-
1
-
-
77958122066
-
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape
-
Agudo R, Ferrer-Orta C, Arias A, la Higuera de I, Perales C, Pérez-Luque R, Verdaguer N, Domingo E (2010) A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathogens 6:e1001072
-
(2010)
Plos Pathogens
, vol.6
-
-
Agudo, R.1
Ferrer-Orta, C.2
Arias, A.3
La Higuera De, I.4
Perales, C.5
Pérez-Luque, R.6
Verdaguer, N.7
Domingo, E.8
-
2
-
-
10644250663
-
Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer
-
Appleby TC, Luecke H, Shim JH, Wu JZ, Cheney IW, Zhong W, Vogeley L, Hong Z, Yao N (2005) Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer. J Virol 79:277–288
-
(2005)
J Virol
, vol.79
, pp. 277-288
-
-
Appleby, T.C.1
Luecke, H.2
Shim, J.H.3
Wu, J.Z.4
Cheney, I.W.5
Zhong, W.6
Vogeley, L.7
Hong, Z.8
Yao, N.9
-
3
-
-
57349131683
-
Determinants of RNA-dependent RNA polymerase (In) fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin
-
Arias A, Arnold JJ, Sierra M, Smidansky ED, Domingo E, Cameron CE (2008) Determinants of RNA-dependent RNA polymerase (in) fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol 82:12346–12355
-
(2008)
J Virol
, vol.82
, pp. 12346-12355
-
-
Arias, A.1
Arnold, J.J.2
Sierra, M.3
Smidansky, E.D.4
Domingo, E.5
Cameron, C.E.6
-
4
-
-
0034090927
-
Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub)
-
Arnold JJ, Cameron CE (2000) Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub). J Biol Chem 275:5329–5336
-
(2000)
J Biol Chem
, vol.275
, pp. 5329-5336
-
-
Arnold, J.J.1
Cameron, C.E.2
-
5
-
-
2442584664
-
Poliovirus RNA-dependent RNA polymerase (3D pol): Pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+
-
Arnold JJ, Cameron CE (2004) Poliovirus RNA-dependent RNA polymerase (3D pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry 43:5126–5137
-
(2004)
Biochemistry
, vol.43
, pp. 5126-5137
-
-
Arnold, J.J.1
Cameron, C.E.2
-
6
-
-
0033601209
-
Poliovirus RNA-dependent RNA Polymerase (3Dpol) divalent cation modulation of primer, template, and nucleotide selection
-
Arnold JJ, Ghosh SKB, Cameron CE (1999) Poliovirus RNA-dependent RNA Polymerase (3Dpol) divalent cation modulation of primer, template, and nucleotide selection. J Biol Chem 274:37060–37069
-
(1999)
J Biol Chem
, vol.274
, pp. 37060-37069
-
-
Arnold, J.J.1
Ghosh, S.2
Cameron, C.E.3
-
7
-
-
2442498536
-
Poliovirus RNA-dependent RNA polymerase (3D pol): Pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+
-
Arnold JJ, Gohara DW, Cameron CE (2004) Poliovirus RNA-dependent RNA polymerase (3D pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry 43:5138–5148
-
(2004)
Biochemistry
, vol.43
, pp. 5138-5148
-
-
Arnold, J.J.1
Gohara, D.W.2
Cameron, C.E.3
-
8
-
-
21844431621
-
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase
-
Arnold JJ, Vignuzzi M, Stone JK, Andino R, Cameron CE (2005) Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem 280:25706–25716
-
(2005)
J Biol Chem
, vol.280
, pp. 25706-25716
-
-
Arnold, J.J.1
Vignuzzi, M.2
Stone, J.K.3
Andino, R.4
Cameron, C.E.5
-
9
-
-
0030581311
-
Mutational studies of human immunodeficiency virus type 1 reverse transcriptase: The involvement of residues 183 and 184 in the fidelity of DNA synthesis
-
Bakhanashvili M, Avidan O, Hizi A (1996) Mutational studies of human immunodeficiency virus type 1 reverse transcriptase: the involvement of residues 183 and 184 in the fidelity of DNA synthesis. FEBS Lett 391:257–262
-
(1996)
FEBS Lett
, vol.391
, pp. 257-262
-
-
Bakhanashvili, M.1
Avidan, O.2
Hizi, A.3
-
10
-
-
80055114848
-
Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency
-
Beaucourt SP, Border AAV, Coffey LL, Gn Dig NF, Sanz-Ramos M, Beeharry Y, Vignuzzi M (2011) Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency. J Vis Exp 52
-
(2011)
J Vis Exp
, pp. 52
-
-
Beaucourt, S.P.1
Border, A.2
Coffey, L.L.3
Gn Dig, N.F.4
Sanz-Ramos, M.5
Beeharry, Y.6
Vignuzzi, M.7
-
11
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
Bressanelli S, Tomei L, Roussel A, Incitti I, Vitale RL, Mathieu M, De Francesco R, Rey FA (1999) Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci 96:13034–13039
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 13034-13039
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
Mathieu, M.6
De Francesco, R.7
Rey, F.A.8
-
12
-
-
0035826258
-
A mechanism for initiating RNA-dependent RNA polymerization
-
Butcher SJ, Grimes JM, Makeyev EV, Bamford DH, Stuart DI (2001) A mechanism for initiating RNA-dependent RNA polymerization. Nature 410:235–240
-
(2001)
Nature
, vol.410
, pp. 235-240
-
-
Butcher, S.J.1
Grimes, J.M.2
Makeyev, E.V.3
Bamford, D.H.4
Stuart, D.I.5
-
13
-
-
70549114081
-
Dynamics: The missing link between structure and function of the viral RNA-dependent RNA polymerase?
