biosystems., 77, 119-136.
-
(2004)
Biosystems.
, vol.77
, pp. 119-136
-
-
Hameroff, S.R.1
-
28
-
-
0030800338
-
The quest by three giants of science for an understanding of cancer
-
Manchester,K. (1997) The quest by three giants of science for an understanding of cancer. Endeavour, 21, 72-76.
-
(1997)
Endeavour
, vol.21
, pp. 72-76
-
-
Manchester, K.1
-
29
-
-
0002431372
-
Theodor Boveri and his book on the problem of the origin of malignant tumors
-
In German, J. (ed.) John Wiley & Sons, New York
-
Wolf,U. (1974) Theodor Boveri and his book, on the problem of the origin of malignant tumors. In German,J. (ed.) Chromosomes and Cancer, John Wiley & Sons, New York, pp. 1-20.
-
(1974)
Chromosomes and Cancer
, pp. 1-20
-
-
Wolf, U.1
-
30
-
-
0033815915
-
Aneuploidy, the somatic mutation that makes cancer a species of its own
-
Duesberg,P. et al. (2000) Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil. Cytoskeleton, 47, 81-107.
-
(2000)
Cell Motil. Cytoskeleton
, vol.47
, pp. 81-107
-
-
Duesberg, P.1
-
31
-
-
75749100093
-
Mutational heterogeneity in human cancers: origin and consequences
-
Salk,J.J. et al. (2010) Mutational heterogeneity in human cancers: origin and consequences. Annu. Rev. Pathol., 5, 51-75.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 51-75
-
-
Salk, J.J.1
-
32
-
-
0019470362
-
The origin of human cancers
-
Cairns,J. (1981) The origin of human cancers. Nature, 289, 353-357.
-
(1981)
Nature
, vol.289
, pp. 353-357
-
-
Cairns, J.1
-
33
-
-
0035870243
-
A mutator phenotype in cancer
-
Loeb,L.A. (2001) A mutator phenotype in cancer. Cancer Res., 61, 3230-3239.
-
(2001)
Cancer Res.
, vol.61
, pp. 3230-3239
-
-
Loeb, L.A.1
-
34
-
-
84965831960
-
Somatic mutations as a factor in the production of cancer; a critical review of von Hansemanns's theory of anaplasia in light of modern knowledge of genetics
-
Whitman,R.C. (1919) Somatic mutations as a factor in the production of cancer; a critical review of von Hansemanns's theory of anaplasia in light of modern knowledge of genetics. J. Cancer Res., 4, 181-202.
-
(1919)
J. Cancer Res.
, vol.4
, pp. 181-202
-
-
Whitman, R.C.1
-
35
-
-
0024387728
-
Mutations in the p53 gene occur in diverse human tumour types
-
Nigro,J.M. et al. (1989) Mutations in the p53 gene occur in diverse human tumour types. Nature, 342, 705-708.
-
(1989)
Nature
, vol.342
, pp. 705-708
-
-
Nigro, J.M.1
-
36
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon,E.R. et al. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
-
37
-
-
0037157786
-
Cancer genetics
-
Knudson,A.G. (2002) Cancer genetics. Am. J. Med. Genet., 111, 96-102.
-
(2002)
Am. J. Med. Genet.
, vol.111
, pp. 96-102
-
-
Knudson, A.G.1
-
38
-
-
0033093982
-
Anecdotal, historical and critical commentaries on genetics, Rudolph Virchow and the genetic basis of somatic ecology
-
Wagner,R.P. (1999) Anecdotal, historical and critical commentaries on genetics. Rudolph Virchow and the genetic basis of somatic ecology. Genetics, 151, 917-920.
-
(1999)
Genetics
, vol.151
, pp. 917-920
-
-
Wagner, R.P.1
-
39
-
-
0005607487
-
The plasmagene theory of the origin of cancer
-
Darlington,C.D. (1948) The plasmagene theory of the origin of cancer. Br. J. Cancer, 2, 118-126.
-
(1948)
Br. J. Cancer
, vol.2
, pp. 118-126
-
-
Darlington, C.D.1
-
40
-
-
0019956116
-
Suppression of tumorigenicity in interspecific reconstituted cells and cybrids
-
Koura,M. et al. (1982) Suppression of tumorigenicity in interspecific reconstituted cells and cybrids. Gann, 73, 574-580.
-
(1982)
Gann
, vol.73
, pp. 574-580
-
-
Koura, M.1
-
41
-
-
0023412031
-
Cytoplasmic suppression of malignancy
-
Israel,B.A. et al. (1987) Cytoplasmic suppression of malignancy. In Vitro Cell. Dev. Biol., 23, 627-632.
-
(1987)
Vitro Cell. Dev. Biol.
, vol.23
, pp. 627-632
-
-
Israel, B.A.1
-
42
-
-
0023878415
-
Cytoplasmic suppression of tumorigenicity in reconstructed mouse cells
-
Shay,J.W. et al. (1988) Cytoplasmic suppression of tumorigenicity in reconstructed mouse cells. Cancer Res., 48, 830-833.
-
(1988)
Cancer Res.
, vol.48
, pp. 830-833
-
-
Shay, J.W.1
-
43
-
-
0018193434
-
Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines
-
Howell,A.N. et al. (1978) Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines. Proc. Natl Acad. Sci. U. S. A., 75, 2358-2362.
-
(1978)
Proc. Natl Acad. Sci. U. S. A.
, vol.75
, pp. 2358-2362
-
-
Howell, A.N.1
-
44
-
-
0017366015
-
The analysis of malignancy by cell fusion, VIII. Evidence for the intervention of an extra-chromosomal element
-
Jonasson,J. et al. (1977) The analysis of malignancy by cell fusion. VIII. Evidence for the intervention of an extra-chromosomal element. J. Cell Sci., 24, 255-263.
-
(1977)
J. Cell Sci.
, vol.24
, pp. 255-263
-
-
Jonasson, J.1
-
45
-
-
0014690730
-
Transplantation of pluripotential nuclei from triploid frog tumors
-
McKinnell,R.G. et al. (1969) Transplantation of pluripotential nuclei from triploid frog tumors. Science, 165, 394-396.
-
(1969)
Science
, vol.165
, pp. 394-396
-
-
McKinnell, R.G.1
-
46
-
-
0345366593
-
Normal genetically mosaic mice produced from malignant teratocarcinoma cells
-
Mintz,B. et al. (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc. Natl Acad. Sci. U. S. A., 72, 3585-3589.
-
(1975)
Proc. Natl Acad. Sci. U. S. A.
, vol.72
, pp. 3585-3589
-
-
Mintz, B.1
-
47
-
-
0038277050
-
Mouse embryos cloned from brain tumors
-
Li,L. et al. (2003) Mouse embryos cloned from brain tumors. Cancer Res., 63, 2733-2736.
-
(2003)
Cancer Res.
, vol.63
, pp. 2733-2736
-
-
Li, L.1
-
48
-
-
3543073392
-
Reprogramming of a melanoma genome by nuclear transplantation
-
Hochedlinger,K. et al. (2004) Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev., 18, 1875-1885.
-
(2004)
Genes Dev.
, vol.18
, pp. 1875-1885
-
-
Hochedlinger, K.1
-
49
-
-
84895797086
-
Mitochondria: the ultimate tumor suppressor
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Mitochondria: the ultimate tumor suppressor. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 195-205.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 195-205
-
-
Seyfried, T.N.1
-
50
-
-
84877317238
-
Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways
-
Kaipparettu,B.A. et al. (2013) Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One, 8, e61747.
