Caffeic acid phenylethyl ester and MG132, two novel nonconventional chemotherapeutic agents, induce apoptosis of human leukemic cells by disrupting mitochondrial function

Targeted Oncology

Volumn 9, Issue 1, 2014, Pages 25-42

  Cavaliere, Victoria ^a   Papademetrio, Daniela L ^a   Lombardo, Tomás ^b   Costantino, Susana N ^a   Blanco, Guillermo A ^b   Álvarez, Elida M C ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

Author keywords

Apoptosis; Caffeic acid phenylethyl ester (CAPE); Leukemia; MG132; Mitochondria

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAFFEIC ACID PHENYLETHYL ESTER; CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; DNA; DOXORUBICIN; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN; UNCLASSIFIED DRUG; VINCRISTINE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CAFFEIC ACID DERIVATIVE; CAFFEIC ACID PHENETHYL ESTER; LEUPEPTIN; NEW DRUG; PHENETHYL ALCOHOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CELL CYCLE G1 PHASE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOBLASTOID CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; ADOLESCENT; ADULT; ANALOGS AND DERIVATIVES; APOPTOSIS; CHILD; DRUG EFFECTS; FEMALE; LEUKEMIA; MALE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; TUMOR CELL CULTURE; YOUNG ADULT;

ADOLESCENT; ADULT; ANTINEOPLASTIC AGENTS; APOPTOSIS; CAFFEIC ACIDS; CHILD; CHILD, PRESCHOOL; DRUGS, INVESTIGATIONAL; FEMALE; HUMANS; LEUKEMIA; LEUPEPTINS; MALE; MIDDLE AGED; MITOCHONDRIA; PHENYLETHYL ALCOHOL; TUMOR CELLS, CULTURED; YOUNG ADULT;

EID: 84899558160     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-013-0256-y     Document Type: Article

References (44)

1. Li X, Gong J, Feldman E, Seiter K, Traganos F, Darzynkiewicz Z (1993) Apoptotic cell death during treatment of leukemias. Leukemia 7:659-670
2. Kaufmann SH, Earnshaw WC (2000) Induction of apoptosis by cancer chemotherapy. Exper Cell Res 256:42-49 (Pubitemid 30211165)
3. Friesen C, Lubatschofki A, Kotzerke J, Buchmann I, Reske SN, Debatin K (2003) Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells. Eur J Nucl Med Mol Im 30:1251-1261 (Pubitemid 37205379)
4. Taraphdar AK, Roy M, Bhattacharya RK (2001) Natural products as inducers of apoptosis: implications for cancer therapy and prevention. Curr Sci 80:1387-1396 (Pubitemid 33620231)
5. Milner AE, Palmer DH, Hodgkin EA, Eliopoulos AG, Knox PG, Poole CJ, Kerr DJ, Young LS (2002) Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells. Cell Death Differ 9:287-300 (Pubitemid 34223872)
6. Somervaille TC, Linch DC, Khwaja A (2001) Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax. Blood 98:1374-1381
7. Santiniab MT, Rainaldi G, Indovina PL (2000) Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids. Oncol Hemat 36:75-87
8. Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, Michaud M, Zischka H, Castedo M, Kroemer G (2010) Mitochondrial gateways to cancer. Mol Aspects Med 31:1-20
9. Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW (1994) Inhibition of HIV integrase by flavones, caffeic phenethyl acid and related compounds. Biochem Pharmacol 48:595-608 (Pubitemid 24257024)
10. Bankova V, Christov R, Kujumgiev A, Marcucci MC, Popov S (1995) Chemical composition and antibacterial activity of Brazilian propolis. Z Naturforsch [C] 50:167-172
11. Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E (2007) Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog 3:168-178
12. Orsolic N, Sver L, Terzic S, Tadic Z, Basic L (2003) Inhibitory effect of water-soluble derivatives of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: a possible mode of antitumor action. Nut Cancer 47:156-163 (Pubitemid 38590888)
13. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NFκB and activation of Fas in human breast cancer MCF -7 cells. J Biol Chem 279:6017-6026 (Pubitemid 38220634)
14. Mc Eleny K, Coffrey R, Morrissey C, Fitzapatrick JM, Watson WG (2004) Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins. BJU Int 94:402-406 (Pubitemid 39120188)
15. Xiang D, Wong D, He Y, Xie J, Zhong Z, Liz Z, Xie J (2006) Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the [beta]-catenin/T-cell factor signaling. Anti-Cancer Drugs 17:753-762 (Pubitemid 44310172)
16. Cavaliere V, Papademetrio D, Lorenzetti M, Valva P, Preciado MV, Larripa I, Monreal MB, Pardo ML, Hajos SE, Blanco G, Álvarez E (2009) CAPE and MG-132 have apoptotic and antiproliferative effects on leukemic cells but not on normal mononuclear cells. Trans Oncol 2:46-58
17. Ha J, Choi HS, Lee Y, Lee ZH, Kim HH (2009) Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF-κB and downregulating NFATc1 and c-Fos. Int Immunopharmacol 9:774-780
18. Yuan BZ, Chapman JA, Reynolds ST (2008) Proteasome Inhibitor MG132 induces apoptosis and inhibits invasion of human malignant pleural mesothelioma cells. Transl Oncol 1:129-140
19. Letoha T, Somlaia C, Taka'csb T, Szabolcsb A, Rakonczay ZJ, Ja'rmayb K, Szalontaic T, Vargad I, Kaszakie J, Borosf I, Dudaf E, Hacklerg L, Kuruczh I, Penkea B (2005) The proteasome inhibitor MG132 protects against acute pancreatitis. Free Radical Biol Med 39:1142-1151 (Pubitemid 41407709)
20. Ustundag Y, Bronk SF, Gores GJ (2007) Proteasome inhibitioninduces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells. World J Gastroenterol 13:851-857 (Pubitemid 46470294)
21. Xingming D, Fengqin G, Stratford May WG (2003) Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood 102:3179-3185
22. Alaniz L, García MG, Cabrera P, Arnaiz M, Cavaliere V, Blanco G, Álvarez E, Hajos S (2004)Modulation of matrix metalloproteinase-9 activity by hyaluronan is dependent on NF-κB activity in lymphoma cell lines with dissimilar invasive behavior. Biochem Biophys Res Commun 324:736-743 (Pubitemid 39359194)
23. Bustamante J, Caldas Lopes E, Garcia M, Di Libero E, Álvarez E, Hajos SE (2004) Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug resistant lymphoid leukemia. Toxicol Appl Pharmacol 199:44-51 (Pubitemid 39099454)
24. Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5:417-421
25. Naujokat C, Sezer O, Zinke H, Leclere A, Hauptmann S, Possinger K (2000) Proteasome inhibitors induce caspase-dependent apoptosis and accumulation of 21WAF1/Cip1 in human immature leukemic cells. Eur J Haematol 65:221 -236
26. Li W, Zhang X, Olumi AF (2007) MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res 67:2247-2252
27. Lin YH, Chiu JH, Tseng EWS, Wong TT, Chiou ESH, Yen ESH (2006) Antiproliferation and radiosensitization of caffeic acid phenethyl ester on human medulloblastoma cells. Cancer Chemother Pharmacol 57:525-532
28. Chen MJ, Chang WH, Lin CC, Liu CY, Wang TE, Chu CH, Shih SC, Chen YJ (2008) Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. Pancreatology 8:566-576
29. Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR (2000) The ubiquitin-proteasome pathway; regulates survivin degradation in a cell cycle-dependent manner. J Cell Sci 13:4363 -4371
30. Kirkland RA, Franklin JL (2001) Evidence for redox regulation of cytochrome C release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. Neurosci 21:1949-1963 (Pubitemid 32221379)
31. Estéve MA, Carré M, Braguer D (2007) Microtubules in apoptosis induction: are they necessary? Curr Cancer Drug Targets 7:713-729
32. Zanotto-Filho A, Delgado-Cañedo A, Schröder R, Becker M, Klamt, Moreira JC (2010) The pharmacological Nfkappa B inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. Cancer Lett 288:192-203
33. Emanuele S, Calvaruso G, Lauricella M, Giuliano M, Bellavia G, D'Anneo A, Vento R, Tesoriere G (2002) Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase 3. Int J Oncol 21:857-865
34. Bernardi P, Scorrano L, Colonna R, Petronilli N, Di Lisa F (1999) Mitochondria and cell death. Eur J Biochem 264:687-701
35. Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G (2006) Mechanisms of cytochrome c release from mitochondria. Cell Death and Differ 13:1423-1433 (Pubitemid 44210346)
36. Nagy K, Szekely-Szuts K, Izeradjene K, Douglas L, Tillman M, Barti-Juhasz H, Dominici M, Spano C, Luca CG, Conte P (2006) Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. Pathol Oncol Res 12:133-142 (Pubitemid 44719639)
37. MacFarlane M, Merrison W, Bratton SB, Cohen GM (2002) Proteasome mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 277:36611-36616
38. Adrain C, Creagh EM, Martin SJ (2001) Apoptosis -associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO 20:6627-6636 (Pubitemid 33134193)
39. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Carl Barrett J (1995) Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res 55:3576-3583
40. Kudugunti SK, Vad NM, Ekogbo E, Moridani MY (2009) Efficacy of caffeic acid phenethyl ester (CAPE) in skin B16-F0 melanoma tumor bearing C57BL/6 mice. Invest New Drugs 29:52-62
41. Han YH, Park WH (2010) MG-132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level. Hum Exp Toxicol 29:607-614
42. Shi R, Huang CC, Aronstam RS, Ercal N, Martin A, Huang YW (2009) N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes. BMP Pharmacol 9:7
43. Lombardo T, Cavaliere V, Costantino SN, Kornblihtt L, Alvarez EM, Blanco GA (2012) Synergism between arsenite and proteasome inhibitor MG132 over cell death in myeloid leukaemic cells U937 and the induction of low levels of intracellular superoxide anion. Toxicol Appl Pharmacol 258:351-366
44. Lombardo T, Anaya L, Kornblihtt L, Blanco G (2012) Median effect dose and combination index analysis of cytotoxic drugs using flow cytometry. Intech Open Publisher Rijeka, Croatia, pp 393-418