Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro

Clinical Cancer Research

Volumn 2, Issue 5, 1996, Pages 843-846

  Zhang, Wei ^a   Anker, Lars ^a   Law, Ronald E ^a   Hinton, David R ^a   Gopalakrishna, Rayudu ^a   Pu, Qian ^a   Gundimeda, Usha ^a   Weiss, Martin H ^a   Couldwell, William T ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERICIN; PROTEIN KINASE INHIBITOR; TETRAZOLIUM;

ARTICLE; CLONOGENIC ASSAY; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIZATION;

GLIOMA; HUMANS; PERYLENE; PROTEIN KINASE C; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0030006904     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Mahaley, M. S., Jr., Mettlin, C., Natarajan, N., Laws, E. R., Jr., and Peace, B. B. National survey of patterns of care for brain-tumor patients. J. Neurosurg., 71: 826-836, 1989.
2. Daniel, K. Kurze Mitteilung über 12 jahrige therapeutische Erfahrungen mit Hypericin. Klin. Wochenschr., 29: 260-262, 1951.
3. Meruelo, D., Lavie, G., and Lavie, D. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc. Natl. Acad. Sci. USA., 85: 5230-5234, 1988.
4. Hudson, J. B., Lopez-Bazzocchi, I., and Towers, G. H. N. Antiviral activities of hypericin. Antiviral Res., 15: 101-112, 1991.
5. Treating AIDS with worts (News). Science (Washington DC), 254: 522, 1991.
6. Takahashi, I., Nakanishi, S., Kobayashi, E., Nakano, H., Suzuki, K., and Tamaoki, T. Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. Biochem. Biophys. Res. Commun., 165: 1207-1212, 1989.
7. Couldwell, W. T., Gopalakrishna, R , Hinton, D. R., He, S., Weiss, M. H., Apuzzo, M. L. J., and Law, R. E. Hypericin. A potential antiglioma therapy. Neurosurgery, 35: 705-710, 1994.
8. Anker, L., Gopalakrishna, R., Jones, K. D., Law, R. E., and Couldwell, W. T. Hypericin in adjuvant brain tumor therapy (Review). Drugs of the Future, 20: 511-517, 1995.
9. Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. Cancer Res., 47: 943-946, 1987.
10. Zhang, W., Yamada, H., Sakai, N., and Nozawa, Y. Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor. J. Neurooncol., 15: 1-7, 1993.
11. Couldwell, W. T., Antel, J. P., and Yong, V. W. Protein kinase C activity correlates with the growth rate of malignant gliomas. Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery, 31: 717-724, 1992.
12. Levin, A. L., Sheline, G. E., and Gutin, P. H. Neoplasms of the central nervous system. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.), Cancer Principles and Practice of Oncology, Ed. 3, Vol. 2., pp. 1557-1611. Philadelphia, PA: J. B. Lippincott Co., 1989.
13. Anderson, A. P. Post-operative irradiation of glioblastomas. Results in a randomised series. Acta Radiol., 17: 475-484, 1978.
14. Ramsay, J., Ward, R., and Bleehen, N. M. Radiosensitivity testing of human malignant gliomas. Int. J. Radiat. Oncol. Biol. Phys., 24: 675-680, 1992.
15. McIlwrath, A. J., Vasey, P. A., Ross, G. M., and Brown, R. Cell cycle arrest and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res, 54: 3718-3722, 1994.
16. Duran, N., and Song, P. S. Hypericin and its photodynamic action. Photochem. Photobiol., 43: 677-680, 1986.
17. Diwu, Z., and Lown, J. W. Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. Free Radical Biol. & Med., 14: 209-215, 1993.
18. Thomas, C., MacGill, R. S., Neill, P., and Pardini, R. S. The in vitro and in vivo photoinduced antineoplastic activity of hypericin. Proc. Am. Assoc. Cancer Res., 33: 500, 1992.
19. Kim, C. Y., Giaccia, A. J., Strulovici, B , and Brown, J. M. Differential expression of protein kinase C ε protein in lung cancer cell lines by ionising radiation. Br. J. Cancer, 66: 844-849, 1992.
20. Haimovitz-Friedman, A., Balaban, N., McLoughlin, M., Ehleiter, D., Michaeli, J., Vlodavsky, I , and Fuks, Z. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res., 54: 2591-2597, 1994.
21. Couldwell, W. T., Weiss, W. H., Weiner, L. P., DeGiorgio, C. M., Hinton, D. R., Ehresmann, G. R., Conti, P. S., and Apuzzo, M. L. J. Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high dose tamoxifen. Neurosurgery (Baltimore), 32: 485-490, 1993.