South asian medicinal compounds as modulators of resistance to chemotherapy and radiotherapy

Cancers

Volumn 8, Issue 3, 2016, Pages

  Rajendra Prasad, N ^a   Muthusamy, Ganesan ^a   Shanmugam, Mohana ^a   Ambudkar, Suresh V ^b  

^a ANNAMALAI UNIVERSITY   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ABC transporter; Chemoresistance; Phytochemicals; Radioresistance; South asian plants

Indexed keywords

ANDROGRAPHOLIDE; ASCORBIC ACID; ASIATICOSIDE; BERBERINE; BEROLINE; BETULIC ACID; BETULIN; BOSWELLIC ACID; BULLATACIN; CAMPTOTHECIN; COUMARIN; DITERPENOID; GALACTITOL; GALLIC ACID; IRINOTECAN; JATROPHONE; KAEMPFEROL; LUPEOL; MYRICETIN; NATURAL PRODUCT; OLEANOLIC ACID; PALMATINE; PINENE; PSORALEN; QUERCETIN; SITOSTEROL; STIGMASTEROL; UNINDEXED DRUG; WITHAFERIN A; WITHANOLIDE;

AEGICERAS CORNICULATUM; ALOE BARBADENIS; ALOE FEROX; AMOORA ROHITUKA; ANDROGRAPHIS PANICULATA; ANNONA MURICATA; BLACK PEPPER; BOSWELLIA SERRATA; BRUGUIERA GYMNORRHIZAIS; CAMELLIA SINENSIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CAPSICUM ANNUUM; CATHARANTHUS ROSEUS; CEDRUS DEODARA; CENTELLA ASIATICA; CHEMICAL STRUCTURE; CHEMOSENSITIZATION; CHLOROXYLON SWIETENIA; COSCINIUM FENESTRATUM; CURCUMA LONGA; CUSCUTA REFLEXA; DENDROPHTHOE FALCATA; DIOSCOREA BULBIFERA; EMBELIA RIBES; EUGENIA SINGAMPATTIANA; FICUS BENGHALENSIS; FICUS RELIGIOSA; GARLIC; GINGER; GLYCYRRHIZA GLABRA; HIBISCUS TILIACEUS; JATROPHA GOSSYPIIFOLIA; LINSEED; MEDICINAL PLANT; MOLLUGO PENTAPHYLLA; NELUMBO NUCIFERA; NONHUMAN; NOTHAPODYTES FOETIDA; NYCTANTHES ARBOR TRISTIS; PHYLLANTHUS AMARUS; PHYTOCHEMISTRY; PODOPHYLLUM HEXANDRUM; RADIATION PROTECTION; RADIOSENSITIZATION; REVIEW; SOLANUM NIGRUM; STRYCHNOS NUX VOMICA; THERAPY RESISTANCE; TRICHOPUS ZEYLANICUS; VITEX AGNUS CASTUS; WITHANIA SOMNIFERA;

EID: 84960104856     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers8030032     Document Type: Review

References (170)

1. Jain, J.B.; Kumane, S.C.; Bhattacharya, S. Medicinal flora of Madhya Pradesh and Chhatisgarh-A review. Indian J. Tradit. Know. 2006, 5, 237–242.
2. Garg, A.; Darokar, M.P.; Sundaresan, V.; Faridi, U.; Luqman, S.R.; Khanuja, S.P.S. Anticancer activity of some medicinal plants from high altitude evergreen elements of IndianWestern Ghats. J. Res. Educ. Indian Med. 2007, 13, 1–6.
3. Molnar, J.; Engi, H.; Hohmann, J.; Molnar, P.; Deli, J.; Wesolowska, O.; Michalak, K.; Wang, Q. Reversal of multidrug resitance by natural substances from plants. Curr. Top. Med. Chem. 2010, 10, 1757–1768. [PubMed]
4. Zhang, S.; Morris, M.E. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J. Pharm. Exp. Ther. 2003, 304, 1258–1267. [CrossRef][PubMed]
5. Aggarwal, B.B.; Ichikawa, H.; Garodia, P.; Weerasinghe, P.; Bhatt, I.D.; Pandey, M.K.; Shishodia, S.; Nair, M.G. From traditional Ayurvedic medicine to modern medicine: Identification of therapeutic targets for suppression of inflammation and cancer. Expert. Opin. Ther. Targets 2006, 10, 87–118. [CrossRef][PubMed]
6. Dhar, M.L.; Dhar, M.M.; Dhawan, B.N.; Mehrotra, B.N.; Ray, C. Screening of Indian plants for biological activity: I. Indian. J. Exp. Biol. 1968, 6, 232–247. [PubMed]
7. Singh, S.S.; Pandey, S.C.; Srivastava, S.; Gupta, V.S.; Patro, B.; Ghosh, A.C. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Indian J. Pharmacol. 2003, 35, 83–91.