-
(2013)
PLoS One
, vol.8
-
-
Kaipparettu, B.A.1
-
51
-
-
84868205667
-
Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity
-
Elliott,R.L. et al. (2012) Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity. Breast Cancer Res. Treat., 136, 347-354.
-
(2012)
Breast Cancer Res. Treat.
, vol.136
, pp. 347-354
-
-
Elliott, R.L.1
-
52
-
-
0023764526
-
Cytoplasmic mediation of malignancy
-
Israel,B.A. et al. (1988) Cytoplasmic mediation of malignancy. In Vitro Cell. Dev. Biol., 24, 487-490.
-
(1988)
Vitro Cell. Dev. Biol.
, vol.24
, pp. 487-490
-
-
Israel, B.A.1
-
53
-
-
20044364344
-
mtDNA mutations increase tumorigenicity in prostate cancer
-
Petros,J.A. et al. (2005) mtDNA mutations increase tumorigenicity in prostate cancer. Proc. Natl Acad. Sci. U. S. A., 102, 719-724.
-
(2005)
Proc. Natl Acad. Sci. U. S. A.
, vol.102
, pp. 719-724
-
-
Petros, J.A.1
-
55
-
-
12444279265
-
On the origin of cancer cells
-
Warburg,O. (1956) On the origin of cancer cells. Science, 123, 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
56
-
-
35448964610
-
Warburg, me and hexokinase 2: multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
-
Pedersen,P.L. (2007) Warburg, me and hexokinase 2: multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J. Bioenerg. Biomembr., 39, 211-222.
-
(2007)
J. Bioenerg. Biomembr.
, vol.39
, pp. 211-222
-
-
Pedersen, P.L.1
-
57
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg,O. (1956) On respiratory impairment in cancer cells. Science, 124, 269-270.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
58
-
-
84895804006
-
-
Revidsed Lindau lectures: the prime cause of cancer and prevention - Parts 1 & 2. In Burk,D. (ed.) Meeting of the Nobel-Laureates. K.Triltsch, Lindau, Lake Constance, Germany.
-
Warburg,O. (1969) Revidsed Lindau lectures: the prime cause of cancer and prevention - Parts 1 & 2. In Burk,D. (ed.) Meeting of the Nobel-Laureates. K.Triltsch, Lindau, Lake Constance, Germany.
-
(1969)
-
-
Warburg, O.1
-
59
-
-
0015251175
-
Bioenergetics and the problem of tumor growth
-
Racker,E. (1972) Bioenergetics and the problem of tumor growth. Am. Sci., 60, 56-63.
-
(1972)
Am. Sci.
, vol.60
, pp. 56-63
-
-
Racker, E.1
-
60
-
-
84895810013
-
-
Lehninger Principles of Biochemistry W. H. Freeman, New York.
-
Nelson,D.L. et al. (2008) Lehninger Principles of Biochemistry W. H. Freeman, New York.
-
(2008)
-
-
Nelson, D.L.1
-
61
-
-
0037112360
-
The bioenergetic signature of cancer: a marker of tumor progression
-
Cuezva,J.M. et al. (2002) The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res., 62, 6674-6681.
-
(2002)
Cancer Res.
, vol.62
, pp. 6674-6681
-
-
Cuezva, J.M.1
-
62
-
-
77950023401
-
Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism
-
Acebo,P. et al. (2009) Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism. Transl. Oncol., 2, 138-145.
-
(2009)
Transl. Oncol.
, vol.2
, pp. 138-145
-
-
Acebo, P.1
-
63
-
-
11444255268
-
On respiratory impairment in cancer cells
-
Weinhouse,S. (1956) On respiratory impairment in cancer cells. Science, 124, 267-269.
-
(1956)
Science
, vol.124
, pp. 267-269
-
-
Weinhouse, S.1
-
64
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol,W.H. et al. (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer, 11, 325-337.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
-
65
-
-
33744919270
-
Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise
-
Stellingwerff,T. et al. (2006) Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise. Am. J. Physiol. Endocrinol. Metab., 290, E1180-E1190.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.290
-
-
Stellingwerff, T.1
-
66
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby,R.A. et al. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer, 4, 891-899.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
-
67
-
-
0017841405
-
Tumor mitochondria and the bioenergetics of cancer cells
-
Pedersen,P.L. (1978) Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res., 22, 190-274.
-
(1978)
Prog. Exp. Tumor Res.
, vol.22
, pp. 190-274
-
-
Pedersen, P.L.1
-
68
-
-
11144350253
-
ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells
-
Chevrollier,A. et al. (2005) ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells. Mol. Carcinog., 42, 1-8.
-
(2005)
Mol. Carcinog.
, vol.42
, pp. 1-8
-
-
Chevrollier, A.1
-
69
-
-
0024421922
-
Studies on the formation of lactate and pyruvate from glucose in cultured skin fibroblasts: implications for detection of respiratory chain defects
-
Wijburg,F.A. et al. (1989) Studies on the formation of lactate and pyruvate from glucose in cultured skin fibroblasts: implications for detection of respiratory chain defects. Biochem. Int., 19, 563-570.
-
(1989)
Biochem. Int.
, vol.19
, pp. 563-570
-
-
Wijburg, F.A.1
-
70
-
-
0034800367
-
Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells
-
Tiefenthaler,M. et al. (2001) Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells. Br. J. Haematol., 114, 574-580.
-
(2001)
Br. J. Haematol.
, vol.114
, pp. 574-580
-
-
Tiefenthaler, M.1
-
71
-
-
0017087846
-
Energy metabolism in respiration-deficient and wild type Chinese hamster fibroblasts in culture
-
Donnelly,M. et al. (1976) Energy metabolism in respiration-deficient and wild type Chinese hamster fibroblasts in culture. J. Cell. Physiol., 89, 39-51.
-
(1976)
J. Cell. Physiol.
, vol.89
, pp. 39-51
-
-
Donnelly, M.1
-
72
-
-
84864876566
-
Seeing the Warburg effect in the developing retina
-
Fiske,B.P. et al. (2012) Seeing the Warburg effect in the developing retina. Nat. Cell Biol., 14, 790-791.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 790-791
-
-
Fiske, B.P.1
-
73
-
-
0026009448
-
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation
-
Prichard,J. et al. (1991) Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proc. Natl Acad. Sci. U. S. A., 88, 5829-5831.
-
(1991)
Proc. Natl Acad. Sci. U. S. A.
, vol.88
, pp. 5829-5831
-
-
Prichard, J.1
-
74
-
-
0023780085
-
Nonoxidative glucose consumption during focal physiologic neural activity
-
Fox,P.T. et al. (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science, 241, 462-464.
-
(1988)
Science
, vol.241
, pp. 462-464
-
-
Fox, P.T.1
-
75
-
-
0000087629
-
Myocardial lactate and pyruvate metabolism
-
Krasnow,N. et al. (1962) Myocardial lactate and pyruvate metabolism. J. Clin. Invest., 41, 2075-2085.
-
(1962)
J. Clin. Invest.
, vol.41
, pp. 2075-2085
-
-
Krasnow, N.1
-
76
-
-
11444255268
-
On respiratory impairment in cancer cells
-
Burk,D. et al. (1956) On respiratory impairment in cancer cells. Science, 124, 270-272.
-
(1956)
Science
, vol.124
, pp. 270-272
-
-
Burk, D.1
-
77
-
-
0014098391
-
On the significance of glucolysis for cancer growth, with special reference to Morris rat hepatomas
-
Burk,D. et al. (1967) On the significance of glucolysis for cancer growth, with special reference to Morris rat hepatomas. J. Natl Cancer Inst., 38, 839-863.
-
(1967)
J. Natl Cancer Inst.
, vol.38
, pp. 839-863
-
-
Burk, D.1
-
78
-
-
84862774556
-
Availability, not respiratory capacity governs oxygen consumption of solid tumors
-
Vaupel,P. et al. (2012) Availability, not respiratory capacity governs oxygen consumption of solid tumors. Int. J. Biochem. Cell Biol., 44, 1477-1481.
-
(2012)
Int. J. Biochem. Cell Biol.
, vol.44
, pp. 1477-1481
-
-
Vaupel, P.1
-
79
-
-
33847367741
-
Energy metabolism in tumor cells
-
Moreno-Sánchez,R. et al. (2007) Energy metabolism in tumor cells. FEBS J., 274, 1393-1418.
-
(2007)
FEBS J.
, vol.274
, pp. 1393-1418
-
-
Moreno-Sánchez, R.1
-
80
-
-
84876436850
-
Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF
-
Haq,R. et al. (2013) Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF. Cancer Cell, 23, 302-315.
-
(2013)
Cancer Cell
, vol.23
, pp. 302-315
-
-
Haq, R.1
-
82
-
-
78249286217
-
Cancer metabolism: the Warburg effect today
-
Ferreira,L.M. (2010) Cancer metabolism: the Warburg effect today. Exp. Mol. Pathol., 89, 372-380.
-
(2010)
Exp. Mol. Pathol.
, vol.89
, pp. 372-380
-
-
Ferreira, L.M.1
-
83
-
-
84879187712
-
Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E) BRAF oncogene
-
Hall,A. et al. (2013) Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E) BRAF oncogene. Oncotarget, 4, 584-599.
-
(2013)
Oncotarget
, vol.4
, pp. 584-599
-
-
Hall, A.1
-
85
-
-
85013685080
-
Is respiration normal in cancer cells?
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Is respiration normal in cancer cells? In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 119-132.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 119-132
-
-
Seyfried, T.N.1
-
86
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan,A. et al. (2005) Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl Acad. Sci. U. S. A., 102, 5992-5997.
-
(2005)
Proc. Natl Acad. Sci. U. S. A.
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
-
87
-
-
84895821359
-
Is mitochondrial glutamine fermentation a missing link in the metabolic theory of cancer?
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Is mitochondrial glutamine fermentation a missing link in the metabolic theory of cancer? In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 133-144.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 133-144
-
-
Seyfried, T.N.1
-
88
-
-
77954429761
-
Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation
-
Chinopoulos,C. et al. (2010) Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation. FASEB J., 24, 2405-2416.
-
(2010)
FASEB J.
, vol.24
, pp. 2405-2416
-
-
Chinopoulos, C.1
-
89
-
-
70350710639
-
Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism
-
Phillips,D. et al. (2009) Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism. Biochemistry, 48, 7140-7149.
-
(2009)
Biochemistry
, vol.48
, pp. 7140-7149
-
-
Phillips, D.1
-
90
-
-
24744444959
-
Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast
-
Schwimmer,C. et al. (2005) Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast. J. Biol. Chem., 280, 30751-30759.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 30751-30759
-
-
Schwimmer, C.1
-
91
-
-
84895781457
-
Respiratory dysfunction in cancer cells
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Respiratory dysfunction in cancer cells. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 73-105.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 73-105
-
-
Seyfried, T.N.1
-
92
-
-
79955630003
-
Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment
-
Arismendi-Morillo,G. (2011) Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment. Biochim. Biophys. Acta, 1807, 602-608.
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 602-608
-
-
Arismendi-Morillo, G.1
-
93
-
-
68949086533
-
Electron microscopy morphology of the mitochondrial network in human cancer
-
Arismendi-Morillo,G. (2009) Electron microscopy morphology of the mitochondrial network in human cancer. Int. J. Biochem. Cell Biol., 41, 2062-2068.
-
(2009)
Int. J. Biochem. Cell Biol.
, vol.41
, pp. 2062-2068
-
-
Arismendi-Morillo, G.1
-
94
-
-
38849191108
-
Ultrastructural mitochondrial pathology in human astrocytic tumors: potentials implications pro-therapeutics strategies
-
Arismendi-Morillo,G.J. et al. (2008) Ultrastructural mitochondrial pathology in human astrocytic tumors: potentials implications pro-therapeutics strategies. J. Electron Microsc. (Tokyo)., 57, 33-39.
-
(2008)
J. Electron Microsc. (Tokyo).
, vol.57
, pp. 33-39
-
-
Arismendi-Morillo, G.J.1
-
95
-
-
77649338652
-
Mitochondrial gateways to cancer
-
Galluzzi,L. et al. (2010) Mitochondrial gateways to cancer. Mol. Aspects Med., 31, 1-20.
-
(2010)
Mol. Aspects Med.
, vol.31
, pp. 1-20
-
-
Galluzzi, L.1
-
96
-
-
77950299725
-
In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours
-
Kiebish,M.A. et al. (2009) In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours. ASN Neuro, 1, e00011.
-
(2009)
ASN Neuro
, vol.1
-
-
Kiebish, M.A.1
-
97
-
-
55349102294
-
Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer
-
Kiebish,M.A. et al. (2008) Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J. Lipid Res., 49, 2545-2556.
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2545-2556
-
-
Kiebish, M.A.1
-
98
-
-
84865988105
-
The bio-energetic theory of carcinogenesis
-
Gonzalez,M.J. et al. (2012) The bio-energetic theory of carcinogenesis. Med. Hypotheses, 79, 433-439.
-
(2012)
Med. Hypotheses
, vol.79
, pp. 433-439
-
-
Gonzalez, M.J.1
-
99
-
-
51749084230
-
Ultrastructure of the mitochondrion and its bearing on function and bioenergetics
-
Benard,G. et al. (2008) Ultrastructure of the mitochondrion and its bearing on function and bioenergetics. Antioxid. Redox Signal., 10, 1313-1342.
-
(2008)
Antioxid. Redox Signal.
, vol.10
, pp. 1313-1342
-
-
Benard, G.1
-
100
-
-
79959341007
-
Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication
-
Shapovalov,Y. et al. (2011) Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J. Biol. Chem., 286, 22331-22338.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22331-22338
-
-
Shapovalov, Y.1
-
101
-
-
33746872880
-
Mitochondria and cancer: is there a morphological connection?
-
Alirol,E. et al. (2006) Mitochondria and cancer: is there a morphological connection? Oncogene, 25, 4706-4716.
-
(2006)
Oncogene
, vol.25
, pp. 4706-4716
-
-
Alirol, E.1
-
102
-
-
0030763027
-
Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure
-
Oudard,S. et al. (1997) Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure. Anticancer Res., 17, 1903-1911.
-
(1997)
Anticancer Res.
, vol.17
, pp. 1903-1911
-
-
Oudard, S.1
-
103
-
-
83255189409
-
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases
-
Wu,S.B. et al. (2012) AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim. Biophys. Acta, 1822, 233-247.
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 233-247
-
-
Wu, S.B.1
-
104
-
-
77953131908
-
Targeting mitochondria for cancer therapy
-
Fulda,S. et al. (2010) Targeting mitochondria for cancer therapy. Nat. Rev. Drug Discov., 9, 447-464.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 447-464
-
-
Fulda, S.1
-
105
-
-
79959341007
-
Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication
-
Shapovalov,Y. et al. (2011) Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J. Biol. Chem., 286, 22331-22338.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22331-22338
-
-
Shapovalov, Y.1
-
106
-
-
0004401731
-
Spectroscopic evidence of metabolic control
-
Chance,B. et al. (1959) Spectroscopic evidence of metabolic control. Science, 129, 700-708.
