-
1
-
-
2442677715
-
Initiation of viral RNA-dependent RNA polymerization
-
A.A. van Dijk, E.V. Makeyev, and D.H. Bamford Initiation of viral RNA-dependent RNA polymerization J Gen Virol 85 2004 1077 1093
-
(2004)
J Gen Virol
, vol.85
, pp. 1077-1093
-
-
Van Dijk, A.A.1
Makeyev, E.V.2
Bamford, D.H.3
-
2
-
-
0001856730
-
Possible unifying mechanism of picornavirus genome replication
-
B.L. Semler E. Wimmer ASM Press
-
A.V. Paul Possible unifying mechanism of picornavirus genome replication B.L. Semler E. Wimmer Molecular Biology of Picornaviruses 2002 ASM Press 227 246
-
(2002)
Molecular Biology of Picornaviruses
, pp. 227-246
-
-
Paul, A.V.1
-
3
-
-
0033571463
-
Crystal structure of the RNA dependent RNA polymerase of hepatitis C virus
-
H. Ago, T. Adachi, A. Yoshida, M. Yamamoto, N. Habuka, K. Yatsunami, and M. Miyano Crystal structure of the RNA dependent RNA polymerase of hepatitis C virus Structure Fold Des 7 1999 1417 1426
-
(1999)
Structure Fold des
, vol.7
, pp. 1417-1426
-
-
Ago, H.1
Adachi, T.2
Yoshida, A.3
Yamamoto, M.4
Habuka, N.5
Yatsunami, K.6
Miyano, M.7
-
4
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
S. Bressanelli, L. Tomei, A. Roussel, I. Incitti, R.L. Vitale, M. Mathieu, R. De Francesco, and F.A. Rey Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus Proc Natl Acad Sci USA 96 1999 13034 13039
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13034-13039
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
Mathieu, M.6
De Francesco, R.7
Rey, F.A.8
-
5
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
C.A. Lesburg, M.B. Cable, E. Ferrari, Z. Hong, A.F. Mannarino, and P.C. Weber Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site Nat Struct Biol 6 1999 937 943
-
(1999)
Nat Struct Biol
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
6
-
-
1842481188
-
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus established the role of GTP in de novo initiation
-
K.H. Choi, J.M. Groarke, D.C. Young, R.J. Kuhn, J.L. Smith, D.C. Pevear, and M.G. Rossmann The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus established the role of GTP in de novo initiation Proc Natl Acad Sci USA 101 2004 4425 4430 The authors describe the structure of the RDRP from BVDV in two different crystal forms and also in complex with GTP, which is required for de novo initiation. The structure reveals a unique N-terminal domain, in addition to the fingers, palm and thumb domains common to other polymerases. The GTP complex identified a new GTP-specific binding site, probably required for the initiation of RNA synthesis.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4425-4430
-
-
Choi, K.H.1
Groarke, J.M.2
Young, D.C.3
Kuhn, R.J.4
Smith, J.L.5
Pevear, D.C.6
Rossmann, M.G.7
-
7
-
-
0037059758
-
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase
-
K.K. Ng, M.M. Cherney, A.L. Vazquez, A. Machin, J.M. Alonso, F. Parra, and M.N. James Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase J Biol Chem 277 2002 1381 1387
-
(2002)
J Biol Chem
, vol.277
, pp. 1381-1387
-
-
Ng, K.K.1
Cherney, M.M.2
Vazquez, A.L.3
MacHin, A.4
Alonso, J.M.5
Parra, F.6
James, M.N.7
-
8
-
-
1942501581
-
Crystal structure of Norwalk virus polymerase reveals the carboxy terminus in the active site cleft
-
K.K. Ng, N. Pendas-Franco, J. Rojo, J.A. Boga, A. Machin, J.M. Alonso, and F. Parra Crystal structure of Norwalk virus polymerase reveals the carboxy terminus in the active site cleft J Biol Chem 279 2004 16638 16645
-
(2004)
J Biol Chem
, vol.279
, pp. 16638-16645
-
-
Ng, K.K.1
Pendas-Franco, N.2
Rojo, J.3
Boga, J.A.4
MacHin, A.5
Alonso, J.M.6
Parra, F.7
-
9
-
-
18744392514
-
RNA synthesis in cage-structural studies of reovirus polymerase λ3
-
Y. Tao, D.L. Farsetta, M.L. Nibert, and S.C. Harrison RNA synthesis in cage-structural studies of reovirus polymerase λ3 Cell 111 2002 733 745
-
(2002)
Cell
, vol.111
, pp. 733-745
-
-
Tao, Y.1
Farsetta, D.L.2
Nibert, M.L.3
Harrison, S.C.4
-
10
-
-
0035826258
-
A mechanism for initiating RNA-dependent RNA polymerization
-
S.J. Butcher, J.M. Grimes, E.V. Makeyev, D.H. Bamford, and D.I. Stuart A mechanism for initiating RNA-dependent RNA polymerization Nature 410 2001 235 240
-
(2001)
Nature
, vol.410
, pp. 235-240
-
-
Butcher, S.J.1
Grimes, J.M.2
Makeyev, E.V.3
Bamford, D.H.4
Stuart, D.I.5
-
12
-
-
4644238112
-
Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
-
A.A. Thompson, and O.B. Peersen Structural basis for proteolysis- dependent activation of the poliovirus RNA-dependent RNA polymerase EMBO J 23 2004 3462 3471 The complete structure of PV 3D polymerase, together with mutational and biochemical data, provides insights into the mechanism responsible for the proteolysis-dependent activation of a polymerase.
-
(2004)
EMBO J
, vol.23
, pp. 3462-3471
-
-
Thompson, A.A.1
Peersen, O.B.2
-
13
-
-
8744222695
-
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA
-
C. Ferrer-Orta, A. Arias, R. Perez-Luque, C. Escarmís, E. Domingo, and N. Verdaguer Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA J Biol Chem 279 2004 47212 47221 The complete structure of FMDV 3D polymerase in complex with an RNA template-primer molecule provides the first structural evidence of how these substrates bind the large exposed active site of an RDRP that follows a primer-dependent mechanism of initiation of replication.
-
(2004)
J Biol Chem
, vol.279
, pp. 47212-47221
-
-
Ferrer-Orta, C.1
Arias, A.2
Perez-Luque, R.3
Escarmís, C.4
Domingo, E.5
Verdaguer, N.6
-
14
-
-
4143147318
-
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: A dual function target for common cold antiviral therapy
-
R.A. Love, K.A. Maegley, X. Yu, R.A. Ferre, L.K. Lingardo, W. Diehl, H.E. Parge, P.S. Dragovich, and S.A. Fuhrman The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy Structure 12 2004 1533 1544
-
(2004)
Structure
, vol.12
, pp. 1533-1544
-
-
Love, R.A.1
Maegley, K.A.2
Yu, X.3
Ferre, R.A.4
Lingardo, L.K.5
Diehl, W.6
Parge, H.E.7
Dragovich, P.S.8
Fuhrman, S.A.9
-
15
-
-
10644250663
-
Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer
-
T.C. Appleby, H. Luecke, J.H. Shim, J.Z. Wu, I.W. Cheney, W. Zhong, L. Vogeley, Z. Hong, and N. Yao Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer J Virol 79 2005 277 288 The authors describe in detail the structural features of a rhinovirus RDRP and suggest a model for the uridylylation of the protein primer.
-
(2005)
J Virol
, vol.79
, pp. 277-288
-
-
Appleby, T.C.1
Luecke, H.2
Shim, J.H.3
Wu, J.Z.4
Cheney, I.W.5
Zhong, W.6
Vogeley, L.7
Hong, Z.8
Yao, N.9
-
16
-
-
0032518374
-
A mechanism for all polymerases
-
T.A. Steitz A mechanism for all polymerases Nature 391 1998 231 232
-
(1998)
Nature
, vol.391
, pp. 231-232
-
-
Steitz, T.A.1
-
17
-
-
0032005866
-
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
-
C.A. Brautigam, and T.A. Steitz Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes Curr Opin Struct Biol 8 1998 54 63
-
(1998)
Curr Opin Struct Biol
, vol.8
, pp. 54-63
-
-
Brautigam, C.A.1
Steitz, T.A.2
-
18
-
-
0037470586
-
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation
-
D. O'Farrell, R. Trowbridge, D. Rowlands, and J. Jager Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation J Mol Biol 326 2003 1025 1035
-
(2003)
J Mol Biol
, vol.326
, pp. 1025-1035
-
-
O'Farrell, D.1
Trowbridge, R.2
Rowlands, D.3
Jager, J.4
-
19
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
S. Bressanelli, L. Tomei, F.A. Rey, and R. De Francesco Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides J Virol 76 2002 3482 3492
-
(2002)
J Virol
, vol.76
, pp. 3482-3492
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
20
-
-
0037386414
-
A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases
-
J.A. Bruenn A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases Nucleic Acids Res 31 2003 1821 1829
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 1821-1829
-
-
Bruenn, J.A.1
-
21
-
-
0032567393
-
Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure
-
E.K. O'Reilly, and C.C. Kao Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure Virology 252 1998 287 303
-
(1998)
Virology
, vol.252
, pp. 287-303
-
-
O'Reilly, E.K.1
Kao, C.C.2
-
23
-
-
0041707714
-
Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: Structural and biochemical analysis
-
V.J. Leveque, R.B. Johnson, S. Parsons, J. Ren, C. Xie, F. Zhang, and Q.M. Wang Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis J Virol 77 2003 9020 9028
-
(2003)
J Virol
, vol.77
, pp. 9020-9028
-
-
Leveque, V.J.1
Johnson, R.B.2
Parsons, S.3
Ren, J.4
Xie, C.5
Zhang, F.6
Wang, Q.M.7
-
24
-
-
0034090927
-
pol). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub)
-
pol). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub) J Biol Chem 275 2000 5329 5336
-
(2000)