-
Cameron CE, Moustafa IM, Arnold JJ (2009) Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase? Curr Opin Struct Biol 19:768–774
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 768-774
-
-
Cameron, C.E.1
Moustafa, I.M.2
Arnold, J.J.3
-
14
-
-
0021770939
-
Reversion to neurovirulence of the live-attenuated Sabin type 3 oral poliovirus vaccine
-
Cann AJ, Stanway G, Hughes PJ, Minor PD, Evans DMA, Schild GT, Almond JW (1984) Reversion to neurovirulence of the live-attenuated Sabin type 3 oral poliovirus vaccine. Nucleic Acids Res 12:7787–7792
-
(1984)
Nucleic Acids Res
, vol.12
, pp. 7787-7792
-
-
Cann, A.J.1
Stanway, G.2
Hughes, P.J.3
Minor, P.D.4
Evans, D.5
Schild, G.T.6
Almond, J.W.7
-
15
-
-
34248349170
-
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA-and DNA-dependent RNA and DNA polymerases
-
Castro C, Smidansky E, Maksimchuk KR, Arnold JJ, Korneeva VS, Götte M, Konigsberg W, Cameron CE (2007) Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA-and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci 104:4267–4272
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 4267-4272
-
-
Castro, C.1
Smidansky, E.2
Maksimchuk, K.R.3
Arnold, J.J.4
Korneeva, V.S.5
Götte, M.6
Konigsberg, W.7
Cameron, C.E.8
-
16
-
-
59649110607
-
Nucleic acid polymerases use a general acid for nucleotidyl transfer
-
Castro C, Smidansky ED, Arnold JJ, Maksimchuk KR, Moustafa I, Uchida A, Götte M, Konigsberg W, Cameron CE (2009) Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol 16:212–218
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 212-218
-
-
Castro, C.1
Smidansky, E.D.2
Arnold, J.J.3
Maksimchuk, K.R.4
Moustafa, I.5
Uchida, A.6
Götte, M.7
Konigsberg, W.8
Cameron, C.E.9
-
17
-
-
84877616491
-
Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation
-
Chen C, Wang Y, Shan C, Sun Y, Xu P, Zhou H, Yang C, Shi P-Y, Rao Z, Zhang B et al (2013) Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation. J Virol 87:5755–5768
-
(2013)
J Virol
, vol.87
, pp. 5755-5768
-
-
Chen, C.1
Wang, Y.2
Shan, C.3
Sun, Y.4
Xu, P.5
Zhou, H.6
Yang, C.7
Shi, P.-Y.8
Rao, Z.9
Zhang, B.10
-
18
-
-
84907300612
-
Generation and characterization of influenza A viruses with altered polymerase fidelity
-
Cheung PPH, Watson SJ, Choy K-T, Fun Sia S, Wong DDY, Poon LLM, Kellam P, Guan Y, Malik Peiris JS, Yen H-L (2014) Generation and characterization of influenza A viruses with altered polymerase fidelity. Nat Commun 5:4794
-
(2014)
Nat Commun
, vol.5
, pp. 4794
-
-
Cheung, P.1
Watson, S.J.2
Choy, K.-T.3
Fun Sia, S.4
Wong, D.5
Poon, L.6
Kellam, P.7
Guan, Y.8
Malik Peiris, J.S.9
Yen, H.-L.10
-
19
-
-
1842481188
-
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation
-
Choi KH, Groarke JM, Young DC, Kuhn RJ, Smith JL, Pevear DC, Rossmann MG (2004) The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc Nat Acad Sci USA 101:4425–4430
-
(2004)
Proc Nat Acad Sci USA
, vol.101
, pp. 4425-4430
-
-
Choi, K.H.1
Groarke, J.M.2
Young, D.C.3
Kuhn, R.J.4
Smith, J.L.5
Pevear, D.C.6
Rossmann, M.G.7
-
20
-
-
80053164707
-
Arbovirus high fidelity variant loses fitness in mosquitoes and mice
-
Coffey LL, Beeharry Y, Bordería AV, Blanc H, Vignuzzi M (2011) Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci USA 108:16038–16043
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16038-16043
-
-
Coffey, L.L.1
Beeharry, Y.2
Bordería, A.V.3
Blanc, H.4
Vignuzzi, M.5
-
21
-
-
84893777917
-
Variation in RNA virus mutation rates across host cells
-
Combe M, Sanjuan R (2014) Variation in RNA virus mutation rates across host cells. PLoS Pathog 10:e1003855
-
(2014)
Plos Pathog
, vol.10
-
-
Combe, M.1
Sanjuan, R.2
-
22
-
-
84871772064
-
Interrelationship between HIV-1 fitness and mutation rate
-
Dapp MJ, Heineman RH, Mansky LM (2013) Interrelationship between HIV-1 fitness and mutation rate. J Mol Biol 425:41–53
-
(2013)
J Mol Biol
, vol.425
, pp. 41-53
-
-
Dapp, M.J.1
Heineman, R.H.2
Mansky, L.M.3
-
24
-
-
0033598717
-
Mutation rates among RNA viruses
-
Drake JW, Holland JJ (1999) Mutation rates among RNA viruses. Proc Natl Acad Sci 96:13910–13913
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 13910-13913
-
-
Drake, J.W.1
Holland, J.J.2
-
26
-
-
36048969246
-
High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants
-
Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR (2007) High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol 81:12135–12144
-
(2007)
J Virol
, vol.81
, pp. 12135-12144
-
-
Eckerle, L.D.1
Lu, X.2
Sperry, S.M.3
Choi, L.4
Denison, M.R.5
-
27
-
-
77954055072
-
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing
-
Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell T et al (2010) Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog 6:e1000896
-
(2010)
Plos Pathog
, vol.6
-
-
Eckerle, L.D.1
Becker, M.M.2
Halpin, R.A.3
Li, K.4
Venter, E.5
Lu, X.6
Scherbakova, S.7
Graham, R.L.8
Baric, R.S.9
Stockwell, T.10
-
28
-
-
0015133749
-
Selforganization of matter and the evolution of biological macromolecules
-
Eigen M (1971) Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften 58:465–523
-
(1971)
Naturwissenschaften
, vol.58
, pp. 465-523
-
-
Eigen, M.1
-
29
-
-
8744222695
-
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA
-
Ferrer-Orta C (2004) Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA. J Biol Chem 279:47212–47221
-
(2004)
J Biol Chem
, vol.279
, pp. 47212-47221
-
-
Ferrer-Orta, C.1
-
31
-
-
34547178347
-
Sequential structures provide insights into the fidelity of RNA replication
-
Ferrer-Orta C, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N (2007) Sequential structures provide insights into the fidelity of RNA replication. Proc Nat Acad Sci 104:9463–9468
-
(2007)
Proc Nat Acad Sci
, vol.104
, pp. 9463-9468
-
-
Ferrer-Orta, C.1
Arias, A.2
Pérez-Luque, R.3
Escarmís, C.4
Domingo, E.5
Verdaguer, N.6
-
32
-
-
77952710653
-
Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
-
Ferrer-Orta C, Sierra M, Agudo R, la Higuera de I, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N (2010) Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol 84:6188–6199
-
(2010)
J Virol
, vol.84
, pp. 6188-6199
-
-
Ferrer-Orta, C.1
Sierra, M.2
Agudo, R.3
La Higuera De, I.4
Arias, A.5
Perez-Luque, R.6
Escarmis, C.7
Domingo, E.8
Verdaguer, N.9
-
33
-
-
0017171254
-
Mutator activity of petite strains of Saccharomyces cerevisiae
-
Flury F, Von Borstel RC, Williamson DH (1976) Mutator activity of petite strains of Saccharomyces cerevisiae. Genetics 83:645–653
-
(1976)
Genetics
, vol.83
, pp. 645-653
-
-
Flury, F.1
Von Borstel, R.C.2
Williamson, D.H.3
-
34
-
-
33846850610
-
Structural and functional characterization of sapovirus RNA-dependent RNA polymerase
-
Fullerton SWB, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA, Rohayem J (2007) Structural and functional characterization of sapovirus RNA-dependent RNA polymerase. J Virol 81:1858–1871
-
(2007)
J Virol
, vol.81
, pp. 1858-1871
-
-
Fullerton, S.1
Blaschke, M.2
Coutard, B.3
Gebhardt, J.4
Gorbalenya, A.5
Canard, B.6
Tucker, P.A.7
Rohayem, J.8
-
35
-
-
22544478419
-
The cost of replicationfidelity in an RNA virus
-
Furió V, Moya A, Sanjuán R (2005) The cost of replication fidelity in an RNA virus. Proc Natl Acad Sci 102:10233–10237
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 10233-10237
-
-
Furió, V.1
Moya, A.2
Sanjuán, R.3
-
36
-
-
39049181029
-
The cost of replicationfidelity in human immunodeficiency virus type 1
-
Furió V, Moya A, Sanjuán R (2007) The cost of replication fidelity in human immunodeficiency virus type 1. Proc Biol Sci 274:225–230
-
(2007)
Proc Biol Sci
, vol.274
, pp. 225-230
-
-
Furió, V.1
Moya, A.2
Sanjuán, R.3
-
37
-
-
0017137313
-
Control of mutation frequency by bacteriophage T4 DNA polymerase. I. The CB120 antimutator DNA polymerase is defective in strand displacement
-
Gillin FD, Nossal NG (1976) Control of mutation frequency by bacteriophage T4 DNA polymerase. I. The CB120 antimutator DNA polymerase is defective in strand displacement. J Biol Chem 251:5219–5224
-
(1976)
J Biol Chem
, vol.251
, pp. 5219-5224
-
-
Gillin, F.D.1
Nossal, N.G.2
-
38
-
-
84865279748
-
Coxsackievirus B3 mutator strains are attenuated in vivo
-
Gnädig NF, Beaucourt S, Campagnola G, Bordería AV, Sanz-Ramos M, Gong P, Blanc H, Peersen OB, Vignuzzi M (2012) Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci USA 109:E2294–E2303
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E2294-E2303
-
-
Gnädig, N.F.1
Beaucourt, S.2
Campagnola, G.3
Bordería, A.V.4
Sanz-Ramos, M.5
Gong, P.6
Blanc, H.7
Peersen, O.B.8
Vignuzzi, M.9
-
39
-
-
0034682792
-
Poliovirus RNA-dependent RNA polymerase (3Dpol): Structural, biochemical, and biological analysis of conserved structural motifs A and B
-
Gohara DW, Crotty S, Arnold JJ, Yoder JD, Andino R, Cameron CE (2000) Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. J Biol Chem 275:25523–25532
-
(2000)
J Biol Chem
, vol.275
, pp. 25523-25532
-
-
Gohara, D.W.1
Crotty, S.2
Arnold, J.J.3
Yoder, J.D.4
Andino, R.5
Cameron, C.E.6
-
40
-
-
2442461170
-
Poliovirus RNA-dependent RNA polymerase (3D pol): Kinetic, thermodynamic, and structural analysis of ribonucleotide selection
-
Gohara DW, Arnold JJ, Cameron CE (2004) Poliovirus RNA-dependent RNA polymerase (3D pol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry 43:5149–5158
-
(2004)
Biochemistry
, vol.43
, pp. 5149-5158
-
-
Gohara, D.W.1
Arnold, J.J.2
Cameron, C.E.3
-
41
-
-
78651097570
-
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
-
Gong P, Peersen OB (2010) Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc Natl Acad Sci 107:22505–22510
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 22505-22510
-
-
Gong, P.1
Peersen, O.B.2
-
42
-
-
84857851921
-
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
-
Graci JD, Gnädig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE (2012) Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol 86:2869–2873
-
(2012)
J Virol
, vol.86
, pp. 2869-2873
-
-
Graci, J.D.1
Gnädig, N.F.2
Galarraga, J.E.3
Castro, C.4
Vignuzzi, M.5
Cameron, C.E.6
-
43
-
-
84870946428
-
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease
-
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS (2012) A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nat Med 18:1820–1826
-
(2012)
Nat Med
, vol.18
, pp. 1820-1826
-
-
Graham, R.L.1
Becker, M.M.2
Eckerle, L.D.3
Bolles, M.4
Denison, M.R.5
Baric, R.S.6
-
44
-
-
0019382868
-
Incidence of mutator strains in Escherichia coli and coliforms in nature
-
Gross MD, Siegel EC (1981) Incidence of mutator strains in Escherichia coli and coliforms in nature. Mutat Res Lett 91:107–110
-
(1981)
Mutat Res Lett
, vol.91
, pp. 107-110
-
-
Gross, M.D.1
Siegel, E.C.2
-
45
-
-
52649173300
-
The crystal structure of coxsackievirus B3 RNA-dependent rna polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on picornaviridae polymerases
-
Gruez A, Selisko B, Roberts M, Bricogne G, Bussetta C, Jabafi I, Coutard B, De Palma AM, Neyts J, Canard B (2008) The crystal structure of coxsackievirus B3 RNA-dependent rna polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on picornaviridae polymerases. J Virol 82:9577–9590
-
(2008)
J Virol
, vol.82
, pp. 9577-9590
-
-
Gruez, A.1
Selisko, B.2
Roberts, M.3
Bricogne, G.4
Bussettajaba, C.5
Fi, I.6
Coutard, B.7
De Palma, A.M.8
Neyts, J.9
Canard, B.10
-
46
-
-
0021364847
-
Generation of genetic diversity in herpes simplex virus: An antimutator phenotype maps to the DNA polymerase locus
-
Hall JD, Coen DM, Fisher BL, Weisslitz M, Randall S, Almy RE, Gelep PT, Schaffer PA (1984) Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology 132:26–37
-
(1984)
Virology
, vol.132
, pp. 26-37
-
-
Hall, J.D.1
Coen, D.M.2
Fisher, B.L.3
Weisslitz, M.4
Randall, S.5
Almy, R.E.6
Gelep, P.T.7
Schaffer, P.A.8
-
47
-
-
0031571638
-
Structure of the RNA-dependent RNA polymerase of poliovirus
-
Hansen JL, Long AM, Schultz SC (1997) Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5:1109–1122
-
(1997)
Structure
, vol.5
, pp. 1109-1122
-
-
Hansen, J.L.1
Long, A.M.2
Schultz, S.C.3
-
48
-
-
38349098724
-
Amiloride derivatives inhibit coxsackievirus B3 RNA replication
-
Harrison DN, Gazina EV, Purcell DF, Anderson DA, Petrou S (2008) Amiloride derivatives inhibit coxsackievirus B3 RNA replication. J Virol 82:1465–1473
-
(2008)
J Virol
, vol.82
, pp. 1465-1473
-
-
Harrison, D.N.1
Gazina, E.V.2
Purcell, D.F.3
Anderson, D.A.4
Petrou, S.5
-
49
-
-
50649089174
-
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus
-
He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z et al (2008) Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454:1123–1126
-
(2008)
Nature
, vol.454
, pp. 1123-1126
-
-
He, X.1
Zhou, J.2
Bartlam, M.3
Zhang, R.4
Ma, J.5
Lou, Z.6
Li, X.7
Li, J.8
Joachimiak, A.9
Zeng, Z.10
-
50
-
-
0000359208
-
Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specificity
-
