Amiloride derivatives inhibit coxsackievirus B3 RNA replication

Journal of Virology

Volumn 82, Issue 3, 2008, Pages 1465-1473

  Harrison, David N ^a   Gazina, Elena V ^a   Purcell, Damian F ^a   Anderson, David A ^b,c   Petrou, Steven ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BURNET INSTITUTE   (Australia)

^c Select Vaccines Ltd   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 (N,N HEXAMETHYLENE)AMILORIDE; AMILORIDE; AMILORIDE DERIVATIVE; BENZAMIL; DNA DIRECTED DNA POLYMERASE ALPHA; SODIUM CHANNEL; SODIUM PROTON EXCHANGE PROTEIN; VIRUS PROTEIN; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B3; EPITHELIUM CELL; GENE MUTATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; RNA REPLICATION; VIRUS INHIBITION;

COXSACKIEVIRUS; HUMAN RHINOVIRUS 2;

EID: 38349098724     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01374-07     Document Type: Article

References (28)

1. Appleby, T. C., H. Luecke, J. H. Shim, J. Z. Wu, I. W. Cheney, W. Zhong, L. Vogeley, Z. Hong, and N. Yao. 2005. Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer. J. Virol. 79:277-288.
2. Bedard, K. M., and B. L. Semler. 2004. Regulation of picornavirus gene expression. Microbes Infect. 6:702-713.
3. Caliguiri, L. A., and I. Tamm. 1968. Action of guanidine on the replication of poliovirus RNA. Virology 35:408-417.
4. Caliguiri, L. A., and I. Tamm. 1968. Distribution and translation of poliovirus RNA in guanidine-treated cells. Virology 36:223-231.
5. Carthy, C. M., B. Yanagawa, H. Luo, D. J. Granville, D. Yang, P. Cheung, C. Cheung, M. Esfandiarei, C. M. Rudin, C. B. Thompson, D. W. Hunt, and B. M. McManus. 2003. Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology 313:147-157.
6. Deszcz, L., J. Seipelt, E. Vassilieva, A. Roetzer, and E. Kuechler. 2004. Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase. FEBS Lett. 560:51-55.
7. Ewart, G. D., K. Mills, G. B. Cox, and P. W. Gage. 2002. Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu. Eur. Biophys. J. 31:26-35.
8. Ewart, G. D., N. Nasr, H. Naif, G. B. Cox, A. L. Cunningham, and P. W. Gage. 2004. Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages. Antimicrob. Agents Chemother. 48:2325-2330.
9. Gazina, E. V., D. N. Harrison, M. Jefferies, H. Tan, D. Williams, D. A. Anderson, and S. Petrou. 2005. Ion transport blockers inhibit human rhinovirus 2 release. Antiviral Res. 67:98-106.
10. pol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry 43:5149-5158.
11. Gohara, D. W., S. Crotty, J. J. Arnold, J. D. Yoder, R. Andino, and C. E. Cameron. 2000. Poliovirus RNA-dependem RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. J. Biol. Chem. 275:25523-25532.
12. Hansen, J. L., A. M. Long, and S. C. Schultz. 1997. Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5:1109-1122.
13. Kim, C. G., V. Lemaitre, A. Watts, and W. B. Fischer. 2006. Drug-protein interaction with Vpu from HIV-1: proposing binding sites for amiloride and one of its derivatives. Anal. Bioanal. Chem. 386:2213-2217.
14. Kleyman, T. R., and E. J. Cragoe, Jr. 1988. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105:1-21.
15. Korneeva, V. S., and C. E. Cameron. 2007. Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J. Biol. Chem. 282:16135-16145.
16. Love, R. A., K. A. Maegley, X. Yu, R. A. Ferre, L. K. Lingardo, W. Diehl, H. E. Parge, P. S. Dragovich, and S. A. Fuhrman. 2004. The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy. Structure 12:1533-1544.
17. Plagemann, P. G., and C. Woffendin. 1987. Effects of Ca2+-channel antagonists on nucleoside and nucleobase transport in human erythrocytes and cultured mammalian cells. Biochim. Biophys. Acta 928:243-250.
18. Premkumar, A., C. R. Horan, and P. W. Gage. 2005. Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels. J. Membr. Biol. 204:33-38.
19. Premkumar, A., L. Wilson, G. D. Ewart, and P. W. Gage. 2004. Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett. 557:99-103.
20. Si, X., H. Luo, A. Morgan, J. Zhang, J. Wong, J. Yuan, M. Esfandiarei, G. Gao, C. Cheung, and B. M. McManus. 2005. Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release. J. Virol. 79:13875-13881.
21. Thompson, A. A., and O. B. Peersen. 2004. Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. EMBO J. 23:3462-3471.
22. van Kuppeveld, F. J., J. G. Hoenderop, R. L. Smeets, P. H. Willems, H. B. Dijkman, J. M. Galama, and W. J. Melchers. 1997. Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO J. 16:3519-3532.
23. Vance, L. M., N. Moscufo, M. Chow, and B. A. Heinz. 1997. Poliovirus 2C region functions during encapsidation of viral RNA. J. Virol. 71:8759-8765.
24. van Ooij, M. J., D. A. Vogt, A. Paul, C. Castro, J. Kuijpers, F. J. van Kuppeveld, C. E. Cameron, E. Wimmer, R. Andino, and W. J. Melchers. 2006. Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J. Gen. Virol. 87:103-113.
25. Wessels, E., D. Duijsings, R. A. Notebaart, W. J. Melchers, and F. J. van Kuppeveld. 2005. A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-Golgi transport. J. Virol. 79:5163-5173.
26. Whitton, J. L., C. T. Cornell, and R. Feuer. 2005. Host and virus determinants of picornavirus pathogenesis and tropism. Nat. Rev. Microbiol. 3:765-776.
27. Wilson, L., P. Gage, and G. Ewart. 2006. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology 353:294-306.
28. Wimmer, E., C. U. Hellen, and X. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27:353-436.