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Volumn 28, Issue 6, 2010, Pages 573-579

Rationalizing the development of live attenuated virus vaccines

Author keywords

[No Author keywords available]

Indexed keywords

EMPIRICAL ATTENUATION; GENE MUTATIONS; HUMAN TESTING; INACTIVATED VIRUS; MICRORNAS; SAFETY ISSUES; SUBUNIT VACCINE; VIRAL DISEASE; VIRAL REPLICATION; ZINC FINGER;

EID: 77953249856     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1635     Document Type: Review
Times cited : (239)

References (69)
  • 1
    • 0017402254 scopus 로고
    • Polio vaccines and polioviruses
    • Salk, J. Polio vaccines and polioviruses. BMJ 2, 765 (1977).
    • (1977) BMJ , vol.2 , pp. 765
    • Salk, J.1
  • 2
    • 29244482595 scopus 로고    scopus 로고
    • New viral vaccines
    • Arvin, A.M. & Greenberg, H.B. New viral vaccines. Virology 344, 240-249 (2006).
    • (2006) Virology , vol.344 , pp. 240-249
    • Arvin, A.M.1    Greenberg, H.B.2
  • 3
    • 23444456490 scopus 로고    scopus 로고
    • Novel vaccines from biotechnology
    • Rogan, D. & Babiuk, L.A. Novel vaccines from biotechnology. Rev. Sci. Tech. 24, 159-174 (2005).
    • (2005) Rev. Sci. Tech. , vol.24 , pp. 159-174
    • Rogan, D.1    Babiuk, L.A.2
  • 4
    • 0037435928 scopus 로고    scopus 로고
    • Liposomes and ISCOMs
    • Kersten, G.F. & Crommelin, D.J. Liposomes and ISCOMs. Vaccine 21, 915-920 (2003).
    • (2003) Vaccine , vol.21 , pp. 915-920
    • Kersten, G.F.1    Crommelin, D.J.2
  • 5
    • 45749103230 scopus 로고    scopus 로고
    • The coming of age of virus-like particle vaccines
    • Jennings, G.T. & Bachmann, M.F. The coming of age of virus-like particle vaccines. Biol. Chem. 389, 521-536 (2008).
    • (2008) Biol. Chem. , vol.389 , pp. 521-536
    • Jennings, G.T.1    Bachmann, M.F.2
  • 6
    • 9244234954 scopus 로고    scopus 로고
    • Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
    • Felnerova, D., Viret, J.F., Gluck, R. & Moser, C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 15, 518-529 (2004).
    • (2004) Curr. Opin. Biotechnol. , vol.15 , pp. 518-529
    • Felnerova, D.1    Viret, J.F.2    Gluck, R.3    Moser, C.4
  • 7
    • 0020170245 scopus 로고
    • Construction of poxviruses as cloning vectors: Insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus
    • Panicali, D. & Paoletti, E. Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. Proc. Natl. Acad. Sci. USA 79, 4927-4931 (1982).
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 4927-4931
    • Panicali, D.1    Paoletti, E.2
  • 8
    • 29144487803 scopus 로고    scopus 로고
    • Replication-defective viruses as vaccines and vaccine vectors
    • Dudek, T. & Knipe, D.M. Replication-defective viruses as vaccines and vaccine vectors. Virology 344, 230-239 (2006).
    • (2006) Virology , vol.344 , pp. 230-239
    • Dudek, T.1    Knipe, D.M.2
  • 9
    • 18044399712 scopus 로고    scopus 로고
    • Preclinical safety testing of DISC-hGMCSF to support phase i clinical trials in cancer patients
    • Loudon, P.T. et al. Preclinical safety testing of DISC-hGMCSF to support phase I clinical trials in cancer patients. J. Gene Med. 3, 458-467 (2001).
    • (2001) J. Gene Med. , vol.3 , pp. 458-467
    • Loudon, P.T.1
  • 10
    • 0026447939 scopus 로고
    • Replication-defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection
    • Nguyen, L.H., Knipe, D.M. & Finberg, R.w. Replication-defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection. J. Virol. 66, 7067-7072 (1992).