8. Bharti, A.C.; Donato, N.; Aggarwal, B.B. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J. Immunol. 2003, 171, 3863–3871. [CrossRef][PubMed]
9. Anto, R.J.; Mukhopadhyay, A.; Denning, K.; Aggarwal, B.B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002, 23, 143–150. [CrossRef][PubMed]
10. Mukhopadhyay, A.; Bueso-Ramos, C.; Chatterjee, D.; Pantazis, P.; Aggarwal, B.B. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 2001, 20, 7597–7609. [CrossRef][PubMed]
11. Bible, K.C.; Kaufmann, S.H. Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res. 1996, 56, 4856–4861. [PubMed]
12. Manna, S.K.; Mukhopadhyay, A.; Aggarwal, B.B. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 2000, 164, 6509–6519. [CrossRef][PubMed]
13. Kim, D.M.; Koo, S.Y.; Jeon, K.; Kim, M.H.; Lee, J.; Hong, C.Y.; Jeong, S. Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. Cancer Res. 2003, 63, 621–626. [PubMed]
14. Murakami, A.; Takahashi, D.; Kinoshita, T.; Koshimizu, K.; Kim, H.W.; Yoshihiro, A.; Nakamura, Y.; Jiwajinda, S.; Terao, J.; Ohigashi, H. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis 2002, 23, 795–802. [CrossRef][PubMed]
15. Kirtikar, K.R.; Basu, B.D. Indian Medicinal Plant; Lalit Mohan Publication: Calcutta, India, 1935.
16. Takada, Y.; Andreeff, M.; Aggarwal, B.B. Indole-3-carbinol suppresses NF-kappaB and Ikappa-balpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 2005, 106, 641–649. [CrossRef][PubMed]
17. Behera, B.; Devi, K.S.; Mishra, D.; Maiti, S.; Maiti, T.K. Biochemical analysis and antitumour effect of Abrus precatorius agglutinin derived peptides in Ehrlich's ascites and B16 melanoma mice tumour model. Environ. Toxicol. Phar. 2014, 38, 288–296. [CrossRef][PubMed]
18. Dhiman, A.; Hiremath, S.K.; Pathak, M.; Mishra, D. A review article on anticancerous drugs in ayurveda and screened anticancer activity of medicinal plants. Int. J. Ayu. Alt. Med. 2014, 2, 54–60.
19. Rai, M.; Jogee, P.S.; Agarkar, G.; Santos, C.A. Anticancer activities ofWithania somnifera: Current research, formulations, and future perspectives. Pharm. Biol. 2015, 7, 1–9.
20. Nasri, H.; Baradaran, A.; Shirzad, H.; Rafieian-Kopaei, M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int. J. Prev. Med. 2014, 5, 1487–1499. [PubMed]
21. Di Domenico, F.; Foppoli, C.; Coccia, R.; Perluigi, M. Antioxidants in cervical cancer: Chemopreventive and chemotherapeutic effects of polyphenols. Biochim. Biophys. Acta 2012, 1822, 737–747. [CrossRef][PubMed]
22. Baguley, B.C. Multidrug resistance in cancer. Methods Mol. Biol. 2010, 596, 1–14. [PubMed]
23. Cort, A.; Ozben, T. Natural product modulators to overcome multidrug resistance in cancer. Nutr. Cancer 2015, 67, 411–423. [CrossRef][PubMed]
24. Chorawala, M.R.; Oza, P.M.; Shah, G.B. Mechanisms of anticancer drugs resistance: An overview. Int. J. Pharm. Sci. Drug Res. 2012, 4, 1–9.
25. Dean, M.; Hamon, Y.; Chimini, G. The human ATP-binding cassette (ABC) transporter super family. J. Lipid Res. 2001, 42, 1007–1017. [PubMed]
26. Coley, H.M. Overcoming multidrug resistance in cancer: Clinical studies of p-glycoprotein inhibitors. Methods Mol. Biol. 2010, 596, 341–358. [PubMed]
27. Gottesman, M.M.; Ambudkar, S.V.; Xia, D. Structure of a multidrug transporter. Nat. Biotechnol. 2009, 27, 546–547. [CrossRef][PubMed]
28. Krishna, R.; Mayer, L.D. Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci. 2000, 11, 265–283. [CrossRef]
29. Kitagawa, S. Inhibitory Effects of Polyphenols on P-Glycoprotein-Mediated Transport. Biol. Pharm. Bull. 2006, 29, 1–6. [CrossRef][PubMed]
30. Chavan, S.S.; Damale, M.G.; Shamkuwar, P.B.; Pawar, D.P. Traditional Medicinal Plants for anticancer activity. Int. J. Curr. Pharm. Res. 2013, 5, 50–54.