Hopfield JJ (1974) Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc Nat Acad Sci 71:4135–4139
-
(1974)
Proc Nat Acad Sci
, vol.71
, pp. 4135-4139
-
-
Hopfield, J.J.1
-
51
-
-
0001566274
-
Observations on two types of genetic instability in Escherichia coli
-
Jyssum K (1960) Observations on two types of genetic instability in Escherichia coli. Acta Pathologica Microbiol Scand 48:113–120
-
(1960)
Acta Pathologica Microbiol Scand
, vol.48
, pp. 113-120
-
-
Jyssum, K.1
-
52
-
-
0037719282
-
Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential
-
Keulen W, van Wijk A, Schuurman R, Berkhout B, Boucher Charles AB (1999) Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential. Aids 13:1343–1349
-
(1999)
Aids
, vol.13
, pp. 1343-1349
-
-
Keulen, W.1
Van Wijk, A.2
Schuurman, R.3
Berkhout, B.4
Boucher Charles, A.B.5
-
53
-
-
0025743809
-
The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses
-
Koonin EV (1991) The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J Gen Virol 72(Pt 9):2197–2206
-
(1991)
J Gen Virol
, vol.72
, pp. 2197-2206
-
-
Koonin, E.V.1
-
54
-
-
34447517120
-
Structure-function relationships of the viral RNA-dependent RNA polymerase: Fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket
-
Korneeva VS, Cameron CE (2007) Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem 282:16135–16145
-
(2007)
J Biol Chem
, vol.282
, pp. 16135-16145
-
-
Korneeva, V.S.1
Cameron, C.E.2
-
55
-
-
77953249856
-
Rationalizing the development of live attenuated virus vaccines
-
Lauring AS, Jones JO, Andino R (2010) Rationalizing the development of live attenuated virus vaccines. Nat Biotechnol 28:573–579
-
(2010)
Nat Biotechnol
, vol.28
, pp. 573-579
-
-
Lauring, A.S.1
Jones, J.O.2
Andino, R.3
-
56
-
-
0029860724
-
High mutation frequencies among Escherichia coliand Salmonella pathogens
-
LeClerc JE, Li B, Payne WL, Cebula TA (1996) High mutation frequencies among Escherichia coli and Salmonella pathogens. Science 274:1208–1211
-
(1996)
Science
, vol.274
, pp. 1208-1211
-
-
Leclerc, J.E.1
Li, B.2
Payne, W.L.3
Cebula, T.A.4
-
57
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
Lesburg CA, Cable MB, Ferrari E, Hong Z, Mannarino AF, Weber PC (1999) Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 6:937–943
-
(1999)
Nat Struct Biol
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
58
-
-
78449244303
-
Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect
-
Levi LI, Gnädig NF, Beaucourt S, McPherson MJ, Baron B, Arnold JJ, Vignuzzi M (2010) Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds 6:e1001163
-
(2010)
Mutagenic Activity of Amiloride Compounds
, vol.6
-
-
Levi, L.I.1
Gnädig, N.F.2
Beaucourt, S.3
McPherson, M.J.4
Baron, B.5
Arnold, J.J.6
Vignuzzi, M.7
-
59
-
-
78449244303
-
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds
-
Levi LI, Gnädig NF, Beaucourt S, McPherson MJ, Baron B, Arnold JJ, Vignuzzi M (2010b) Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. PLoS Pathog 6:e1001163
-
(2010)
Plos Pathog
, vol.6
-
-
Levi, L.I.1
Gnädig, N.F.2
Beaucourt, S.3
McPherson, M.J.4
Baron, B.5
Arnold, J.J.6
Vignuzzi, M.7
-
60
-
-
84887467058
-
Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity
-
Liu X, Yang X, Lee CA, Moustafa IM, Smidansky ED, Lum D, Arnold JJ, Cameron CE, Boehr DD (2013) Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity. J Biol Chem 288:32753–32765
-
(2013)
J Biol Chem
, vol.288
, pp. 32753-32765
-
-
Liu, X.1
Yang, X.2
Lee, C.A.3
Moustafa, I.M.4
Smidansky, E.D.5
Lum, D.6
Arnold, J.J.7
Cameron, C.E.8
Boehr, D.D.9
-
61
-
-
4143147318
-
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus
-
Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA (2004) The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus. Structure 12:1533–1544
-
(2004)
Structure
, vol.12
, pp. 1533-1544
-
-
Love, R.A.1
Maegley, K.A.2
Yu, X.3
Ferre, R.A.4
Lingardo, L.K.5
Diehl, W.6
Parge, H.E.7
Dragovich, P.S.8
Fuhrman, S.A.9
-
62
-
-
84883381606
-
Crystal structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface
-
Lu G, Gong P (2013) Crystal structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. PLoS Pathog 9:e1003549
-
(2013)
Plos Pathog
, vol.9
-
-
Lu, G.1
Gong, P.2
-
63
-
-
34249845069
-
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
-