    • (1992) J. Virol. , vol.66 , pp. 7067-7072
    • Nguyen, L.H.1    Knipe, D.M.2    Finberg, R.W.3
  • 11
    • 0029897416 scopus 로고    scopus 로고
    • Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1
    • Morrison, L.A. & Knipe, D.M. Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1. Virology 220, 402-413 (1996).
    • (1996) Virology , vol.220 , pp. 402-413
    • Morrison, L.A.1    Knipe, D.M.2
  • 12
    • 0033882023 scopus 로고    scopus 로고
    • Phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2
    • Da Costa, X., Kramer, M.F., Zhu, J., Brockman, M.A. & Knipe, D.M. Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2. J. Virol. 74, 7963-7971 (2000).
    • (2000) J. Virol. , vol.74 , pp. 7963-7971
    • Da Costa, X.1    Kramer, M.F.2    Zhu, J.3    Brockman, M.A.4    Construction, K.M.D.5
  • 13
    • 10644231702 scopus 로고    scopus 로고
    • Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs
    • Hoshino, Y. et al. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs. J. Virol. 79, 410-418 (2005).
    • (2005) J. Virol. , vol.79 , pp. 410-418
    • Hoshino, Y.1
  • 14
    • 0033536011 scopus 로고    scopus 로고
    • Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection
    • Da Costa, X.J., Jones, C.A. & Knipe, D.M. Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection. Proc. Natl. Acad. Sci. USA 96, 6994-6998 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6994-6998
    • Da Costa, X.J.1    Jones, C.A.2    Knipe, D.M.3
  • 15
    • 0028020595 scopus 로고
    • Protective vaccination against primary and recurrent disease caused by herpes simplex virus (HSV) type 2 using a genetically disabled HSV-1
    • McLean, C.S. et al. Protective vaccination against primary and recurrent disease caused by herpes simplex virus (HSV) type 2 using a genetically disabled HSV-1. J. Infect. Dis. 170, 1100-1109 (1994).
    • (1994) J. Infect. Dis. , vol.170 , pp. 1100-1109
    • McLean, C.S.1
  • 16
    • 0028039848 scopus 로고
    • Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted
    • Farrell, H.E. et al. Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted. J. Virol. 68, 927-932 (1994).
    • (1994) J. Virol. , vol.68 , pp. 927-932
    • Farrell, H.E.1
  • 17
    • 0036139062 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles
    • watanabe, T., watanabe, S., Neumann, G., Kida, H. & Kawaoka, Y. Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles. J. Virol. 76, 767-773 (2002).
    • (2002) J. Virol. , vol.76 , pp. 767-773
    • Watanabe, T.1    Watanabe, S.2    Neumann, G.3    Kida, H.4    Kawaoka, Y.5
  • 18
    • 49449109457 scopus 로고    scopus 로고
    • Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines
    • Stech, J. Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines. Expert Rev. Vaccines 7, 739-743 (2008)
    • (2008) Expert Rev. Vaccines , vol.7 , pp. 739-743
    • Stech, J.1
  • 19
    • 57149089647 scopus 로고    scopus 로고
    • Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses
    • widman, D.G., Frolov, I. & Mason, P.w. Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses. Adv. Virus Res. 72, 77-126 (2008).
    • (2008) Adv. Virus Res. , vol.72 , pp. 77-126
    • Widman, D.G.1    Frolov, I.2    Mason, P.W.3
  • 20
    • 0020075533 scopus 로고
    • Rapid evolution of RNA genomes
    • Holland, J. et al. Rapid evolution of RNA genomes. Science 215, 1577-1585 (1982).