-
(1959)
Science
, vol.129
, pp. 700-708
-
-
Chance, B.1
-
107
-
-
67649733861
-
The status of Warburg's theory of glycolysis and respiration in tumors
-
Colowick,S.P. (1961) The status of Warburg's theory of glycolysis and respiration in tumors. Quart. Rev. Biol., 36, 273-276.
-
(1961)
Quart. Rev. Biol.
, vol.36
, pp. 273-276
-
-
Colowick, S.P.1
-
108
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns,R.A. et al. (2011) Regulation of cancer cell metabolism. Nat. Rev. Cancer, 11, 85-95.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
-
109
-
-
84858604270
-
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
-
Ward,P.S. et al. (2012) Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell, 21, 297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
-
110
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden,M.G. et al. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
-
111
-
-
0842325793
-
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
-
Rossignol,R. et al. (2004) Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res., 64, 985-993.
-
(2004)
Cancer Res.
, vol.64
, pp. 985-993
-
-
Rossignol, R.1
-
112
-
-
79955581213
-
Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism
-
Chevrollier,A. et al. (2011) Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism. Biochim. Biophys. Acta, 1807, 562-567.
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 562-567
-
-
Chevrollier, A.1
-
113
-
-
77649174549
-
Evidence for mitochondrial respiratory deficiency in rat rhabdomyosarcoma cells
-
Jahnke,V.E. et al. (2010) Evidence for mitochondrial respiratory deficiency in rat rhabdomyosarcoma cells. PLoS One, 5, e8637.
-
(2010)
PLoS One
, vol.5
-
-
Jahnke, V.E.1
-
114
-
-
84860595795
-
Composition of molecular cardiolipin species correlates with proliferation of lymphocytes
-
Schild,L. et al. (2012) Composition of molecular cardiolipin species correlates with proliferation of lymphocytes. Exp. Biol. Med. (Maywood)., 237, 372-379.
-
(2012)
Exp. Biol. Med. (Maywood).
, vol.237
, pp. 372-379
-
-
Schild, L.1
-
115
-
-
61749093672
-
Acidic lipids, H(+)-ATPases, and mechanism of oxidative phosphorylation, Physico-chemical ideas 30 years after P. Mitchell's Nobel Prize award
-
Kocherginsky,N. (2009) Acidic lipids, H(+)-ATPases, and mechanism of oxidative phosphorylation. Physico-chemical ideas 30 years after P. Mitchell's Nobel Prize award. Prog. Biophys. Mol. Biol., 99, 20-41.
-
(2009)
Prog. Biophys. Mol. Biol.
, vol.99
, pp. 20-41
-
-
Kocherginsky, N.1
-
116
-
-
84855581252
-
The complexity of cardiolipin in health and disease
-
Claypool,S.M. et al. (2012) The complexity of cardiolipin in health and disease. Trends Biochem. Sci., 37, 32-41.
-
(2012)
Trends Biochem. Sci.
, vol.37
, pp. 32-41
-
-
Claypool, S.M.1
-
117
-
-
0347694776
-
Cancer metabolism: facts, fantasy, and fiction
-
Zu,X.L. et al. (2004) Cancer metabolism: facts, fantasy, and fiction. Biochem. Biophys. Res. Commun., 313, 459-465.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
-
118
-
-
0017153683
-
Aerobic glycolysis during lymphocyte proliferation
-
Wang,T. et al. (1976) Aerobic glycolysis during lymphocyte proliferation. Nature, 261, 702-705.
-
(1976)
Nature
, vol.261
, pp. 702-705
-
-
Wang, T.1
-
119
-
-
80054046029
-
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
-
Lunt,S.Y. et al. (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol., 27, 441-464.
-
(2011)
Annu. Rev. Cell Dev. Biol.
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
-
120
-
-
78650722178
-
Anticancer drugs that target metabolism: is dichloroacetate the new paradigm?
-
Papandreou,I. et al. (2011) Anticancer drugs that target metabolism: is dichloroacetate the new paradigm? Int. J. Cancer, 128, 1001-1008.
-
(2011)
Int. J. Cancer
, vol.128
, pp. 1001-1008
-
-
Papandreou, I.1
-
121
-
-
84887168951
-
Metabolism of butter yellow rat liver cancers
-
Burk,D. et al. (1941) Metabolism of butter yellow rat liver cancers. Canc. Res., 1, 733-734.
-
(1941)
Canc. Res.
, vol.1
, pp. 733-734
-
-
Burk, D.1
-
122
-
-
0013847433
-
Effect of glucose administered in vivo or in vitro on the respiratory quotient of rat liver tissue after partial hepatectomy
-
Simek,J. et al. (1965) Effect of glucose administered in vivo or in vitro on the respiratory quotient of rat liver tissue after partial hepatectomy. Nature, 207, 761-762.
-
(1965)
Nature
, vol.207
, pp. 761-762
-
-
Simek, J.1
-
123
-
-
0015518729
-
[Cardiolipins of mitochondria and microsomes of Jensen's sarcoma]
-
Diatlovitskaia,E.V. et al. (1972) [Cardiolipins of mitochondria and microsomes of Jensen's sarcoma]. Dokl. Akad. Nauk SSSR, 206, 737-739.
-
(1972)
Dokl. Akad. Nauk SSSR
, vol.206
, pp. 737-739
-
-
Diatlovitskaia, E.V.1
-
124
-
-
0017227506
-
[Positional distribution of fatty acids in the phospholipids of regenerating rat liver]
-
Diatlovitskaia,E.V. et al. (1976) [Positional distribution of fatty acids in the phospholipids of regenerating rat liver]. Biokhimiia., 41, 538-542.
-
(1976)
Biokhimiia.
, vol.41
, pp. 538-542
-
-
Diatlovitskaia, E.V.1
-
125
-
-
0000089325
-
Observations on the carbohydrate metabolism of tumours
-
Crabtree,H.G. (1929) Observations on the carbohydrate metabolism of tumours. Biochem. J., 23, 536-545.
-
(1929)
Biochem. J.
, vol.23
, pp. 536-545
-
-
Crabtree, H.G.1
-
126
-
-
84873177341
-
Role of p90(RSK) in regulating the Crabtree effect: implications for cancer
-
Redman,E.K. et al. (2013) Role of p90(RSK) in regulating the Crabtree effect: implications for cancer. Biochem. Soc. Trans., 41, 124-126.
-
(2013)
Biochem. Soc. Trans.
, vol.41
, pp. 124-126
-
-
Redman, E.K.1
-
127
-
-
55249118618
-
Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?
-
Díaz-Ruiz,R. et al. (2008) Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction? J. Biol. Chem., 283, 26948-26955.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26948-26955
-
-
Díaz-Ruiz, R.1
-
128
-
-
79953684503
-
The Warburg and Crabtree effects: on the origin of cancer cell energy metabolism and of yeast glucose repression
-
Diaz-Ruiz,R. et al. (2011) The Warburg and Crabtree effects: on the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim. Biophys. Acta, 1807, 568-576.
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 568-576
-
-
Diaz-Ruiz, R.1
-
129
-
-
0029591465
-
Glutamine metabolism in AS-30D hepatoma cells, Evidence for its conversion into lipids via reductive carboxylation
-
Holleran,A.L. et al. (1995) Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem., 152, 95-101.
-
(1995)
Mol. Cell. Biochem.
, vol.152
, pp. 95-101
-
-
Holleran, A.L.1
-
130
-
-
84881329062
-
Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells
-
Fendt,S.M. et al. (2013) Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells. Nat. Commun., 4, 2236.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2236
-
-
Fendt, S.M.1
-
131
-
-
0348107409
-
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
-
Pollard,P.J. et al. (2003) The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase. Ann. Med., 35, 632-639.
-
(2003)
Ann. Med.
