Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 16, 2011, Pages 6603-6608

  D'Errico, Ilenia ^a,b   Salvatore, Lorena ^a,b   Murzilli, Stefania ^a,b   Lo Sasso, Giuseppe ^a,b   Latorre, Dominga ^b   Martelli, Nicola ^a,b   Egorova, Anastasia V ^c   Polishuck, Roman ^c   Madeyski Bengtson, Katja ^d   Lelliott, Christopher ^d   Vidal Puig, Antonio J ^e   Seibel, Peter ^f   Villani, Gaetano ^b   Moschetta, Antonio ^a,b  

^a Laboratory of Lipid Metabolism and Cancer   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c AstraZeneca Research and Development ^*  (Italy)

^d ASTRAZENECA R AND D   (Sweden)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Colon cancer; Medical physiology; Metabolism; Mitochondria; Nuclear receptors

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOGENESIS; CARCINOGENESIS; CELL FATE; CELL RESPIRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CELL TRANSFORMATION, NEOPLASTIC; ENTEROCYTES; HEAT-SHOCK PROTEINS; HUMANS; INTESTINAL NEOPLASMS; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; OXYGEN CONSUMPTION; TRANSCRIPTION FACTORS;

EID: 79955634801     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1016354108     Document Type: Article

References (43)

1. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
2. Rubinfeld B, et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272:1023-1026. (Pubitemid 26259322)
3. Morin PJ, Vogelstein B, Kinzler KW (1996) Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci USA 93:7950-7954. (Pubitemid 26277145)
4. Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159-170. (Pubitemid 26358996)
5. Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799. (Pubitemid 39070849)
6. Kelly DP, Scarpulla RC (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18:357-368. (Pubitemid 38316342)
7. Wu Z, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124. (Pubitemid 29331201)
8. Puigserver P, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839. (Pubitemid 28155321)
9. Lin J, et al. (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418:797-801.
10. Puigserver P, Spiegelman BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90. (Pubitemid 36223280)
11. D'Aurelio M, et al. (2001) In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. J Biol Chem 276:46925-46932.
12. Villani G, Greco M, Papa S, Attardi G (1998) Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem 273:31829-31836. (Pubitemid 29177118)
13. Villani G, Attardi G (1997) In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci USA 94:1166-1171.
14. Turan A, Mahmood A (2007) The profile of antioxidant systems and lipid peroxidation across the crypt-villus axis in rat intestine. Dig Dis Sci 52:1840-1844. (Pubitemid 47024667)
15. Turan A, Gill R, Dudeja PK, Mohan H, Mahmood A (2009) Effect of fat feeding on pro-oxidant and anti-oxidant enzyme systems in rat intestine: Possible role in the turnover of enterocytes. Dig Dis Sci 54:1229-1236.
16. Fodde R, Smits R, Clevers H (2001) APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1:55-67. (Pubitemid 33741881)
17. Bienz M, Clevers H (2000) Linking colorectal cancer to Wnt signaling. Cell 103:311-320.
18. Powell SM, et al. (1993) Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 329:1982-1987. (Pubitemid 24015041)
19. Su LK, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-670.
20. Shakya A, et al. (2009) Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol 11:320-327.
21. Bonnet S, et al. (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37-51. (Pubitemid 46054520)
22. Hájek P, Villani G, Attardi G (2001) Rate-limiting step preceding cytochrome c release in cells primed for Fas-mediated apoptosis revealed by analysis of cellular mosaicism of respiratory changes. J Biol Chem 276:606-615. (Pubitemid 32050357)
23. Reed JC (2003) Apoptosis-targeted therapies for cancer. Cancer Cell 3:17-22.
24. Lehman JJ, et al. (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106:847-856.
25. St-Pierre J, et al. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127:397-408. (Pubitemid 44572377)
26. Christofk HR, et al. (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452:230-233. (Pubitemid 351380249)
27. King MP, Attardi G (1989) Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation. Science 246:500-503. (Pubitemid 19273941)
28. Rong Y, Doctrow SR, Tocco G, Baudry M (1999) EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96:9897-9902. (Pubitemid 29398829)
29. Papanikolaou A, et al. (1998) Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice. Toxicol Appl Pharmacol 150:196-203. (Pubitemid 28288435)
30. Popivanova BK, et al. (2008) Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 118:560-570. (Pubitemid 351206546)
31. Drori S, et al. (2005) Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev 19:362-375. (Pubitemid 40189299)
32. Arany Z, et al. (2008) HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451:1008-1012. (Pubitemid 351301733)
33. Lefebvre AM, et al. (1998) Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 4:1053-1057.
34. Saez E, Olson P, Evans RM (2003) Genetic deficiency in Pparg does not alter development of experimental prostate cancer. Nat Med 9:1265-1266. (Pubitemid 37279847)
35. Sarraf P, et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 4:1046-1052. (Pubitemid 28417337)
36. Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A (2008) Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res 68:9589-9594.
37. Xiao JH, et al. (2003) Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem 278:29954-29962.
38. Modica S, et al. (2010) The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors. Gastroenterology 138: 636-648, 648, e1-e12.
39. Murphy MP (2009) Howmitochondria produce reactive oxygen species. Biochem J 417:1-13.
40. St-Pierre J, et al. (2003) Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem 278:26597-26603. (Pubitemid 36876804)
41. Valle I, Alvarez-Barrientos A, Arza E, Lamas S, Monsalve M (2005) PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res 66:562-573. (Pubitemid 40725768)
42. Kukidome D, et al. (2006) Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 55:120-127. (Pubitemid 43343306)
43. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922. (Pubitemid 23260825)