3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9532-9539

  Mansky, L M ^a   Bernard, L C ^a  

^a 2078 Graves Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANIMAL; ANTI-HIV AGENTS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; GENETIC VECTORS; HELA CELLS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; LAMIVUDINE; MUTATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ZIDOVUDINE;

EID: 0033819409     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9532-9539.2000     Document Type: Article

References (41)

1. Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase
2. The fidelity of retroviral reverse transcriptases
3. High rates of frameshift mutations within homo-oligomeric runs during a single cycle of retroviral replication
4. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
5. Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitro
6. A new type of G-A hypermutation affecting human immunodeficiency virus
7. Genetic consequences of packaging two RNA genomes in one retroviral particle: Pseudodiploidy and high rate of genetic recombination
8. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
9. A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction
10. The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate
11. Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate
12. New procedure for DNA transfection with polycation and dimethyl sulfoxide
13. Misalignment-mediated DNA synthesis errors
14. The base substitution fidelity of eukaryotic DNA polymerasesmispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation
15. Modulation of mutagenesis by deoxyribonucleotide levels
16. Clinical significance of drug resistance in HIV-1 infection
17. Equilibrium and kinetic studies of Escherichia coli lac repressor-inducer interactions
18. Packaging system for rapid product on of murine leukemia virus vectors with variable tropism
19. Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase
20. Forward mutation rate of human immunodeficiency virus type 1 in a T-lymphoid cell line
21. The mutation rate of human immunodeficiency virus type 1 is influenced by the vpr gene
22. Retroviral-vector-mediated gene transfer
23. The interaction of Vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 in vivo mutation rate
24. Lower in vivo mutation rate of human immunodeficiency virus type 1 than predicted from the fidelity of purified reverse transcriptase
25. Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus
26. DNA precursor asymmetries, replication fidelity, and variable genome evolution
27. A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
28. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools
29. V3 loop of the human immunodeficiency virus type 1 Env protein: Interpreting sequence variability
30. 5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate
31. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: Deletions and deletions with insertions
32. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: Substitutions, frameshifts, and hypermutations
33. Characterization of large deletions occurring during a single round of retrovirus vector replication: Novel deletion mechanism involving errors in strand transfer
34. Human immunodeficiency virus type 1 Pr55gag and Pr160gag-pol expressed from a simian virus 40 late replacement vector are efficiently processed and assembled into viruslike particles
35. Frameshift mutations and the genetic code
36. Mechanism of spontaneous and induced frameshift mutation in bacteriophage T4
37. Retrovirus variation and reverse transcription: Abnormal strand transfers result in retrovirus genetic variation
38. Selection, recombination, and G-to-A hypermutation of human immunodeficiency virus type 1 genomes
39. G-A hypermutation of the human immunodeficiency virus type 1 genome: Evidence for dCTP pool imbalance during reverse transcription
40. Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase