The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats

International Journal of Molecular Medicine

Volumn 34, Issue 1, 2014, Pages 92-102

  You, Hua ^a   Wei, Li ^b   Sun, Wan Liang ^a   Wang, Lei ^c   Yang, Zai Liang ^d   Liu, Yuan ^d   Zheng, Ke ^e   Wang, Ying ^f   Zhang, Wei Jing ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b Chongqing Key Laboratory of Birth Defects and Reproductive Health   (China)

^c WUHAN UNIVERSITY   (China)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

^e CHONGQING MEDICAL UNIVERSITY   (China)

^f CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Alveolar epithelial type II cell; Epigallocatechin 3 gallate; Irradiation pulmonary fibrosis; Nuclear transcription factor NF E2 related factor 2; Superoxide dismutase

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COBALT 60; COLLAGEN; DEXAMETHASONE; EPIGALLOCATECHIN GALLATE; HEME OXYGENASE 1; HYDROXYPROLINE; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE; SURFACTANT PROTEIN B; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; ACTIN; ANTIOXIDANT; CATECHIN; NFE2L2 PROTEIN, RAT; NQO1 PROTEIN, RAT; TEA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COBALT THERAPY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IRRADIATION; LIVER FIBROSIS; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; MORTALITY; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; GAMMA RADIATION; GENE EXPRESSION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; LUNG; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT; TEA;

ACTINS; ANIMALS; ANTIOXIDANTS; CATECHIN; DEXAMETHASONE; GAMMA RAYS; GENE EXPRESSION; HEME OXYGENASE-1; HYDROXYPROLINE; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-10; INTERLEUKIN-6; LUNG; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN B; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TEA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902649489     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1745     Document Type: Article

References (37)

