Generation and characterization of influenza A viruses with altered polymerase fidelity

Nature Communications

Volumn 5, Issue , 2014, Pages

  Cheung, Peter P H ^a   Watson, Simon J ^b   Choy, Ka Tim ^a   Sia, Sin Fun ^a   Wong, Diana D Y ^a   Poon, Leo L M ^a   Kellam, Paul ^b,c   Guan, Yi ^a   Malik Peiris, J S ^a   Yen, Hui Ling ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; FAVIPIRAVIR; GUANOSINE; RIBAVIRIN; ADENOSINE; ANTIVIRUS AGENT; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ENZYME ACTIVITY; EPIDEMIC; GENETIC VARIATION; INFLUENZA; INOCULATION; MUTATION; RNA; VIRAL DISEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA A; INFLUENZA VIRUS A; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; LETHALITY; MOUSE; MUTATION RATE; NEUROTROPISM; NONHUMAN; PATHOGENESIS; VIRUS CHARACTERIZATION; VIRUS GENOME; VIRUS RECOMBINANT; VIRUS VIRULENCE; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; FEMALE; GENETIC REASSORTMENT; GENETICS; INFLUENZA A VIRUS (H3N2); INFLUENZA A VIRUS (H5N1); LUNG; METABOLISM; MORTALITY; MUTATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; SURVIVAL; VIRAL TROPISM; VIROLOGY;

ADENOSINE; ANIMALS; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; FEMALE; GENETIC VARIATION; GUANOSINE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; LUNG; MICE; MICE, INBRED BALB C; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; REASSORTANT VIRUSES; RIBAVIRIN; RNA REPLICASE; SURVIVAL ANALYSIS; VIRAL PROTEINS; VIRAL TROPISM;

EID: 84907300612     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5794     Document Type: Article

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