Determinants of RNA-dependent RNA polymerase (In)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin

Journal of Virology

Volumn 82, Issue 24, 2008, Pages 12346-12355

  Arias, Armando ^a   Arnold, Jamie J ^b   Sierra, Macarena ^a   Smidansky, Eric D ^b   Domingo, Esteban ^a,c   Cameron, Craig E ^b  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

RIBAVIRIN; RNA POLYMERASE;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; FOOT AND MOUTH DISEASE VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ENZYME ACTIVATION; ENZYME STABILITY; FOOT-AND-MOUTH DISEASE VIRUS; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBAVIRIN; RNA; RNA REPLICASE; SUBSTRATE SPECIFICITY; TEMPERATURE; TIME FACTORS;

FOOT-AND-MOUTH DISEASE VIRUS; POLIOVIRUS;

EID: 57349131683     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01297-08     Document Type: Article

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