1. Almeida C, Nagarajan D, Tian J, et al: The role of alveolar epithelium in radiation-induced lung injury. PLoS One 8: e53628, 2013.
2. Epperly MW, Guo H, Gretton JE and Greenberger JS: Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. Am J Respir Cell Mol Biol 29: 213-224, 2003. (Pubitemid 36936649)
3. Matsuo Y, Shibuya K, Nakamura M, et al: Dose-volume metrics associated with radiation pneumonitis after stereotactic body radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 83: e545-e549, 2012.
4. Minor GI, Yashar CM, Spanos WJ Jr, et al: The relationship of radiation pneumonitis to treated lung volume in breast conservation therapy. Breast J 12: 48-52, 2006. (Pubitemid 43381449)
5. Rosenzweig KE, Zauderer MG, Laser B, et al : Pleural intensity-modulated radiotherapy for malignant pleural meso thelioma. Int J Radiat Oncol Biol Phys 83: 1278-1283, 2012.
6. Liu HW, Seftel MD, Rubinger M, et al: Total body irradiation compared with BEAM: long-term outcomes of peripheral blood autologous stem cell transplantation for non-Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys 78: 513-520, 2010.
7. Zhang Y, Zhang X, Rabbani ZN, Jackson IL and Vujaskovic Z: Oxidative stress mediates radiation lung injury by inducing apoptosis. Int J Radiat Oncol Biol Phys 83: 740-748, 2012.
8. Mak JC: Potential role of green tea catechins in various disease therapies: progress and promise. Clin Exp Pharmacol Physiol 39: 265-273, 2012.
9. Li CP, Yao J, Tao ZF, Li XM, Jiang Q and Yan B: Epigallocatechin-gallate (EGCG) regulates autophagy in human retinal pigment epithelial cells: a potential role for reducing UVB light-induced retinal damage. Biochem Biophys Res Commun 438: 739-745, 2013.
10. Donà M, Dell'Aica I, Calabrese F, et al: Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. J Immunol 170: 4335-4341, 2003. (Pubitemid 36428203)
11. Sriram N, Kalayarasan S and Sudhandiran G: Epigallocatechin-3-gallate exhibits anti-fibrotic effect by attenuating bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in rat model pulmonary fibrosis. Chem Biol Interact 180: 271-280, 2009.
12. Sriram N, Kalayarasan S and Sudhandiran G: Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm Pharmacol Ther 22: 221-236, 2009.
13. Sriram N, Kalayarasan S and Sudhandiran G: Enhancement of antioxidant defense system by epigallocatechin-3-gallate during bleomycin induced experimental pulmonary fibrosis. Biol Pharm Bull 31: 1306-1311, 2008. (Pubitemid 351930637)
14. Tipoe GL, Leung TM, Liong EC, Lau TY, Fung ML and Nanji AA: Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology 273: 45-52, 2010.
15. de Vries HE, Witte M, Hondius D, et al: Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med 45: 1375-1383, 2008.
16. Zhang L, Dong XW, Wang JN, et al: PEP-1-CAT-transduced mesenchymal stem cells acquire an enhanced viability and promote ischemia-induced angiogenesis. PLoS One 7: e52537, 2012.
17. Zhang YE, Fu SZ, Li XQ, et al: PEP-1-SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats. Resuscitation 82: 1081-1086, 2011.
18. Szapiel SV, Elson NA, Fulmer JD, Hunninghake GW and Crystal RG: Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis 120: 893-899, 1979. (Pubitemid 10194957)
19. Williams JP, Johnston CJ and Finkelstein JN: Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets 11: 1386-1394, 2010.
20. Rizvi M, Pathak D, Freedman JE and Chakrabarti S: CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med 14: 530-538, 2008.
21. Mikkelsen RB and Wardman P: Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 22: 5734-5754, 2003. (Pubitemid 37176697)
22. Hügel HM and Jackson N: Redox chemistry of green tea polyphenols: therapeutic benefits in neurodegenerative diseases. Mini Rev Med Chem 12: 380-387, 2012.
23. Del Rio D, Stewart AJ and Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 15: 316-328, 2005. (Pubitemid 41190990)
24. Lefaix JL, Delanian S, Leplat JJ, et al: Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study. Int J Radiat Oncol Biol Phys 35: 305-312, 1996.
25. Vujaskovic Z, Batinic-Haberle I, Rabbani ZN, et al: A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med 33: 857-863, 2002. (Pubitemid 35232320)
26. Schaue D, Kachikwu EL and McBride WH: Cytokines in radiobiological responses: a review. Radiat Res 178: 505-523, 2012.
27. Martin M, Lefaix J and Delanian S: TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 47: 277-290, 2000. (Pubitemid 30236366)
28. Wang J, Qiao XY, Lu FH, et al: TGF-beta1 in serum and induced sputum for predicting radiation pneumonitis in patients with non-small cell lung cancer after radiotherapy. Chin J Cancer 29: 325-329, 2010.
29. Dong XR, Wang JN, Liu L, et al: Modulation of radiation-induced tumour necrosis factor- á and transforming growth factor â1 expression in the lung tissue by Shengqi Fuzheng injection. Mol Med Rep 3: 621-627, 2010.
30. Wynn TA: Integrating mechanisms of pulmonary fibrosis. J Exp Med 208: 1339-1350, 2011.
31. Denis M: Interleukin-6 in mouse hypersensitivity pneumonitis: changes in lung free cells following depletion of endogenous IL-6 or direct administration of IL-6. J Leukoc Biol 52: 197-201, 1992.
32. Zdanov A: Structural features of the interleukin-10 family of cytokines. Curr Pharm Des 10: 3873-3884, 2004.
33. Alhamad EH, Cal JG, Shakoor Z, Almogren A and Alboukai AA: Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis. BMC Med Genet 14: 66, 2013.
34. Barbarin V, Xing Z, Delos M, Lison D and Huaux F: Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am J Physiol Lung Cell Mol Physiol 288: L841-L848, 2005. (Pubitemid 40547909)
35. Bae HB, Li M, Kim JP, et al: The effect of epigallocatechin gallate on lipopolysaccharide-induced acute lung injury in a murine model. Inflammation 33: 82-91, 2010.
36. Sun Q, Zheng Y, Zhang X, et al: Novel immunoregulatory properties of EGCG on reducing inflammation in EAE. Front Biosci (Landmark Ed) 18: 332-342, 2013.
37. Sahin K, Tuzcu M, Gencoglu H, et al: Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Life Sci 87: 240-245, 2010.