, vol.35
, pp. 632-639
-
-
Pollard, P.J.1
-
132
-
-
28544446058
-
Mitochondrial tumour suppressors: a genetic and biochemical update
-
Gottlieb,E. et al. (2005) Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer, 5, 857-866.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
-
133
-
-
84895787017
-
Cancer models
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Cancer models. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 31-46.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 31-46
-
-
Seyfried, T.N.1
-
134
-
-
0033038789
-
Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice
-
Ecsedy,J.A. et al. (1999) Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. J. Neurochem., 73, 254-259.
-
(1999)
J. Neurochem.
, vol.73
, pp. 254-259
-
-
Ecsedy, J.A.1
-
135
-
-
0032578387
-
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence
-
Chou,H.H. et al. (1998) A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc. Natl Acad. Sci. U. S. A., 95, 11751-11756.
-
(1998)
Proc. Natl Acad. Sci. U. S. A.
, vol.95
, pp. 11751-11756
-
-
Chou, H.H.1
-
136
-
-
13844267152
-
Human embryonic stem cells express an immunogenic nonhuman sialic acid
-
Martin,M.J. et al. (2005) Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat. Med., 11, 228-232.
-
(2005)
Nat. Med.
, vol.11
, pp. 228-232
-
-
Martin, M.J.1
-
137
-
-
0027275566
-
Physiological parameters in laboratory animals and humans
-
Davies,B. et al. (1993) Physiological parameters in laboratory animals and humans. Pharm. Res., 10, 1093-1095.
-
(1993)
Pharm. Res.
, vol.10
, pp. 1093-1095
-
-
Davies, B.1
-
138
-
-
33746336247
-
Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans
-
Mahoney,L.B. et al. (2006) Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids Health Dis., 5, 13.
-
(2006)
Lipids Health Dis.
, vol.5
, pp. 13
-
-
Mahoney, L.B.1
-
139
-
-
84861719757
-
Patient-derived tumour xenografts as models for oncology drug development
-
Tentler,J.J. et al. (2012) Patient-derived tumour xenografts as models for oncology drug development. Nat. Rev. Clin. Oncol., 9, 338-350.
-
(2012)
Nat. Rev. Clin. Oncol.
, vol.9
, pp. 338-350
-
-
Tentler, J.J.1
-
140
-
-
33747598510
-
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes
-
Chaparro,R.J. et al. (2006) Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc. Natl Acad. Sci. U. S. A., 103, 12475-12480.
-
(2006)
Proc. Natl Acad. Sci. U. S. A.
, vol.103
, pp. 12475-12480
-
-
Chaparro, R.J.1
-
141
-
-
84895781457
-
Mitochondrial respiratory dysfunction and the extrachromosomal origin of cancer
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Mitochondrial respiratory dysfunction and the extrachromosomal origin of cancer. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 253-259.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 253-259
-
-
Seyfried, T.N.1
-
142
-
-
84856595714
-
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
-
Hu,Y. et al. (2012) K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res., 22, 399-412.
-
(2012)
Cell Res.
, vol.22
, pp. 399-412
-
-
Hu, Y.1
-
143
-
-
84856609056
-
K-Ras and mitochondria: dangerous liaisons
-
Neuzil,J. et al. (2012) K-Ras and mitochondria: dangerous liaisons. Cell Res., 22, 285-287.
-
(2012)
Cell Res.
, vol.22
, pp. 285-287
-
-
Neuzil, J.1
-
145
-
-
56849131881
-
The cancer cell-leukocyte fusion theory of metastasis
-
Pawelek,J.M. et al. (2008) The cancer cell-leukocyte fusion theory of metastasis. Adv. Cancer Res., 101, 397-444.
-
(2008)
Adv. Cancer Res.
, vol.101
, pp. 397-444
-
-
Pawelek, J.M.1
-
146
-
-
84875360501
-
On the origin of cancer metastasis
-
Seyfried,T.N. et al. (2013) On the origin of cancer metastasis. Crit. Rev. Oncog., 18, 43-73.
-
(2013)
Crit. Rev. Oncog.
, vol.18
, pp. 43-73
-
-
Seyfried, T.N.1
-
147
-
-
79951825045
-
Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming
-
Powell,A.E. et al. (2011) Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res., 71, 1497-1505.
-
(2011)
Cancer Res.
, vol.71
, pp. 1497-1505
-
-
Powell, A.E.1
-
148
-
-
28044432759
-
Tumour-cell fusion as a source of myeloid traits in cancer
-
Pawelek,J.M. (2005) Tumour-cell fusion as a source of myeloid traits in cancer. Lancet Oncol., 6, 988-993.
-
(2005)
Lancet Oncol.
, vol.6
, pp. 988-993
-
-
Pawelek, J.M.1
-
149
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin,D. et al. (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science, 250, 1233-1238.
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
-
150
-
-
34547509586
-
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
-
Funes,J.M. et al. (2007) Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc. Natl Acad. Sci. U. S. A., 104, 6223-6228.
-
(2007)
Proc. Natl Acad. Sci. U. S. A.
, vol.104
, pp. 6223-6228
-
-
Funes, J.M.1
-
151
-
-
84880301631
-
Mitochondrial respiration protects against oxygen-associated DNA damage
-
Sung,H.J. et al. (2011) Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun, 1, 1-8.
-
(2011)
Nat Commun
, vol.1
, pp. 1-8
-
-
Sung, H.J.1
-
152
-
-
79961204091
-
p53, aerobic metabolism, and cancer
-
Lago,C.U. et al. (2011) p53, aerobic metabolism, and cancer. Antioxid. Redox Signal., 15, 1739-1748.
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 1739-1748
-
-
Lago, C.U.1
-
153
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba,S. et al. (2006) p53 regulates mitochondrial respiration. Science, 312, 1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
-
154
-
-
0037716990
-
Mitochondrial impairment in p53-deficient human cancer cells
-
Zhou,S. et al. (2003) Mitochondrial impairment in p53-deficient human cancer cells. Mutagenesis, 18, 287-292.
-
(2003)
Mutagenesis
, vol.18
, pp. 287-292
-
-
Zhou, S.1
-
155
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee,A.C. et al. (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem., 274, 7936-7940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
-
156
-
-
77952737658
-
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
-
Weinberg,F. et al. (2010) Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc. Natl Acad. Sci. U. S. A., 107, 8788-8793.
-
(2010)
Proc. Natl Acad. Sci. U. S. A.
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
-
157
-
-
77955967332
-
Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L)
-
Yang,D. et al. (2010) Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol. Ther., 9, 122-133.
-
(2010)
Cancer Biol. Ther.
, vol.9
, pp. 122-133
-
-
Yang, D.1
-
158
-
-
68949096538
-
Mitochondrial dysfunction contributes to oncogene-induced senescence
-
Moiseeva,O. et al. (2009) Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol. Cell. Biol., 29, 4495-4507.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4495-4507
-
-
Moiseeva, O.1
-
159
-
-
84895781457
-
Respiratory insufficiency, the retrograde response, and the origin of cancer
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Respiratory insufficiency, the retrograde response, and the origin of cancer. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 177-194.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 177-194
-
-
Seyfried, T.N.1
-
160
-
-
84884337715
-
Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics
-
Guha,M. et al. (2013) Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion, 13, 577-591.
-
(2013)
Mitochondrion
, vol.13
, pp. 577-591
-
-
Guha, M.1
-
161
-
-
23644434087
-
Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis
-
Singh,K.K. et al. (2005) Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene, 354, 140-146.
-
(2005)
Gene
, vol.354
, pp. 140-146
-
-
Singh, K.K.1
-
162
-
-
23644443813
-
The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging
-
Jazwinski,S.M. (2005) The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging. Gene, 354, 22-27.