31. Shishodia, S.; Potdar, P.; Gairola, C.G.; Aggarwal, B.B. Curcumin (diferuloylmethane) downregulates cigarette smoke-induced NFkappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 2003, 24, 1269–1279. [CrossRef][PubMed]
32. Bharti, A.; Takada, Y.; Aggarwal, B. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J. Immunol. 2004, 172, 5940–5947. [CrossRef][PubMed]
33. Bharti, A.C.; Shishodia, S.; Reuben, J.M.; Weber, D.; Alexanian, R.; Raj-Vadhan, S.; Estrov, Z.; Talpaz, M.; Aggarwal, B.B. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood 2004, 103, 3175–3184. [CrossRef][PubMed]
34. Iersel, M.L.; Ploemen, J.P.; Struik, I.; van Amersfoort, C.; Keyzer, A.E.; Schefferlie, J.G.; van Bladeren, P.J. Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. Chem. Biol. Interact. 1996, 102, 117–132. [CrossRef]
35. Duvoix, A.; Morceau, F.; Delhalle, S.; Schmitz, M.; Schnekenburger, M.; Galteau, M.M.; Dicato, M.; Diederich, M. Induction of apoptosis by curcumin: Mediation by glutathione S-transferase P1-1 inhibition. Biochem. Pharmacol. 2003, 66, 1475–1483. [CrossRef]
36. Liang, C.; Li, H.; Shen, C.; Lai, J.; Shi, Z.; Liu, B.; Tao, H.M. Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-kappaB pathway. Anticancer Agents Med. Chem. 2012, 12, 554–563. [CrossRef][PubMed]
37. Zhang, B.; Shi, Z.L.; Liu, B.; Yan, X.B.; Feng, J.; Tao, H.M. Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: The role of Akt and nuclear factor-kappaB. Anticancer Drugs 2010, 21, 288–296. [CrossRef][PubMed]
38. Park, S.Y.; Seol, D.W. Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochem. Biophys. Res. Commun. 2002, 295, 515–518. [CrossRef]
39. Jian, L.; Xie, L.P.; Lee, A.H.; Binns, C.W. Protective effect of green tea against prostate cancer: A case-control study in southeast China. Int. J. Cancer 2004, 108, 130–135. [CrossRef][PubMed]
40. Du, G.; Lin, H.; Wang, M.; Zhang, S.; Wu, X.; Lu, L.; Ji, L.; Yu, L. Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1alpha in tumor and normal cells. Cancer Chemother. Pharmacol. 2010, 65, 277–287. [CrossRef][PubMed]
41. Zhang, L.; Hung, M.C. Sensitization of HER-2/neuoverexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. Oncogene 1996, 12, 571–576. [PubMed]
42. Li, J.; Liu, P.; Mao, H.; Wanga, A.; Zhang, X. Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro. Oncol. Rep. 2009, 21, 1605–1610. [CrossRef][PubMed]
43. Huang, X.Z.; Wang, J.; Huang, C.; Chen, Y.Y.; Shi, G.Y.; Hu, Q.S.; Yi, J. Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: The mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1. Cancer Biol. Ther. 2008, 7, 468–475. [CrossRef][PubMed]
44. Zhang, L.; Lau, Y.K.; Xia, W.; Hortobagyi, G.N.; Hung, M.C. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin. Cancer Res. 1999, 5, 343–353. [PubMed]
45. Sallman, D.A.; Chen, X.; Zhong, B.; Gilvary, D.L.; Zhou, J.; Wei, S.; Djeu, J.Y. Clusterin mediates TRAIL resistance in prostate tumor cells. Mol. Cancer Ther. 2007, 6, 2938–2947. [CrossRef][PubMed]
46. Ivanov, V.N.; Partridge, M.A.; Johnson, G.E.; Huang, S.X.; Zhou, H.; Hei, T.K. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp. Cell Res. 2008, 314, 1163–1176. [CrossRef][PubMed]
47. Shankar, S.; Chen, Q.; Siddiqui, I.; Sarva, K.; Srivastava, R.K. Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4’, 5 tri-hydroxystilbene): Molecular mechanisms and therapeutic potential. J. Mol. Signal 2007. [CrossRef][PubMed]
48. Jazirehi, A.R.; Bonavida, B. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin’s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol. Cancer Ther. 2004, 3, 71–84. [PubMed]
49. Quan, F.; Pan, C.; Ma, Q.; Zhang, S.; Yan, L. Reversal effect of resveratrol on multidrug resistance in KBv200 cell line. Biomed. Pharmacother. 2008, 62, 622–629. [CrossRef][PubMed]
50. Rezk, Y.A.; Balulad, S.S.; Keller, R.S.; Bennett, J.A. Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: Study in human gynecologic cancer cell lines and in rodent heart. Am. J. Obstet Gynecol. 2006, 194, 23–26. [CrossRef][PubMed]
51. Rigolio, R.; Miloso, M.; Nicolini, G.; Villa, D.; Scuteri, A.; Simone, M.; Tredici, G. Resveratrol interference with the cell cycle protects human neuroblastoma SH-SY5Y cell from paclitaxel-induced apoptosis. Neurochem. Int. 2005, 46, 205–211. [CrossRef][PubMed]
52. Scarlatti, F.; Sala, G.; Ricci, C.; Maioli, C.; Milani, F.; Minella, M.; Botturi, M.; Ghidoni, R. Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase. Cancer Lett. 2007, 253, 124–130. [CrossRef][PubMed]
53. Pirzadeh, S.; Fakhari, S.; Jalili, A.; Mirzai, S.; Ghaderi, B.; Haghshenas, V. Glycyrrhetinic acid induces apoptosis in Leukemic HL60 cells through upregulating of CD95/ CD178. Int. J. Mol. Cell Med. 2014, 3, 272–278. [PubMed]
