A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

Nature Medicine

Volumn 18, Issue 12, 2012, Pages 1820-1826

  Graham, Rachel L ^a   Becker, Michelle M ^b   Eckerle, Lance D ^b   Bolles, Meagan ^b   Denison, Mark R ^b,c   Baric, Ralph S ^a,b  

^a IL   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEVERE ACUTE RESPIRATORY SYNDROME VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS VIRULENCE; WEIGHT REDUCTION;

AGE FACTORS; ANIMALS; BASE SEQUENCE; DNA PRIMERS; DRUG DESIGN; EXORIBONUCLEASES; FEMALE; IMMUNOCOMPROMISED HOST; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PLASMIDS; REAL-TIME POLYMERASE CHAIN REACTION; SARS VIRUS; SEQUENCE ANALYSIS, DNA; SEVERE ACUTE RESPIRATORY SYNDROME; STATISTICS, NONPARAMETRIC; VIRAL VACCINES; VIRUS REPLICATION;

CORONAVIRUS; MUS; RNA VIRUSES;

EID: 84870946428     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2972     Document Type: Article

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