A mechanism for initiating RNA-dependent RNA polymerization

Nature

Volumn 410, Issue 6825, 2001, Pages 235-240

  Butcher, Sarah J ^a   Grimes, Jonathan M ^b   Makeyev, Eugeny V ^a   Bamford, Dennis H ^a   Stuart, David I ^b,c  

^a Viikki Biocenter   (Finland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED RNA POLYMERASE; VIRUS RNA;

ARTICLE; BACTERIOPHAGE; ENZYME SUBUNIT; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REOVIRUS; RNA REPLICATION; VIRUS CAPSID; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

BACTERIOPHAGE PHI 6; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HEPACIVIRUS; MAGNESIUM; MANGANESE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RNA, DOUBLE-STRANDED; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; TEMPLATES, GENETIC; TRANSCRIPTION, GENETIC;

HEPATITIS C VIRUS; MIRIDAE; REOVIRUS SP.; RNA VIRUSES;

EID: 0035826258     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35065653     Document Type: Article

References (28)

1. Structure of the reovirus core at 3.6Å resolution
2. The atomic structure of the bluetongue virus core
3. Replicase activity of purified recombinant protein P2 of double-stranded RNA bacteriophage φ6
4. Crystallization and preliminary X-ray crystallographic studies on the bacteriophage φ6 RNA-dependent RNA polymerase
5. Reverse genetics of dsRNA bacteriophage φ6
6. In vitro replication, packaging, and transcription of the segmented, double-stranded RNA genome of bacteriophage φ6: Studies with procapsids assembled from plasmid-encoded proteins
7. Precise packaging of the three genomic segments of the double-stranded-RNA bacteriophage φ6
8. The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism
9. Domain of E. coli DNA polymerase I showing sequence homology to T7 DNA polymerase
10. An attempt to unify the structure of polymerases
11. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
12. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
13. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
14. Crystal structure of cat muscle pyruvate kinase at resolution of 2.6Å
15. A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA
16. Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP
17. The large genome segment of dsRNA bacteriophage φ6 is the key regulator in the in vitro minus and plus strand synthesis
18. Differentitation between minus- and plus-strand synthesis: Polymerase activity of dsRNA bacteriophage φ6 in an in vitro packaging and replication system
19. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
20. De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase
21. Relation of the structure of cytoplasmic polyhedrosis virus and the synthesis of its messenger RNA
22. Determination of macromolecular structures from anomalous diffraction of synchrotron radiation
23. Crystallography and NMR system: A new software suite for macromolecular structure determination
24. AMoRe: An automated package for molecular replacement
25. PROCHECK: A program to check the stereochemical quality of protein structures
26. An extensively modified version of MolScript that includes greatly enhanced colouring capabilities
27. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons