An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo

Antiviral Research

Volumn 100, Issue 1, 2013, Pages 1-7

  Zeng, Jianxiong ^a   Wang, Haiwei ^a   Xie, Xiaochun ^a   Yang, Decheng ^a   Zhou, Guohui ^a   Yu, Li ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Foot and mouth disease virus; Mutagen resistant mutant; Replication fidelity; RNA dependent RNA polymerase

Indexed keywords

AZACITIDINE; FLUOROURACIL; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; MUTAGENIC AGENT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FOOT AND MOUTH DISEASE VIRUS; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; MOUSE; MUTATION RATE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; VIRUS ATTENUATION; VIRUS ISOLATION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; FOOT AND MOUTH DISEASE; GENETICS; HUMAN; MUTAGEN-RESISTANT MUTANT; MUTATION; PATHOGENICITY; PHYSIOLOGY; REPLICATION FIDELITY; RNA-DEPENDENT RNA POLYMERASE; VIROLOGY; VIRULENCE;

FOOT-AND-MOUTH DISEASE VIRUS; MUS; RNA VIRUSES;

FOOT-AND-MOUTH DISEASE VIRUS; MUTAGEN-RESISTANT MUTANT; REPLICATION FIDELITY; RNA-DEPENDENT RNA POLYMERASE;

ANIMALS; FLUOROURACIL; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; HUMANS; MICE; MICE, INBRED BALB C; MUTAGENS; MUTATION; VIRULENCE; VIRUS REPLICATION;

EID: 84881162575     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.07.008     Document Type: Article

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