    • (1982) Science , vol.215 , pp. 1577-1585
    • Holland, J.1
  • 21
    • 11844292013 scopus 로고    scopus 로고
    • Ribavirin and lethal mutagenesis of poliovi-rus: Molecular mechanisms, resistance and biological implications
    • Vignuzzi, M., Stone, J.K. & Andino, R. Ribavirin and lethal mutagenesis of poliovi-rus: molecular mechanisms, resistance and biological implications. Virus Res. 107, 173-181 (2005)
    • (2005) Virus Res. , vol.107 , pp. 173-181
    • Vignuzzi, M.1    Stone, J.K.2    Andino, R.3
  • 22
    • 44049108744 scopus 로고    scopus 로고
    • Toward an AIDS vaccine
    • walker, B.D. & Burton, D. Toward an AIDS vaccine. Science 320, 760-764 (2008).
    • (2008) Science , vol.320 , pp. 760-764
    • Walker, B.D.1    Burton, D.2
  • 23
    • 51649126684 scopus 로고    scopus 로고
    • Seasonal inactivated influenza virus vaccines
    • Couch, R.B. Seasonal inactivated influenza virus vaccines. Vaccine 26 Suppl 4, D5-D9 (2008).
    • (2008) Vaccine , vol.26 , Issue.SUPPL. 4
    • Couch, R.B.1
  • 24
    • 64649098944 scopus 로고    scopus 로고
    • Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradication
    • Minor, P. Vaccine-derived poliovirus (VDPV): impact on poliomyelitis eradication. Vaccine 27, 2649-2652 (2009).
    • (2009) Vaccine , vol.27 , pp. 2649-2652
    • Minor, P.1
  • 25
    • 30644478836 scopus 로고    scopus 로고
    • Viruses as quasispecies: Biological implications
    • Domingo, E. et al. Viruses as quasispecies: biological implications. Curr. Top. Microbiol. Immunol. 299, 51-82 (2006).
    • (2006) Curr. Top. Microbiol. Immunol. , vol.299 , pp. 51-82
    • Domingo, E.1
  • 26
    • 11844274684 scopus 로고    scopus 로고
    • The error threshold
    • Biebricher, C.K. & Eigen, M. The error threshold. Virus Res. 107, 117-127 (2005).
    • (2005) Virus Res. , vol.107 , pp. 117-127
    • Biebricher, C.K.1    Eigen, M.2
  • 27
    • 21844431621 scopus 로고    scopus 로고
    • Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase
    • Arnold, J.J., Vignuzzi, M., Stone, J.K., Andino, R. & Cameron, C.E. Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J. Biol. Chem. 280, 25706-25716 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 25706-25716
    • Arnold, J.J.1    Vignuzzi, M.2    Stone, J.K.3    Andino, R.4    Cameron, C.E.5
  • 28
    • 0038809107 scopus 로고    scopus 로고
    • A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
    • Pfeiffer, J.K. & Kirkegaard, K. A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc. Natl. Acad. Sci. USA 100, 7289-7294 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7289-7294
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 29
    • 33846813925 scopus 로고    scopus 로고
    • Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: Implications for error catastrophe
    • Sierra, M. et al. Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J. Virol. 81, 2012-2024 (2007).
    • (2007) J. Virol. , vol.81 , pp. 2012-2024
    • Sierra, M.1
  • 30
    • 31144465690 scopus 로고    scopus 로고
    • Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
    • Vignuzzi, M., Stone, J.K., Arnold, J.J., Cameron, C.E. & Andino, R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439, 344-348 (2006).
    • (2006) Nature , vol.439 , pp. 344-348
    • Vignuzzi, M.1    Stone, J.K.2    Arnold, J.J.3    Cameron, C.E.4    Andino, R.5
  • 31
    • 33745490138 scopus 로고    scopus 로고
    • Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice
    • Pfeiffer, J.K. & Kirkegaard, K. Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice. PLoS Pathog. 1, e11 (2005).
    • (2005) PLoS Pathog. , vol.1
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 32
    • 38949184924 scopus 로고    scopus 로고
    • Engineering attenuated virus vaccines by controlling replication fidelity
    • Vignuzzi, M., wendt, E. & Andino, R. Engineering attenuated virus vaccines by controlling replication fidelity. Nat. Med. 14, 154-161 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 154-161
    • Vignuzzi Wendt, M.E.1    Andino, R.2
  • 33
    • 56749106906 scopus 로고    scopus 로고
    • New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis
    • Chumakov, K. & Ehrenfeld, E. New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis. Clin. Infect. Dis. 47, 1587-1592 (2008).