Malet H, Egloff MP, Selisko B, Butcher RE, Wright PJ, Roberts M, Gruez A, Sulzenbacher G, Vonrhein C, Bricogne G et al (2007) Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. J Biol Chem 282:10678–10689
-
(2007)
J Biol Chem
, vol.282
, pp. 10678-10689
-
-
Malet, H.1
Egloff, M.P.2
Selisko, B.3
Butcher, R.E.4
Wright, P.J.5
Roberts, M.6
Gruez, A.7
Sulzenbacher, G.8
Vonrhein, C.9
Bricogne, G.10
-
64
-
-
0033819409
-
3′-Azido-3′-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1
-
Mansky LM, Bernard LC (2000) 3′-Azido-3′-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1. J Virol 74:9532–9539
-
(2000)
J Virol
, vol.74
, pp. 9532-9539
-
-
Mansky, L.M.1
Bernard, L.C.2
-
65
-
-
33947386595
-
Crystal structure of poliovirus 3CD protein: Virally encoded protease and precursor to the RNA-dependent RNA polymerase
-
Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM (2007) Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol 81:3583–3596
-
(2007)
J Virol
, vol.81
, pp. 3583-3596
-
-
Marcotte, L.L.1
Wass, A.B.2
Gohara, D.W.3
Pathak, H.B.4
Arnold, J.J.5
Filman, D.J.6
Cameron, C.E.7
Hogle, J.M.8
-
66
-
-
0029757502
-
Human immunodeficiency virus type 1 reverse transcriptase: Role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis
-
Martin-Hernandez AM, Domingo E, Menendez-Arias L (1996) Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis. EMBO J 15:4434–4442
-
(1996)
EMBO J
, vol.15
, pp. 4434-4442
-
-
Martin-Hernandez, A.M.1
Domingo, E.2
Menendez-Arias, L.3
-
67
-
-
84899079298
-
Attenuation of human enterovirus 71 high-replication-fidelity variants in AG129 mice
-
Meng T, Kwang J (2014) Attenuation of human enterovirus 71 high-replication-fidelity variants in AG129 mice. J Virol 88:5803–5815
-
(2014)
J Virol
, vol.88
, pp. 5803-5815
-
-
Meng, T.1
Kwang, J.2
-
68
-
-
0015524064
-
Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4
-
Muzyczka N, Poland RL, Bessman MJ (1972) Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4. J Biol Chem 247:7116–7122
-
(1972)
J Biol Chem
, vol.247
, pp. 7116-7122
-
-
Muzyczka, N.1
Poland, R.L.2
Bessman, M.J.3
-
69
-
-
0037059758
-
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase
-
Ng K, Cherney MM, Vázquez AL (2002) Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J Biol Chem 277:1381–1387
-
(2002)
J Biol Chem
, vol.277
, pp. 1381-1387
-
-
Ng, K.1
Cherney, M.M.2
Vázquez, A.L.3
-
70
-
-
1942501581
-
Crystal structure of Norwalk virus polymerase reveals the carboxyl terminus in the active site cleft
-
Ng K, Pendás-Franco N, Rojo J, Boga JA (2004) Crystal structure of Norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J Biol Chem 279:16638–16645
-
(2004)
J Biol Chem
, vol.279
, pp. 16638-16645
-
-
Ng, K.1
Pendás-Franco, N.2
Rojo, J.3
Boga, J.A.4
-
71
-
-
40649100793
-
Structure-function relationships among RNA-dependent RNA polymerases
-
Ng KKS, Arnold JJ, Cameron CE (2008) Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol 320:137–156
-
(2008)
Curr Top Microbiol Immunol
, vol.320
, pp. 137-156
-
-
Ng, K.1
Arnold, J.J.2
Cameron, C.E.3
-
72
-
-
0037470586
-
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation
-
O’Farrell D, Trowbridge R, Rowlands D, Jäger J (2003) Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J Mol Biol 326:1025–1035
-
(2003)
J Mol Biol
, vol.326
, pp. 1025-1035
-
-
O’Farrell, D.1
Trowbridge, R.2
Rowlands, D.3
Jäger, J.4
-
73
-
-
34250643613
-
The structure of a birnavirus polymerase reveals a distinct active site topology
-
Pan J, Vakharia VN, Tao YJ (2007) The structure of a birnavirus polymerase reveals a distinct active site topology. Proc Nat Acad Sci 104:7385–7390
-
(2007)
Proc Nat Acad Sci
, vol.104
, pp. 7385-7390
-
-
Pan, J.1
Vakharia, V.N.2
Tao, Y.J.3
-
74
-
-
0038809107
-
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
-
Pfeiffer JK, Kirkegaard K (2003) A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci USA 100:7289–7294
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7289-7294
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
75
-
-
33745490138
-
Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice
-
Pfeiffer JK, Kirkegaard K (2005) Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice. PLoS Pathog 1:e11
-
(2005)
Plos Pathog
, vol.1
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
76
-
-
0026089496
-
DNA polymerization in the absence of exonucleolytic proofreading: In vivo and in vitro studies