-
(2005)
Gene
, vol.354
, pp. 22-27
-
-
Jazwinski, S.M.1
-
163
-
-
84864744900
-
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
-
Nargund,A.M. et al. (2012) Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science, 337, 587-590.
-
(2012)
Science
, vol.337
, pp. 587-590
-
-
Nargund, A.M.1
-
164
-
-
84870665519
-
Identity and function of a large gene network underlying mutagenic repair of DNA breaks
-
Al Mamun,A.A. et al. (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science, 338, 1344-1348.
-
(2012)
Science
, vol.338
, pp. 1344-1348
-
-
Al Mamun, A.A.1
-
165
-
-
77958492734
-
Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
-
Dang,C.V. (2010) Glutaminolysis: supplying carbon or nitrogen or both for cancer cells? Cell Cycle, 9, 3884-3886.
-
(2010)
Cell Cycle
, vol.9
, pp. 3884-3886
-
-
Dang, C.V.1
-
167
-
-
34447094919
-
Glycolysis in cancer: a potential target for therapy
-
Gatenby,R.A. et al. (2007) Glycolysis in cancer: a potential target for therapy. Int. J. Biochem. Cell Biol., 39, 1358-1366.
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 1358-1366
-
-
Gatenby, R.A.1
-
168
-
-
84880648196
-
Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells
-
Husain,Z. et al. (2013) Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J. Immunol., 191, 1486-1495.
-
(2013)
J. Immunol.
, vol.191
, pp. 1486-1495
-
-
Husain, Z.1
-
169
-
-
84875548961
-
Grappling with cancer
-
Liu,E.T. (2013) Grappling with cancer. Science, 339, 1493.
-
(2013)
Science
, vol.339
, pp. 1493
-
-
Liu, E.T.1
-
170
-
-
84875508302
-
Steering cancer genomics into the fast lane
-
Pennisi,E. (2013) Steering cancer genomics into the fast lane. Science, 339, 1540-1542.
-
(2013)
Science
, vol.339
, pp. 1540-1542
-
-
Pennisi, E.1
-
171
-
-
64749094310
-
The cancer genome
-
Stratton,M.R. et al. (2009) The cancer genome. Nature, 458, 719-724.
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
-
172
-
-
24944468183
-
Evolutionary biology of cancer
-
Crespi,B. et al. (2005) Evolutionary biology of cancer. Trends Ecol. Evol., 20, 545-552.
-
(2005)
Trends Ecol. Evol.
, vol.20
, pp. 545-552
-
-
Crespi, B.1
-
173
-
-
33845243362
-
Cancer as an evolutionary and ecological process
-
Merlo,L.M. et al. (2006) Cancer as an evolutionary and ecological process. Nat. Rev. Cancer, 6, 924-935.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 924-935
-
-
Merlo, L.M.1
-
174
-
-
79951873316
-
Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors
-
Davies,P.C. et al. (2011) Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors. Phys. Biol., 8, 015001.
-
(2011)
Phys. Biol.
, vol.8
, pp. 015001
-
-
Davies, P.C.1
-
175
-
-
84895808233
-
Evolution before Darwin
-
Belknap Harvard, Cambridge, MA
-
Mayer,E. (1982) Evolution before Darwin. In The Growth of Biological Thought: Diversity, Evolution, and Inheritance. Belknap Harvard, Cambridge, MA, pp. 343-362.
-
(1982)
The Growth of Biological Thought: Diversity, Evolution, and Inheritance
, pp. 343-362
-
-
Mayer, E.1
-
176
-
-
77952035328
-
Is Lamarckian evolution relevant to medicine?
-
Handel,A.E. et al. (2010) Is Lamarckian evolution relevant to medicine? BMC Med. Genet., 11, 73.
-
(2010)
BMC Med. Genet.
, vol.11
, pp. 73
-
-
Handel, A.E.1
-
177
-
-
77649218943
-
Is evolution Darwinian or/and Lamarckian?
-
Koonin,E.V. et al. (2009) Is evolution Darwinian or/and Lamarckian? Biol. Direct, 4, 42.
-
(2009)
Biol. Direct
, vol.4
, pp. 42
-
-
Koonin, E.V.1
-
178
-
-
49749121841
-
A novel role for mitochondria in regulating epigenetic modification in the nucleus
-
Smiraglia,D.J. et al. (2008) A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol. Ther., 7, 1182-1190.
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1182-1190
-
-
Smiraglia, D.J.1
-
179
-
-
84860586157
-
Mitochondrial regulation of epigenetics and its role in human diseases
-
Minocherhomji,S. et al. (2012) Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics, 7, 326-334.
-
(2012)
Epigenetics
, vol.7
, pp. 326-334
-
-
Minocherhomji, S.1
-
180
-
-
1042278765
-
The history of cancer epigenetics
-
Feinberg,A.P. et al. (2004) The history of cancer epigenetics. Nat. Rev. Cancer, 4, 143-153.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 143-153
-
-
Feinberg, A.P.1
-
181
-
-
0034537496
-
Tumour cell hybridization and metastasis revisited
-
Pawelek,J.M. (2000) Tumour cell hybridization and metastasis revisited. Melanoma Res., 10, 507-514.
-
(2000)
Melanoma Res.
, vol.10
, pp. 507-514
-
-
Pawelek, J.M.1
-
182
-
-
78449273861
-
Perspectives on the mesenchymal origin of metastatic cancer
-
Huysentruyt,L.C. et al. (2010) Perspectives on the mesenchymal origin of metastatic cancer. Cancer Metastasis Rev., 29, 695-707.
-
(2010)
Cancer Metastasis Rev.
, vol.29
, pp. 695-707
-
-
Huysentruyt, L.C.1
-
183
-
-
0033152288
-
Horizontal transfer of DNA by the uptake of apoptotic bodies
-
Holmgren,L. et al. (1999) Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood, 93, 3956-3963.
-
(1999)
Blood
, vol.93
, pp. 3956-3963
-
-
Holmgren, L.1
-
184
-
-
84859557807
-
HCMV and Gliomas Symposium. Consensus on the role of human cytomegalovirus in glioblastoma
-
Dziurzynski,K. et al.; HCMV and Gliomas Symposium. (2012) Consensus on the role of human cytomegalovirus in glioblastoma. Neuro. Oncol., 14, 246-255.
-
(2012)
Neuro. Oncol.
, vol.14
, pp. 246-255
-
-
Dziurzynski, K.1
-
185
-
-
35448960851
-
Functions and dysfunctions of mitochondrial dynamics
-
Detmer,S.A. et al. (2007) Functions and dysfunctions of mitochondrial dynamics. Nat. Rev. Mol. Cell Biol., 8, 870-879.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 870-879
-
-
Detmer, S.A.1
-
186
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu,R.H. et al. (2005) Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res., 65, 613-621.
-
(2005)
Cancer Res.
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
-
187
-
-
0141919698
-
Ketones: metabolism's ugly duckling
-
VanItallie,T.B. et al. (2003) Ketones: metabolism's ugly duckling. Nutr. Rev., 61, 327-341.
-
(2003)
Nutr. Rev.
, vol.61
, pp. 327-341
-
-
VanItallie, T.B.1
-
188
-
-
0015413298
-
Resistance to symptomatic insulin reactions after fasting
-
Drenick,E.J. et al. (1972) Resistance to symptomatic insulin reactions after fasting. J. Clin. Invest., 51, 2757-2762.
-
(1972)
J. Clin. Invest.
, vol.51
, pp. 2757-2762
-
-
Drenick, E.J.1
-
189
-
-
1042299789
-
The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
-
Veech,R.L. (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins. Leukot. Essent. Fatty Acids, 70, 309-319.