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 1587-1592
    • Chumakov, K.1    Ehrenfeld, E.2
  • 36
    • 0023046874 scopus 로고
    • Codon usage in yeast: Cluster analysis clearly differentiates highly and lowly expressed genes
    • Sharp, P.M., Tuohy, T.M. & Mosurski, K.R. Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes. Nucleic Acids Res. 14, 5125-5143 (1986).
    • (1986) Nucleic Acids Res. , vol.14 , pp. 5125-5143
    • Sharp, P.M.1    Tuohy, T.M.2    Mosurski, K.R.3
  • 37
    • 43149120657 scopus 로고    scopus 로고
    • Codon bias is a major factor explaining phage evolution in translationally biased hosts
    • Carbone, A. Codon bias is a major factor explaining phage evolution in translationally biased hosts. J. Mol. Evol. 66, 210-223 (2008).
    • (2008) J. Mol. Evol. , vol.66 , pp. 210-223
    • Carbone, A.1
  • 38
    • 0037372775 scopus 로고    scopus 로고
    • The extent of codon usage bias in human RNA viruses and its evolutionary origin
    • Jenkins, G.M. & Holmes, E.C. The extent of codon usage bias in human RNA viruses and its evolutionary origin. Virus Res. 92, 1-7 (2003).
    • (2003) Virus Res. , vol.92 , pp. 1-7
    • Jenkins, G.M.1    Holmes, E.C.2
  • 39
    • 33745654553 scopus 로고    scopus 로고
    • Evolutionary basis of codon usage and nucleotide composition bias in vertebrate DNA viruses
    • Shackelton, L.A., Parrish, C.R. & Holmes, E.C. Evolutionary basis of codon usage and nucleotide composition bias in vertebrate DNA viruses. J. Mol. Evol. 62, 551-563 (2006).
    • (2006) J. Mol. Evol. , vol.62 , pp. 551-563
    • Shackelton, L.A.1    Parrish, C.R.2    Holmes, E.C.3
  • 40
    • 0038133117 scopus 로고    scopus 로고
    • Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus
    • Plotkin, J.B. & Dushoff, J. Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus. Proc. Natl. Acad. Sci. USA 100, 7152-7157 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7152-7157
    • Plotkin, J.B.1    Dushoff, J.2
  • 41
    • 0032998243 scopus 로고    scopus 로고
    • Codon bias and mutability in HIV sequences
    • Stephens, C.R. & waelbroeck, H. Codon bias and mutability in HIV sequences. J. Mol. Evol. 48, 390-397 (1999).
    • (1999) J. Mol. Evol. , vol.48 , pp. 390-397
    • Stephens, C.R.1    Waelbroeck, H.2
  • 42
    • 33645215084 scopus 로고    scopus 로고
    • Modulation of poliovirus replicative fitness in HeLa cells by deopti-mization of synonymous codon usage in the capsid region
    • Burns, C.C. et al. Modulation of poliovirus replicative fitness in HeLa cells by deopti-mization of synonymous codon usage in the capsid region. J. Virol. 80, 3259-3272 (2006).
    • (2006) J. Virol. , vol.80 , pp. 3259-3272
    • Burns, C.C.1
  • 43
    • 70349272204 scopus 로고    scopus 로고
    • Genetic inactivation of poliovirus infectivity by increasing the frequencies of CpG and UpA dinucleotides within and across synonymous capsid region codons
    • Burns, C.C. et al. Genetic inactivation of poliovirus infectivity by increasing the frequencies of CpG and UpA dinucleotides within and across synonymous capsid region codons. J. Virol. 83, 9957-9969 (2009).
    • (2009) J. Virol. , vol.83 , pp. 9957-9969
    • Burns, C.C.1
  • 44
    • 33748923860 scopus 로고    scopus 로고
    • Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity
    • Mueller, S., Papamichail, D., Coleman, J.R., Skiena, S. & wimmer, E. Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity. J. Virol. 80, 9687-9696 (2006).