54. Jung, G.R.; Kim, K.J.; Choi, C.H.; Lee, T.B.; Han, S.I.; Han, H.K.; Lim, S.C. Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic Clin. Pharmacol. Toxicol. 2007, 101, 277–285. [CrossRef][PubMed]
55. Nabekura, T.; Hiroi, T.; Kawasaki, T.; Uwai, Y. Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein. Biomed. Pharmacother. 2015, 70, 140–145. [CrossRef][PubMed]
56. Suttana, W.; Mankhetkorn, S.; Poompimon, W.; Palagani, A.; Zhokhov, S.; Gerlo, S.; Haegeman, G.; Berghe, W.V. Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. Mol. Cancer 2010. [CrossRef][PubMed]
57. Ikegawa, T.; Ushigome, F.; Koyabu, N.; Morimoto, S.; Shoyama, Y.; Naito, M.; Tsuruo, T.; Ohtani, H.; Sawada, Y. Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett. 2000, 160, 21–28. [CrossRef]
58. Ikegawa, T.; Ohtani, H.; Koyabu, N.; Juichi, M.; Iwase, Y.; Ito, C.; Furukawa, H.; Naito, M.; Tsuruo, T.; Sawada, Y. Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett. 2002, 177, 89–93. [CrossRef]
59. Mitsunaga, Y.; Takanaga, H.; Matsuo, H.; Naito, M.; Tsuruo, T.; Ohtani, H.; Sawada, Y. Effect of bioflavonoids on vincristine transport across blood-brain barrier. Eur. J. Pharmacol. 2000, 395, 193–201. [CrossRef]
60. Chieli, E.; Romiti, N.; Cervelli, F.; Tongiani, R. Effects of flavonols on Pglycoprotein activity in cultured rat hepatocytes. Life Sci. 1995, 57, 1741–1751. [CrossRef]
61. Shin, S.C.; Choi, J.S.; Li, X. Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Int. J. Pharm. 2006, 313, 144–149. [CrossRef][PubMed]
62. Choi, J.S.; Jo, B.W.; Kim, Y.C. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Eur. J. Pharm. Biopharm. 2004, 57, 313–318. [CrossRef][PubMed]
63. Limtrakul, P.; Khantamat, O.; Pintha, K. Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J. Chemother. 2005, 17, 86–95. [CrossRef][PubMed]
64. Sharma, V.; Joseph, C.; Ghosh, S.; Agarwal, A.; Mishra, M.K.; Sen, E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Ther. 2007, 6, 2544–2553. [CrossRef][PubMed]
65. Wang, S.; Chen, R.; Zhong, Z.; Shi, Z.; Chen, M.; Wang, Y. Epigallocatechin-3-gallate potentiates the effect of curcumin in inducing growth inhibition and apoptosis of resistant breast cancer cells. Am. J. Chin. Med. 2014, 42, 1279–1300. [CrossRef][PubMed]
66. Qian, F.; Wei, D.; Zhang, Q.; Yang, S. Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-epigallocatechin gallate in human cancer cells. Biomed. Pharmacother. 2005, 59, 64–69. [CrossRef][PubMed]
67. Jodoin, J.; Demeule, M.; Beliveau, R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta 2002, 1542, 149–159. [CrossRef]
68. Castro, A.F.; Altenberg, G.A. Inhibition of drug transport by genistein in multidrugresistant cells expressing P-glycoprotein. Biochem. Pharmacol. 1997, 53, 89–93. [CrossRef]
69. Sak, K. Cytotoxicity of dietary flavonoids on different human cancer types. Pharmacogn. Rev. 2014, 8, 122–146. [CrossRef][PubMed]
70. Luo, H.; Daddysman, M.K.; Rankin, G. O.; Jiang, B.H. Kaempferol enhances cisplatin’s effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int. 2010. [CrossRef][PubMed]
71. Piao, Y.; Shin, S.C.; Choi, J.S. Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats. Biopharm. Drug Dispos. 2008, 29, 245–249. [CrossRef][PubMed]
72. Chen, H.; Landen, C.N.; Li, Y.; Alvarez, R.D.; Tollefsbol, T.O. Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation. Exp. Cell Res. 2013, 319, 697–706. [CrossRef][PubMed]
73. Luo, T.; Wang, J.; Yin, Y.; Hua, H.; Jing, J.; Sun, X.; Li, M.; Zhang, Y.; Jiang, Y. (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Res. 2010. [CrossRef][PubMed]
74. Park, S.; Kim, J.H.; Hwang, Y.I.; Jung, K.S.; Jang, Y.S.; Jang, S.H. Schedule-dependent effect of Epigallocatechin-3-Gallate (EGCG) with paclitaxel on H460 cells. Tuberc. Respir Dis. (Seoul) 2014, 76, 114–119. [CrossRef][PubMed]
75. Rak, S.; Cimbora-Zovko, T.; Gajski, G.; Dubravčić, K.; Domijan, A.M.; Delaš, I.; Garaj-Vrhovac, V.; Batinić, D.; Sorić, J.; Osmak, M. Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation. Toxicol. In Vitro 2013, 27, 523–532. [CrossRef][PubMed]
76. Sreenivasan, S.; Krishnakumar, S. Synergistic effect of curcumin in combination with anticancer agents in human retinoblastoma cancer cell lines. Curr. Eye Res. 2015, 40, 1153–1165. [CrossRef][PubMed]
77. Saha, S.; Adhikary, A.; Bhattacharyya, P.; Das, T.; Sa, G. Death by design: Where curcumin sensitizes drug-resistant tumours. Anticancer Res. 2012, 32, 2567–2584. [PubMed]
78. Cridge, B.J.; Larsen, L.; Rosengren, R.J. Curcumin and its derivatives in breast cancer: Current developments and potential for the treatment of drug-resistant cancers. Oncol. Discov. 2013. [CrossRef]