-
(2004)
Prostaglandins. Leukot. Essent. Fatty Acids
, vol.70
, pp. 309-319
-
-
Veech, R.L.1
-
190
-
-
0001114030
-
The role of ketone bodies in caloric homeostasis
-
Krebs,H.A. et al. (1971) The role of ketone bodies in caloric homeostasis. Adv. Enzyme Reg., 9, 387-409.
-
(1971)
Adv. Enzyme Reg.
, vol.9
, pp. 387-409
-
-
Krebs, H.A.1
-
191
-
-
77956419439
-
Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
Bonuccelli,G. et al. (2010) Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle, 9, 3506-3514.
-
(2010)
Cell Cycle
, vol.9
, pp. 3506-3514
-
-
Bonuccelli, G.1
-
192
-
-
84895794271
-
Metabolic management of cancer
-
John Wiley & Sons, Hoboken, NJ
-
Seyfried,T.N. (2012) Metabolic management of cancer. In Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. John Wiley & Sons, Hoboken, NJ, pp. 291-354.
-
(2012)
Cancer As a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
, pp. 291-354
-
-
Seyfried, T.N.1
-
193
-
-
79960661966
-
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
-
Maurer,G.D. et al. (2011) Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer, 11, 315.
-
(2011)
BMC Cancer
, vol.11
, pp. 315
-
-
Maurer, G.D.1
-
194
-
-
58149514084
-
Ketone bodies inhibit the viability of human neuroblastoma cells
-
discussion 216
-
Skinner,R. et al. (2009) Ketone bodies inhibit the viability of human neuroblastoma cells. J. Pediatr. Surg., 44, 212-6; discussion 216.
-
(2009)
J. Pediatr. Surg.
, vol.44
, pp. 212-216
-
-
Skinner, R.1
-
195
-
-
0242266477
-
Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
-
Seyfried,T.N. et al. (2003) Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br. J. Cancer, 89, 1375-1382.
-
(2003)
Br. J. Cancer
, vol.89
, pp. 1375-1382
-
-
Seyfried, T.N.1
-
196
-
-
84881171944
-
Caloric restriction reduces edema and prolongs survival in a mouse glioma model
-
Jiang,Y.S. et al. (2013) Caloric restriction reduces edema and prolongs survival in a mouse glioma model. J. Neurooncol., 114, 25-32.
-
(2013)
J. Neurooncol.
, vol.114
, pp. 25-32
-
-
Jiang, Y.S.1
-
197
-
-
4143146391
-
Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors
-
Mukherjee,P. et al. (2004) Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Clin. Cancer Res., 10, 5622-5629.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5622-5629
-
-
Mukherjee, P.1
-
198
-
-
0037141346
-
Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
-
Mukherjee,P. et al. (2002) Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Br. J. Cancer, 86, 1615-1621.
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1615-1621
-
-
Mukherjee, P.1
-
199
-
-
79953315614
-
Influence of caloric restriction on constitutive expression of NF-?B in an experimental mouse astrocytoma
-
Mulrooney,T.J. et al. (2011) Influence of caloric restriction on constitutive expression of NF-?B in an experimental mouse astrocytoma. PLoS One, 6, e18085.
-
(2011)
PLoS One
, vol.6
-
-
Mulrooney, T.J.1
-
200
-
-
84880231512
-
Selectively starving cancer cells through dietary manipulation: methods and clinical implications
-
Simone,B.A. et al. (2013) Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol., 9, 959-976.
-
(2013)
Future Oncol.
, vol.9
, pp. 959-976
-
-
Simone, B.A.1
-
201
-
-
77956465178
-
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
-
Stafford,P. et al. (2010) The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr. Metab. (Lond)., 7, 74.
-
(2010)
Nutr. Metab. (Lond).
, vol.7
, pp. 74
-
-
Stafford, P.1
-
202
-
-
84865427329
-
Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients
-
Fine,E.J. et al. (2012) Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition, 28, 1028-1035.
-
(2012)
Nutrition
, vol.28
, pp. 1028-1035
-
-
Fine, E.J.1
-
203
-
-
77951028897
-
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
-
Zuccoli,G. et al. (2010) Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr. Metab. (Lond)., 7, 33.
-
(2010)
Nutr. Metab. (Lond).
, vol.7
, pp. 33
-
-
Zuccoli, G.1
-
204
-
-
0028946933
-
Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports
-
Nebeling,L.C. et al. (1995) Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. J. Am. Coll. Nutr., 14, 202-208.
-
(1995)
J. Am. Coll. Nutr.
, vol.14
, pp. 202-208
-
-
Nebeling, L.C.1
-
205
-
-
33847780073
-
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
-
Zhou,W. et al. (2007) The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr. Metab. (Lond)., 4, 5.
-
(2007)
Nutr. Metab. (Lond).
, vol.4
, pp. 5
-
-
Zhou, W.1
-
206
-
-
5144225468
-
Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
-
Gottschalk,S. et al. (2004) Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin. Cancer Res., 10, 6661-6668.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6661-6668
-
-
Gottschalk, S.1
-
207
-
-
79959861423
-
Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism
-
Zhao,Y. et al. (2011) Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res., 71, 4585-4597.
-
(2011)
Cancer Res.
, vol.71
, pp. 4585-4597
-
-
Zhao, Y.1
-
208
-
-
58149175598
-
Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/ tuberous sclerosis complex 2-deficient mouse astrocytoma
-
Marsh,J. et al. (2008) Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/ tuberous sclerosis complex 2-deficient mouse astrocytoma. Clin. Cancer Res., 14, 7751-7762.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7751-7762
-
-
Marsh, J.1
-
209
-
-
0034844219
-
Ketone bodies, potential therapeutic uses
-
Veech,R.L. et al. (2001) Ketone bodies, potential therapeutic uses. IUBMB Life, 51, 241-247.
-
(2001)
IUBMB Life
, vol.51
, pp. 241-247
-
-
Veech, R.L.1
-
210
-
-
70349266564
-
Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect
-
Chen,Y. et al. (2009) Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One, 4, e7033.
-
(2009)
PLoS One
, vol.4
-
-
Chen, Y.1
-
211
-
-
0034038708
-
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?
-
Spitz,D.R. et al. (2000) Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann. N. Y. Acad. Sci., 899, 349-362.
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.899
, pp. 349-362
-
-
Spitz, D.R.1
-
212
-
-
10644283057
-
Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
-
Harrison,L. et al. (2004) Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? Oncologist, 9 (suppl. 5), 31-40.
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 5
, pp. 31-40
-
-
Harrison, L.1
-
213
-
-
84881135707
-
Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts
-
Allen,B.G. et al. (2013) Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clin. Cancer Res., 19, 3905-3913.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 3905-3913
-
-
Allen, B.G.1
-
214
-
-
84860521413
-
The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma
-
Abdelwahab,M.G. et al. (2012) The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS One, 7, e36197.
-
(2012)
PLoS One
, vol.7
-
-
Abdelwahab, M.G.1
-
215
-
-
77956186419
-
Does the existing standard of care increase glioblastoma energy metabolism?
-
Seyfried,T.N. et al. (2010) Does the existing standard of care increase glioblastoma energy metabolism? Lancet Oncol., 11, 811-813.
-
(2010)
Lancet Oncol.
, vol.11
, pp. 811-813
-
-
Seyfried, T.N.1
-
216
-
-
47749116480
-
Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells
-
Yuneva,M. (2008) Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells. Cell Cycle, 7, 2083-2089.
-
(2008)
Cell Cycle
, vol.7
, pp. 2083-2089
-
-
Yuneva, M.1
-
217
-
-
75149148563
-
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis,R.J. et al. (2010) Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene, 29, 313-324.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
-
218
-
-
84879469812
-
A melanoma brain metastasis with a donor-patient hybrid genome following bone marrow transplantation: first evidence for fusion in human cancer
-
Lazova,R. et al. (2013) A melanoma brain metastasis with a donor-patient hybrid genome following bone marrow transplantation: first evidence for fusion in human cancer. PLoS One, 8, e66731.
-
(2013)
PLoS One
, vol.8
-
-
Lazova, R.1
-
219
-
-
0034843181
-
Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?
-
Discussion 2523S
-
Newsholme,P. (2001) Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J. Nutr., 131(suppl. 9), 2515S-2522S; discussion 2523S.
-
(2001)
J. Nutr.
, vol.131
, Issue.SUPPL. 9
-
-
Newsholme, P.1
-
220
-
-
84877130578
-
Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer
-
Mates,J.M. et al. (2012) Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer. Current Mol. Med., 12, 1-21.
-
(2012)
Current Mol. Med.
, vol.12
, pp. 1-21
-
-
Mates, J.M.1
-
221
-
-
78049515429
-
Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model
-
Shelton,L.M. et al. (2010) Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model. Int. J. Cancer, 127, 2478-2485.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2478-2485
-
-
Shelton, L.M.1
-
222
-
-
58549097263
-
Glutamine prevents DMBA-induced squamous cell cancer
-
Lim,V. et al. (2009) Glutamine prevents DMBA-induced squamous cell cancer. Oral Oncol., 45, 148-155.
-
(2009)
Oral Oncol.
, vol.45
, pp. 148-155
-
-
Lim, V.1
-
223
-
-
80053061834
-
Cancer: beyond speciation
-
Vincent,M.D. (2011) Cancer: beyond speciation. Adv. Cancer Res., 112, 283-350.
-
(2011)
Adv. Cancer Res.
, vol.112
, pp. 283-350
-
-
Vincent, M.D.1
-
224
-
-
57049155406
-
Press-pulse: a general theory of mass extinction?
-
Arens,N.C. et al. (2008) Press-pulse: a general theory of mass extinction? Paleobiology, 34, 456-471.
-
(2008)
Paleobiology
, vol.34
, pp. 456-471
-
-
Arens, N.C.1
-
225
-
-
4744341871
-
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
-
Ko,Y.H. et al. (2004) Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem. Biophys. Res. Commun., 324, 269-275.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 269-275
-
-
Ko, Y.H.1
-
226
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet,S. et al. (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell, 11, 37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
-
227
-
-
58149161852
-
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
-
Marsh,J. et al. (2008) Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr. Metab. (Lond)., 5, 33.
-
(2008)
Nutr. Metab. (Lond).
, vol.5
, pp. 33
-
-
Marsh, J.1
-
228
-
-
58249118272
-
The story of human cytomegalovirus and cancer: increasing evidence and open questions
-
Michaelis,M. et al. (2009) The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia, 11, 1-9.
-
(2009)
Neoplasia
, vol.11
, pp. 1-9
-
-
Michaelis, M.1
-
229
-
-
84890065440
-
Genome-wide identification and characterization of polygalacturonase genes in Cucumis sativus and Citrullus lanatus
-
Yu,Y. et al. (2013) Genome-wide identification and characterization of polygalacturonase genes in Cucumis sativus and Citrullus lanatus. Plant Physiol. Biochem., 74C, 263-275.
-
(2013)
Plant Physiol. Biochem.
, vol.74 C
, pp. 263-275
-
-
Yu, Y.1
-
230
-
-
77954514089
-
Trafficking of UL37 proteins into mitochondrionassociated membranes during permissive human cytomegalovirus infection
-
Bozidis,P. et al. (2010) Trafficking of UL37 proteins into mitochondrionassociated membranes during permissive human cytomegalovirus infection. J. Virol., 84, 7898-7903.
-
(2010)
J. Virol.
, vol.84
, pp. 7898-7903
-
-
Bozidis, P.1
-
231
-
-
67449119450
-
Access of viral proteins to mitochondria via mitochondria-associated membranes
-
Williamson,C.D. et al. (2009) Access of viral proteins to mitochondria via mitochondria-associated membranes. Rev. Med. Virol., 19, 147-164.
-
(2009)
Rev. Med. Virol.
, vol.19
, pp. 147-164
-
-
Williamson, C.D.1
-
232
-
-
79960432578
-
Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype
-
Dziurzynski,K. et al. (2011) Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clin. Cancer Res., 17, 4642-4649.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 4642-4649
-
-
Dziurzynski, K.1
-
233
-
-
0025800077
-
Do some malignant melanoma cells share antigens with the myeloid monocyte lineage?
-
Munzarová,M. et al. (1991) Do some malignant melanoma cells share antigens with the myeloid monocyte lineage? Neoplasma, 38, 401-405.
-
(1991)
Neoplasma
, vol.38
, pp. 401-405
-
-
Munzarová, M.1
-
234
-
-
84883439743
-
Survival in patients with glioblastoma receiving valganciclovir
-
Söderberg-Nauclér,C. et al. (2013) Survival in patients with glioblastoma receiving valganciclovir. N. Engl. J. Med., 369, 985-986.
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 985-986
-
-
Söderberg-Nauclér, C.1
-
235
-
-
84862236426
-
Kinetics, safety and tolerability of ®-3-hydroxybutyl ®-3-hydroxybutyrate in healthy adult subjects
-
Clarke,K. et al. (2012) Kinetics, safety and tolerability of ®-3-hydroxybutyl ®-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol., 63, 401-408.
-
(2012)
Regul. Toxicol. Pharmacol.
, vol.63
, pp. 401-408
-
-
Clarke, K.1
-
236
-
-
84878652279
-
Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats
-
D'Agostino,D.P. et al. (2013) Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 304, R829-R836.
-
(2013)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.304
-
-
D'Agostino, D.P.1
-
237
-
-
84861534727
-
Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
-
Lu,W. et al. (2012) Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol., 10, e1001326.
-
(2012)
PLoS Biol.
, vol.10
-
-
Lu, W.1
-
238
-
-
69849090667
-
Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype
-
de Groof,A.J. et al. (2009) Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype. Mol. Cancer, 8, 54.
-
(2009)
Mol. Cancer
, vol.8
, pp. 54
-
-
de Groof, A.J.1
-
239
-
-
73249137166
-
Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells
-
Baracca,A. et al. (2010) Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells. Biochim. Biophys. Acta, 1797, 314-323.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 314-323
-
-
Baracca, A.1
-
240
-
-
77950299104
-
Studies in cancer, VII. Enzyme deficiency in human and experimental cancer
-
Roskelley,R.C. et al. (1943) Studies in cancer. VII. Enzyme deficiency in human and experimental cancer. J. Clin. Invest., 22, 743-751.
-
(1943)
J. Clin. Invest.
, vol.22
, pp. 743-751
-
-
Roskelley, R.C.1
-
241
-
-
55349138793
-
Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets
-
Seyfried,T.N. et al. (2008) Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. Epilepsia, 49 Suppl 8, 114-116.
-
(2008)
Epilepsia 49 Suppl
, vol.8
, pp. 114-116
-
-
Seyfried, T.N.1
-
242
-
-
43949100999
-
Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model
-
Huysentruyt,L.C. et al. (2008) Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model. Int. J. Cancer, 123, 73-84.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 73-84
-
-
Huysentruyt, L.C.1
-
243
-
-
84878758801
-
The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer
-
Poff,A.M. et al. (2013) The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One, 8, e65522.
-
(2013)
PLoS One
, vol.8
-
-
Poff, A.M.1
|