Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase

Journal of Biological Chemistry

Volumn 280, Issue 27, 2005, Pages 25706-25716

  Arnold, Jamie J ^a   Vignuzzi, Marco ^b   Stone, Jeffrey K ^b   Andino, Raul ^b   Cameron, Craig E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DRUG PRODUCTS; NUCLEIC ACIDS; PHOSPHATES; VIRUSES;

CATALYTIC CENTERS; PATHOGENESIS; RNA-DEPENDENT RNA POLYMERASE (RDRP);

RNA;

ANTIVIRUS AGENT; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; RNA POLYMERASE; VIRUS RNA;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DRUG RESEARCH; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMODYNAMICS; VIRUS RESISTANCE; VIRUS VIRULENCE;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; BINDING SITES; DNA-DIRECTED RNA POLYMERASES; ENZYME ACTIVATION; HELA CELLS; HUMANS; NUCLEOTIDES; PHOSPHORYLATION; POINT MUTATION; POLIOVIRUS; PROTEIN STRUCTURE, TERTIARY; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP; VARIATION (GENETICS);

POLIOVIRUS;

EID: 21844431621     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503444200     Document Type: Article

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