79. Ganta, S.; Amiji, M. Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol. Pharmacol. 2009, 6, 928–939. [CrossRef][PubMed]
80. Limtrakul, P.; Anuchapreeda, S.; Buddhasukh, D. Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer 2004. [CrossRef][PubMed]
81. Anuchapreeda, S.; Leechanachai, P.; Smith, M.M.; Ambudkar, S.V.; Limtrakul, P.N. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem. Pharmacol. 2002, 64, 573–578. [CrossRef]
82. Wang, P.; Yang, H.L.; Yang, Y.J.; Wang, L.; Lee, S.C. Overcome cancer cell drug resistance Using natural products. Evid. Based Complement. Alternat. Med. 2015. [CrossRef][PubMed]
83. Yunos, N.M.; Beale, P.; Yu, J.Q.; Huq, F. Synergism from sequenced combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells. Anticancer Res. 2011, 31, 1131–1140. [PubMed]
84. Cromie, M.M.; Gao,W. Epigallocatechin-3-gallate enhances the therapeutic effects of leptomycin B on human lung cancer a549 cells. Oxid. Med. Cell Longev. 2015. [CrossRef][PubMed]
85. Frampton, G.A.; Lazcano, E.A.; Li, H.; Mohamad, A.; DeMorrow, S. Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents. Lab. Invest. 2010, 90, 1325–1338. [CrossRef][PubMed]
86. Lee, S.H.; Koo, B.S.; Park, S.Y.; Kim, Y.M. Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells. Mol. Med. Rep. 2015, 12, 2777–2783. [CrossRef][PubMed]
87. Kweon, S.H.; Song, J.H.; Kim, T.S. Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression. Biochem. Biophys. Res. Commun. 2010, 395, 104–110. [CrossRef][PubMed]
88. Hsieh, T.C.; Wu, J.M. Resveratrol: Biological and pharmaceutical properties as anticancer molecule. Biofactors 2010, 36, 360–369. [CrossRef][PubMed]
89. Cavaliere, V.; Papademetrio, D.L.; Lombardo, T.; Costantino, S.N.; Blanco, G.A.; Alvarez, E.M. Caffeic acid phenylethyl ester and MG132, two novel nonconventional chemotherapeutic agents, induce apoptosis of human leukemic cells by disrupting mitochondrial function. Target Oncol. 2014, 9, 25–42. [CrossRef][PubMed]
90. Sugiyama, T.; Sadzuka, Y. Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin. Cancer Res. 1999, 5, 413–416. [PubMed]
91. Liang, Y.R.; Liu, C.; Xiang, L.P.; Zheng, X.Q. Health Benefits of Theanine in Green Tea: A Review. Trop. J. Pharm. Res. 2015, 14, 1943–1949. [CrossRef]
92. Bhardwaj, R.K.; Glaeser, H.; Becquemont, L.; Klotz, U.; Gupta, S.K.; Fromm, M.F. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 2002, 302, 645–650. [CrossRef][PubMed]
93. Meral, O.; Alpay, M.; Kismali, G.; Kosova, F.; Cakir, D.U.; Pekcan, M.; Yigit, S.; Sel, T. Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells. Tumour Biol. 2014, 35, 6485–6492. [CrossRef][PubMed]
94. Xia, Q.; Wang, Z.Y.; Li, H.Q.; Diao, Y.T.; Li, X.L.; Cui, J.; Chen, X.L.; Li, H. Reversion of p-glycoprotein-mediated multidrug resistance in human leukemic cell line by diallyl trisulfide. Evid. Based Complement. Alternat. Med. 2012. [CrossRef][PubMed]
95. Arora, A.; Seth, K.; Shukla, Y. Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver. Carcinogenesis 2004, 25, 941–949. [CrossRef][PubMed]
96. Rao, P.S.S.; Midde, N.M.; Miller, D.D.; Chauhan, S.; Kumar, A.; Kumar, S. Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1. Curr. Drug Metab. 2015, 16, 486–503. [CrossRef][PubMed]
97. Nabekura, T.; Yamaki, T.; Ueno, K.; Kitagawa, S. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother. Pharmacol. 2008, 62, 867–873. [CrossRef][PubMed]
98. Nabekura, T. Overcoming multidrug resistance in human cancer cells by natural compounds. Toxins (Basel). 2010, 2, 1207–1224. [CrossRef][PubMed]
99. Bueno Pérez, L.; Pan, L.; Sass, E.; Gupta, S.V.; Lehman, A.; Kinghorn, A.D.; Lucas, D.M. Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line. Phytother. Res. 2013, 27, 1735–1738. [CrossRef][PubMed]
100. Febriansah, R.; Putri, D.D.; Sarmoko; Nurulita, N.A.; Meiyanto, E.; Nugroho, A.E. Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin. Asian Pac. J. Trop. Biomed. 2014, 4, 228–233. [CrossRef]
101. Nygren, P.; Glimelius, B. The Swedish Council on Technology assessment in Health Care (SBU) report on Cancer Chemotherapy—-Project objectives, the working process, key definitions and general aspects on cancer trial methodology and interpretation. Acta Oncol. 2001, 40, 155–165. [PubMed]
102. Impicciatore, G.; Sancilio, S.; Miscia, S.; Di Pietro, R. Nutlins and ionizing radiation in cancer therapy. Curr. Pharm. Des. 2010, 16, 1427–1442. [CrossRef][PubMed]
103. Sun, L.; Cabarcas, S.M.; Farrar, W.L. Radioresistance and Cancer Stem Cells: Survival of the Fittest. J. Carcinogene Mutagene 2011, 4172, 2157–2518.
104. Biard, D.S.; Martin, M.; Rhun, Y.L.; Duthu, A.; Lefaix, J.L.; May, P. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Res. 1994, 54, 3361–3364. [PubMed]
105. Sklar, M.D. The ras oncogene increases the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 1988, 239, 645–647. [CrossRef][PubMed]
106. Kasid, U.; Pfeifer, A.; Weichselbaum, R.R.; Dritschilo, A.; Mark, G.E. The raf oncogene is associated with a radiation resistant human laryngeal cancer. Science 1987, 237, 1039–1041. [CrossRef][PubMed]
107. Lee, J.U.; Hosotani, R.; Wada, M.; Doi, R.; Kosiba, T.; Fujimoto, K.; Miyamoto, Y.; Tsuji, S.; Nakajima, S.; Nishimura, Y.; et al. Role of bcl-2 family proteins (Bax, Bcl-2, Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells. Eur. J. Cancer 1999, 35, 1374–1380. [CrossRef]
108. Asanuma, K.; Moriai, R.; Yajima, T.; Yagihashi, A.; Yamada, M.; Kobayashi, D.; Watanabe, N. Survivin as a radioresistant factor in pancreatic cancer. Jpn. J. Cancer Res. 2000, 91, 1204–1209. [CrossRef][PubMed]
109. Bao, S.; Wu, Q.; McLendon, R.E.; Hao, Y.; Shi, Q.; Hjelmeland, A.B.; Dewhirst, M.W.; Bigner, D.D.; Rich, J.N. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444, 756–760. [CrossRef][PubMed]
110. Zhang, S.; Wang, L.; Liu, H.; Zhao, G.; Ming, L. Enhancement of recombinant myricetin on the radiosensitivity of lung cancer A549 and H1299 cells. Diagn. Pathol. 2014. [CrossRef][PubMed]
111. Sheehan, J.P.; Shaffrey, M.E.; Gupta, B.; Larner, J.; Rich, J.N.; Park, D.M. Improving the radiosensitivity of radioresistant and hypoxic glioblastoma. Future Oncol. 2010, 6, 1591–1601. [CrossRef][PubMed]
112. Zhang, M.; Chakravarti, A. Novel radiationenhancing agents in malignant gliomas. Semin. Radiat. Oncol. 2006, 16, 29–37. [CrossRef][PubMed]
113. Henriksson, R.; Malmstrom, A.; Bergstrom, P.; Bergh, G.; Trojanowski, T.; Andreasson, L.; Blomquist, E.; Jonsborg, S.; Edekling, T.; Salander, P.; et al. High-grade astrocytoma treated concomitantly with estramustine and radiotherapy. J. Neurooncol. 2006, 78, 321–326. [CrossRef][PubMed]
114. Sartor, C.I. Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors. Nat. Clin. Pract. Oncol. 2004, 1, 80–87. [CrossRef][PubMed]
115. Mehta, M.P.; Shapiro, W.R.; Phan, S.C.; Gervais, R.; Carrie, C.; Chabot, P.; Patchell, R.A.; Glantz, M.J.; Recht, L.; Langer, C.; et al. Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: Results of a Phase III trial. Int. J. Radiat. Oncol. Biol. Phys. 2009, 73, 1069–1076. [CrossRef][PubMed]
116. Criswell, T.; Leskov, K.; Miyamoto, S.; Luo, G.; Boothman, D.A. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 2003, 22, 5813–5827. [CrossRef][PubMed]
117. Deorukhkar, A.; Krishnan, S.; Sethi, G.; Aggarwal, B.B. Back to basics: How natural products can provide the basis for new therapeutics. Expert Opin. Investig. Drugs 2007, 16, 1753–1773. [CrossRef][PubMed]
118. Fabricant, D.S.; Farnsworth, N.R. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 2001, 109, 69–75. [CrossRef][PubMed]
119. Donehower, R.C. The clinical development of paclitaxel: A successful collaboration of academia, industry and the National Cancer Institute. Stem Cells 1996, 14, 25–28. [CrossRef][PubMed]
120. Shao, R.G.; Cao, C.X.; Zhang, H.; Kohn, K.W.; Wold, M.S.; Pommier, Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 1999, 18, 1397–1406. [CrossRef][PubMed]
121. Chen, Y.; Pandya, K.J.; Feins, R.; Johnstone, D.W.; Watson, T.; Keng, P.C. Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2008, 71, 407–413. [CrossRef][PubMed]
122. Kurdoglu, B.; Cheong, N.; Guan, J.; Corn, B.W.; Curran, W.J.,; Iliakis, G. Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines. Clin. Cancer Res. 1999, 5, 2580–2587. [PubMed]
123. Girdhani, S.; Bhosle, S.M.; Thulsidas, S.A.; Kumar, A.; Mishra, K.P. Potential of radiosensitizing agents in cancer chemoradiotherapy. J. Cancer Res. Ther. 2005, 1, 129–131. [PubMed]
124. Arora, R.; Gupta, D.; Chawla, R.; Sagar, R.; Sharma, A.; Kumar, R.; Prasad, J.; Singh, S.; Samanta, N.; Sharma, R.K. Radioprotection by plant products: Present status and future prospects. Phytother. Res. 2005, 19, 1–22. [CrossRef][PubMed]
125. Gault, N.; Lefaix, J.L. Infrared microspectroscopic characteristics of radiation-induced apoptosis in human lymphocytes. Radiat. Res. 2003, 160, 238–250. [CrossRef][PubMed]
126. Hosseinimehr, S.J. Flavonoids and genomic instability induced by ionizing radiation. Drug Discov. Today 2010, 15, 907–918. [CrossRef][PubMed]