-
Reha-Krantz LJ, Stocki S, Nonay RL, Dimayuga E, Goodrich LD, Konigsberg WH, Spicer EK (1991) DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies. Proc Natl Acad Sci 88:2417–2421
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 2417-2421
-
-
Reha-Krantz, L.J.1
Stocki, S.2
Nonay, R.L.3
Dimayuga, E.4
Goodrich, L.D.5
Konigsberg, W.H.6
Spicer, E.K.7
-
77
-
-
84893756804
-
Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models
-
Rozen-Gagnon K, Stapleford KA, Mongelli V, Blanc H, Failloux A-B, Saleh M-C, Vignuzzi M (2014) Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models. PLoS Pathog 10:e1003877
-
(2014)
Plos Pathog
, vol.10
-
-
Rozen-Gagnon, K.1
Stapleford, K.A.2
Mongelli, V.3
Blanc, H.4
Failloux, A.-B.5
Saleh, M.-C.6
Vignuzzi, M.7
-
78
-
-
84881378030
-
A study of the virulence in mice of high copying fidelity variants of human enterovirus 71
-
Sadeghipour S, McMinn PC (2013) A study of the virulence in mice of high copying fidelity variants of human enterovirus 71. Virus Res 176:265–272
-
(2013)
Virus Res
, vol.176
, pp. 265-272
-
-
Sadeghipour, S.1
McMinn, P.C.2
-
79
-
-
84873023551
-
Ribavirin-resistant mutants of human enterovirus 71 express a high replication fidelity phenotype during growth in cell culture
-
Sadeghipour S, Bek EJ, McMinn PC (2013) Ribavirin-resistant mutants of human enterovirus 71 express a high replication fidelity phenotype during growth in cell culture. J Virol 87:1759–1769
-
(2013)
J Virol
, vol.87
, pp. 1759-1769
-
-
Sadeghipour, S.1
Bek, E.J.2
McMinn, P.C.3
-
80
-
-
1242283840
-
The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase
-
Salgado PS, Makeyev EV, Butcher SJ, Bamford DH, Stuart DI, Grimes JM (2004) The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase. Structure 12:307–316
-
(2004)
Structure
, vol.12
, pp. 307-316
-
-
Salgado, P.S.1
Makeyev, E.V.2
Butcher, S.J.3
Bamford, D.H.4
Stuart, D.I.5
Grimes, J.M.6
-
81
-
-
0027482444
-
Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli
-
Schaaper RM (1993) Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli. J Biol Chem 268:23762–23765
-
(1993)
J Biol Chem
, vol.268
, pp. 23762-23765
-
-
Schaaper, R.M.1
-
82
-
-
33846813925
-
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: Implications for error catastrophe
-
Sierra M, Airaksinen A, Gonzalez-Lopez C, Agudo R, Arias A, Domingo E (2007) Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J Virol 81:2012–2024
-
(2007)
J Virol
, vol.81
, pp. 2012-2024
-
-
Sierra, M.1
Airaksinen, A.2
Gonzalez-Lopez, C.3
Agudo, R.4
Arias, A.5
Domingo, E.6
-
83
-
-
0030620273
-
Evolution of high mutation rates in experimental populations of
-
Sniegowski PD, Gerrish PJ, Lenski RE (1997) Evolution of high mutation rates in experimental populations of E. coli. Nature 387:703–705
-
(1997)
E. Coli. Nature
, vol.387
, pp. 703-705
-
-
Sniegowski, P.D.1
Gerrish, P.J.2
Lenski, R.E.3
-
84
-
-
0032518374
-
Structural biology: A mechanism for all polymerases
-
Steitz TA (1998) Structural biology: a mechanism for all polymerases. Nature 391:231–232
-
(1998)
Nature
, vol.391
, pp. 231-232
-
-
Steitz, T.A.1
-
85
-
-
0026561520
-
Heterogeneity of the mutation rates of influenza A viruses: Isolation of mutator mutants
-
Suárez P, Valcárcel J, Ortín J (1992) Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. J Virol 66:2491–2494
-
(1992)
J Virol
, vol.66
, pp. 2491-2494
-
-
Suárez, P.1
Valcárcel, J.2
Ortín, J.3
-
86
-
-
0030620272
-
Role of mutator alleles in adaptive evolution
-
Taddei F, Radman M, Maynard-Smith J, Toupance B, Gouyon PH, Godelle B (1997) Role of mutator alleles in adaptive evolution. Nature 387:700–702
-
(1997)
Nature
, vol.387
, pp. 700-702
-
-
Taddei, F.1
Radman, M.2
Maynard-Smith, J.3
Toupance, B.4
Gouyon, P.H.5
Godelle, B.6
-
87
-
-
18744392514
-
RNA synthesis in a cage–structural studies of reovirus polymerase lambda3
-
Tao Y, Farsetta DL, Nibert ML, Harrison SC (2002) RNA synthesis in a cage–structural studies of reovirus polymerase lambda3. Cell 111:733–745
-
(2002)
Cell
, vol.111
, pp. 733-745
-
-
Tao, Y.1
Farsetta, D.L.2
Nibert, M.L.3
Harrison, S.C.4
-
88
-
-
4644238112
-
Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
-
Thompson AA, Peersen OB (2004) Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. EMBO J 23:3462–3471
