-
1
-
-
31144445870
-
Mechanisms of action of ribavirin against distinct viruses
-
Graci J.D., and Cameron C.E. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 16 (2006) 37-48
-
(2006)
Rev Med Virol
, vol.16
, pp. 37-48
-
-
Graci, J.D.1
Cameron, C.E.2
-
2
-
-
40649100793
-
Structure-function relationships among RNA-dependent RNA polymerases
-
Ng K.K., Arnold J.J., and Cameron C.E. Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol 320 (2008) 137-156
-
(2008)
Curr Top Microbiol Immunol
, vol.320
, pp. 137-156
-
-
Ng, K.K.1
Arnold, J.J.2
Cameron, C.E.3
-
3
-
-
53049106343
-
Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase
-
Nikonov A., Juronen E., and Ustav M. Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem 283 (2008) 24089-24102
-
(2008)
J Biol Chem
, vol.283
, pp. 24089-24102
-
-
Nikonov, A.1
Juronen, E.2
Ustav, M.3
-
5
-
-
36048969246
-
High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants
-
This is the first demonstration that an exonuclease contributes to replication fidelity of RNA virus.
-
Eckerle L.D., Lu X., Sperry S.M., Choi L., and Denison M.R. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol 81 (2007) 12135-12144. This is the first demonstration that an exonuclease contributes to replication fidelity of RNA virus.
-
(2007)
J Virol
, vol.81
, pp. 12135-12144
-
-
Eckerle, L.D.1
Lu, X.2
Sperry, S.M.3
Choi, L.4
Denison, M.R.5
-
7
-
-
8744222695
-
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA
-
Ferrer-Orta C., Arias A., Perez-Luque R., Escarmis C., Domingo E., and Verdaguer N. Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA. J Biol Chem 279 (2004) 47212-47221
-
(2004)
J Biol Chem
, vol.279
, pp. 47212-47221
-
-
Ferrer-Orta, C.1
Arias, A.2
Perez-Luque, R.3
Escarmis, C.4
Domingo, E.5
Verdaguer, N.6
-
8
-
-
34547178347
-
Sequential structures provide insights into the fidelity of RNA replication
-
This is the first report of structures of RdRp elongation complexes.
-
Ferrer-Orta C., Arias A., Perez-Luque R., Escarmis C., Domingo E., and Verdaguer N. Sequential structures provide insights into the fidelity of RNA replication. Proc Natl Acad Sci U S A 104 (2007) 9463-9468. This is the first report of structures of RdRp elongation complexes.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9463-9468
-
-
Ferrer-Orta, C.1
Arias, A.2
Perez-Luque, R.3
Escarmis, C.4
Domingo, E.5
Verdaguer, N.6
-
9
-
-
21844431621
-
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase
-
Arnold J.J., Vignuzzi M., Stone J.K., Andino R., and Cameron C.E. Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem 280 (2005) 25706-25716
-
(2005)
J Biol Chem
, vol.280
, pp. 25706-25716
-
-
Arnold, J.J.1
Vignuzzi, M.2
Stone, J.K.3
Andino, R.4
Cameron, C.E.5
-
10
-
-
0038809107
-
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
-
Pfeiffer J.K., and Kirkegaard K. A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci U S A 100 (2003) 7289-7294
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 7289-7294
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
11
-
-
67649303095
-
Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection
-
Beaulieu P.L. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Expert Opin Ther Pat 19 (2009) 145-164
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 145-164
-
-
Beaulieu, P.L.1
-
12
-
-
33745490138
-
Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice
-
This report describes RdRp fidelity as a determinant of viral virulence.
-
Pfeiffer J.K., and Kirkegaard K. Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice. PLoS Pathog 1 (2005) e11. This report describes RdRp fidelity as a determinant of viral virulence.
-
(2005)
PLoS Pathog
, vol.1
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
13
-
-
31144465690
-
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
-
This report describes RdRp fidelity and the corresponding quasispecies as a determinant of viral virulence and pathogenesis.
-
Vignuzzi M., Stone J.K., Arnold J.J., Cameron C.E., and Andino R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439 (2006) 344-348. This report describes RdRp fidelity and the corresponding quasispecies as a determinant of viral virulence and pathogenesis.