127. Jebahi, S.; Saoudi, M.; Farhat, L.; Oudadesse, H.; Rebai, T.; Kabir, A.; El Feki, A.; Keskes, H. Effect of novel curcumin-encapsulated chitosan-bioglass drug on bone and skin repair after gamma radiation: Experimental study on aWistar rat model. Cell Biochem. Funct. 2015, 33, 150–159. [CrossRef][PubMed]
128. Rajendra Prasad, N.; Menon, V.P.; Vasudev, V.; Pugalendi, K.V. Radioprotective effect of sesamol on g-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology 2005, 209, 225–235. [CrossRef][PubMed]
129. Khan, S.; Kumar, A.; Adhikari, J.S.; Rizvi, M.A.; Chaudhury, N.K. Protective effect of sesamol against Co g-ray-induced hematopoietic and gastrointestinal injury in C57BL/6 male mice. Free Radic. Res. 2015, 49, 1344–1361. [CrossRef][PubMed]
130. Rajendra Prasad, N.; Srinivasan, M.; Pugalendi, K.V.; Menon, V.P. Protective effect of ferulic acid on g-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes. Mutat. Res. 2006, 603, 129–134. [CrossRef][PubMed]
131. Maurya, D.K.; Devasagayam, T.P. Ferulic acid inhibits gamma radiation-induced DNA strand breaks and enhances the survival of mice. Cancer Biother. Radiopharm. 2013, 28, 51–57. [CrossRef][PubMed]
132. Sharma, N.K. Modulation of radiation-induced and mitomycin C-induced chromosome damage by apigenin in human lymphocytes in vitro. J. Radiat. Res. 2013, 54, 789–797. [CrossRef][PubMed]
133. Rodeiro, I.; Delgado, R.; Garrido, G. Effects of a Mangifera indica L. stem bark extract and mangiferin on radiation-induced DNA damage in human lymphocytes and lymphoblastoid cells. Cell Prolif. 2014, 47, 48–55. [CrossRef][PubMed]
134. Manna, K.; Das, U.; Das, D.; Kesh, S.B.; Khan, A.; Chakraborty, A.; Dey, S. Naringin inhibits gamma radiation-induced oxidative DNA damage and inflammation, by modulating p53 and NF-kB signaling pathways in murine splenocytes. Free Radic. Res. 2015, 49, 422–439. [CrossRef][PubMed]
135. Li, C.R.; Zhou, Z.; Zhu, S.; Sun, Y.N.; Dai, J.N.; Wang, S.Q. Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. Int. J. Biochem. Cell Biol. 2007, 39, 426–438. [CrossRef][PubMed]
136. Yu, J.; Zhu, X.; Qi, X.; Che, J.; Cao, B. Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway. Toxicol Lett. 2013, 218, 224–234. [CrossRef][PubMed]
137. Shimoi, K.; Masuda, S.; Shen, B.; Furugori, M.; Kinae, N. Radioprotective effects of antioxidative plant flavonoids in mice. Mutat. Res. 1996, 350, 153–161. [CrossRef]
138. Rahul, C.; Chatterjee, S.; Sharma, D.; Sumit, G.; Prasad, V.; Arun, S.; Poduval, T.B. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Inter. Immunopharm. 2008, 8, 661–669.
139. Pradeep, K.; Ko, K.C.; Choi, M.H.; Kang, J.A.; Chung, Y.J.; Park, S.H. Protective effect of hesperidin, a citrus flavanoglycone, against g-radiation-induced tissue damage in Sprague-Dawley rats. J. Med. Food. 2012, 15, 419–427. [CrossRef][PubMed]
140. Gomes, C.C.; Ramos-Perez, F.M.; Perez, D.E.; Novaes, P.D.; Bóscolo, F.N.; Almeida, S.M. Radioprotective effect of vitamin E in parotid glands: A morphometric analysis in rats. Braz. Dent. J. 2013, 24, 183–187. [CrossRef][PubMed]
141. Richi, B.; Kale, R.K.; Tiku, A.B. Radio-modulatory effects of green tea catechin EGCG on pBR322 plasmid DNA and murine splenocytes against gamma-radiation induced damage. Mutat. Res. 2012, 747, 62–70. [CrossRef][PubMed]
142. Nayak, V.; Uma Devi, P. Protection of mouse bone marrow against radiation induced chromosome damage and stem cell death by the Ocimum Flavonoids orientin and vicenin. Radiat. Res. 2005, 163, 165–171. [CrossRef][PubMed]
143. Ramadan, L.A.; Roushdy, H.M.; Abu Senna, G.M.; Amin, N.E.; EL-Deshw, O.A. Radioprotective effect of silymarin against radiation induced hepatotoxicity. Pharmacol. Res. 2002, 45, 447–454. [CrossRef][PubMed]
144. Rao, B.N.; Archana, P.R.; Aithal, B.K.; Rao, B.S. Protective effect of Zingerone, a dietary compound against radiation induced genetic damage and apoptosis in human lymphocytes. Eur. J. Pharmacol. 2011, 657, 59–66. [CrossRef][PubMed]
145. Patil, S.L.; Rao, N.B.; Somashekarappa, H.M.; Rajashekhar, K.P. Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation. Biomed. J. 2014, 37, 305–313. [CrossRef][PubMed]
146. Saada, H.N.; Rezk, R.G.; Eltahawy, N.A. Lycopene protects the structure of the small intestine against gamma-radiation-induced oxidative stress. Phytother. Res. 2010. [CrossRef][PubMed]
147. Gandhi, N.M.; Maurya, D.K.; Salvi, V.; Kapoor, S.; Mukherjee, T.; Nair, C.K.K. Radioprotection of DNA by glycyrrhizic acid through scavenging free radicals. J. Radiat. Res. 2004, 45, 461–468. [CrossRef][PubMed]
148. Jagetia, G.C.; Venkatesha, V.A. Treatment of mice with stem bark extract of Aphanamixis polystachya reduces radiation-induced chromosome damage. Int. J. Radiat. Biol. 2006, 82, 197–209. [CrossRef][PubMed]
