A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 12, 2003, Pages 7289-7294

  Pfeiffer, Julie K ^a   Kirkegaard, Karla ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; NUCLEOTIDE DERIVATIVE; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; DRUG RESISTANCE; GENE AMPLIFICATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; REPLICON; RNA SYNTHESIS; VIRUS GENOME;

ANTIVIRAL AGENTS; BASE SEQUENCE; DNA, VIRAL; DRUG RESISTANCE, VIRAL; HELA CELLS; HUMANS; MODELS, MOLECULAR; POINT MUTATION; POLIOVIRUS; RIBAVIRIN; RNA REPLICASE; RNA, VIRAL;

HEPATITIS C VIRUS; POLIOVIRUS;

EID: 0038809107     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1232294100     Document Type: Article

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