    • (2006) J. Virol. , vol.80 , pp. 9687-9696
    • Mueller, S.1    Papamichail, D.2    Coleman, J.R.3    Skiena, S.4    Wimmer, E.5
  • 45
    • 46449120581 scopus 로고    scopus 로고
    • Virus attenuation by genome-scale changes in codon pair bias
    • Coleman, J.R. et al. Virus attenuation by genome-scale changes in codon pair bias. Science 320, 1784-1787 (2008).
    • (2008) Science , vol.320 , pp. 1784-1787
    • Coleman, J.R.1
  • 46
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew, R.w. & Sontheimer, E.J. Origins and mechanisms of miRNAs and siRNAs. Cell 136, 642-655 (2009).
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 47
    • 36849042601 scopus 로고    scopus 로고
    • RNA interference against viruses: Strike and counterstrike
    • Haasnoot, J., westerhout, E.M. & Berkhout, B. RNA interference against viruses: strike and counterstrike. Nat. Biotechnol. 25, 1435-1443 (2007).
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1435-1443
    • Haasnoot Westerhout, J.E.M.1    Berkhout, B.2
  • 48
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D.P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 49
    • 44649110160 scopus 로고    scopus 로고
    • Viral and cellular microRNAs as determinants of viral pathogenesis and immunity
    • Gottwein, E. & Cullen, B.R. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3, 375-387 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 375-387
    • Gottwein, E.1    Cullen, B.R.2
  • 50
    • 0037197803 scopus 로고    scopus 로고
    • Identification of tissue-specific microRNAs from mouse
    • Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735-739 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 735-739
    • Lagos-Quintana, M.1
  • 51
    • 67651087321 scopus 로고    scopus 로고
    • Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
    • Brown, B.D. & Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat. Rev. Genet. 10, 578-585 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 578-585
    • Brown, B.D.1    Naldini, L.2
  • 52
    • 33646564701 scopus 로고    scopus 로고
    • Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
    • Brown, B.D., Venneri, M.A., Zingale, A., Sergi Sergi, L. & Naldini, L. Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat. Med. 12, 585-591 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 585-591
    • Brown, B.D.1    Venneri, M.A.2    Zingale, A.3    Sergi Sergi, L.4    Naldini, L.5
  • 53
    • 55549100223 scopus 로고    scopus 로고
    • Engineering microRNA responsiveness to decrease virus pathogenicity
    • Kelly, E.J., Hadac, E.M., Greiner, S. & Russell, S.J. Engineering microRNA responsiveness to decrease virus pathogenicity. Nat. Med. 14, 1278-1283 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1278-1283
    • Kelly, E.J.1    Hadac, E.M.2    Greiner, S.3    Russell, S.J.4
  • 54
    • 67249084276 scopus 로고    scopus 로고
    • Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells
    • Cawood, R. et al. Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog. 5, e1000440 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Cawood, R.1
  • 55
    • 55549108699 scopus 로고    scopus 로고
    • Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific microRNA
    • Ylösmäki, E. et al. Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific microRNA. J. Virol. 82, 11009-11015 (2008).
    • (2008) J. Virol. , vol.82 , pp. 11009-11015
    • Ylösmäki, E.1
  • 56
    • 51049109002 scopus 로고    scopus 로고
    • Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines
    • Barnes, D., Kunitomi, M., Vignuzzi, M., Saksela, K. & Andino, R. Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines. Cell Host Microbe 4, 239-248 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 239-248
    • Barnes, D.1    Kunitomi, M.2    Vignuzzi, M.3    Saksela, K.4    Andino, R.5
  • 57
    • 67149084571 scopus 로고    scopus 로고
    • MicroRNA-mediated species-specific attenuation of influenza A virus
    • Perez, J.T. et al. MicroRNA-mediated species-specific attenuation of influenza A virus. Nat. Biotechnol. 27, 572-576 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 572-576
    • Perez, J.T.1
  • 58
    • 0034744439 scopus 로고    scopus 로고
    • Three classes of C2H2 zinc finger proteins
    • Iuchi, S. Three classes of C2H2 zinc finger proteins. Cell. Mol. Life Sci. 58, 625-635 (2001).
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 625-635
    • Iuchi, S.1
  • 59
    • 34248220864 scopus 로고    scopus 로고
    • Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly
    • wright, D.A. et al. Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly. Nat. Protoc. 1, 1637-1652 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 1637-1652
    • Wright, D.A.1
  • 60
    • 33344464022 scopus 로고    scopus 로고
    • Designer zinc finger proteins: Tools for creating artificial DNA-binding functional proteins
    • Dhanasekaran, M., Negi, S. & Sugiura, Y. Designer zinc finger proteins: tools for creating artificial DNA-binding functional proteins. Acc. Chem. Res. 39, 45-52 (2006).
    • (2006) Acc. Chem. Res. , vol.39 , pp. 45-52
    • Dhanasekaran, M.1    Negi, S.2    Sugiura, Y.3
  • 61
    • 84934444085 scopus 로고    scopus 로고
    • And testing of zinc finger nucleases for use in mammalian cells
    • Porteus, M. Design and testing of zinc finger nucleases for use in mammalian cells. Methods Mol. Biol. 435, 47-61 (2008).
    • (2008) Methods Mol. Biol. , vol.435 , pp. 47-61
    • Porteus, M.1    Design2
  • 62
    • 0034283804 scopus 로고    scopus 로고
    • Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
    • Smith, J. et al. Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Res. 28, 3361-3369 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3361-3369
    • Smith, J.1
  • 63
    • 23044460704 scopus 로고    scopus 로고
    • Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage
    • Mani, M., Smith, J., Kandavelou, K., Berg, J.M. & Chandrasegaran, S. Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage. Biochem. Biophys. Res. Commun. 334, 1191-1197 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.334 , pp. 1191-1197
    • Mani, M.1    Smith, J.2    Kandavelou, K.3    Berg, J.M.4    Chandrasegaran, S.5
  • 64
    • 0037452614 scopus 로고    scopus 로고
    • Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
    • Papworth, M. et al. Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors. Proc. Natl. Acad. Sci. USA 100, 1621-1626 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1621-1626
    • Papworth, M.1
  • 65
    • 33646739107 scopus 로고    scopus 로고
    • Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins
    • Mino, T. et al. Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins. J. Virol. 80, 5405-5412 (2006).
    • (2006) J. Virol. , vol.80 , pp. 5405-5412
    • Mino, T.1
  • 66
    • 77953241224 scopus 로고    scopus 로고
    • Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases. Nucleic Acids Symp
    • Mino, T., Mori, T., Aoyama, Y. & Sera, T. Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases. Nucleic Acids Symp. Ser. (Oxf) 52, 185-186 (2008).
    • (2008) Ser. (Oxf) , vol.52 , pp. 185-186
    • Mino, T.1    Mori, T.2    Aoyama, Y.3    Sera, T.4
  • 68
    • 0036426634 scopus 로고    scopus 로고
    • Tetracycline-controlled tran-scriptional regulation systems: Advances and application in transgenic animal modeling
    • Zhu, Z., Zheng, T., Lee, C.G., Homer, R.J. & Elias, J.A. Tetracycline-controlled tran-scriptional regulation systems: advances and application in transgenic animal modeling. Semin. Cell Dev. Biol. 13, 121-128 (2002).
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 121-128
    • Zhu, Z.1    Zheng, T.2    Lee, C.G.3    Homer, R.J.4    Elias, J.A.5
  • 69
    • 61449266636 scopus 로고    scopus 로고
    • Reading, D.w., Porter, S.N. & Porteus, M.H. Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels
    • Pruett-Miller, S.M., Reading, D.w., Porter, S.N. & Porteus, M.H. Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet. 5, e1000376 (2009).
    • (2009) PLoS Genet. , vol.5
    • Pruett-Miller, S.M.1


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