-
(2006)
Nature
, vol.439
, pp. 344-348
-
-
Vignuzzi, M.1
Stone, J.K.2
Arnold, J.J.3
Cameron, C.E.4
Andino, R.5
-
14
-
-
38949184924
-
Engineering attenuated virus vaccines by controlling replication fidelity
-
This report describes RdRp fidelity as a target for viral attenuation and vaccine development.
-
Vignuzzi M., Wendt E., and Andino R. Engineering attenuated virus vaccines by controlling replication fidelity. Nat Med 14 (2008) 154-161. This report describes RdRp fidelity as a target for viral attenuation and vaccine development.
-
(2008)
Nat Med
, vol.14
, pp. 154-161
-
-
Vignuzzi, M.1
Wendt, E.2
Andino, R.3
-
15
-
-
0032005866
-
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
-
Brautigam C.A., and Steitz T.A. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol 8 (1998) 54-63
-
(1998)
Curr Opin Struct Biol
, vol.8
, pp. 54-63
-
-
Brautigam, C.A.1
Steitz, T.A.2
-
16
-
-
34248349170
-
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
-
Castro C., Smidansky E., Maksimchuk K.R., Arnold J.J., Korneeva V.S., Gotte M., Konigsberg W., and Cameron C.E. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci U S A 104 (2007) 4267-4272
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4267-4272
-
-
Castro, C.1
Smidansky, E.2
Maksimchuk, K.R.3
Arnold, J.J.4
Korneeva, V.S.5
Gotte, M.6
Konigsberg, W.7
Cameron, C.E.8
-
17
-
-
59649110607
-
Nucleic acid polymerases use a general acid for nucleotidyl transfer
-
This report describes the discovery of a general acid for nucleotidyl transfer by polymerases.
-
Castro C., Smidansky E.D., Arnold J.J., Maksimchuk K.R., Moustafa I., Uchida A., Gotte M., Konigsberg W., and Cameron C.E. Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol 16 (2009) 212-218. This report describes the discovery of a general acid for nucleotidyl transfer by polymerases.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 212-218
-
-
Castro, C.1
Smidansky, E.D.2
Arnold, J.J.3
Maksimchuk, K.R.4
Moustafa, I.5
Uchida, A.6
Gotte, M.7
Konigsberg, W.8
Cameron, C.E.9
-
18
-
-
0026029379
-
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity
-
Carroll S.S., Cowart M., and Benkovic S.J. A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity. Biochemistry 30 (1991) 804-813
-
(1991)
Biochemistry
, vol.30
, pp. 804-813
-
-
Carroll, S.S.1
Cowart, M.2
Benkovic, S.J.3
-
19
-
-
0030906056
-
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain
-
Bell J.B., Eckert K.A., Joyce C.M., and Kunkel T.A. Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. J Biol Chem 272 (1997) 7345-7351
-
(1997)
J Biol Chem
, vol.272
, pp. 7345-7351
-
-
Bell, J.B.1
Eckert, K.A.2
Joyce, C.M.3
Kunkel, T.A.4
-
20
-
-
0030897085
-
Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I
-
Suzuki M., Avicola A.K., Hood L., and Loeb L.A. Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I. J Biol Chem 272 (1997) 11228-11235
-
(1997)
J Biol Chem
, vol.272
, pp. 11228-11235
-
-
Suzuki, M.1
Avicola, A.K.2
Hood, L.3
Loeb, L.A.4
-
21
-
-
0037114247
-
A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs
-
Padilla R., and Sousa R. A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs. Nucleic Acids Res 30 (2002) e138
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Padilla, R.1
Sousa, R.2
-
22
-
-
33751235874
-
Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
-
Wang D., Bushnell D.A., Westover K.D., Kaplan C.D., and Kornberg R.D. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell 127 (2006) 941-954
-
(2006)
Cell
, vol.127
, pp. 941-954
-
-
Wang, D.1
Bushnell, D.A.2
Westover, K.D.3
Kaplan, C.D.4
Kornberg, R.D.5
-
23
-
-
44449103640
-
The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin
-
This report describes the use of the trigger loop for the fidelity of nucleotide addition by multisubunit RNA polymerases.
