Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Nature Structural Biology

Volumn 6, Issue 10, 1999, Pages 937-943

  Lesburg, C A ^a   Cable, M B ^a   Ferrari, E ^a   Hong, Z ^a   Mannarino, A F ^a   Weber, P C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE;

ALPHA HELIX; ARTICLE; BASE PAIRING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RNA BINDING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOENZYMES; BASE PAIRING; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; HIV-1 REVERSE TRANSCRIPTASE; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; RNA; RNA REPLICASE; TEMPLATES, GENETIC; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0032876683     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/13305     Document Type: Article

References (38)