Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32753-32765

  Liu, Xinran ^a   Yang, Xiaorong ^a   Lee, Cheri A ^a   Moustafa, Ibrahim M ^a   Smidansky, Eric D ^a   Lum, David ^a   Arnold, Jamie J ^a   Cameron, Craig E ^a   Boehr, David D ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL EXPERIMENTS; CONFORMATIONAL CHANGE; MUTAGENIC ACTIVITY; NORMAL GROWTH; RNA-DEPENDENT RNA POLYMERASE; STRUCTURAL ELEMENTS; VACCINE STRAINS;

CELL CULTURE; NUCLEOTIDES; STRUCTURAL DYNAMICS; VACCINES;

RNA;

ISOLEUCINE; NUCLEOTIDE; POLIOMYELITIS VACCINE; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME ANALYSIS; IN VITRO STUDY; MOLECULAR DYNAMICS; MUTAGENIC ACTIVITY; MUTATION; NONHUMAN; PHENOTYPE; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; VACCINE PRODUCTION; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS VIRULENCE;

ENZYME KINETICS; NMR; POSITIVE-STRAND RNA VIRUSES; PROTEIN DYNAMICS; VIRAL POLYMERASE;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLIOVIRUS; POLIOVIRUS VACCINES; RECOMBINANT PROTEINS; RIBAVIRIN; RNA REPLICASE; VIRAL PROTEINS; VIRULENCE;

EID: 84887467058     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.484428     Document Type: Article

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