149. Zbikowska, H.M.; Antosik, A.; Szejk, M.; Bijak, M.; Nowak, P. A moderate protective effect of quercetin against g-irradiation-and storage-induced oxidative damage in red blood cells for transfusion. Int. J. Radiat. Biol. 2014, 90, 1201–1210. [CrossRef][PubMed]
150. Zhang, R.; Kang, K.A.; Kang, S.S.; Park, J.W.; Hyun, J.W. Morin (2',3,4',5,7-pentahydroxyflavone) protected cells against g-radiation-induced oxidative stress. Basic Clin. Pharmacol. Toxicol. 2011, 108, 63–72. [CrossRef][PubMed]
151. Parihar, V.K.; Dhawan, J.; Kumar, S.; Manjula, S.N.; Subramanian, G.; Unnikrishnan, M.K.; Rao, C.M. Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice. Chem. Biol. Interact. 2007, 170, 49–58. [CrossRef][PubMed]
152. Mozdarani, H.; Ghoraeian, P. Modulation of gamma-ray-induced apoptosis in human peripheral blood leukocytes by famotidine and vitamin C. Mutat. Res. 2008, 649, 71–78. [CrossRef][PubMed]
153. Burlage, F.R.; Roesink, J.M.; Faber, H.; Vissink, A.; Langendijk, J.A.; Kampinga, H.H.; Coppes, R.P. Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment. Radiother. Oncol. 2008, 86, 347–353. [CrossRef][PubMed]
154. Cho, J.H.; Hong, W.G.; Jung, Y.J.; Lee, J.; Lee, E.; Hwang, S.G.; Um, H.D.; Park, J.K. G-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate. Tumour Biol. 2015. [CrossRef][PubMed]
155. Zhang, W.; Anker, L.; Law, R.E.; Hinton, D.R.; Gopalakrishna, R.; Pu, Q.; Gundimeda, U.; Weiss, M.H.; Couldwell, W.T. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin. Cancer Res. 1996, 2, 843–846. [PubMed]
156. You, H.; Wei, L.; Sun, W.L.; Wang, L.; Yang, Z.L.; Liu, Y.; Zheng, K.; Wang, Y.; Zhang, W.J. The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats. Int. J. Mol. Med. 2014, 34, 92–102. [CrossRef][PubMed]
157. Byun, E.B.; Sung, N.Y.; Park, J.N.; Yang, M.S.; Park, S.H.; Byun, E.H. Gamma-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-kB signaling through TLR4 in macrophages. Int. Immunopharmacol. 2015, 25, 249–259. [CrossRef][PubMed]
158. Seong, K.M.; Yu, M.; Lee, K.S.; Park, S.; Jin, Y.W.; Min, K.J. Curcumin mitigates accelerated aging after irradiation in Drosophila by reducing oxidative stress. Biomed Res. Int. 2015. [CrossRef][PubMed]
159. Kasten-Pisula, U.; Windhorst, S.; Dahm-Daphi, J.; Mayr, G.; Dikomey, E. Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. Mol. Radiobiol. 2007, 83, 296–303. [CrossRef][PubMed]
160. Bache, M.; Zschornak, M.P.; Passin, S.; Kessler, J.; Wichmann, H.; Kappler, M.; Paschke, R.; Kaluđerović G.N.; Kommera, H.; Taubert, H.; et al. Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions. Radiat. Oncol. 2011. [CrossRef][PubMed]
161. Nair, S.; Nair, R.R.; Srinivas, P.; Srinivas, G.; Pillai, M.R. Radiosensitizing Effects of Plumbagin in Cervical Cancer Cells Is Through Modulation of Apoptotic Pathway. Mol. Carcinog. 2008, 47, 22–33. [CrossRef][PubMed]
162. Yang, E.S.L.; Choi, M.J.; Kim, J.H.; Choi, K.S.; Kwon, T.K. Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chem. Biol. Interact. 2011, 190, 9–15. [CrossRef][PubMed]
163. Bhoslea, S.M.; Huilgola, N.G.; Mishra, K.P. Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid. Clin. Chim. Acta 2005, 359, 89–100. [CrossRef][PubMed]
164. Mansour, H.H.; Tawfik, S.S. Early treatment of radiation-induced heart damage in rats by caffeic acid phenethyl ester. Eur. J. Pharmacol. 2012, 692, 46–51. [CrossRef][PubMed]
165. Kim, I.G.; Kim, J.S.; Lee, J.H.; Cho, E.W. Genistein decreases cellular redox potential, partially suppresses cell growth in HL-60 leukemia cells and sensitizes cells to g-radiation-induced cell death. Mol. Med. Rep. 2014, 10, 2786–2792. [CrossRef][PubMed]
166. Puthli, A.; Tiwari, R.; Mishra, K.P. Biochanin A enhances the radiotoxicity in colon tumor cells in vitro. J. Environ. Pathol. Toxicol. Oncol. 2013, 32, 189–203. [CrossRef][PubMed]
167. Venier, N.A.; Colquhoun, A.J.; Sasaki, H.; Kiss, A.; Sugar, L.; Adomat, H.; Fleshner, N.E.; Klotz, L.H.; Venkateswaran, V. Capsaicin enhances the effect of radiation in prostate cancer through NF-kB suppression. Cancer Res. 2013. [CrossRef]
168. Tak, J.K.; Lee, J.H.; Park, J.W. Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep. 2012, 45, 242–246. [CrossRef][PubMed]
169. Jin, Y.; Lyu, Y.; Tang, X.; Zhang, Y.; Chen, J.; Zheng, D.; Liang, Y. Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo. Int. J. Radiat. Biol. 2015, 91, 202–208. [CrossRef][PubMed]
170. Wang, J.; Yu, M.; Xiao, L.; Xu, S.; Yi, Q.; Jin, W. Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro. Oncol. Rep. 2013, 30, 917–924. [PubMed]