-
Kaplan C.D., Larsson K.M., and Kornberg R.D. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell 30 (2008) 547-556. This report describes the use of the trigger loop for the fidelity of nucleotide addition by multisubunit RNA polymerases.
-
(2008)
Mol Cell
, vol.30
, pp. 547-556
-
-
Kaplan, C.D.1
Larsson, K.M.2
Kornberg, R.D.3
-
24
-
-
0027181612
-
A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice
-
Tardy-Panit M., Blondel B., Martin A., Tekaia F., Horaud F., and Delpeyroux F. A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice. J Virol 67 (1993) 4630-4638
-
(1993)
J Virol
, vol.67
, pp. 4630-4638
-
-
Tardy-Panit, M.1
Blondel, B.2
Martin, A.3
Tekaia, F.4
Horaud, F.5
Delpeyroux, F.6
-
25
-
-
4644238112
-
Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
-
Thompson A.A., and Peersen O.B. Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. EMBO J 23 (2004) 3462-3471
-
(2004)
EMBO J
, vol.23
, pp. 3462-3471
-
-
Thompson, A.A.1
Peersen, O.B.2
-
26
-
-
33947386595
-
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase
-
This is the first structure for a biologically relevant fusion of the RdRp.
-
Marcotte L.L., Wass A.B., Gohara D.W., Pathak H.B., Arnold J.J., Filman D.J., Cameron C.E., and Hogle J.M. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol 81 (2007) 3583-3596. This is the first structure for a biologically relevant fusion of the RdRp.
-
(2007)
J Virol
, vol.81
, pp. 3583-3596
-
-
Marcotte, L.L.1
Wass, A.B.2
Gohara, D.W.3
Pathak, H.B.4
Arnold, J.J.5
Filman, D.J.6
Cameron, C.E.7
Hogle, J.M.8
-
27
-
-
0031443372
-
Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant
-
Cameron C.E., and Benkovic S.J. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. Biochemistry 36 (1997) 15792-15800
-
(1997)
Biochemistry
, vol.36
, pp. 15792-15800
-
-
Cameron, C.E.1
Benkovic, S.J.2
-
29
-
-
64649104893
-
Elucidating the inhibition mechanism of HIV-1 non-nucleoside reverse transcriptase inhibitors through multicopy molecular dynamics simulations
-
This report describes the use of molecular dynamics simulations to study the basis for the inhibition of HIV RT by a non-nucleoside inhibitor.
-
Ivetac A., and McCammon J.A. Elucidating the inhibition mechanism of HIV-1 non-nucleoside reverse transcriptase inhibitors through multicopy molecular dynamics simulations. J Mol Biol 388 (2009) 644-658. This report describes the use of molecular dynamics simulations to study the basis for the inhibition of HIV RT by a non-nucleoside inhibitor.
-
(2009)
J Mol Biol
, vol.388
, pp. 644-658
-
-
Ivetac, A.1
McCammon, J.A.2
-
30
-
-
68849132703
-
Solution structural dynamics of HIV-1 reverse transcriptase heterodimer
-
This report describes the use of hydrogen-deuterium exchange to study HIV RT dynamics.
-
Seckler J.M., Howard K.J., Barkley M.D., and Wintrode P.L. Solution structural dynamics of HIV-1 reverse transcriptase heterodimer. Biochemistry (2009). This report describes the use of hydrogen-deuterium exchange to study HIV RT dynamics.
-
(2009)
Biochemistry
-
-
Seckler, J.M.1
Howard, K.J.2
Barkley, M.D.3
Wintrode, P.L.4
-
31
-
-
57349131683
-
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin
-
Arias A., Arnold J.J., Sierra M., Smidansky E.D., Domingo E., and Cameron C.E. Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol 82 (2008) 12346-12355
-
(2008)
J Virol
, vol.82
, pp. 12346-12355
-
-
Arias, A.1
Arnold, J.J.2
Sierra, M.3
Smidansky, E.D.4
Domingo, E.5
Cameron, C.E.6
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