-
(2004)
EMBO J
, vol.23
, pp. 3462-3471
-
-
Thompson, A.A.1
Peersen, O.B.2
-
89
-
-
84936758206
-
Sequence-specific fidelity alterations associated with west nile virus attenuation in mosquitoes
-
Van Slyke GA, Arnold JJ, Lugo AJ, Griesemer SB, Moustafa IM, Kramer LD, Cameron CE, Ciota AT (2015) Sequence-specific fidelity alterations associated with west nile virus attenuation in mosquitoes. PLoS Pathog 11:e1005009
-
(2015)
Plos Pathog
, vol.11
-
-
Van Slyke, G.A.1
Arnold, J.J.2
Lugo, A.J.3
Griesemer, S.B.4
Moustafa, I.M.5
Kramer, L.D.6
Cameron, C.E.7
Ciota, A.T.8
-
90
-
-
31144465690
-
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
-
Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R (2006) Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439:344–348
-
(2006)
Nature
, vol.439
, pp. 344-348
-
-
Vignuzzi, M.1
Stone, J.K.2
Arnold, J.J.3
Cameron, C.E.4
Andino, R.5
-
91
-
-
38949184924
-
Engineering attenuated virus vaccines by controlling replication fidelity
-
Vignuzzi M, Wendt E, Andino R (2008) Engineering attenuated virus vaccines by controlling replication fidelity. Nat Med 14:154–161
-
(2008)
Nat Med
, vol.14
, pp. 154-161
-
-
Vignuzzi, M.1
Wendt, E.2
Andino, R.3
-
92
-
-
84899093998
-
The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
-
Vives-Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, Canard B, van Kuppeveld FJM, Ferrer-Orta C, Verdaguer N (2014) The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site. J Virol 88:5595–5607
-
(2014)
J Virol
, vol.88
, pp. 5595-5607
-
-
Vives-Adrian, L.1
Lujan, C.2
Oliva, B.3
Van Der Linden, L.4
Selisko, B.5
Coutard, B.6
Canard, B.7
Van Kuppeveld, F.8
Ferrer-Orta, C.9
Verdaguer, N.10
-
93
-
-
13344294407
-
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase
-
Wainberg MA, Drosopoulos WC, Salomon H, Hsu M, Borkow G, Parniak MA, Gu Z, Song Q, Manne J, Islam S et al (1996) Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science 271:1282–1285
-
(1996)
Science
, vol.271
, pp. 1282-1285
-
-
Wainberg, M.A.1
Drosopoulos, W.C.2
Salomon, H.3
Hsu, M.4
Borkow, G.5
Parniak, M.A.6
Gu, Z.7
Song, Q.8
Manne, J.9
Islam, S.10
-
94
-
-
84907704014
-
Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated
-
Xie X, Wang H, Zeng J, Li C, Zhou G, Yang D, Yu L (2014) Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated. Arch Virol 159:2641–2650
-
(2014)
Arch Virol
, vol.159
, pp. 2641-2650
-
-
Xie, X.1
Wang, H.2
Zeng, J.3
Li, C.4
Zhou, G.5
Yang, D.6
Yu, L.7
-
95
-
-
78049295254
-
Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance
-
Yang X, Welch JL, Arnold JJ, Boehr DD (2010) Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance. Biochemistry 49:9361–9371
-
(2010)
Biochemistry
, vol.49
, pp. 9361-9371
-
-
Yang, X.1
Welch, J.L.2
Arnold, J.J.3
Boehr, D.D.4
-
96
-
-
84865768433
-
Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition
-
Yang X, Smidansky ED, Maksimchuk KR, Lum D, Welch JL, Arnold JJ, Cameron CE, Boehr DD (2012) Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure 20:1519–1527
-
(2012)
Structure
, vol.20
, pp. 1519-1527
-
-
Yang, X.1
Smidansky, E.D.2
Maksimchuk, K.R.3
Lum, D.4
Welch, J.L.5
Arnold, J.J.6
Cameron, C.E.7
Boehr, D.D.8
-
97
-
-
34247610261
-
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution
-
Yap TL, Xu T, Chen Y-L, Malet H, Egloff M-P, Canard B, Vasudevan SG, Lescar J (2007) Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol 81:4753–4765
-
(2007)
J Virol
, vol.81
, pp. 4753-4765
-
-
Yap, T.L.1
Xu, T.2
Chen, Y.-L.3
Malet, H.4
Egloff, M.-P.5
Canard, B.6
Vasudevan, S.G.7
Lescar, J.8
-
98
-
-
84881162575
-
An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo
-
Zeng J, Wang H, Xie X, Yang D, Zhou G, Yu L (2013) An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo. Antiviral Res 100:1–7
-
(2013)
Antiviral Res
, vol.100
, pp. 1-7
-
-
Zeng, J.1
Wang, H.2
Xie, X.3
Yang, D.4
Zhou, G.5
Yu, L.6
-
99
-
-
84896904367
-
Ribavirin-resistant variants of foot-and-mouth disease virus: The effect of restricted quasispecies diversity on viral virulence
-
Zeng J, Wang H, Xie X, Li C, Zhou G, Yang D, Yu L (2014) Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence. J Virol 88:4008–4020
-
(2014)
J Virol
, vol.88
, pp. 4008-4020
-
-
Zeng, J.1
Wang, H.2
Xie, X.3
Li, C.4
Zhou, G.5
Yang, D.6
Yu, L.7
|