J Biol Chem
, vol.275
, pp. 5329-5336
-
-
Arnold, J.J.1
Cameron, C.E.2
-
25
-
-
1542268890
-
RNA-dependent RNA polymerases of dsRNA bacteriophages
-
E.V. Makeyev, and J.M. Grimes RNA-dependent RNA polymerases of dsRNA bacteriophages Virus Res 101 2004 45 55
-
(2004)
Virus Res
, vol.101
, pp. 45-55
-
-
Makeyev, E.V.1
Grimes, J.M.2
-
26
-
-
1342302799
-
The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase
-
T.A. Steitz The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase Curr Opin Struct Biol 14 2004 4 9
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 4-9
-
-
Steitz, T.A.1
-
27
-
-
23944482649
-
Challenges and successes in developing new therapies for hepatitis C
-
R. De Francesco, and G. Migliaccio Challenges and successes in developing new therapies for hepatitis C Nature 436 2005 953 960
-
(2005)
Nature
, vol.436
, pp. 953-960
-
-
De Francesco, R.1
Migliaccio, G.2
-
28
-
-
23744436747
-
Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non nucleoside inhibitors
-
B.K. Biswal, M.M. Cherney, M. Wang, L. Chan, C.G. Yannopoulos, D. Bilimoria, O. Nicolas, J. Bedard, and M.N.G. James Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non nucleoside inhibitors J Biol Chem 280 2005 18202 18210 Two different conformations of the HCV RDRP are reported. The first corresponds to the 'closed' conformation reported in [ 3-5 ]. The second is a more 'open' conformation, in which the connection between the fingers and thumb domains is disrupted, and is believed to be an inactive form of the enzyme. The authors also show how some allosteric inhibitors work by freezing the enzyme in the open inactive conformation.
-
(2005)
J Biol Chem
, vol.280
, pp. 18202-18210
-
-
Biswal, B.K.1
Cherney, M.M.2
Wang, M.3
Chan, L.4
Yannopoulos, C.G.5
Bilimoria, D.6
Nicolas, O.7
Bedard, J.8
James, M.N.G.9
-
29
-
-
23744452229
-
Interdomain communication in hepatitis C virus polymerase abolished by small-molecule inhibitors bound to a novel allosteric site
-
S. Di Marco, C. Volpari, L. Tomei, S. Altamura, S. Harper, F. Narjes, U. Koch, M. Rowley, R. De Francesco, G. Migliaccio, and A. Carfí Interdomain communication in hepatitis C virus polymerase abolished by small-molecule inhibitors bound to a novel allosteric site J Biol Chem 280 2005 29765 29770
-
(2005)
J Biol Chem
, vol.280
, pp. 29765-29770
-
-
Di Marco, S.1
Volpari, C.2
Tomei, L.3
Altamura, S.4
Harper, S.5
Narjes, F.6
Koch, U.7
Rowley, M.8
De Francesco, R.9
Migliaccio, G.10
Carfí, A.11
-
30
-
-
23944462641
-
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
-
J.J. Feld, and J.H. Hoofnagle Mechanism of action of interferon and ribavirin in treatment of hepatitis C Nature 436 2005 967 972
-
(2005)
Nature
, vol.436
, pp. 967-972
-
-
Feld, J.J.1
Hoofnagle, J.H.2
-
31
-
-
0034532953
-
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
-
S. Crotty, D. Maag, J.J. Arnold, W. Zhong, J.Y. Lau, Z. Hong, R. Andino, and C.E. Cameron The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen Nat Med 6 2000 1375 1379
-
(2000)
Nat Med
, vol.6
, pp. 1375-1379
-
-
Crotty, S.1
Maag, D.2
Arnold, J.J.3
Zhong, W.4
Lau, J.Y.5
Hong, Z.6
Andino, R.7
Cameron, C.E.8
-
32
-
-
11844256382
-
Virus entry into error catastrophe as a new antiviral strategy
-
Domingo E (Ed):
-
Domingo E (Ed): Virus entry into error catastrophe as a new antiviral strategy. Virus Res 2005, 107:115-228.
-
(2005)
Virus Res
, vol.107
, pp. 115-228
-
-
-
33
-
-
27144462037
-
Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding
-
A. Arias, R. Agudo, C. Ferrer-Orta, R. Pérez-Luqe, A. Airaksinen, E. Brocchi, E. Domingo, N. Verdaguer, and C. Escarmís Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding J Mol Biol 353 2005 1021 1032
-
(2005)
J Mol Biol
, vol.353
, pp. 1021-1032
-
-
Arias, A.1
Agudo, R.2
Ferrer-Orta, C.3
Pérez-Luqe, R.4
Airaksinen, A.5
Brocchi, E.6
Domingo, E.7
Verdaguer, N.8
Escarmís, C.9
-
35
-
-
0026240806
-
RIBBONS 2.0
-
M. Carson RIBBONS 2.0 J Appl Cryst 24 1991 958 961
-
(1991)
J Appl Cryst
, vol.24
, pp. 958-961
-
-
Carson, M.1
|